6 terminated, 5 completed, 4 unknown, 3 recruiting. 18 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 18 | Terminated 6, Completed 5, Unknown 4, Recruiting 3 |
Follow Endocarditis: new trials by email Literature Review of Endocarditis trials Research Report on Endocarditis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Anemia Therapy in Patients With Infective Endocarditis Adjunctive anemia therapy - Infective Endocarditis (IE), Severe Anemia | Phase 4 | Recruiting | Copenhagen University Hospital, Rigshospitalet | 74 | 2026-05-15 | 2026-05-29 |
| Ampicillin and Ceftriaxone for the Treatment of Enterococcus Faecalis Infective Endocarditis. Ampicillin plus ceftriaxone in continuous infusion, Ampicillin plus ceftriaxone in intermittent infusion of 14 days, after which the treatment may be changed - Endocarditis, Infective | Phase 4 | Recruiting | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | 284 | 2024-10-09 | 2025-07-25 |
| An Oral Doxycycline Regimen to Prevent Bacteremia Following Dental Procedures Clindamycin, Doxycycline - Bacteremia, Endocarditis | Phase 4 | Unknown | University of Santiago de Compostela | 150 | 2024-07-15 | 2024-06-17 |
| Oral Antimicrobial Treatment vs. Outpatient Parenteral for Infective Endocarditis Cefaclor, Ciprofloxacin Tablets, Ciprofloxacin Injection - Endocarditis Infective | Phase 4 | Recruiting | Fundacion Clinic per a la Recerca Biomédica | 360 | 2022-08-17 | 2026-07-07 |
| Postoperative Antibiotic Management Duration Following Surgery for Intravenous Drug Abuse (IVDA) Endocarditis (OPTIMAL) Amoxycillin, Cefalexin, Dicloxacillin, Linezolid, Levofloxacin, Rifampicin, Ampicillin, Oxacillin, Vancomycin, Daptomycin, Ceftriaxone, Cefepime, Ceftaroline - Endocarditis | Phase 4 | Terminated | West Virginia University | 5 | 2022-03-16 | 2026-05-05 |
| Short-course Antibiotic Treatment in Gram-positive Cocci Infective Endocarditis Antibiotics - Endocarditis, Bacterial | Phase 4 | Terminated | Carmen Olmos Blanco | 20 | 2021-01-26 | 2023-09-28 |
| The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials 99mTc-Leukoscan® scintigraphy - Endocarditis | Phase 4 | Unknown | Hospices Civils de Lyon | 30 | 2017-06-14 | 2017-06-20 |
| An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Dental Procedures Amoxicillin, Amoxicillin-Potassium Clavulanate - Bacteraemia, Endocarditis | Phase 4 | Terminated | University of Santiago de Compostela | 40 | 2017-02-27 | 2022-05-24 |
| Pharmacokinetics/ Pharmacodynamics (PK/PD) Study of Vancomycin Vancomycin - Blood Stream Infections, Endocarditis | Phase 4 | Unknown | Zhejiang University | 100 | 2014-01-01 | 2015-05-13 |
| The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery sodium bicarbonate, Saline - Acute Kidney Injury | Phase 4 | Completed | Yonsei University | 70 | 2013-08-13 | 2018-07-17 |
| Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Vancomycin, Ceftaroline, Daptomycin - Health Care Associated Pneumonia, Osteomyelitis/Septic Arthritis | Phase 4 | Terminated | Henry Ford Health System | 100 | 2011-10-01 | 2023-05-03 |
| Partial Oral Treatment of Endocarditis Oral treatment with antibiotics for endocarditis, Guideline treatment with parenteral antibiotics - Endocarditis | Phase 4 | Completed | Copenhagen University Hospital, Rigshospitalet | 400 | 2011-07-01 | 2019-03-12 |
| Fosfomycin Plus Imipenem for Treatment of Infective Endocarditis Fosfomycin and imipenem, Vancomycin - Infective Endocarditis | Phase 4 | Completed | Juan A. Arnaiz | 50 | 2009-07-01 | 2018-03-08 |
| Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis (SAIE) daptomycin, daptomycin and gentamicin - Infective Endocarditis | Phase 4 | Terminated | Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 24 | 2009-02-13 | 2021-02-02 |
| Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections Detection of microbial DNA in blood by SeptiFast®, detection of microbial DNA in blood by blood culture - Febrile Neutropenia, Endocarditis | Phase 4 | Completed | Assistance Publique - Hôpitaux de Paris | 2000 | 2008-05-01 | 2011-12-29 |
| Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study (ENDOVAL) Cardiac surgery, State-to-the-art treatment - Infective Endocarditis | Phase 4 | Unknown | Instituto de Ciencias del Corazon | 216 | 2007-09-01 | 2008-02-26 |
| Early Surgery Versus Conventional Treatment in Infective Endocarditis Valve surgery with removal of vegetations - Endocarditis | Phase 4 | Completed | Asan Medical Center | 76 | 2006-09-01 | 2015-04-23 |
| Daptomycin as an Adjuvant Agent in the Treatment of Enterococcal Native Valve Endocarditis. Daptomycin - Endocarditis, Bacterial | Phase 4 | Terminated | Weill Medical College of Cornell University | 6 | 2006-09-01 | 2017-05-03 |
Bacteremia (3) · Endocarditis, Bacterial (2) · Acute Kidney Injury (1) · Anemia (1) · Arthritis, Infectious (1) · Endocarditis, Subacute Bacterial (1) · Febrile Neutropenia (1) · Gram-Positive Bacterial Infections (1) · Inflammation (1) · Osteomyelitis (1) · Sepsis (1) · Staphylococcal Infections (1) · Toxemia (1)
Cardiovascular Diseases (18) · Heart Diseases (18) · Infections (8) · Bacterial Infections (6) · Bacterial Infections and Mycoses (6) · Pathologic Processes (5) · Pathological Conditions, Signs and Symptoms (5) · Inflammation (4) · Systemic Inflammatory Response Syndrome (4) · Cardiovascular Infections (3) · Sepsis (3) · Hematologic Diseases (2) · Hemic and Lymphatic Diseases (2) · Agranulocytosis (1) · Arthritis (1)
Daptomycin (4) · Vancomycin (4) · Amoxicillin (3) · Linezolid (3) · Ampicillin (2) · Anti-Bacterial Agents (2) · Ceftaroline (2) · Ceftriaxone (2) · Clindamycin (2) · Dicloxacillin (2) · Injections (2) · Levofloxacin (2) · Amoxicillin-Potassium Clavulanate Combination (1) · Cardiac Surgical Procedures (1) · Cefaclor (1)
Copenhagen University Hospital, Rigshospitalet (2) · University of Santiago de Compostela (2) · Asan Medical Center (1) · Assistance Publique - Hôpitaux de Paris (1) · Carmen Olmos Blanco (1) · Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (1) · Fundacion Clinic per a la Recerca Biomédica (1) · Fundación Pública Andaluza para la gestión de la Investigación en Sevilla (1) · Henry Ford Health System (1) · Hospices Civils de Lyon (1) · Instituto de Ciencias del Corazon (1) · Juan A. Arnaiz (1) · Weill Medical College of Cornell University (1) · West Virginia University (1) · Yonsei University (1)
Spain (7) · United States (4) · Denmark (2) · France (2) · South Korea (2) · China (1)
Duk-Hyun Kang, MD, PhD (1) · Henning Bundgaard, Professor, Dr. med (1) · Jose Vazquez, M.D. (1) · Kyu Y Rhee, MD, PhD (1) · Mia Marie Pries-Heje, MD, PhD (1) · Paula Bokesch, M.D. (1) · Pedro Diz Dios (1) · Pedro Diz, MD, DDS, PhD (1) · Vinay Badhwar, MD (1)
PMID 15509186, PMID 16940094, PMID 18477269, PMID 18760122, PMID 20636419, PMID 20701619, PMID 22738096, PMID 23351813, PMID 25048851, PMID 27029851, PMID 27826345, PMID 28057030, PMID 28374097, PMID 30152252, PMID 32029130, PMID 32546269, PMID 33413809, PMID 33560404, PMID 35349038, PMID 40024946