22 completed, 6 recruiting, 6 unknown, 5 terminated. 48 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 48 | Completed 22, Recruiting 6, Unknown 6, Terminated 5, Not yet recruiting 4, Withdrawn 4, Active not recruiting 1 |
Follow Dyssomnias: new trials by email Literature Review of Dyssomnias trials Research Report on Dyssomnias
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Kava Aging and Mobility Study AB-free kava, Placebo - Old Adults, Sleep Quality | Early Phase 1 | Not yet recruiting | University of Florida | 40 | 2026-12-01 | 2026-08-31 |
| Qing-Xin-Jiao-Tai Decoction for Insomnia Comorbid With Obesity Presenting With Heart-Kidney Non-interaction Syndrome Qingxin Jiaotai Decoction, Placebo - Insomnia, Obesity | Early Phase 1 | Not yet recruiting | Fohow Pharmaceutical Group | 72 | 2026-10-01 | 2026-08-10 |
| Impacts of Opioids on Respiratory Drive During Sleep Morphine p.o., Placebo - Opioids, Obstructive Sleep Apnea (OSA) | Early Phase 1 | Not yet recruiting | Brigham and Women's Hospital | 26 | 2026-07-01 | 2026-01-29 |
| CBTi for the Treatment of Insomnia in Type 1 Diabetes Sleep quality improvement therapy, Healthy Living - Diabetes Mellitus Type 1, Insomnia | Early Phase 1 | Recruiting | University of Illinois at Chicago | 15 | 2025-12-01 | 2026-10-06 |
| A Novel Inhaled Formulation of Melatonin to Treat Adults With Insomnia: Pharmacokinetic Study Inhaled Melatonin (100 μg), Oral Melatonin (4 mg) - Insomnia | Early Phase 1 | Unknown | Woolcock Institute of Medical Research | 5 | 2025-07-01 | 2025-07-18 |
| A Novel Inhaled Formulation of Melatonin to Treat Adults With Insomnia: Efficacy Study Inhaled Melatonin (100 μg), Oral Melatonin (4 mg) - Insomnia | Early Phase 1 | Recruiting | Woolcock Institute of Medical Research | 10 | 2025-07-01 | 2025-07-18 |
| Effects of Intranasal Ketamine on Depression and Anxiety in Palliative Care Cancer Patients Intranasal ketamine hydrochloride - Depressive Symptoms Mild to Moderate in Severity, Anxiety | Early Phase 1 | Not yet recruiting | University of Zurich | 100 | 2025-04-01 | 2025-05-01 |
| Assessment of OSA in Latin American and Response to Neuromod Therapy Drug Induced Sleep Endoscopy with PNS - Obstructive Sleep Apnea | Early Phase 1 | Recruiting | Lunair Medical | 50 | 2024-11-21 | 2025-09-03 |
| Cognitive Behavioral Therapy and Trazodone Effects on Sleep and Blood Pressure in Insomnia Cognitive Behavioral Treatment for Insomnia (CBT-I), Trazodone, Placebo - Insomnia, Insomnia Chronic | Early Phase 1 | Recruiting | Milton S. Hershey Medical Center | 600 | 2024-03-20 | 2025-11-10 |
| Time Restricted Eating in Sleep Apnea Time restricted eating - Time Restricted Eating, Obstructive Sleep Apnea | Early Phase 1 | Recruiting | University of California, San Diego | 80 | 2024-01-05 | 2024-01-16 |
| Social Determinants of Sleep and Obesity Sleep intervention, Contact Control - Insufficient Sleep, Physical Inactivity | Early Phase 1 | Completed | University of Minnesota | 80 | 2023-11-01 | 2026-07-14 |
| Improving 24-hour Blood Pressure in Obstructive Sleep Apnea Continuous Positive Airway Pressure CPAP, Telmisartan 80mg, Alpha-Lipoic Acid 600mg - Obstructive Sleep Apnea | Early Phase 1 | Withdrawn | University of British Columbia | 2023-05-01 | 2023-05-19 | |
| Investigating the Efficacy of Sleepgift Blanket on Sleep Quality and Heart Health Active sleepgift blanket, Sham Sleepgift Blanket - Sleep | Early Phase 1 | Completed | University of Manitoba | 31 | 2023-01-01 | 2025-04-03 |
| Effect of Melatonin on Sleep Patterns of Resident Trainees During Night Float Shift Melatonin, Placebo - Sleep Disorders, Circadian Rhythm | Early Phase 1 | Recruiting | University of Virginia | 50 | 2022-05-30 | 2026-05-04 |
| New Perspective on Exploring the Post-apneic BP Surge in Patients With OSA Phentolamine Injection - Obstructive Sleep Apnea | Early Phase 1 | Unknown | Xu J | 350 | 2022-04-01 | 2023-12-15 |
| Feasibility of a Personalized SMS Intervention for Insomnia SMS Personalized Sleep Intervention - Insomnia, Sleep Disorder | Early Phase 1 | Unknown | University of Missouri, St. Louis | 50 | 2021-11-15 | 2022-04-25 |
| Obstructive Sleep Apnea and Arousal Threshold in Patients With Post-traumatic Stress Disorder Trazodone, Placebo, Epiglottic catheter - Sleep Apnea, Obstructive; Post-Traumatic Stress Disorders | Early Phase 1 | Withdrawn | University of California, San Diego | 2021-10-01 | 2019-07-10 | |
| Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders HP 3He, HP 129Xe, PFP - Lung Transplant, Lung Resection | Early Phase 1 | Terminated | Thunder Bay Regional Health Research Institute | 10 | 2020-11-10 | 2024-10-15 |
| Evaluatation of Appscent Device Safety and Effectiveness for Relief of Obstructive Sleep Apnea (OSA) Syndrome in Adults. Appscent Device - Obstructive Sleep Apnea | Early Phase 1 | Completed | Y.A. Appscent Ltd. | 23 | 2020-10-15 | 2023-01-04 |
| Evaluation of the Efficacy of Sodium Oxybate (Xyrem®) in Treatment of Post-traumatic Narcolepsy and Post-traumatic Hypersomnia Sodium Oxybate Oral Solution [Xyrem] - Hypersomnia, Narcolepsy | Early Phase 1 | Withdrawn | Brigham and Women's Hospital | 2020-09-01 | 2021-03-04 |
Showing 20 of 48. Sign in to see all of them.
Sleep Apnea, Obstructive (19) · Sleep Initiation and Maintenance Disorders (18) · Sleep Apnea Syndromes (7) · Anxiety Disorders (4) · Depression (4) · Motor Activity (4) · Sleep Wake Disorders (4) · Obesity (3) · Sleep Deprivation (3) · Disorders of Excessive Somnolence (2) · Hypertension (2) · Inflammation (2) · Occupational Stress (2) · Pain (2) · Parkinson Disease (2)
Nervous System Diseases (48) · Sleep Disorders, Intrinsic (44) · Sleep Wake Disorders (44) · Respiratory Tract Diseases (26) · Apnea (25) · Respiration Disorders (25) · Mental Disorders (24) · Sleep Apnea Syndromes (18) · Pathological Conditions, Signs and Symptoms (16) · Signs and Symptoms (15) · Neurologic Manifestations (10) · Behavior (9) · Behavioral Symptoms (5) · Nutritional and Metabolic Diseases (5)
Continuous Positive Airway Pressure (4) · Melatonin (4) · Exercise (2) · Trazodone (2) · 4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene (1) · Anti-Inflammatory Agents, Non-Steroidal (1) · Aspirin (1) · Bosentan (1) · Carvedilol (1) · Doxepin (1) · Eszopiclone (1) · Fentanyl (1) · Hydromorphone (1) · Masks (1) · Nitroglycerin (1)
Brigham and Women's Hospital (4) · Washington University School of Medicine (3) · University of California, San Diego (2) · Woolcock Institute of Medical Research (2) · AGIR à Dom (1) · Beth Israel Deaconess Medical Center (1) · Boston University (1) · Fohow Pharmaceutical Group (1) · George Washington University (1) · Gitte Moos Knudsen (1) · Glenn Green (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Lunair Medical (1) · McGill University Health Centre/Research Institute of the McGill University Health Centre (1) · Milton S. Hershey Medical Center (1)
United States (28) · Canada (5) · Australia (2) · China (2) · France (2) · Israel (2) · Brazil (1) · Denmark (1) · Paraguay (1) · Switzerland (1) · United Kingdom (1)
Hui Xin Ong, PhD (2) · Ron Grunstein, MBBS MD PhD FRACP (2) · Alexandros Vgontzas, MD (1) · Anshuman Sharma, MD (1) · Ari Derowe, prof (1) · Atul Malhotra, MD (1) · Chelsey R Wilks, PhD (1) · Danny J Eckert, PhD (1) · Dardo G Tomasi, Ph.D. (1) · Dawson Church, PhD (1) · Evan Kharasch, MD, PhD (1) · Glenn E Green, MD (1) · Ivan Wu (1) · Jacqueline K Limberg, Ph.D. (1) · Jason H Mateika, PhD MS BS (1)
PMID 20057899, PMID 20562120, PMID 20974339, PMID 21269278, PMID 21539679, PMID 22926176, PMID 23139361, PMID 23587570, PMID 25182079, PMID 32627860, PMID 32665041, PMID 35584850, PMID 35762891, PMID 37945413, PMID 39837697, PMID 41264592, PMID 42312422
1UG3HL161342-01A1 (1), K99HL130339 (1), P01HL095491 (1), P30CA042014 (1), R00HL130339 (1), RC2AG036592 (1), UL1TR002345 (1)