14 completed, 6 recruiting, 6 unknown, 2 not yet recruiting. 13 Not applicable, 4 Phase 2, 3 Phase 1, 1 Early Phase 1.
Follow Dysautonomia: new trials by email Literature Review of Dysautonomia trials Research Report on Dysautonomia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Guanfacine and Cromolyn Sodium for POTS: The DBPOTS Trial Guanfacine (GFC), Cromolyn Sodium, Placebo - Postural Orthostatic Tachycardia Syndrome (POTS), Dysautonomia | Early Phase 1 | Not yet recruiting | Johns Hopkins University | 25 | 2026-11-15 | 2026-10-09 |
| Non-invasive Vagus Nerve Stimulation for Chronic Musculoskeletal Pain Active Vagus Nerve Stimulation, Subtherapeutic Stimulation (Sham Control) - Chronic Musculoskeletal Pain, Autonomic Dysfunction | Not applicable | Not yet recruiting | University of Leeds | 12 | 2026-05-14 | 2026-05-11 |
| Neuro-Emotional Release: Veins and Endocrine System (NERVE) Therapy for Children With Dysautonomia Dysautonomia, Dysautonomia Like Disorder | Completed | Life University | 25 | 2026-03-14 | 2026-08-19 | |
| Screening for Alterations in the Autonomic Nervous System Progressive standing test - Dysautonomia, ACCUVEIN | Not applicable | Completed | University Hospital, Angers | 12 | 2025-11-21 | 2025-12-24 |
| Autonomic Reactivity and Personalized Neurostimulation Percutaneous electrical nerve field stimulation, Hypnotherapy - Functional Gastrointestinal Disorders (FGIDs), Cyclic Vomiting Syndrome | Not applicable | Recruiting | Medical College of Wisconsin | 120 | 2025-01-24 | 2026-02-13 |
| Diagnostic Accuracy of The Water Immersion Wrinkle Test for Small Fiber Neuropathy Small-Fiber Neuropathy, Dysautonomia | Completed | HOSPITAL BRITANICO DE BUENOS AIRES | 38 | 2024-11-01 | 2025-12-08 | |
| Data Collection of Standard Care of Patients in the EMG Section Neuropathy, Muscle Disorders | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 200 | 2024-06-24 | 2026-09-14 | |
| Effects of Osteopathic Technique on Autonomic Nervous System Activity CV4 + RR, CV4, sham ultrasound transducer - Healthy, Dysautonomia | Not applicable | Unknown | SomaticMed | 109 | 2024-06-20 | 2024-08-16 |
| Personalized Brain Stimulation to Treat Chronic Concussive Symptoms Active cTBS, Inactive/Sham cTBS, Imaginal exposure - Post-Concussion Syndrome, Concussion, Brain | Phase 2 | Recruiting | University of California, Los Angeles | 75 | 2024-03-06 | 2026-02-24 |
| Pathophysiology of Dysautonomia and Postural Tachycardia Syndrome (POTS) in Post-viral Syndromes and COVID-19 Blood Sample Collection - POTS, POTS - Postural Orthostatic Tachycardia Syndrome | Not applicable | Active not recruiting | Brigham and Women's Hospital | 100 | 2024-02-02 | 2026-02-12 |
| The Long COVID-19 Wearable Device Study Wearable device - Long COVID, Postural Orthostatic Tachycardia Syndrome | Not applicable | Recruiting | Scripps Translational Science Institute | 100500 | 2023-11-16 | 2025-05-11 |
| Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research Post-Acute COVID-19 Syndrome, ME/CFS | Recruiting | Brain Inflammation Collaborative | 10000 | 2023-07-05 | 2026-01-22 | |
| Physiotherapy for Persistent Function by Superficial Neuromodulation Neuromodulation NESA NXSIGNAL® device - Post-Acute COVID-19 Syndrome, Dysautonomia | Not applicable | Unknown | Universidad Rey Juan Carlos | 24 | 2023-06-15 | 2023-06-06 |
| Mindfulness in Post Acute Sequelae of SARS-CoV-2 Infection (PASC) Dysautonomia Mindfulness - Mindful Awareness Practices ( MAPs) - Long COVID, Dysautonomia | Not applicable | Completed | University of California, Los Angeles | 20 | 2023-02-28 | 2024-06-14 |
| Post Covid-19 Dysautonomia Rehabilitation Randomized Controlled Trial Rehabilitation, Standard of Care - Post-Acute COVID-19 Syndrome, Dysautonomia | Not applicable | Unknown | Evangelismos Hospital | 50 | 2023-02-01 | 2023-05-11 |
| Dual Sympathetic Blocks for Patients Experiencing Sympathetically-Mediated Symptoms From Long COVID stellate ganglion block with 0.5% bupivacaine - Post Acute COVID-19 Syndrome, Long COVID | Phase 1 | Completed | Jonathann Kuo, MD | 20 | 2023-01-03 | 2025-03-13 |
| VNS for Long-COVID-19 Non-invasive vagus nerve stimulation, Sham Intervention - Post-COVID-19 Syndrome, Postural Tachycardia Syndrome | Not applicable | Completed | Icahn School of Medicine at Mount Sinai | 40 | 2022-11-11 | 2024-11-08 |
| Stellate Ganglion Block to Treat Long COVID 19 Case Series Stellate Ganglion Block - Long COVID, Long Covid19 | Completed | Metamorphosis LTD | 41 | 2022-09-01 | 2023-04-13 | |
| Blood Pressure Effects on Cognition and Brain Blood Flow in PD Tilt table (upright position) - Parkinson Disease, Orthostatic Hypotension | Not applicable | Recruiting | University of California, San Diego | 60 | 2021-12-14 | 2026-08-07 |
| Dysautonomic Phenotype in Male Patients With MECP2 Mutation non interventional study - MECP2-Related Severe Neonatal Encephalopathy, Dysautonomia | Unknown | University Hospital, Brest | 20 | 2020-08-15 | 2020-08-06 |
Showing 20 of 31. Sign in to see all of them.
Autonomic Nervous System Diseases (31) · Postural Orthostatic Tachycardia Syndrome (9) · Post-Acute COVID-19 Syndrome (8) · Brain Injuries, Traumatic (4) · Primary Dysautonomias (4) · Anxiety Disorders (3) · Depression (3) · Ehlers-Danlos Syndrome (3) · Fatigue Syndrome, Chronic (3) · Mental Fatigue (3) · Brain Injuries (2) · Cognitive Dysfunction (2) · Dizziness (2) · Dysautonomia like disorder (2) · Encephalitis (2)
Nervous System Diseases (31) · Pathological Conditions, Signs and Symptoms (13) · Pathologic Processes (10) · Chronic Disease (9) · Disease Attributes (9) · Orthostatic Intolerance (9) · Primary Dysautonomias (9) · Coronaviridae Infections (8) · Coronavirus Infections (8) · Infections (8) · Lung Diseases (8) · Nidovirales Infections (8) · Pneumonia (8) · Pneumonia, Viral (8) · Post-Infectious Disorders (8)
Baclofen (1) · Bupivacaine (1) · Cromolyn Sodium (1) · Electroencephalography (1) · Guanfacine (1) · Hypnosis (1) · Implosive Therapy (1) · Pharmaceutical Preparations (1) · Propranolol (1) · Pyridostigmine Bromide (1) · Rehabilitation (1) · Standard of Care (1) · Vagus Nerve Stimulation (1) · Wearable Electronic Devices (1) · esmolol (1)
Johns Hopkins University (3) · Brigham and Women's Hospital (2) · University of California, Los Angeles (2) · Brain Inflammation Collaborative (1) · Evangelismos Hospital (1) · Genetic Disease Investigators (1) · HOSPITAL BRITANICO DE BUENOS AIRES (1) · Icahn School of Medicine at Mount Sinai (1) · Instituto Nacional de Cardiologia Ignacio Chavez (1) · Jonathann Kuo, MD (1) · Karolinska University Hospital (1) · Life University (1) · Medical College of Wisconsin (1) · Metamorphosis LTD (1) · National Institute of Dental and Craniofacial Research (NIDCR) (1)
United States (19) · France (3) · Argentina (1) · Germany (1) · Greece (1) · Mexico (1) · Pakistan (1) · Poland (1) · Spain (1) · Sweden (1) · United Kingdom (1)
Andrea Maier, Dr. (1) · Christos Georgiades, MD, PhD (1) · Darren C Greenwood, PhD (1) · David Putrino, PT, PhD (1) · David Systrom, MD (1) · David W Nelson, M.D., Ph.D. (1) · Debra Diz, M.D. (1) · Diana L Driscoll, O.D. (1) · Emmanuel Cuny, Professor (1) · Jeffrey J. Hsu, MD, PhD (1) · Jessica Malmberg, PhD (1) · Jonathann Kuo, MD (1) · Katja Karrento, MD (1) · Lisa Pearson, DNAP (1) · Lucas A Piedrafita Vico, MD (1)
PMID 25622919, PMID 33634830, PMID 34606665, PMID 35526605, PMID 35816681, PMID 37261636
R01DK140255 (1)