133 completed, 37 unknown, 32 recruiting, 29 not yet recruiting. 174 Not applicable, 14 Phase 2, 4 Phase 4, 3 Early Phase 1, 2 Phase 1.
Follow Mental Fatigue: new trials by email Literature Review of Mental Fatigue trials Research Report on Mental Fatigue
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sildenafil to Prevent and Reduce Cancer Related Cognitive Impairment Sildenafil - Cancer | Phase 2 / Phase 3 | Not yet recruiting | The University of Texas Medical Branch, Galveston | 30 | 2027-06-15 | 2026-05-11 |
| Predicting Declines in Attention and Memory During a Prolonged Mental Task Individually Calibrated Time Load Dual-back Task With Seated Rest - Mental Fatigue, Cognitive Performance | Not applicable | Not yet recruiting | DSW Ideis University | 250 | 2026-12-01 | 2026-10-16 |
| Guanfacine and Cromolyn Sodium for POTS: The DBPOTS Trial Guanfacine (GFC), Cromolyn Sodium, Placebo - Postural Orthostatic Tachycardia Syndrome (POTS), Dysautonomia | Early Phase 1 | Not yet recruiting | Johns Hopkins University | 25 | 2026-11-15 | 2026-10-09 |
| COG+OT Telerehabilitation for Adults With Subjective Cognitive Complaints COG+OT Telerehabilitation - Subjective Cognitive Complaints, Ehlers-Danlos Syndrome | Not applicable | Not yet recruiting | Medical University of South Carolina | 16 | 2026-11-01 | 2026-11-04 |
| Effects of a Mobile Game in Menopausal Women Menopause Mobile Game - Menopause, Brain Fog | Not applicable | Not yet recruiting | Medipol University | 82 | 2026-10-15 | 2026-09-17 |
| PATH to Reducing Burnout Among Peers Who Deliver Overdose Prevention Services (R33 Phase Clinical Trial) PATH (Peer Advanced Training for total Health) - Burnout, Secondary Trauma | Not applicable | Enrolling by invitation | Chestnut Health Systems | 200 | 2026-10-12 | 2026-10-27 |
| The Effect of Web-Based Compassion-Focused Structured Writing Programs on Well-Being in Midwives Working in Delivery Rooms Compassion-Focused Writing Program, Reflective Writing Program - Psychological Well-being, Secondary Traumatic Stress | Not applicable | Not yet recruiting | Mersin University | 90 | 2026-10-01 | 2026-07-14 |
| Trauma-Informed Education and Self-Care for Social Work Students During Field Practicum Trauma-Informed Education and Self-Care Psychoeducational Workshop, Self-Help and Peer-Sharing Group Sessions - Secondary Traumatic Stress | Not applicable | Not yet recruiting | Manisa Celal Bayar University | 80 | 2026-09-25 | 2026-10-01 |
| Acute Mental Fatigue and Muscle Strength Computer-Based Mental Fatigue Protocol - Mental Fatigue, Muscle Strength Dynamometer | Not applicable | Recruiting | Florida Institute for Human and Machine Cognition | 50 | 2026-09-23 | 2026-09-29 |
| Transcranial Direct Current Stimulation for Long COVID Brain Fog and Fatigue Transcranial Direct Current Stimulation - Long COVID, Post-COVID Conditions | Not applicable | Not yet recruiting | University of Las Palmas de Gran Canaria | 20 | 2026-09-15 | 2026-07-22 |
| TCP-600 Supplementation and Performance Response in Professional Football Players Placebo, Taurine, Caffeine - Athletic Performance, Cognitive Fatigue | Not applicable | Completed | Vizja University in Warsaw | 65 | 2026-09-07 | 2026-11-04 |
| A Study to Evaluate the Effects of a Beef Liver Supplement on Energy, Mood, and Mental Clarity Intervention, Placebo - Fatigue, Low Mood | Not applicable | Active not recruiting | Ancestral Supplements, LLC | 100 | 2026-09-01 | 2026-10-23 |
| Single Arm, Monocentric, Pilot Feasibility Study on an Interactive Virtual Reality Program in 20 Complex In-clinic Palliative Care Patients ZenctuaryVR+ Interactive Virtual Reality - Palliative Care, Refractory Pain | Not applicable | Not yet recruiting | University Hospital, Strasbourg, France | 20 | 2026-09-01 | 2026-04-22 |
| Effects of Cognitive Fatigue on Gait Mental fatigue - Mental Fatigue | Not applicable | Not yet recruiting | State University of New York at Buffalo | 30 | 2026-09-01 | 2026-07-17 |
| The Effect of Laughter Yoga on Individual and Organizational Outcomes in Nurse Managers Laughter Yoga Program - Burnout, Professional, Stress, Psychological | Not applicable | Not yet recruiting | Zonguldak Bulent Ecevit University | 80 | 2026-09-01 | 2026-09-21 |
| Mental Fatigue, Attentional Focus, and Countermovement Jump Performance Mental-Fatigue Protocol (Stroop Task), Control Protocol (Nature Video), No Prescribed Focus Instruction - Mental Fatigue, Athletic Performance | Not applicable | Not yet recruiting | Inonu University | 32 | 2026-09-01 | 2026-08-21 |
| Effects of Caffeine on Chess Performance and Cognitive Function in Professional Chess Players Caffeinated Coffee, Decaffeinated Coffee Placebo - Cognitive Performance, Attention | Not applicable | Recruiting | St. Louis University | 12 | 2026-08-25 | 2026-09-30 |
| Phosphatidylserine, Taurine, and Caffeine for Cognitive Fatigue in Professional Football Players Placebo, Taurine Plus Caffeine, Taurine, Caffeine, and Phosphatidylserine - Mental Fatigue, Cognitive Performance | Not applicable | Completed | Vizja University in Warsaw | 65 | 2026-08-06 | 2026-09-14 |
| Virtual Reality - Gamma Sensory Stimulation for Improving Fatigue in People With Multiple Sclerosis Virtual Reality Gamma Sensory Stimulation, Virtual Reality Sham Sensory Stimulation - Multiple Sclerosis | Not applicable | Recruiting | Clarity Health Technologies, Inc | 30 | 2026-08-03 | 2026-10-22 |
| The Effect of Brain Endurance Training on Motor Skill Learning in Adolescents With Mild Mental Fatigue Motor Skill Learning - Mental Fatigue, Motor Skill Learning | Not applicable | Not yet recruiting | Yunliang Zhang | 58 | 2026-08-02 | 2026-08-05 |
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Compassion Fatigue (57) · Fatigue (40) · Post-Acute COVID-19 Syndrome (26) · Burnout, Psychological (24) · Cognitive Dysfunction (21) · Alert Fatigue, Health Personnel (19) · Anxiety Disorders (19) · COVID-19 (18) · Depression (14) · Stress, Psychological (13) · Occupational Stress (12) · Psychological Well-Being (10) · Burnout, Professional (8) · Fatigue Syndrome, Chronic (8)
Behavior (251) · Pathological Conditions, Signs and Symptoms (251) · Signs and Symptoms (251) · Behavioral Symptoms (250) · Fatigue (211) · Mental Disorders (56) · Stress, Psychological (55) · Occupational Stress (46) · Pathologic Processes (46) · Respiratory Tract Diseases (39) · Infections (38) · Nervous System Diseases (38) · Disease Attributes (37) · Lung Diseases (37)
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2016 (1), R33DA061340 (1), U54MD013368 (1)