24 completed, 9 recruiting, 7 unknown, 2 terminated. 31 Not applicable, 6 Phase 2, 5 Phase 1, 3 Phase 4, 1 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of a Personalized, Response-based Transdiagnostic Intervention for Emotional Disorders Delivered Via the Internet: A Protocol for an Adaptive Randomized Controlled Trial UJI Online Transdiagnostic Protocol, UJI On Line Transdiagnostic Hibrid Protocol - Emotional Disorders, Anxiety | Not applicable | Not yet recruiting | Universitat Jaume I | 366 | 2027-05-01 | 2026-05-27 |
| Maternal Mindfulness: Depression and Postpartum Pain Mindfulness - Depression, Unipolar, Pain, Postoperative | Not applicable | Recruiting | University of Illinois at Urbana-Champaign | 75 | 2025-12-01 | 2026-08-06 |
| Adjunctive Bright Light Therapy in Adolescents With Depression and Eveningness Bright light therapy, Dim red light - Depression, Unipolar | Not applicable | Recruiting | Chinese University of Hong Kong | 90 | 2025-11-01 | 2026-03-19 |
| Development and Evaluation of a Digital Aftercare Program for Adolescents (12-17 Years) With Depressive Symptoms After Hospital Discharge (Mind-WIN Pilot Study) (Mind-WIN Pilot) Mind-WIN self-help only, Mind-WIN blended care - Depressive Disorder, Depression, Unipolar | Not applicable | Enrolling by invitation | Universitätsklinikum Hamburg-Eppendorf | 120 | 2025-05-13 | 2025-06-29 |
| Repeated Neurocognitive Measurements in Depressed Patients Intravenous Ketamine - Depression, Unipolar | Phase 1 / Phase 2 | Withdrawn | Jay Fournier | 2025-05-01 | 2026-02-25 | |
| Psychotherapy Feasibility Pilot of the Carolina Recovery From Depression Protocol Single Session Psychotherapy Intervention - Depression, Unipolar | Not applicable | Completed | University of North Carolina, Chapel Hill | 10 | 2025-03-03 | 2025-06-04 |
| Pilot Study: Investigating Mood Changes After Slow-wave Enhancement Slow-wave enhancement, Sham device - Depressive Disorder, Major, Depression | Not applicable | Withdrawn | University of Pennsylvania | 2025-01-01 | 2025-02-03 | |
| Natural History of Depression, Bipolar Disorder and Suicide Risk Behavioral Symptoms, Suicide | Recruiting | National Institute of Mental Health (NIMH) | 500 | 2024-09-09 | 2026-10-01 | |
| The Cerebral and Cognitive Changes After Intermittent Theta Burst Stimulation (iTBS) Treatment for Depression Intermittent Theta Burst Stimulation - Depression, Unipolar, Depression Moderate | Not applicable | Recruiting | University Hospital of North Norway | 50 | 2024-02-12 | 2024-08-02 |
| BioClock: Bright Light Therapy for Depressive Disorders Bright Light Therapy, Blue Light Blocking Glasses - Depression, Unipolar, Depression, Bipolar | Not applicable | Recruiting | Universiteit Leiden | 231 | 2024-02-08 | 2025-01-09 |
| Intermittent Theta-burst Stimulation for Major Depression: an Intensity-response Study intermittent theta-burst stimulation (iTBS) - Depression, Unipolar | Not applicable | Recruiting | The Hong Kong Polytechnic University | 246 | 2024-01-08 | 2025-03-14 |
| CRISOL Mente: A Multilevel Community Intervention to Reduce Mental Health Disparities Among Latinos Outreach/navigator, Auxiliary to care, Stepped care and task shifting - Depression, Unipolar, Anxiety Disorders | Not applicable | Active not recruiting | Drexel University | 603 | 2023-11-10 | 2026-04-15 |
| Effects of CBT and BLT in Youth With Unipolar Depression and Evening Chronotype Cognitive Behavioural Therapy for Depression, Bright Light Therapy - Depression, Unipolar, Eveningness | Not applicable | Recruiting | The University of Hong Kong | 162 | 2023-10-31 | 2024-04-22 |
| Safety, Tolerability and Antidepressant Effects of DMT in Patients With Depression N,N-Dimethyltryptamine - Depressive Disorder, Depression, Unipolar | Phase 2 | Completed | Universidade Federal do Rio Grande do Norte | 14 | 2023-10-09 | 2024-05-08 |
| Lifestyle InterVEntion Study in General Practice: LIVES - GP GLI-LEEF - Depression, Unipolar, Cardiovascular Diseases | Not applicable | Unknown | University Medical Center Groningen | 50 | 2023-08-01 | 2024-03-04 |
| Psychiatric Orders in Psychoanalytic Treatment of ASD Psychoanalysis, sertraline 50mg, Duloxetine 20 MG - PTSD, Autism Spectrum Disorder High-Functioning | Unknown | Yang I. Pachankis, PhD | 1 | 2023-06-01 | 2023-07-05 | |
| FMRI-neurofeedback in Depression fMRI-based neurofeedback - Depression, Unipolar | Not applicable | Recruiting | Maastricht University Medical Center | 120 | 2023-01-25 | 2026-10-13 |
| Ketamine + Mindfulness for Depression Intravenous Ketamine, Brief Mindfulness Exercises, Academic Exercises - Depression, Unipolar | Phase 1 / Phase 2 | Completed | Rebecca Price | 43 | 2022-02-01 | 2024-08-20 |
| Integrated Tele-Behavioral Activation and Fall Prevention for Low-income Homebound Seniors With Depression Behavioral Activation, Fall Prevention, Telephone support - Depression, Unipolar, Fall | Not applicable | Recruiting | University of Texas at Austin | 320 | 2021-11-01 | 2024-01-09 |
| Acceptability and Feasibility of an 8-week Online Mindfulness-Based Cognitive Therapy Program Among Undergraduate Students Mindfulness-Based Cognitive Therapy - Stress, Psychological, Anxiety Disorders | Not applicable | Completed | Universidad de los Andes, Chile | 62 | 2021-09-23 | 2026-10-20 |
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Depressive Disorder (48) · Depression (25) · Depressive Disorder, Major (13) · Bipolar Disorder (8) · Anxiety Disorders (4) · Depressive Disorder, Treatment-Resistant (3) · Mental Disorders (3) · Stress Disorders, Post-Traumatic (3) · Behavioral Symptoms (2) · Hyperthermia (2) · Mood Disorders (2) · Phobia, Social (2) · Suicide (2) · Adjustment Disorders (1) · Anhedonia (1)
Mood Disorders (46) · Mental Disorders (45) · Behavior (27) · Behavioral Symptoms (24) · Bipolar and Related Disorders (8) · Pathological Conditions, Signs and Symptoms (5) · Signs and Symptoms (4) · Stress Disorders, Traumatic (3) · Trauma and Stressor Related Disorders (3) · Body Temperature Changes (2) · Heat Stress Disorders (2) · Neurologic Manifestations (2) · Pathologic Processes (2) · Phobic Disorders (2) · Self-Injurious Behavior (2)
Ketamine (3) · Ultraviolet Therapy (3) · Cognitive Behavioral Therapy (2) · Duloxetine Hydrochloride (2) · Therapeutics (2) · Bupropion (1) · Citalopram (1) · Clinical Trials, Phase I as Topic (1) · Clinical Trials, Phase II as Topic (1) · Clinical Trials, Phase III as Topic (1) · Dexetimide (1) · Escitalopram (1) · Esketamine (1) · Exercise (1) · Fluoxetine (1)
University of Pennsylvania (3) · Massachusetts General Hospital (2) · Rebecca Price (2) · University Medical Center Groningen (2) · University of California, San Francisco (2) · University of Oxford (2) · Universität Duisburg-Essen (2) · Brown University (1) · Charite University, Berlin, Germany (1) · Chinese University of Hong Kong (1) · Drexel University (1) · Jay Fournier (1) · Johannes Gutenberg University Mainz (1) · King's College London (1) · Maastricht University Medical Center (1)
United States (19) · Germany (5) · Netherlands (4) · China (3) · Hong Kong (3) · United Kingdom (3) · Denmark (2) · Brazil (1) · Chile (1) · Israel (1) · Kenya (1) · Norway (1) · Sweden (1)
Catherine Harmer (2) · Gustav Dobos, Prof. MD (2) · Amin Zand Vakili, MD, PhD (1) · Andrew Nierenberg, M.D. (1) · Charles Conway, MD (1) · Danielle Cath, MD PhD (1) · David E Linden, Prof. (1) · David Mischoulon, M.D. (1) · David Veale (1) · Draulio Araujo, Ph.D (1) · Elizabeth D Ballard, Ph.D. (1) · Erik R. Larsen, MD (1) · Fernanda Palhano-Fontes, Ph.D (1) · Flavio Frohlich, Ph.D. (1) · Georg Kranz, PhD (1)
PMID 32241310, PMID 27736689, PMID 28114915, PMID 28301561, PMID 29789277, PMID 30314962, PMID 31883526, PMID 37106559, PMID 39236052, PMID 39529199, PMID 39557549, PMID 40069356, PMID 40258990, PMID 40337754, PMID 40766223, PMID 40854809, PMID 40964432, PMID 41088238, PMID 41184028, PMID 42204761, PMID 42865738
2019 (1), P50MH113838 (1), R01MH113722 (1), R01MH115512 (1), R01MH125155 (1)