12 unknown, 10 completed, 2 recruiting, 2 withdrawn. 29 Phase 2, 4 Phase 3, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 29 | Unknown 12, Completed 10, Recruiting 2, Withdrawn 2, Active not recruiting 1, Not yet recruiting 1, Terminated 1 |
| Phase 3 | 4 | Unknown 4 |
| Phase 1 | 3 | Recruiting 2, Unknown 1 |
Follow Dementia, Vascular: new trials by email Literature Review of Dementia, Vascular trials Research Report on Dementia, Vascular
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Efficacy of Edaravone Dexborneol Sublingual Tablets for Blood-Brain Barrier Dysfunction in CADASIL Edaravone Dexborneol Sublingual Tablets - CADASIL | Phase 2 | Not yet recruiting | Huashan Hospital | 60 | 2026-07-01 | 2026-07-09 |
| Rifaximin SSD in Dementia Trial Rifaximin SSD 40 mg IR tablet, Placebo - Dementia Alzheimer Type, Dementia Associated With Cerebrovascular Disease | Phase 1 / Phase 2 | Recruiting | Jasmohan Bajaj | 20 | 2024-12-30 | 2026-04-03 |
| Cannabidiol's Role in Dementia Management Cannabidiol Oil - Dementia, Vascular, Dementia, Mixed | Phase 2 / Phase 3 | Unknown | Hospital Pengajar Universiti Putra Malaysia | 486 | 2024-09-01 | 2024-07-23 |
| CERebrolysin In CADASIL Cerebrolysin, 0.9 % NaCl - Cadasil | Phase 2 | Active not recruiting | Ever Neuro Pharma GmbH | 30 | 2023-11-29 | 2025-02-25 |
| Efficacy and Safety of Tian Ma Bian Chun Zhi Gan Tablets in Mild to Moderate Vascular Dementia Tian Ma Bian Chun Zhi Gan Tablets, Placebo - Vascular Dementia, Cognitive Impairment | Phase 2 | Unknown | Dongzhimen Hospital, Beijing | 360 | 2022-05-25 | 2022-11-22 |
| Adrenomedullin for CADASIL Adrenomedullin - Cadasil | Phase 2 | Completed | National Cerebral and Cardiovascular Center, Japan | 60 | 2022-01-06 | 2023-10-10 |
| Safety and Efficacy of Fremanezumab for Migraine in Adult CADASIL Fremanezumab, Placebo - Cadasil, Migraine | Phase 2 | Withdrawn | Mayo Clinic | 2021-12-01 | 2022-02-28 | |
| A Study of the Effects of CY6463 in Participants With Alzheimer's Disease With Vascular Pathology CY6463, Placebo - Alzheimer's Disease With Vascular Pathology | Phase 2 | Terminated | Tisento Therapeutics | 12 | 2021-11-02 | 2024-10-30 |
| Retina is a Marker for Cerebrovascular Heath Cilostazol - Cerebral Small Vessel Diseases, Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy | Phase 1 / Phase 2 | Recruiting | Mayo Clinic | 100 | 2021-02-09 | 2026-08-03 |
| Efficacy and Safety of Tocotrienols in CADASIL HOV-12020 (Palm tocotrienols complex), Placebo - Cadasil | Phase 2 | Completed | Hovid Berhad | 50 | 2020-12-21 | 2026-02-02 |
| Dapagliflozin Effect in Cognitive Impairment in Stroke Trial Dapagliflozin 10mg Tab, Statins (Cardiovascular Agents), Platelet Antiaggregant - Stroke, Ischemic, Mild Cognitive Impairment | Phase 2 / Phase 3 | Unknown | Jaime Daniel Mondragon | 270 | 2020-08-01 | 2022-10-04 |
| A Noval Tau Tracer in Young Onset Dementia 18F-PM-PBB3 - Alzheimer's Disease, Vascular Dementia | Phase 1 / Phase 2 | Unknown | Chang Gung Memorial Hospital | 100 | 2020-02-20 | 2020-01-30 |
| Trial of Remote Ischemic Pre-conditioning in Vascular Cognitive Impairment Remote ischemic conditioning - Vascular Dementia, Cerebral Small Vessel Diseases | Phase 2 | Unknown | University of Calgary | 24 | 2019-09-26 | 2022-06-09 |
| Efficacy and Safety of Ferrous Iron on the Prevention of Vascular Cognitive Impairment Among Patients With Cerebral Infarction/TIA (FAVORITE) Ferrous succinate - Vascular Cognitive Impairment, Dementia, Vascular | Phase 2 | Unknown | Beijing Tiantan Hospital | 1006 | 2019-04-01 | 2020-07-13 |
| A Double-Blind, Placebo-Controlled Safety and Efficacy Study of NA-831 N-831(Traneurocin) 10 mg QD, NA-831 (Traneurocin) 20 mg QD, NA-831 (Traneurocin) 40 mg QD - Mild Cognitive Impairment, Alzheimer Disease | Phase 2 | Completed | Biomed Industries, Inc. | 126 | 2018-09-15 | 2020-06-30 |
| Efficacy and Safety of TMBCZG in Mild to Moderate Vascular Dementia TMBCZG, placebo - Vascular Dementia | Phase 2 | Completed | Dongzhimen Hospital, Beijing | 160 | 2017-07-28 | 2021-03-02 |
| BAC in Patient With Alzheimer's Disease or Vascular Dementia BAC, BAC Matched Vehicle - Alzheimer's Disease, Vascular Dementia | Phase 2 | Withdrawn | Botanicure Co., Ltd. | 2017-01-30 | 2026-05-20 | |
| A Study to Evaluate Efficacy and Safety of BAC in Patient With Alzheimer's Disease or Vascular Dementia BAC treatment, Matched vehicle - Alzheimer's Disease or Vascular Dementia | Phase 2 | Completed | Charsire Biotechnology Corp. | 80 | 2016-12-01 | 2022-10-13 |
| Perfusion by Arterial Spin Labelling Following Single Dose Tadalafil in Small Vessel Disease (PASTIS) Trial Tadalafil, Placebo, Cognitive functioning tests - Dementia, Vascular | Phase 2 | Completed | St George's, University of London | 55 | 2015-09-01 | 2022-10-27 |
| n-3 PUFA for Vascular Cognitive Aging Omega 3 PUFA, Placebo - Age Related Cognitive Decline, Alzheimer's Disease | Phase 2 | Unknown | Oregon Health and Science University | 102 | 2014-05-01 | 2020-09-04 |
Showing 20 of 29. Sign in to see all of them.
Alzheimer Disease (10) · CADASIL (7) · Dementia (7) · Cognitive Dysfunction (6) · Cerebral Small Vessel Diseases (3) · Lewy Body Disease (2) · Memory Disorders (2) · Mixed Dementias (2) · Neurocognitive Disorders (2) · Stroke (2) · Anemia, Iron-Deficiency (1) · Cerebral Infarction (1) · Cerebrovascular Disorders (1) · Iron Deficiencies (1)
Brain Diseases (29) · Cardiovascular Diseases (29) · Central Nervous System Diseases (29) · Intracranial Arterial Diseases (29) · Nervous System Diseases (29) · Vascular Diseases (29) · Cerebrovascular Disorders (28) · Arterial Occlusive Diseases (22) · Arteriosclerosis (22) · Dementia (22) · Intracranial Arteriosclerosis (22) · Leukoencephalopathies (22) · Mental Disorders (22) · Neurocognitive Disorders (21) · Pathological Conditions, Signs and Symptoms (11)
Acetaminophen (1) · Adrenomedullin (1) · Aspirin (1) · Atorvastatin (1) · Biguanides (1) · Bromocriptine (1) · Cannabidiol (1) · Cardiovascular Agents (1) · Cilostazol (1) · Clopidogrel (1) · Dabigatran (1) · Dronabinol (1) · Ergoloid Mesylates (1) · Fish Oils (1) · Galantamine (1)
Dongzhimen Hospital, Beijing (3) · Mayo Clinic (2) · Amsterdam UMC, location VUmc (1) · Beijing Tiantan Hospital (1) · Biomed Industries, Inc. (1) · Botanicure Co., Ltd. (1) · Chang Gung Memorial Hospital (1) · Charsire Biotechnology Corp. (1) · Ever Neuro Pharma GmbH (1) · Hospital Pengajar Universiti Putra Malaysia (1) · Hovid Berhad (1) · Huashan Hospital (1) · Jaime Daniel Mondragon (1) · Jasmohan Bajaj (1) · National Ageing Research Institute, Australia (1)
China (7) · United States (6) · Netherlands (2) · Australia (1) · Canada (1) · Czechia (1) · France (1) · Italy (1) · Japan (1) · Malaysia (1) · Mexico (1) · New Zealand (1) · South Korea (1) · Taiwan (1) · United Kingdom (1)
Baojun Wang, Doctor (1) · Benyan Luo, Doctor (1) · Changshan Ai, Master (1) · David Ho (1) · Desheng Zhou, Doctor (1) · Dongdong Yang, Doctor (1) · Duk L. Na, MD. PhD. (1) · Eric Smith, MD (1) · Francesco Orzi, MD (1) · Gene Bowman, ND, MPH (1) · James F Meschia (1) · Jasmohan Bajaj (1)
PMID 20204386, PMID 23040716, PMID 27266867, PMID 28095900, PMID 28950419, PMID 29016744, PMID 29371333, PMID 29446769, PMID 29559423, PMID 29573529, PMID 30572524, PMID 30934894, PMID 31236801, PMID 31248555, PMID 31535829, PMID 31910895, PMID 32115470, PMID 32144994, PMID 32178931, PMID 32317958, PMID 32352644, PMID 32559474, PMID 32854852, PMID 33030307, PMID 33055122, PMID 33282811, PMID 33894597, PMID 34532852, PMID 34813630, PMID 35080734, PMID 35135037, PMID 38160357, PMID 38789134, PMID 39088212, PMID 40049590, PMID 42005919
2015 (1), R01AG043398 (1)