110 completed, 39 unknown, 31 terminated, 27 recruiting. 100 Not applicable, 24 Phase 2, 22 Phase 1, 14 Phase 3, 8 Phase 4.
Follow Degenerative Disc Disease: new trials by email Literature Review of Degenerative Disc Disease trials Research Report on Degenerative Disc Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Determine the Safety and Tolerability of TG-C in Subjects With Back Pain Due to Degenerative Disc Disease TG-C High Dose, TG-C Mid Dose, TG-C Low Dose - Degenerative Disc Disease | Phase 1 | Not yet recruiting | Kolon TissueGene, Inc. | 24 | 2027-01-19 | 2026-08-20 |
| Prospective Study of ProteiOS in Lumbar Interbody Fusion (TLIF) Allograft-derived growth factor (ProteiOS®), Standard of Care (SOC) - Degenerative Disc Disease, Spinal Stenosis Lumbar | Not applicable | Not yet recruiting | Isto Biologics | 280 | 2026-12-01 | 2026-08-20 |
| Lumbar Fusion With Nanotube Versus Titanium Cage Adaptix nanoPEEK Cage, Capstone PTC Cage - Degenerative Disc Disease, Lumbar Fusion | Not applicable | Not yet recruiting | Francis Farhadi | 108 | 2026-10-01 | 2026-10-16 |
| Biologic Injection For Adults With Lumbar Disc Herniation Bone Marrow Aspirate Concentrate (BMAC) - Degenerative Disc Disease, DDD | Not applicable | Recruiting | Weill Medical College of Cornell University | 90 | 2026-08-30 | 2026-07-29 |
| Efficacy and Safety of Novosis Putty in Transforaminal Lumbar Interbody Fusion for Patients With Lumbar Degenerative Disc Disease Novosis Putty, Standard of Care - Degenerative Disc Disease | Phase 3 | Recruiting | CGBio Inc. | 316 | 2026-06-11 | 2026-08-26 |
| Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury EC5026 oral tablet, Placebo oral tablet - Spinal Cord Injuries, Neuropathic Pain | Phase 1 | Recruiting | EicOsis Human Health Inc. | 36 | 2026-05-01 | 2026-07-10 |
| Long-term Assessment of BDyn Dynamic Stabilization Device in Patients With Lumbar Degenerative Disc Disease Dynamic Lumbar Stabilization Device - Degenerative Disc Disease | Not applicable | Not yet recruiting | Cousin Biotech | 150 | 2026-04-01 | 2026-05-12 |
| Assessing Safety of Cervical Spine Fusion With NMP® Natural Matrix Protein (NMP) Fibers, Cervical interbody fusion - Degenerative Disc Disease, Degenerative Spondylolisthesis | Not yet recruiting | Red Rock Regeneration Inc. | 300 | 2026-01-15 | 2025-11-24 | |
| A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc Disease IDCT (rebonuputemcel), Sham (No Treatment) - Degenerative Disc Disease | Phase 3 | Recruiting | DiscGenics, Inc. | 162 | 2025-12-23 | 2026-10-15 |
| Retrospective Analysis of Patients Implanted With 2 Levels of Prodisc® C Vivo Devices Prodisc C Vivo - Degenerative Disc Disease, Cervical Spine Degenerative Disease | Enrolling by invitation | Centinel Spine | 200 | 2025-11-01 | 2026-01-27 | |
| Assessing Microbiome in Primary Anterior Cervical Fusion Patients Primary Anterior Cervical Discectomy Procedures - Cervical Stenosis, Myelopathy | Not applicable | Enrolling by invitation | Hospital for Special Surgery, New York | 76 | 2025-10-14 | 2026-10-16 |
| Effect of RECK in Posterior Spinal Fusion Ropivacaine, Epinephrine, Clonidine, and Ketorolac Injection Cocktail, Placebo - Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease | Phase 1 / Phase 2 | Withdrawn | University of Maryland, Baltimore | 2025-10-01 | 2025-07-31 | |
| Stem Cells vs. Steroids for Discogenic Back Pain Autologous stem cells, Corticosteroid, Local anesthetic - Chronic Low Back Pain, Degenerative Disc Disease | Not applicable | Withdrawn | Johns Hopkins University | 2025-09-30 | 2025-10-07 | |
| Virtuos Bone Graft in Lumbar Fusion Degenerative Disc Disease | Enrolling by invitation | Orthofix Inc. | 150 | 2025-06-05 | 2025-11-28 | |
| Clinical Trial Evaluating the Safety and Efficacy of Nucleus Pulposus Allograft in Participants With Degenerative Disc Disease VIA Disc NP, Sham - Degenerative Disc Disease, Disc Degeneration | Not applicable | Recruiting | VIVEX Biologics, Inc. | 325 | 2025-02-17 | 2026-09-14 |
| Clinical Outcome Measure at Stryker Spine Spinal Fusion, Spinal Deformities Correction - Degenerative Disc Disease, Degenerative Scoliosis | Recruiting | VB Spine, LLC | 5222 | 2025-01-28 | 2026-06-26 | |
| Post Marketing Study of MagnetOs Easypack Putty Standalone Compared to Demineralized Bone Matrix or Fibers Mixed With Autograft in Patients Undergoing Posterolateral Lumbar Fusion MagnetOs Easypack Putty, Demineralized Bone Matrix or Fibers mixed with local autograft bone - Degenerative Disc Disease, Spine Fusion | Not applicable | Recruiting | Kuros Biosurgery AG | 60 | 2024-12-06 | 2026-03-20 |
| LDGraft in Single Level Anterior Lumbar Interbody Fusion (ALIF) LDGraft, Allograft Bone - Degenerative Disc Disease, Lumbar Disc Disease | Phase 1 / Phase 2 | Recruiting | Locate Bio Pty Ltd | 40 | 2024-11-12 | 2026-08-26 |
| Conduit Cages and Fibergraft BG Putty Use of conduit cages and fibergraft BG Putty - Degenerative Disc Disease, Herniated Disc | Recruiting | Nitin Agarwal | 100 | 2024-11-04 | 2026-01-22 | |
| ASCEND: A Clinical Trial to Evaluate the Safety and Effectiveness of VIA Disc NP, a Supplement for Degenerated Intervertebral Discs VIA Disc NP, Sham Injection - Degenerative Disc Disease, Disc Degeneration | Phase 2 | Active not recruiting | VIVEX Biologics, Inc. | 121 | 2024-10-04 | 2026-10-05 |
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Intervertebral Disc Degeneration (256) · Spondylolisthesis (53) · Spinal Stenosis (39) · Low Back Pain (24) · Intervertebral Disc Displacement (15) · Spondylosis (14) · Back Pain (11) · Radiculopathy (11) · Intervertebral disc disease (6) · Scoliosis (6) · Constriction, Pathologic (5) · Neoplasms (5) · Spinal Diseases (5) · Wounds and Injuries (5) · Klippel-Feil Syndrome (4)
Bone Diseases (255) · Musculoskeletal Diseases (253) · Spinal Diseases (251) · Pathological Conditions, Signs and Symptoms (57) · Spondylolysis (53) · Spondylosis (43) · Signs and Symptoms (38) · Neurologic Manifestations (37) · Pain (34) · Pathological Conditions, Anatomical (21) · Back Pain (19) · Nervous System Diseases (19) · Hernia (15) · Neuromuscular Diseases (12) · Peripheral Nervous System Diseases (12)
Transplantation, Autologous (14) · Sodium Chloride (6) · Spinal Fusion (5) · Saline Solution (4) · salicylhydroxamic acid (4) · Anesthetics, Local (2) · Clonidine (2) · Epinephrine (2) · Gene Fusion (2) · Genes, mos (2) · Hyaluronic Acid (2) · Injections (2) · Magnetic Resonance Imaging (2) · Morphine (2) · N-methylpyrrolidone (2)
Medtronic Spinal and Biologics (16) · NuVasive (15) · Zimmer Biomet (8) · Mesoblast, Ltd. (6) · Orthofix Inc. (6) · Aesculap AG (5) · DePuy Spine (5) · Kuros Biosurgery AG (5) · Rush University Medical Center (5) · VIVEX Biologics, Inc. (5) · Globus Medical Inc (4) · LDR Spine USA (4) · Pioneer Surgical Technology, Inc. (4) · Spinal Stabilization Technologies (4) · Baxter Healthcare Corporation (3)
United States (154) · Germany (15) · Australia (8) · France (7) · China (6) · Netherlands (6) · Belgium (5) · Canada (5) · Italy (5) · Czechia (4) · Spain (4) · Switzerland (4) · Israel (3) · Sweden (3) · Hungary (2)
Kyle Malone, MS (8) · Kern Singh, MD (5) · Michael Hess, MD (4) · Joel Batts (3) · Roger Brown (3) · Domagoj Coric, MD (2) · Donna Skerrett, MD (2) · Eeric Truumees, MD (2) · Huub Kreuwel, Ph.D (2) · Jad G Khalil, MD (2) · Jadwiga Kuciel-Lewandowska, MD (2) · James T Ryaby, PhD (2) · Jaroslav Plas (2) · Jeff Golan, MD (2)
PMID 21286714, PMID 22885827, PMID 25839385, PMID 31442616, PMID 31451936, PMID 36477416, PMID 38127138, PMID 10795032, PMID 15346999, PMID 15995108, PMID 16025024, PMID 16025025, PMID 16784908, PMID 17141065, PMID 17206138, PMID 18038420, PMID 19564761, PMID 19699503, PMID 20084410, PMID 20380708, PMID 21596740, PMID 22246644, PMID 22460400, PMID 22706091, PMID 22744618, PMID 23307678, PMID 23783372, PMID 24010901, PMID 24365899, PMID 24554334, PMID 25380538, PMID 25694918, PMID 26272373, PMID 26799118, PMID 26863261, PMID 27015130, PMID 27258476, PMID 27661661, PMID 27689425, PMID 28288396, PMID 28376754, PMID 28446192, PMID 29372135, PMID 29487870, PMID 29957147, PMID 30680635, PMID 31428637, PMID 31431873, PMID 31501123, PMID 32089783
2019 (1), K23DA020681 (1)