26 completed, 9 unknown, 5 recruiting, 4 terminated. 51 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 51 | Completed 26, Unknown 9, Recruiting 5, Terminated 4, Withdrawn 3, Active not recruiting 2, Not yet recruiting 2 |
| Phase 2 | 2 | Active not recruiting 1, Completed 1 |
Follow Cough: new trials by email Literature Review of Cough trials Research Report on Cough
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Finnish Children´s Protracted Cough Fluticasone propionate inhalation, Amoxicillin-clavulanic acid oral suspension, Placebo inhalation - Chronic Cough | Phase 3 | Recruiting | Tampere University Hospital | 100 | 2025-12-22 | 2026-05-13 |
| A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough - China Extension BLU-5937, Placebo - Refractory Chronic Cough | Phase 3 | Recruiting | GlaxoSmithKline | 75 | 2025-11-21 | 2026-06-16 |
| Efficacy and Safety of AG2001 in Patients With Acute Bronchitis AG2001, AG20011, AG20012 - Acute Bronchitis | Phase 3 | Not yet recruiting | Ahn-Gook Pharmaceuticals Co.,Ltd | 300 | 2025-11-01 | 2025-09-30 |
| Efficacy and Safety of Rengalin in the Treatment of ARVI Cough in Children Rengalin, Placebo - Cough | Phase 3 | Recruiting | Materia Medica Holding | 264 | 2025-10-03 | 2026-02-13 |
| Phase III Trial of Susu Zhike Granules in Children With Cold-cough Syndrome for Acute Cough Treatment Susu Xiao'er Zhike Granules, Extremely-low dose Susu Xiao'er Zhike Granules - Cough | Phase 3 | Not yet recruiting | Tasly Pharmaceutical Group Co., Ltd | 360 | 2025-09-01 | 2025-08-19 |
| Air Versus Lignocaine for Endotracheal Tube Cuff Inflation and Effect on Postoperative Sore Throat and Intracuff Pressure Xylocaine - Postoperative Sore Throat, Cough, Hoarseness | Phase 2 / Phase 3 | Active not recruiting | PAEC General Hospital, Islamabad | 80 | 2025-08-02 | 2026-01-02 |
| The Efficacy and Safety of Reconyl in Acute Cough Treatment Reconyl, Placebo of Reconyl - Cough | Phase 3 | Completed | Dexa Medica Group | 144 | 2025-06-26 | 2026-02-19 |
| Dexmedetomidine, Magnesium Sulphate and Lidocaine for Cough Suppression After General Anesthesia Dexmedetomidine, Magnesium sulfate, Lidocaine - Cough | Phase 3 | Recruiting | Al-Azhar University | 300 | 2025-06-02 | 2025-06-11 |
| A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough BLU-5937, Placebo - Cough, Refractory Chronic Cough | Phase 3 | Active not recruiting | Bellus Health Inc. - a GSK company | 997 | 2022-12-05 | 2026-07-14 |
| Efficacy and Safety of Zihua Wenfei Granules in Treatment of Postinfectious Cough (Wind-cold Invading Lungs Syndrome) Zihua Wenfei Zhisou Granule, Placebo - Cough | Phase 3 | Unknown | DoCare Pharmaceutial Technology Co.,Ltd | 480 | 2022-11-15 | 2023-03-13 |
| A 52-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough BLU-5937, Placebo - Cough, Refractory Chronic Cough | Phase 3 | Completed | Bellus Health Inc. - a GSK company | 957 | 2022-10-25 | 2026-07-14 |
| Treating People With Idiopathic Pulmonary Fibrosis With the Addition of Lansoprazole Lansoprazole, Matched placebo - Idiopathic Pulmonary Fibrosis | Phase 3 | Recruiting | Norfolk and Norwich University Hospitals NHS Foundation Trust | 298 | 2021-06-16 | 2025-12-22 |
| Randomized Placebo-controlled Analysis of Superior Laryngeal Nerve Block for Neurogenic Cough Superior laryngeal nerve block - Intervention (Bupivacaine and triamcinolone acetonide suspension), Superior laryngeal nerve block - Placebo (saline) - Cough, Nerve Block | Phase 3 | Unknown | University of South Florida | 65 | 2021-01-12 | 2022-11-08 |
| Efficacy of SLN Block for Chronic Cough Superior laryngeal nerve block, Injection of placebo (saline), Injection of steroid-lidocaine mixture - Cough, Superior Laryngeal Nerve Block | Phase 3 | Completed | Medical University of South Carolina | 17 | 2020-07-22 | 2025-10-23 |
| Efficacy and Safety of Gefapixant (MK-7264) in Adult Participants With Recent Onset Chronic Cough (MK-7264-043) Gefapixant, Placebo - Chronic Cough | Phase 3 | Completed | Merck Sharp & Dohme LLC | 419 | 2020-05-21 | 2023-05-16 |
| Efficacy and Safety of Gefapixant (MK-7264) in Women With Chronic Cough and Stress Urinary Incontinence (MK-7264-042) Gefapixant, Placebo - Chronic Cough | Phase 3 | Completed | Merck Sharp & Dohme LLC | 376 | 2020-05-10 | 2024-11-05 |
| A Clinical Trial to Compare the Efficacy and Safety of 1-week Treatment of Intravenous N-acetylcysteine (NAC) 600 mg Twice Daily, Ambroxol Hydrochloride 30 mg Twice Daily and Placebo as Expectorant Therapies in Adult Chinese Patients With Respiratory Tract Diseases and Abnormal Mucus Secretions N-acetylcysteine (NAC) 600 mg, Ambroxol hydrochloride 30 mg, placebo - Respiratory Tract Diseases, Abnormal Mucus Secretions | Phase 3 | Completed | Zambon SpA | 333 | 2019-06-25 | 2025-09-05 |
| A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-030)-China Extension Gefapixant 45 mg twice daily (BID), Gefapixant 15 mg BID, Placebo - Chronic Cough | Phase 3 | Completed | Merck Sharp & Dohme LLC | 161 | 2019-05-17 | 2024-01-12 |
| Accuracy and Consequences of Using Trial-of-antibiotics for TB Diagnosis (ACT-TB Study) Azithromycin, Amoxicillin - Tuberculosis, Respiratory Tract Infections | Phase 3 | Completed | London School of Hygiene and Tropical Medicine | 1583 | 2019-02-25 | 2021-04-28 |
| Formoterol-beclomethasone in Patients With Bronchiectasis: a Randomized Controlled Trial Formoterol-beclomethasone, Placebo - Bronchiectasis | Phase 3 | Terminated | Erasmus Medical Center | 34 | 2019-01-29 | 2023-03-01 |
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Chronic Cough (14) · Influenza, Human (6) · Pharyngitis (6) · Bronchitis (5) · Headache (5) · Nasal Obstruction (5) · Respiratory Tract Diseases (5) · Common Cold (4) · Fever (4) · Respiration Disorders (4) · Signs and Symptoms, Respiratory (4) · Fatigue (3) · Hoarseness (3) · Respiratory Tract Infections (3)
Pathological Conditions, Signs and Symptoms (51) · Signs and Symptoms (49) · Respiration Disorders (47) · Signs and Symptoms, Respiratory (47) · Respiratory Tract Diseases (46) · Infections (21) · Respiratory Tract Infections (17) · Lung Diseases (12) · Bronchial Diseases (9) · Otorhinolaryngologic Diseases (9) · Lung Diseases, Obstructive (8) · Neurologic Manifestations (8) · RNA Virus Infections (8) · Virus Diseases (8)
Gefapixant (6) · Lidocaine (5) · Azithromycin (3) · BLU-5937 (3) · dipropizine (3) · BID protein, human (2) · Guaiacol (2) · Omeprazole (2) · Sodium Chloride (2) · Theobromine (2) · favipiravir (2) · Acetylcysteine (1) · Ambroxol (1) · Amoxicillin (1) · Brompheniramine (1)
Merck Sharp & Dohme LLC (6) · Ache Laboratorios Farmaceuticos S.A. (3) · Ahn-Gook Pharmaceuticals Co.,Ltd (3) · Bellus Health Inc. - a GSK company (2) · BioCryst Pharmaceuticals (2) · MDVI, LLC (2) · Aboca Spa Societa' Agricola (1) · Al-Azhar University (1) · Azidus Brasil (1) · Brasilia University Hospital (1) · CSPC ZhongQi Pharmaceutical Technology Co., Ltd. (1) · Dexa Medica Group (1) · DoCare Pharmaceutial Technology Co.,Ltd (1) · Dompé Farmaceutici S.p.A (1) · EMS (1)
United States (14) · United Kingdom (11) · Canada (9) · China (9) · Brazil (6) · Germany (6) · Peru (6) · Poland (6) · Russia (6) · South Korea (6) · Ukraine (6) · Argentina (5) · Colombia (5) · Hungary (5) · Israel (5)
Carol Epstein, MD (2) · Alan Jackson, MB, BS (1) · Alun George, MA MBBS, DRCOG, DCH, MRCGP (1) · Alyn H Morice, Professor (1) · Alyn Morice, BA(Hons) MB.B.Chir MA FRCP (1) · Arienne de Jong, PhD (1) · Bernard Higgins, MB ChB, MRCP, MD (1) · Cao Zhaolong, M.D. (1) · Choon-Taek Lee, MD, PhD (1) · Chris Strang, MB BS, D. Obst, RCOG M (1) · Christopher J Hartnick, MD (1) · Chul-min Ahn, MD, PhD (1)
PMID 35248186, PMID 35569802, PMID 35639525, PMID 22230731, PMID 22986377, PMID 23985625, PMID 24229360, PMID 25115871, PMID 25811287, PMID 25985845, PMID 28839984, PMID 30722097, PMID 32217561, PMID 35752582, PMID 36879087, PMID 36925176, PMID 39222649, PMID 39706278, PMID 39909521
2017 (2), 2019 (2), 2025 (1)