28 completed, 8 unknown, 6 recruiting, 3 withdrawn. 50 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 50 | Completed 28, Unknown 8, Recruiting 6, Withdrawn 3, Not yet recruiting 2, Terminated 2, Suspended 1 |
Follow Cough: new trials by email Literature Review of Cough trials Research Report on Cough
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Gabapentin vs. Benzonatate vs. Standard of Care for Cough in ILD Gabapentin, Benzonatate 200 mg, Standard of care treatment for ILD - Interstitial Lung Disease | Phase 4 | Not yet recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 177 | 2026-10-07 | 2026-10-08 |
| Remifentanil Versus Remifentanil-Lidocaine for Tracheal Extubation After Thyroidectomy remifentanil, Lidocaine %2 ampoule - Tracheal Extubation, Cough | Phase 4 | Recruiting | Pamukkale University | 60 | 2026-10-01 | 2026-11-12 |
| A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough Morphine Sulphate, Morphine Sulphate + Cough Control Therapy, Pregabalin - Cough, Refractory Chronic Cough | Phase 4 | Not yet recruiting | McMaster University | 124 | 2026-09-30 | 2026-10-19 |
| Oliceridine vs Sufentanil for Cough During Anesthesia Induction Oliceridine, Sufentanil - Cough, Anesthesia | Phase 4 | Recruiting | Shiyou Wei | 62 | 2026-06-27 | 2026-07-21 |
| Evaluation of Treatments for Dry or Productive Cough Group CDN, Group CW - Cough | Phase 4 | Recruiting | University Hospital, Clermont-Ferrand | 58 | 2026-01-19 | 2026-04-28 |
| Sore Throat After Open Neck Elective Surgery Hydrocortisone Acetate 1% Ointment, Lidocaine hydrochloride 0,05% with chlorhexidine - Postoperative Sore Throat, Cough, Hoarseness, Thyroid and Parathyroid Surgery | Phase 4 | Recruiting | Saint Petersburg State University, Russia | 764 | 2025-09-15 | 2026-04-13 |
| The Mechanism Versus PPI Trial Omeprazole 40 MG, Laryngeal Recalibration Therapy, GERD Lifestyle Recommendations - Laryngopharyngeal Reflux, Cough | Phase 4 | Recruiting | University of California, San Diego | 160 | 2025-06-04 | 2025-08-01 |
| CHAO Tos: Codeina, HederA Helix, LevOdropropizina Para la TOS Codeine, Levodropropizine, Ivy Leaves Cough Liquid - Upper Resp Tract Infection | Phase 4 | Completed | Pontificia Universidad Catolica de Chile | 196 | 2025-05-13 | 2025-12-03 |
| A Clinical Evidence Study Evaluating Quality of Life Parameters Following Treatment With Robitussin Robitussin Maximum Strength Cough and Chest Congestion DM, Robitussin Maximum Strength Nighttime Cough DM - Common Cold, Cough | Phase 4 | Completed | HALEON | 244 | 2024-12-04 | 2026-02-20 |
| Efficacy of Lavender Essential Oil Chest Wraps in Infants With Bronchiolitis Lavender essential oil 10%, diluted in 90% olive oil, Control - Bronchiolitis | Phase 4 | Recruiting | University Hospital, Geneva | 400 | 2023-12-07 | 2025-03-30 |
| Triple vs High Dose Inhaled CORticosteroids To compare in both treatment arms the percentage of patients controlled at week 52. - Asthma | Phase 4 | Withdrawn | Galaxia Empírica | 2023-06-01 | 2025-09-04 | |
| Interest of Lidocaine in Children with Upper Airway Infection Undergoing General Anesthesia Lidocaine (drug), Saline (NaCl 0,9 %) (placebo) - Upper Respiratory Tract Infections, Perioperative Respiratory Complications | Phase 4 | Completed | Tunis University | 102 | 2023-01-02 | 2024-09-19 |
| Kesuting Syrup in the Treatment of Corona Virus Disease 2019 (COVID-19) Kesuting syrup, LianHuaQingWen Granules - COVID-19 Pneumonia, Cough | Phase 4 | Completed | Guizhou Bailing Group Pharmaceutical Co Ltd | 200 | 2022-05-08 | 2022-09-19 |
| Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol Methacholine (MCh) Challenge Testing, Eucapneic Voluntary Hyperventilation (EVH), Mannitol Inhalation Kit - Asthma, Cough | Phase 4 | Completed | Dr. Diane Lougheed | 45 | 2022-03-01 | 2026-08-12 |
| Effect of Magnesium on Remifentanil Induced Cough Magnesium sulfate, Placebo - Cough | Phase 4 | Unknown | Seoul National University Bundang Hospital | 78 | 2022-02-03 | 2022-02-14 |
| Mepolizumab for the Treatment of Chronic Cough With Eosinophilic Airways Diseases Mepolizumab, Normal Saline - Chronic Cough, Eosinophilic Bronchitis | Phase 4 | Completed | McMaster University | 46 | 2021-12-14 | 2025-09-16 |
| Effects of Second-generation Antihistamine Bepotastine on Cough Outcomes in Cough Patients With Allergic Rhinitis Bepotastine, Placebo - Allergic Rhinitis, Cough | Phase 4 | Completed | Asan Medical Center | 50 | 2021-10-01 | 2023-01-05 |
| Laryngeal Nerve Block for Chronic Cough Steroid/Anesthesia Mixture, Placebo - Laryngeal Nerve Block, Chronic Neurogenic Cough | Phase 4 | Unknown | Eastern Virginia Medical School | 40 | 2021-07-21 | 2022-03-23 |
| Trial on The Efficacy of Hypertonic Saline on Non-CF CSLD. Nebulized 5% Hypertonic saline - Bronchiectasis | Phase 4 | Completed | University of Malaya | 46 | 2021-02-04 | 2023-12-01 |
| BNO 1030 Extract (Imupret) in the Treatment of Mild Forms of COVID-19 BNO 1030, Standard care - Covid19, Nasopharyngitis | Phase 4 | Completed | Ivano-Frankivsk National Medical University | 133 | 2020-05-01 | 2021-03-15 |
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Chronic Cough (7) · Common Cold (5) · Respiratory Tract Infections (5) · Asthma (4) · Dyspnea (3) · COVID-19 (2) · Gastroesophageal Reflux (2) · Hoarseness (2) · Respiratory Sounds (2) · Agnosia (1) · Alveolitis, Extrinsic Allergic (1) · Anosmia (1) · Bronchial Hyperreactivity (1) · Bronchial Spasm (1)
Pathological Conditions, Signs and Symptoms (50) · Respiration Disorders (50) · Respiratory Tract Diseases (50) · Signs and Symptoms (50) · Signs and Symptoms, Respiratory (50) · Infections (14) · Lung Diseases (11) · Bronchial Diseases (10) · Respiratory Tract Infections (9) · Lung Diseases, Obstructive (8) · Otorhinolaryngologic Diseases (8) · Immune System Diseases (7) · RNA Virus Infections (7) · Virus Diseases (7) · Hypersensitivity (6)
montelukast (6) · Saline Solution (5) · Remifentanil (4) · Dextromethorphan (3) · Lidocaine (3) · Sodium Chloride (3) · ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine (1) · 13-valent pneumococcal vaccine (1) · Antitussive Agents (1) · Beclomethasone (1) · Bromelains (1) · Chlorhexidine (1) · Cholinergic Antagonists (1) · Codeine (1) · Cyclodextrins (1)
Hull University Teaching Hospitals NHS Trust (2) · McMaster University (2) · Montefiore Medical Center (2) · Pfizer (2) · Yonsei University (2) · Asan Medical Center (1) · Association Asthma, Bulgaria (1) · B.P. Koirala Institute of Health Sciences (1) · Beijing Chao Yang Hospital (1) · Cedars-Sinai Medical Center (1) · Clalit Health Services (1) · Dr. Diane Lougheed (1) · Eastern Virginia Medical School (1) · Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina (1) · Fundacion Clinica Valle del Lili (1)
United States (9) · United Kingdom (6) · Canada (4) · China (4) · South Korea (3) · Colombia (2) · Israel (2) · Spain (2) · Argentina (1) · Australia (1) · Brazil (1) · Bulgaria (1) · Chile (1) · France (1) · India (1)
Alyn H Morice, FRCP (1) · Alyn Morice, Professor (1) · Amanda J Leach, PhD (1) · Ana Moragas, MD PhD (1) · Anna M Nathan (1) · Anthony R Harnden (1) · Ashley Woodcock, MD, FRCP (1) · Asish Subedi, MD (1) · Benjamin Rubinstein, MD (1) · David Price, Prof (1) · Decio M Peixoto, MD, PhD (1) · Dov Heimer, M.D (1) · Eduardo Lema, MD (1) · Elie Sarraf, MD.CM. (1)
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R01DK139089 (1)