24 unknown, 18 recruiting, 17 completed, 9 not yet recruiting. 48 Not applicable, 9 Phase 2, 8 Phase 3, 2 Phase 1, 2 Phase 4.
Follow Chronic Subdural Hematoma: new trials by email Literature Review of Chronic Subdural Hematoma trials Research Report on Chronic Subdural Hematoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Template-Guided Burr-Hole Drainage With Middle Meningeal Artery Coagulation for Chronic Subdural Hematoma Standard Burr-Hole Drainage Group, 3D-Printed Template-Guided Burr-Hole Drainage With Attempted MMA Coagulation Group - Chronic Subdural Hematoma | Not applicable | Not yet recruiting | The Second Hospital of Anhui Medical University | 440 | 2027-01-01 | 2026-07-23 |
| Intra-Arterial Bevacizumab as an Adjunct to Middle Meningeal Artery Embolization for Chronic Subdural Hematoma Bevacizumab (intra-arterial) - Chronic Subdural Hematoma | Phase 1 | Not yet recruiting | Dheeraj Gandhi | 18 | 2027-01-01 | 2026-07-27 |
| Frontal vs Parietal Eminence Drainage for Chronic Subdural Hematoma Frontal-region puncture drainage, Parietal Eminence region puncture drainage - Chronic Subdural Hematoma | Not applicable | Not yet recruiting | The Second Hospital of Anhui Medical University | 440 | 2027-01-01 | 2026-07-28 |
| Comparative Study of Embolic Agents in Patients With Subdural Hemorrhage Undergoing Middle Meningeal Artery (MMA) Embolization Particles (polyvinyl alcohol or similar microspheres), Liquid Embolics (Onyx, n-BCA, or equivalent), Phenox Coils (Avenir UNO Helical Coil) - Chronic Subdural Hematoma, Stroke | Not applicable | Not yet recruiting | Sanford Health | 30 | 2026-09-01 | 2026-08-11 |
| Post-Market Active Surveillance and Health Economic Evaluation of Cerebrovascular Diagnostic and Therapeutic Devices Endovascular Treatment for Acute Ischemic Stroke - Acute Ischemic Stroke, Intracranial Arterial Stenosis | Not yet recruiting | Changhai Hospital | 2000 | 2026-09-01 | 2026-09-18 | |
| Middle Meningeal Artery Embolisation in Chronic Subdural Hematoma Middle Meningeal Artery Embolisation - Chronic Subdural Hematoma | Not applicable | Active not recruiting | University Hospital Hradec Kralove | 200 | 2026-06-01 | 2026-09-30 |
| Non-Thermal Plasma to Reduce Recurrence in Chronic Subdural Hematoma Standard Surgery Protocol, Non-Thermal Plasma - Chronic Subdural Hematoma, Subdural Hematoma | Not applicable | Recruiting | Benjamín Gonzalo Rodríguez Méndez | 40 | 2026-03-02 | 2026-06-18 |
| Adjuvant Tranexamic Acid (TXA) Versus Surgery Alone for Adult Patients With Chronic Subdural Hematoma (CSDH) Tranexamic Acid (Cyklokapron) - Chronic Subdural Hematoma | Phase 2 / Phase 3 | Recruiting | St. Olavs Hospital | 274 | 2025-12-10 | 2026-07-17 |
| Prospective Multi-center Single Arm Study for Subjects With Chronic Subdural Hematoma Treated With i-ED COILs, Either Alone or in Combination With Burr-holes or Mini-craniotomy Neuro endovascular embolic coil - Chronic Subdural Hematoma, cSDH | Not yet recruiting | Kaneka Medical America LLC | 200 | 2025-11-30 | 2025-10-09 | |
| The CHALLENGER Registry Numen SILK coil embolization system - Chronic Subdural Hematoma | Suspended | Icahn School of Medicine at Mount Sinai | 100 | 2025-11-20 | 2026-10-28 | |
| Neuroendoscopy-assisted Drainage Versus Burr Hole Drainage for Chronic Subdural Hematoma Endoscope-assisted hematoma drainage, Burr hole hematoma drainage - Chronic Subdural Hematoma | Not applicable | Recruiting | Beijing Tiantan Hospital | 770 | 2025-11-19 | 2026-02-09 |
| Microfabricated Microcatheter Advantages in Middle Meningeal Artery Embolization: an Early Experience at a Single Center Matched pair Aristotle 14 guidewire and Plato 17 microcatheter, Surgeon combination preference - Chronic Subdural Hematoma, Hemorrhage Brain | Recruiting | Ohio State University | 100 | 2025-11-03 | 2026-01-07 | |
| Aspirin Continuation or Discontinuation in Conservative Treatment for Chronic Subdural Hematoma Aspirin Continuation, Aspirin Discontinuation - Chronic Subdural Hematoma | Not applicable | Recruiting | Tao Liu | 143 | 2025-10-15 | 2025-11-21 |
| Tranexamic Acid Therapy For The Treatment of Subdural Hematomas Tranexamic Acid 650 MG, Placebo - Chronic Subdural Hematoma | Phase 2 | Not yet recruiting | Baylor College of Medicine | 240 | 2025-10-01 | 2025-05-14 |
| A National Study Examining the Most Effective Drainage Method After Burr Hole Evacuation of Chronic Subdural Hematoma 24 hours active subperiostal drainage, 24 hours passive subdural drainage - Chronic Subdural Hematoma, Surgical Procedures, Operative | Not applicable | Recruiting | Aalborg University Hospital | 354 | 2025-09-01 | 2025-11-25 |
| Restarting Early Versus Later Anticoagulation for Chronic Subdural Hematoma With Atrial Fibrillation Early Resumption of Oral Anticoagulation Therapy, Late Resumption of Oral Anticoagulation Therapy - Chronic Subdural Hematoma, Atrial Fibrillation (AF) | Not applicable | Recruiting | Rahul Raj | 332 | 2025-07-07 | 2025-08-22 |
| Puerto Rico Embolization of the Middle Meningeal Artery for the Treatment of Chronic Subdural Hematoma Trial (PREMMA) Embolization of the middle meningeal artery, Surgical Evacuation via burr hole or craniotomy - Chronic Subdural Hematoma | Not applicable | Not yet recruiting | Juan M. Ramos Acevedo | 658 | 2025-05-01 | 2025-05-07 |
| Assessing Outcomes of Coil Embolization for Unilateral vs Bilateral Chronic Subdural Hematomas embolization therapy Bilateral, embolization therapy Unilateral - Chronic Subdural Hematoma | Not applicable | Recruiting | Lahey Clinic | 400 | 2025-04-09 | 2026-07-20 |
| Neurologic Deficits and Recovery in Chronic Subdural Hematoma ECoG monitoring - Chronic Subdural Hematoma | Not applicable | Withdrawn | University of New Mexico | 2025-03-01 | 2025-05-01 | |
| Efficacy and Safety of Chinese Herbal HuoXue LiShui Formula for Chronic Subdural Hematoma Chinese Herbal formula HuoXue LiShui, Chinese Herbal formula Placebo - Chronic Subdural Hematoma | Not applicable | Not yet recruiting | Beijing Tiantan Hospital | 160 | 2025-02-01 | 2024-12-30 |
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Hematoma, Subdural, Chronic (81) · Recurrence (10) · Intracranial Hemorrhages (5) · Brain Injuries, Traumatic (3) · Craniocerebral Trauma (3) · Hematoma, Subdural (3) · Hemorrhage (3) · Intracranial Hypotension (2) · Stroke (2) · Atrial Fibrillation (1) · Brain Neoplasms (1) · Cerebrospinal Fluid Otorrhea (1) · Cerebrovascular Disorders (1) · Chronic Disease (1) · Craniosynostoses (1)
Brain Diseases (81) · Cardiovascular Diseases (81) · Central Nervous System Diseases (81) · Disease Attributes (81) · Hematoma (81) · Intracranial Hemorrhage, Traumatic (81) · Nervous System Diseases (81) · Pathologic Processes (81) · Pathological Conditions, Signs and Symptoms (81) · Trauma, Nervous System (81) · Vascular Diseases (81) · Wounds and Injuries (81) · Cerebrovascular Disorders (80) · Chronic Disease (80) · Craniocerebral Trauma (78)
Tranexamic Acid (6) · Atorvastatin (4) · Dexamethasone (4) · Trephining (3) · Bevacizumab (2) · Craniotomy (2) · Ethanol (2) · ethylene-vinyl alcohol copolymer (2) · Anesthesia, General (1) · Angioplasty (1) · Aspirin (1) · Calcium Dobesilate (1) · Desmoglein 3 (1) · Diet (1) · Dimethyl Sulfoxide (1)
Beijing Tiantan Hospital (5) · Chinese University of Hong Kong (3) · Huashan Hospital (2) · Oriental Neurosurgery Evidence-Based-Study Team (2) · Sahlgrenska University Hospital (2) · The Second Hospital of Anhui Medical University (2) · Unity Health Toronto (2) · University of New Mexico (2) · Aalborg University Hospital (1) · Assistance Publique - Hôpitaux de Paris (1) · Atlantic Health System (1) · Baylor College of Medicine (1) · Benjamín Gonzalo Rodríguez Méndez (1) · Carilion Clinic (1) · Centre de recherche du Centre hospitalier universitaire de Sherbrooke (1)
United States (17) · China (15) · Canada (7) · Sweden (4) · Finland (3) · France (3) · Hong Kong (3) · Switzerland (3) · Belgium (2) · Germany (2) · Australia (1) · Austria (1) · Colombia (1) · Czechia (1) · Denmark (1)
Weiming Liu, M.D. (4) · Ajith J Thomas, MD (1) · Alejandro Tomasello, MD (1) · Andreas Bartley, MD (1) · Ansaar Rai, MD (1) · Asgeir Jakola, MD, PhD (1) · Carsten R Bjarkam, MD, PhD, DMSc (1) · Chandrashekhar Gendle, MD PhD (1) · Christian Iorio-Morin, MD (1) · Christopher Kellner, MD (1) · Dagmar Verbaan (1) · David Altschul, MD (1) · David Mathieu, M.D. (1) · David YC Chan, MBBS, FRCS (1)
PMID 26581842, PMID 27059872, PMID 27150916, PMID 28287909, PMID 29021000, PMID 30073290, PMID 30665464, PMID 32565480, PMID 35133631, PMID 35593710, PMID 36129273, PMID 36348417, PMID 36409480, PMID 36933251, PMID 37948693, PMID 38307722, PMID 38647289, PMID 38753579, PMID 38753580, PMID 38753581, PMID 38852600, PMID 39815109, PMID 40024327, PMID 40287938, PMID 40471557, PMID 41326886, PMID 41546119, PMID 41608698, PMID 41608724, PMID 41628070, PMID 41845395, PMID 41985955, PMID 42055825, PMID 42060283, PMID 42295790, PMID 42423601
2017 (1), 2023 (1), UG3NS128397 (1), UH3NS128397 (1)