16 completed, 8 unknown, 4 terminated, 2 not yet recruiting. 10 Phase 2, 9 Not applicable, 7 Phase 1, 5 Phase 3, 3 Phase 4.
Follow Dimethyl Sulfoxide: new trials by email Literature Review of Dimethyl Sulfoxide trials Research Report on Dimethyl Sulfoxide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Stop Air Leak by Talc or Autologous Blood Patch Therapy talc powder, patient's own venous blood - Pneumothorax Spontaneous Secondary | Phase 2 / Phase 3 | Not yet recruiting | Chinese University of Hong Kong | 30 | 2026-11-01 | 2026-09-04 |
| Effect of Local Use of Vitamin D on the Rate of Canine Distillization: a Split Mouth Randomized Control Trial Experimental: 1,25 DHC injection, Placebo: plain DMSO solvent - Malocclusion of Anterior Teeth | Phase 1 | Recruiting | Foundation University Islamabad | 30 | 2026-02-20 | 2026-03-18 |
| Bond Strength Evaluation dimethyl sulfoxide, Cholorhexidine - Bonding | Not applicable | Completed | Al-Azhar University | 30 | 2025-11-01 | 2026-08-12 |
| Clinical Evaluation of Dimethyl Sulfoxide Wet Bonding Technique Universal single bond adhesive, DMSO - Dimethyl Sulfoxide | Not applicable | Not yet recruiting | Manipal University College Malaysia | 68 | 2024-10-20 | 2024-10-10 |
| Impact of Dentin Pretreatment With Dimethyl Sulfoxide on Behavior of Resin Composite Restorations in Non-Carious Cervical Lesions Dimethyl sulfoxide (DMSO), NO dimethyl sulfoxide - Class V Non-carious Cervical Dental Lesions | Not applicable | Completed | Mansoura University | 30 | 2023-12-15 | 2026-09-22 |
| Topical Ascorbic Acid for Treatment of Squamous Cell Skin Cancer 30% ascorbic acid in DMSO - Squamous Cell Cancer, Squamous Cell Carcinoma | Early Phase 1 | Unknown | Center for Biomedical Research, Inc. | 15 | 2023-06-12 | 2023-08-30 |
| Endovascular Embolization of Chronic Subdural Hematomas After Surgery Post surgical embolization of middle meningeal artery with liquid embolic agents (ethylene vinyl alcohol copolymers as Onix, Squid, Phil or Libro) - Chronic Subdural Hematoma | Not applicable | Unknown | Hospital Universitari Vall d'Hebron Research Institute | 280 | 2022-02-11 | 2022-03-21 |
| Acceleration of Orthodontic Tooth Movement Dihydroxycholecalciferols, dimethyl sulfoxide, serum - Mild to Moderate Anterior Mandibular Segment Crowdind | Phase 2 / Phase 3 | Completed | Latakia University | 18 | 2021-09-20 | 2022-09-30 |
| Clinical Evaluation of Dimethyl Sulfoxide Dentin Pre-treatment Dimethyl Sulfoxide, 3M ESPE Single bond 2, Filtek Z350 XT, 3 M ESPE, St Paul, MN, USA) - Dental Diseases | Not applicable | Completed | Cairo University | 24 | 2020-11-17 | 2023-02-09 |
| Melatonin Cream Against Acute Radiation Dermatitis in Patients With Early Breast Cancer Melatonin, Dimethyl Sulfoxide, Placebos - Radiation Dermatitis, Radiation Dermatitis Acute | Phase 2 | Completed | Dennis Bregner Zetner | 48 | 2019-04-30 | 2021-09-10 |
| Topical Amphotericin B in 30% Dimethylsulphoxide in Treating of Non-dermatophytes Onychomycosis amphotericin B in 30% DMSO, 30% DMSO - Fungal Infection, Onychomycosis | Phase 4 | Completed | Mahidol University | 19 | 2019-01-15 | 2021-09-28 |
| Continuous Alloreactive T Cell Depletion and Regulatory T Cell Expansion for the Treatment of Steroid-refractory or Dependent Chronic GVHD Autologous peripheral blood mononuclear cells ex vivo depleted for reactive T cells, using TH9402 based photodynamic therapy, in a final formulation of 10% DMSO, 30% autologous plasma in PlasmaLyte. - Chronic GVHD After HCT for Cancer or Immune Disease | Phase 2 | Unknown | daphne brockington | 17 | 2016-03-01 | 2019-08-14 |
| Comparison of the Treatment of Refractory Bladder Pain Syndrome With DMSO and DMSO With Botulinum Toxin A DMSO, Botox - Bladder Pain Syndrome | Early Phase 1 | Completed | University of Pennsylvania | 2 | 2015-08-01 | 2017-06-09 |
| Protocol for the Infusion of Buffy Coat-derived Cryopreserved Platelets in Patients With Severe Thrombocytopenia Transfusion of Pooled Platelets Cryopreserved In DMSO - Thrombocytopenia, Primary Thrombocytopenia,Unspecified | Phase 4 | Terminated | Napolitano Mariasanta | 5 | 2015-07-01 | 2017-10-18 |
| Efficacy of Oral Probiotic and Antibiotic Administration in Patients With Chronic Periodontitis Lactobacillus rhamnosus SP1, Azithromycin, Talc powder - Chronic Periodontitis | Phase 2 | Unknown | University of Chile | 54 | 2015-06-01 | 2016-09-27 |
| Phase 1 Safety Study of Dimethyl Sulfoxide Cryopreserved Platelets CPP, LSP - Thrombocytopenia | Phase 1 | Completed | U.S. Army Medical Research and Development Command | 28 | 2014-11-05 | 2021-05-20 |
| DMSO for Prevention of Capsular Contraction in Alloplastic Breast Reconstruction Dimethyl Sulfoxide, Saline 0.9% - Breast Capsular Contracture, Dimethyl Sulfoxide | Phase 2 / Phase 3 | Unknown | Rabin Medical Center | 110 | 2014-08-01 | 2014-08-01 |
| Efficacy of Oral Probiotic Administration in Patients With Chronic Periodontitis Lactobacillus rhamnosus SP1, Talc powder, Periodontal treatment - -Chronic Periodontitis | Phase 2 | Unknown | Jorge Gamonal | 36 | 2014-06-01 | 2016-06-15 |
| Metformin and Dietary Restriction to Prevent Age-related Morbid Events in People With Metabolic Syndrome Metformin Hydrochloride 850 MG Oral Tablet [Glucophage], Ludipress, mg stereate, micronized hydrated silica, talcum - Metabolic Syndrome | Phase 3 | Completed | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | 1600 | 2014-02-01 | 2021-09-28 |
| Antimicrobial Photodynamic Therapy Applied in Orthodontic. Orthodontic Patients. Curcumin, LED, Surfactant - Dentist-Patient Relations | Phase 1 | Completed | University of Sao Paulo | 24 | 2014-01-01 | 2015-01-13 |
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Cystitis, Interstitial (5) · Chronic Periodontitis (2) · Thrombocytopenia (2) · Urinary Bladder, Overactive (2) · Acquired Immunodeficiency Syndrome (1) · Breast Neoplasms (1) · Carcinoma, Squamous Cell (1) · HIV Infections (1) · Hematoma, Subdural, Chronic (1) · Immune System Diseases (1) · Joint Diseases (1) · Lentivirus Infections (1) · Malocclusion (1) · Melanoma (1) · Metabolic Syndrome (1)
Assaf-Harofeh Medical Center (2) · Mayo Clinic (2) · Al-Azhar University (1) · Cairo University (1) · Center for Biomedical Research, Inc. (1) · Chinese University of Hong Kong (1) · Craig L Slingluff, Jr (1) · Dennis Bregner Zetner (1) · Endeavor Health (1) · Erasme University Hospital (1) · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano (1) · Foundation University Islamabad (1) · Hospital Universitari Vall d'Hebron Research Institute (1) · Jorge Gamonal (1) · Latakia University (1)
United States (5) · Canada (3) · Egypt (3) · Israel (3) · Chile (2) · Italy (2) · Belgium (1) · Brazil (1) · Denmark (1) · Pakistan (1) · Spain (1) · Syria (1) · Thailand (1) · United Kingdom (1)
Kobi Stav, MD (2) · Aisha Zahran (1) · Alejandro Tomasello, MD (1) · Anne Delbaere, Ph.D. (1) · Ariana Smith, MD (1) · Charussri Leeyaphan, MD (1) · Craig L. Slingluff, MD (1) · David SC Hui, MD (1) · Dennis B Zetner, MD (1) · Franco Berrino, MD (1) · Jerzy Gajewski, MD, FRCSC (1) · Jorge Gamonal, Professor (1) · Jose A Cancelas-Perez, MD, PhD (1) · Jose Luis Cuevas, MD (1) · Mariasanta Napolitano, MD (1)
PMID 10233295, PMID 10642676, PMID 14723731, PMID 15183555, PMID 19648387, PMID 20347657, PMID 21820203, PMID 22236569, PMID 22976905, PMID 23416171, PMID 24069230, PMID 24079583, PMID 24124451, PMID 24558525, PMID 24703280, PMID 25013957, PMID 25639524, PMID 26471716, PMID 27799043, PMID 27815659, PMID 28106245, PMID 28740367, PMID 30204953, PMID 30794607, PMID 31753773, PMID 33413320, PMID 33523325, PMID 35333878, PMID 36504246
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