14 completed, 3 active not recruiting, 3 not yet recruiting, 2 recruiting. 9 Phase 1, 8 Not applicable, 4 Phase 2, 1 Early Phase 1, 1 Phase 4.
Follow Craniotomy: new trials by email Literature Review of Craniotomy trials Research Report on Craniotomy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fluorescence-Guided Imaging of Brain Tumors: A Safety Study Using SBK2-ICG SBK2-ICG, Craniotomy (Standard of Care) - Malignant Brain Tumors, Glioma | Phase 1 | Not yet recruiting | Tiffany Hodges | 12 | 2026-11-02 | 2026-10-06 |
| Efficacy and Safety of NeuroEndoscopic Surgery for Large IntraCerebral Hemorrhage neuroendoscopic surgery, craniotomy - Intracerebral Haemorrhage | Not applicable | Recruiting | Southwest Hospital, China | 280 | 2025-06-01 | 2025-05-18 |
| Puerto Rico Embolization of the Middle Meningeal Artery for the Treatment of Chronic Subdural Hematoma Trial (PREMMA) Embolization of the middle meningeal artery, Surgical Evacuation via burr hole or craniotomy - Chronic Subdural Hematoma | Not applicable | Not yet recruiting | Juan M. Ramos Acevedo | 658 | 2025-05-01 | 2025-05-07 |
| Comparison of Surgical Outcomes of Craniotomy and Craniectomy in Posterior Fossa Lesions Craniotomy, Craniectomy - Posterior Fossa Lesion | Not applicable | Not yet recruiting | University of Health Sciences Lahore | 80 | 2025-03-04 | 2025-02-18 |
| Investigational Imaging Technique During Brain Surgery Craniotomy, Quantitative Oblique Back-Illumination Microscopy - Astrocytoma, Glioblastoma | Not applicable | Suspended | Emory University | 24 | 2024-03-11 | 2026-04-24 |
| Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Recurrent Glioblastoma or Recurrent Astrocytoma in Patients Undergoing Craniotomy Allogeneic Adipose-derived Mesenchymal Stem Cells, Biospecimen Collection, Craniotomy - Recurrent Glioblastoma, IDH-Wildtype, Recurrent Astrocytoma, IDH-Mutant, Grade 4 | Phase 1 | Recruiting | Mayo Clinic | 20 | 2023-06-16 | 2026-04-02 |
| Sellar Masses: Clinical and Imaging Features With Correlation to Histopathology and Surgical Approach Craniectomy - Sellar Mass, Pituitray Tumor | Completed | Arab Board of Neurosurgery | 49 | 2022-12-01 | 2026-06-10 | |
| Intracavitary Carrier-embedded Cs131 Brachytherapy for Recurrent Brain Metastases: a Randomized Phase II Study Craniotomy, Cesium-131 brachytherapy - Recurrent Brain Metastases | Phase 2 | Active not recruiting | Memorial Sloan Kettering Cancer Center | 103 | 2020-12-24 | 2026-06-04 |
| Prospective Randomized Evaluation of Decompressive Ipsilateral Craniectomy for Traumatic Acute Epidural Hematoma Decompressive Craniectomy, Craniotomy - Epidural Hematoma, Brain Herniation | Not applicable | Active not recruiting | RenJi Hospital | 120 | 2020-05-23 | 2025-10-01 |
| Middle Meningeal Artery Embolization for Chronic Subdural Hematoma Middle Meningeal Artery Embolization with polyvinyl alcohol particles (PVA), Drainage of Subdural Hematoma - Chronic Subdural Hematoma | Withdrawn | Washington University School of Medicine | 2019-09-19 | 2025-07-22 | ||
| Endovascular Embolization for Chronic Subdural Hematomas Following Surgical Evacuation Craniotomy only, Craniotomy + Endovascular embolization of the middle meningeal vessels - Chronic SDH and the Efficacy of Embolization | Not applicable | Unknown | Augusta University | 60 | 2019-03-01 | 2023-06-18 |
| Comparison of the Effect of Low and High Fraction of Inspired Oxygen on Postoperative Surgical Field Infection Craniotomy - Supratentorial Brain Tumor | Unknown | Istanbul University | 80 | 2018-04-01 | 2018-03-06 | |
| Dose Escalation Trial of Neoadjuvant Radiosurgery for the Treatment of Metastatic Brain Tumors Neoadjuvant stereotactic radiosurgery, Neurosurgical resection - Brain Metastases | Early Phase 1 | Active not recruiting | Cedars-Sinai Medical Center | 25 | 2017-05-09 | 2026-04-17 |
| Enhancing Optune Therapy With Targeted Craniectomy Optune, Craniectomy - Glioblastoma | Phase 1 | Completed | Aarhus University Hospital | 15 | 2016-10-01 | 2019-11-27 |
| Minimally-invasive Surgery Versus Craniotomy in Patients With Supratentorial Hypertensive Intracerebral Hemorrhage Endoscopic Evacuation, Stereotactic Aspiration, Craniotomy - Intracranial Hemorrhage, Hypertensive | Not applicable | Completed | Chinese PLA General Hospital | 733 | 2016-07-01 | 2023-02-22 |
| Antisense102: Pilot Immunotherapy for Newly Diagnosed Malignant Glioma IGF-1R/AS ODN; Surgery with tissue harvest and implantation 20 diffusion chambers in the rectus sheath with IGF-1R/AS ODN within 24 hours of craniotomy, implanted for 48 hours. - Malignant Glioma, Neoplasms | Phase 1 | Completed | david andrews | 33 | 2015-09-01 | 2025-05-07 |
| Preoperative Chemoradiation for Glioblastoma Temozolomide, partial brain irradiation, stereotactic biopsy of brain tumor - Glioblastoma | Phase 1 | Completed | Tampa General Hospital | 1 | 2014-11-01 | 2015-11-10 |
| Amniotic Membrane in Decompressive Craniectomy to Reduce Scarring dHACM, Craniectomy - Scarring | Not applicable | Completed | MiMedx Group, Inc. | 7 | 2014-04-01 | 2018-08-23 |
| Prospective, Multicenter Observational Study Evaluating the Long Term Safety of the Custombone Implant craniectomy - Surgery | Completed | Integra LifeSciences Corporation | 110 | 2012-12-01 | 2018-07-02 | |
| Carboplatin in Treating Patients With Recurrent High-Grade Gliomas carboplatin, Surgery - Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma | Phase 1 | Completed | James Elder | 10 | 2012-06-11 | 2018-07-02 |
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Brain Neoplasms (10) · Glioblastoma (6) · Glioma (4) · Astrocytoma (3) · Central Nervous System Neoplasms (2) · Hematoma, Subdural, Chronic (2) · Neoplasm Metastasis (2) · Oligodendroglioma (2) · Carcinoma (1) · Carcinoma, Non-Small-Cell Lung (1) · Central Nervous System Diseases (1) · Cerebral Hemorrhage (1) · Cerebrovascular Disorders (1) · Chronic Disease (1) · Cicatrix (1)
National Institute of Neurological Disorders and Stroke (NINDS) (2) · University of California, San Francisco (2) · Aarhus University Hospital (1) · Arab Board of Neurosurgery (1) · Augusta University (1) · Cedars-Sinai Medical Center (1) · Chinese PLA General Hospital (1) · DNAtrix, Inc. (1) · Department of Medical Services Ministry of Public Health of Thailand (1) · Emory University (1) · Integra LifeSciences Corporation (1) · Istanbul University (1) · James Elder (1) · Juan M. Ramos Acevedo (1) · Mayo Clinic (1)
United States (15) · China (3) · Denmark (1) · France (1) · Taiwan (1) · Thailand (1) · Yemen (1)
Jennifer Clarke, MD (2) · Adnan Al- Awdi, Neurosurgical consultant (1) · Alfredo Quinones-Hinojosa, MD (1) · Anders R Korshoej, MD (1) · Chris Clare, MD (1) · Fernando L. Vale, M.D. (1) · Frederick F. Lang, MD, BS (1) · James Elder (1) · John K Park, M.D. (1) · Joshua W Osbun, MD (1) · Juan M Ramos Acevedo, MD (1) · Junfeng Feng, MD (1) · Kevin Judy, MD (1) · Kimberly J. Hoang, MD (1) · Lawrence Berk, MD, PhD (1)
PMID 24335700, PMID 28193626, PMID 28659171, PMID 28935548, PMID 29019449, PMID 29432077, PMID 30418606, PMID 30641498, PMID 30798265, PMID 33500356, PMID 34187537, PMID 38311852, PMID 38867192, PMID 41529871, PMID 42309085
P30CA138292 (1), P50CA097257 (1), R01CA164714 (1)