51 completed, 13 unknown, 10 withdrawn, 4 terminated. 39 Not applicable, 15 Phase 3, 13 Phase 2, 8 Phase 4, 1 Early Phase 1.
Follow Chronic Sinusitis: new trials by email Literature Review of Chronic Sinusitis trials Research Report on Chronic Sinusitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| FESS With or Without Intranasal Desmopressin in Chronic Rhinosinusitis With Nasal Polyps Desmopressin Acetate Nasal, 10 μg/0.1 ml per spray, Functional Endoscopic Sinus Surgery - Chronic Sinusitis, Nasal Polyposis | Not applicable | Not yet recruiting | Services Institute of Medical Sciences, Pakistan | 174 | 2026-10-15 | 2026-10-23 |
| Efficacy of Bee Venom Phonophoresis in Treating Chronic Sinusitis: Bee Venom Phonophoresis, Standard Care (oral decongestants + saline nasal irrigation) - Chronic Sinusitis, Acute Sinusitis | Not applicable | Not yet recruiting | Sinai University | 30 | 2026-08-15 | 2026-08-04 |
| Opioid-Free Anesthesia in FESS: A Prospective ERAS Study Dexmedetomidine, Remifentanil - Chronic Sinusitis, Postoperative Pain | Recruiting | Filiz Kaya | 104 | 2026-08-15 | 2026-09-10 | |
| Biologics in Chronic Rhinosinusitis With Nasal Polyposis Biologic Agents - Chronic Sinusitis, Nasal Polyps | Phase 4 | Recruiting | Medical University of South Carolina | 504 | 2026-06-03 | 2026-11-10 |
| A Study Evaluating the Efficacy of Endoscope Ethmoid Infundibulum Expansion Surgery (EEIES) Combined With Stapokibart in the Treatment of Type 2 Chronic Rhinosinusitis The surgical side of Endoscope Ethmoid Infundibulum Expansion Surgery (EEIES), The surgical side of Endoscopic Sinus Surgery (ESS) - Chronic Sinusitis | Not applicable | Enrolling by invitation | China-Japan Union Hospital | 30 | 2025-04-21 | 2025-07-24 |
| Craniosacral Osteopathic Treatment for Chronic Sinusitis Standard Medical Treatment, Craniosacral Osteopathic Manipulative Treatment (OM-KST) - Craniosacral Osteopathic Manipulation, Chronic Sinusitis | Not applicable | Completed | Alanya Alaaddin Keykubat University | 50 | 2024-11-15 | 2026-11-02 |
| Clinical and Radiographic Evidence of Alleviation of Preoperative Chronic Sinusitis After Open Sinus Allogeneic Bone Augmentation Surgery: A Retrospective Observational Study Chronic Sinusitis, Open Sinus Elevation | Completed | Misr International University | 36 | 2024-05-29 | 2025-01-14 | |
| Sugammadex v.s. Neostigmine/Glycopyrrolate Group S: sugammadex injection, Group N: neostigmine/glycopyrrolate - Head and Neck Surgery, Chronic Sinusitis | Not applicable | Completed | National Taiwan University Hospital | 124 | 2024-05-01 | 2025-09-12 |
| Steroid-eluting Sinus Stent for Chronic Rhinosinusitis Patients With Uncontrolled Postoperative Symptoms steroid-eluting sinus stent implant, Systemic glucocorticoids, saline irrigations - Chronic Sinusitis | Not applicable | Unknown | Zheng Liu | 96 | 2024-01-10 | 2024-01-18 |
| Endotypic Stability in CRS no intervention - Chronic Sinusitis | Active not recruiting | Thomas Jefferson University | 200 | 2024-01-01 | 2026-10-01 | |
| A Clinical Study of TQC2731 Injection in the Treatment of Chronic Rhinosinusitis With Nasal Polyps TQC2731 injection, TQC2731 matching placebo - Chronic Sinusitis, Nasal Polyps | Phase 2 | Completed | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 80 | 2023-12-08 | 2025-04-16 |
| Wound Healing After Endoscopic Sinus Surgery Thymoquinone (0.5%) and Olive oil ointment - Nasal Polyps, Chronic Sinusitis | Not applicable | Unknown | Assiut University | 50 | 2023-10-01 | 2023-10-06 |
| A Clinical Study to Evaluate the Safety and Effectiveness of Novabel Bioabsorbable Steroid-releasing Stent for the Chronic Sinusitis bioabsorbable steroid-releasing stent - Chronic Sinusitis | Not applicable | Unknown | Enlight Medical Technologies (Shanghai) Co., Ltd | 93 | 2023-08-25 | 2023-10-26 |
| Utility of Indocyanine Green Fluorescence in Endoscopic Sinonasal and Skull Base Surgery Sinonasal Benign or Malignant Tumor Resection, Skull Base Surgery (Assessment of Nasoseptal Flap), Endoscopic Sinus Surgery - Chronic Sinusitis, Tumor of Nasal Sinus | Not applicable | Unknown | St. Paul's Sinus Centre | 40 | 2023-01-01 | 2022-11-14 |
| Post-radiotherapy Rhinosinusitis in Children SNOT 22 questionnaire - Pediatric Cancer, Chronic Sinusitis | Withdrawn | University Hospital, Lille | 2022-10-01 | 2026-05-22 | ||
| Roflumilust in Chronic Rhinosinusitis With Nasal Polyposis. Roflumilust, Prednisolone - Chronic Sinusitis | Phase 2 | Unknown | Menoufia University | 60 | 2022-06-01 | 2022-05-11 |
| Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults (ENLIGHTEN 2) LYR-210, Sham procedure control, Background therapy - Chronic Sinusitis, Chronic Rhinosinusitis (Diagnosis) | Phase 3 | Completed | Lyra Therapeutics | 182 | 2022-05-13 | 2026-02-19 |
| Efficacy of ArchSinus, NasoPore & Propel to Prevent Post-Surgical MT Lateralization and Improve Symptomatic Outcomes ArchSinus stent - Chronic Sinusitis | Not applicable | Unknown | STS Medical | 50 | 2022-03-01 | 2021-12-14 |
| Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults LYR-210, Sham procedure control, Background Therapy - Chronic Sinusitis, Chronic Rhinosinusitis (Diagnosis) | Phase 3 | Completed | Lyra Therapeutics | 196 | 2022-01-27 | 2025-05-02 |
| LYR-220 for Adult Subjects With Chronic Rhinosinusitis (BEACON Study) LYR-220 Design 1 (Part 1 only), LYR-220 Design 2 (Part 1 and Part 2), Bilateral sham procedure control (Part 2) - Chronic Sinusitis, Chronic Rhinosinusitis (Diagnosis) | Phase 2 | Completed | Lyra Therapeutics | 48 | 2021-11-23 | 2024-12-17 |
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Nasal Polyps (11) · Sinusitis (11) · Disease (6) · Rhinosinusitis (3) · Asthma (2) · Bronchiolitis Obliterans Syndrome (2) · Nasal Obstruction (2) · Paranasal Sinus Diseases (2) · Rhinitis (2) · Skull Base Neoplasms (2) · Anosmia (1) · Blood Loss, Surgical (1) · Cognitive Dysfunction (1) · Depression (1) · Disease Progression (1)
Respiratory Tract Diseases (28) · Otorhinolaryngologic Diseases (27) · Nose Diseases (26) · Pathological Conditions, Signs and Symptoms (23) · Infections (15) · Respiratory Tract Infections (14) · Paranasal Sinus Diseases (13) · Pathological Conditions, Anatomical (12) · Polyps (11) · Pathologic Processes (9) · Bronchial Diseases (4) · Immune System Diseases (4) · Lung Diseases (4) · Lung Diseases, Obstructive (4) · Rhinitis (3)
Budesonide (5) · Mometasone Furoate (3) · Sodium Chloride (3) · Anti-Bacterial Agents (2) · Bacitracin (2) · Dexmedetomidine (2) · Epinephrine (2) · Prednisone (2) · Remifentanil (2) · Steroids (2) · Tranexamic Acid (2) · Vitamin D (2) · dupilumab (2) · Acetaminophen (1) · Adenoidectomy (1)
Intersect ENT (10) · Lyra Therapeutics (5) · Integra LifeSciences Corporation (3) · Zheng Liu (3) · Assiut University (2) · Entellus Medical, Inc. (2) · Lahey Clinic (2) · Medical University of South Carolina (2) · STS Medical (2) · University Hospital, Lille (2) · University of Calgary (2) · University of Chicago (2) · Accentia Biopharmaceuticals (1) · Alanya Alaaddin Keykubat University (1) · Bionorica SE (1)
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Jayant Pinto, MD (2) · Zheng Liu, Doctor (2) · Aaron Pearlman, MD (1) · Ahmed Gamal Sholkamy, Doctor (1) · Alan H. Shikani, MD (1) · Ali Moshaver, MD (1) · Amber U. Luong, MD, PhD (1) · Amin Javer, MD (1) · Andrew Goldberg, MD (1) · Angelos M Stergiou, MD (1) · B.Todd Schaeffer, MD (1) · Brad D Mechor, MD (1) · Bradley Marple, MD (1) · Brent Lanier, MD (1) · Christopher Church, MD (1)
PMID 12172251, PMID 15182211, PMID 15224630, PMID 15564850, PMID 16274802, PMID 16360518, PMID 16500451, PMID 19841339, PMID 20738346, PMID 21605125, PMID 22252861, PMID 22550039, PMID 23193904, PMID 23920419, PMID 24482348, PMID 24678064, PMID 24817242, PMID 24823902, PMID 25625809, PMID 25631304, PMID 26228589, PMID 26992115, PMID 27363723, PMID 28542675, PMID 28972988, PMID 29098299, PMID 30645028, PMID 32077450, PMID 36608352, PMID 41417228
1KL2RR025015-01 (1), 2018 (1), KL2RR025754 (1), R37HL068546 (1)