11 completed, 1 unknown, 1 withdrawn. 13 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 13 | Completed 11, Unknown 1, Withdrawn 1 |
| Phase 3 | 2 | Completed 1, Withdrawn 1 |
Follow Chronic Sinusitis: new trials by email Literature Review of Chronic Sinusitis trials Research Report on Chronic Sinusitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Study of TQC2731 Injection in the Treatment of Chronic Rhinosinusitis With Nasal Polyps TQC2731 injection, TQC2731 matching placebo - Chronic Sinusitis, Nasal Polyps | Phase 2 | Completed | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 80 | 2023-12-08 | 2025-04-16 |
| Roflumilust in Chronic Rhinosinusitis With Nasal Polyposis. Roflumilust, Prednisolone - Chronic Sinusitis | Phase 2 | Unknown | Menoufia University | 60 | 2022-06-01 | 2022-05-11 |
| LYR-220 for Adult Subjects With Chronic Rhinosinusitis (BEACON Study) LYR-220 Design 1 (Part 1 only), LYR-220 Design 2 (Part 1 and Part 2), Bilateral sham procedure control (Part 2) - Chronic Sinusitis, Chronic Rhinosinusitis (Diagnosis) | Phase 2 | Completed | Lyra Therapeutics | 48 | 2021-11-23 | 2024-12-17 |
| Dupilumab in CRSsNP Dupilumab SAR231893, Placebo - Chronic Rhinosinusitis Without Nasal Polyps, Sinusitis | Phase 2 | Completed | Sanofi | 71 | 2020-12-02 | 2026-07-30 |
| Efficacy of Dupilumab for Patients With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) dupilumab, placebo - Chronic Sinusitis | Phase 2 | Completed | Johns Hopkins University | 33 | 2020-10-15 | 2025-11-03 |
| Nitric Oxide Releasing Sinus Irrigation (NOSi) to Treat Recalcitrant Chronic Rhinosinusitis (RCRS) Nitric Oxide, Budesonide - Chronic Sinusitis | Phase 2 | Completed | Sanotize Research and Development corp. | 56 | 2019-10-27 | 2022-06-30 |
| Impact of Budesonide Irrigations on Patients With Chronic Rhinosinusitis and Impact on Sinus Surgery Rates Budesonide - Chronic Sinus Infection, Chronic Sinusitis | Phase 2 / Phase 3 | Withdrawn | Kaiser Permanente | 2019-08-13 | 2021-01-14 | |
| LYR-210 Depot (LYR-210) for Adult Subjects With Chronic Sinusitis (LANTERN Study) LYR-210, Sham comparator - Chronic Sinusitis, Chronic Rhinosinusitis (Diagnosis) | Phase 2 | Completed | Lyra Therapeutics | 71 | 2019-05-09 | 2023-07-25 |
| Esmolol vs. Labetalol in Endoscopic Sinus Surgery Labetalol, Esmolol - Chronic Sinusitis | Phase 2 | Completed | The University of Texas Medical Branch, Galveston | 28 | 2017-03-01 | 2021-02-08 |
| Safety and Performance of the Steroid-Releasing S8 Sinus Implant S8 Sinus Implant (mometasone furoate, 1350 mcg) - Chronic Sinusitis | Phase 2 | Completed | Intersect ENT | 5 | 2013-06-01 | 2018-07-18 |
| Steroid-Releasing S8 Sinus Implant for Recurrent Nasal Polyps S8 Sinus Implant, Sham procedure, Mometasone furoate nasal spray - Chronic Sinusitis, Nasal Polyps | Phase 2 / Phase 3 | Completed | Intersect ENT | 100 | 2013-01-01 | 2018-07-20 |
| Gulf War Illness Nasal Irrigation Study Nasal Irrigation - Saline, Nasal Irrigation - Xylitol - Persian Gulf Syndrome, Chronic Sinusitis | Phase 2 | Completed | University of Wisconsin, Madison | 40 | 2012-10-01 | 2019-05-21 |
| Evaluating SPRC-AB01 in Post-Surgical Subjects With Chronic Sinusitis SPRC-AB01 - Chronic Sinusitis | Phase 2 | Completed | Naryx Pharma | 180 | 2006-10-01 | 2008-03-17 |
Sinusitis (3) · Disease (2) · Nasal Polyps (2) · Bronchiolitis Obliterans Syndrome (1) · Fatigue (1) · Paranasal Sinus Diseases (1) · Persian Gulf Syndrome (1) · Respiration Disorders (1)
Nose Diseases (5) · Otorhinolaryngologic Diseases (5) · Pathological Conditions, Signs and Symptoms (5) · Respiratory Tract Diseases (5) · Infections (3) · Respiratory Tract Infections (3) · Paranasal Sinus Diseases (2) · Pathologic Processes (2) · Pathological Conditions, Anatomical (2) · Polyps (2) · Bronchial Diseases (1) · Bronchiolitis (1) · Bronchiolitis Obliterans (1) · Bronchitis (1) · Graft vs Host Disease (1)
Budesonide (2) · Mometasone Furoate (2) · dupilumab (2) · Labetalol (1) · Nitric Oxide (1) · Prednisolone (1) · Therapeutics (1) · esmolol (1)
Intersect ENT (2) · Lyra Therapeutics (2) · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (1) · Johns Hopkins University (1) · Kaiser Permanente (1) · Menoufia University (1) · Naryx Pharma (1) · Sanofi (1) · Sanotize Research and Development corp. (1) · The University of Texas Medical Branch, Galveston (1) · University of Wisconsin, Madison (1)
United States (9) · Australia (2) · Canada (2) · China (2) · Argentina (1) · Austria (1) · Belgium (1) · Chile (1) · Czechia (1) · Egypt (1) · Hungary (1) · New Zealand (1) · Poland (1) · Portugal (1) · Russia (1)
Amin Javer, MD (1) · David P Rabago, MD (1) · Jody Tversky (1) · Joseph K Han, MD (1) · Keith D Forwith, MD (1) · Mohamad Chaaban, MD (1) · Rachel Molander, MD (1) · Randall Ow, MD (1)
2018 (1)