12 completed, 2 unknown, 1 withdrawn. 15 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 15 | Completed 12, Unknown 2, Withdrawn 1 |
| Phase 2 | 2 | Completed 1, Withdrawn 1 |
Follow Chronic Sinusitis: new trials by email Literature Review of Chronic Sinusitis trials Research Report on Chronic Sinusitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults (ENLIGHTEN 2) LYR-210, Sham procedure control, Background therapy - Chronic Sinusitis, Chronic Rhinosinusitis (Diagnosis) | Phase 3 | Completed | Lyra Therapeutics | 182 | 2022-05-13 | 2026-02-19 |
| Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults LYR-210, Sham procedure control, Background Therapy - Chronic Sinusitis, Chronic Rhinosinusitis (Diagnosis) | Phase 3 | Completed | Lyra Therapeutics | 196 | 2022-01-27 | 2025-05-02 |
| Impact of Budesonide Irrigations on Patients With Chronic Rhinosinusitis and Impact on Sinus Surgery Rates Budesonide - Chronic Sinus Infection, Chronic Sinusitis | Phase 2 / Phase 3 | Withdrawn | Kaiser Permanente | 2019-08-13 | 2021-01-14 | |
| Safety Evaluation of Repeat Placement of the S8 Sinus Implant in Chronic Sinusitis Patients With Nasal Polyps (ENCORE) S8 Sinus Implant - Chronic Sinusitis, Nasal Polyposis | Phase 3 | Completed | Intersect ENT | 50 | 2017-11-13 | 2019-11-27 |
| Gel-Sinuplasty for Chronic Rhinosinusitis With and Without Nasal Polyposis gel loaded with steroids (momentasone), gel loaded with antibiotic (Levofloxacin), gel loaded with both steroids and antibiotic - Chronic Sinusitis, Ethmoidal, Chronic Sinusitis - Ethmoidal Anterior | Phase 3 | Unknown | LifeBridge Health | 60 | 2017-07-07 | 2018-03-21 |
| S8 Sinus Implant in Chronic Sinusitis Patients With Recurrent Nasal Polyps S8 Sinus Implant, Mometasone furoate nasal spray, Sham - Chronic Sinusitis, Nasal Polyposis | Phase 3 | Completed | Intersect ENT | 300 | 2014-12-01 | 2018-08-15 |
| Safety and Efficacy of the Propel Mini and Propel Nova Steroid-Eluting Sinus Implant in Frontal Sinus PROPEL Mini Sinus Implant., Sinus Surgery alone, Propel Nova Sinus Implant - Chronic Sinusitis | Phase 3 | Completed | Intersect ENT | 160 | 2014-09-01 | 2018-08-15 |
| Steroid-Releasing S8 Sinus Implant for Recurrent Nasal Polyps S8 Sinus Implant, Sham procedure, Mometasone furoate nasal spray - Chronic Sinusitis, Nasal Polyps | Phase 2 / Phase 3 | Completed | Intersect ENT | 100 | 2013-01-01 | 2018-07-20 |
| Efficacy and Safety of Two Dosages of a Herbal Medicinal Product (Dry Extract BNO 1016) in Chronic Rhinosinusitis BNO 1016 - Chronic Sinusitis | Phase 3 | Completed | Bionorica SE | 927 | 2012-09-01 | 2014-07-08 |
| Nasal Packing as a Drug Delivery System Postoperatively in Chronic Sinusitis With Polyposis pulmicort - Chronic Sinusitis, Polyposis | Phase 3 | Completed | University of Michigan | 23 | 2010-09-01 | 2018-05-29 |
| A Clinical Evaluation of a Steroid-Coated Sinus Stent When Used Following Functional Endoscopic Sinus Surgery in Patients With Chronic Sinusitis Sinus Stent with drug coating, Non Coated Sinus Stent - Chronic Sinusitis | Phase 3 | Completed | Intersect ENT | 105 | 2009-12-01 | 2015-06-22 |
| The Hemostatic and Hemodynamic Effects of Adrenaline During Endoscopic Sinus Surgery 1% lidocaine with 1:100,000 adrenaline, 1% lidocaine with 1:200,000 adrenaline - Chronic Sinusitis | Phase 3 | Unknown | University of Toronto | 140 | 2009-03-01 | 2010-06-30 |
| Amphotericin B Suspension in Refractory Chronic Sinusitis SinuNase - Chronic Sinusitis | Phase 3 | Completed | Accentia Biopharmaceuticals | 300 | 2006-12-01 | 2007-11-30 |
| Study of ONO-1078 in Patients With Chronic Sinusitis Placebo, Pranlukast hydrate - Chronic Sinusitis | Phase 3 | Completed | Ono Pharmaceutical Co., Ltd. | 495 | 2006-12-01 | 2012-06-13 |
| Clinical Evaluation to Confirm Safety and Efficacy of Sinuplasty in the Paranasal Sinuses (CLEAR) Sinuplasty - Chronic Sinusitis | Phase 3 | Completed | Integra LifeSciences Corporation | 115 | 2005-04-01 | 2024-08-06 |
Nasal Polyps (4) · Disease (2) · Rhinitis (1) · Sinusitis (1)
Pathological Conditions, Signs and Symptoms (6) · Nose Diseases (5) · Otorhinolaryngologic Diseases (5) · Respiratory Tract Diseases (5) · Pathological Conditions, Anatomical (4) · Polyps (4) · Pathologic Processes (2) · Infections (1) · Paranasal Sinus Diseases (1) · Respiratory Tract Infections (1)
Budesonide (2) · Mometasone Furoate (2) · Anti-Bacterial Agents (1) · BNO 1016 (1) · Epinephrine (1) · Levofloxacin (1) · Lidocaine (1) · Plant Extracts (1) · Steroids (1) · salicylhydroxamic acid (1)
Intersect ENT (5) · Lyra Therapeutics (2) · Accentia Biopharmaceuticals (1) · Bionorica SE (1) · Integra LifeSciences Corporation (1) · Kaiser Permanente (1) · LifeBridge Health (1) · Ono Pharmaceutical Co., Ltd. (1) · University of Michigan (1) · University of Toronto (1)
United States (11) · Belgium (2) · Poland (2) · Austria (1) · Bulgaria (1) · Canada (1) · Czechia (1) · Germany (1) · Hungary (1) · Japan (1) · Spain (1)
Alan H. Shikani, MD (1) · Ali Moshaver, MD (1) · Amber U. Luong, MD, PhD (1) · Angelos M Stergiou, MD (1) · Bradley Marple, MD (1) · Christopher Church, MD (1) · Claus Bachert, Prof. Dr. (1) · Garrett R Griffin, MD (1) · Hajime Yamamotoya (1) · Jose P. Stolovitzky, MD (1) · Joseph K Han, MD (1) · Keith D Forwith, MD (1) · Neil Bhattacharyya, MD (1) · Peter Manes, MD (1) · Robert C Kern, MD (1)
PMID 19841339, PMID 20738346, PMID 22550039, PMID 23193904, PMID 24817242, PMID 26992115, PMID 27363723, PMID 29098299