58 completed, 24 recruiting, 23 unknown, 8 active not recruiting. 53 Not applicable, 17 Phase 3, 17 Phase 4, 11 Phase 2, 2 Phase 1.
Follow this condition Literature Review of Chronic Migraine trials Research Report on Chronic Migraine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| EMBRACE Study: Enduring Migraine Benefit From Responsive Artery Coil Embolization TEMMA Endovascular Treatment - Migraine Disorders, Refractory Migraine | Not applicable | Not yet recruiting | Cortex Neurovascular | 25 | 2028-03-01 | 2026-10-20 |
| Sequential, Multiple Assignment, Double Randomized Preference, Migraine Behavioral Trial Migraine Behavioral Treatment - Migraine, Headache | Not applicable | Not yet recruiting | Mayo Clinic | 24 | 2026-12-01 | 2026-06-16 |
| Mechanism-Based Cervical Rehabilitation for Chronic Migraine cervical sensorimotor rehabilitation, conventional physiotherapy programme - Chronic Migraine | Not applicable | Enrolling by invitation | Beni-Suef University | 80 | 2026-10-25 | 2026-10-13 |
| Comparison of the Effectiveness of Greater Occipital Nerve and Supratrochlear Nerve Pulsed Radiofrequency Versus Botulinum Toxin Type A Injection in Chronic Migraine OnabotulinumtoxinA, Ultrasound-guided pulsed radiofrequency (PRF) of the greater occipital nerve (GON) and supratrochlear nerve - Chronic Migraine | Phase 4 | Not yet recruiting | Assiut University | 70 | 2026-10-01 | 2026-09-23 |
| Evolution of the Cognitive Profile and Quality of Life of Adult Patients Suffering From Severe Migraines Under Preventive Treatment Cognitive assessment mapping - Chronic Migraine | Not applicable | Not yet recruiting | University Hospital, Strasbourg, France | 60 | 2026-10-01 | 2026-07-08 |
| Suppressive Functions of Regulatory T Cells in Migraine Blood sampling, questionnaire and phone call - Chronic Migraine | Not applicable | Recruiting | University Hospital, Clermont-Ferrand | 24 | 2026-09-10 | 2026-10-14 |
| Effect of Nebulized Dexmedetomidine on Central Sensitization and Chronification in Migraine Dexmedetomidine - Chronic Migraine | Not applicable | Recruiting | Beni-Suef University | 146 | 2026-09-01 | 2026-08-17 |
| Fire Needling Plus Filiform Needling for Chronic Migraine With Comorbid Tension-Type Headache filiform needling, fire needling combined with filiform needling - Chronic Migraine, Tension-type Headache | Not applicable | Not yet recruiting | Beijing Hospital of Traditional Chinese Medicine | 88 | 2026-08-01 | 2026-06-08 |
| Cannabis for the Prophylactic Treatment of Migraine CBD 100 mg OD, CBD 200 mg OD, Placebo - Chronic Migraine | Phase 2 | Recruiting | University of Calgary | 72 | 2026-04-01 | 2026-05-01 |
| A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine Xeomin, Placebo - Chronic Migraine | Phase 3 | Active not recruiting | Merz Therapeutics GmbH | 808 | 2025-08-21 | 2026-10-14 |
| Effects of Online Mindfulness Therapy on Pain and Stress in Adults With Chronic Migraine and Adverse Childhood Experiences Online Mindfulness-Based Cognitive Therapy - Chronic Migraine, Adverse Childhood Experiences | Not applicable | Not yet recruiting | Fundación Cardiovascular de Colombia | 60 | 2025-07-01 | 2025-06-26 |
| Sphenopalatine Block Versus BOTOX in Management of Chronic Migraine Sphenopalatine block, Botulinum Toxin Type A - Sphenopalatine Block, BOTOX | Not applicable | Recruiting | Cairo University | 64 | 2025-05-15 | 2025-05-16 |
| Eptinezumab as an Adjunct to Standard of Care for Migraine in an Acute Emergency Context Eptinezumab, Standard of Care - Migraine, Chronic Migraine | Phase 3 | Enrolling by invitation | Dr George Medvedev | 102 | 2025-05-05 | 2026-09-30 |
| Acceptance and Commitment Therapy to Improve Disability in Chronic Migraine acceptance and commitment therapy - Chronic Migraine | Not applicable | Recruiting | Brigham and Women's Hospital | 40 | 2025-04-21 | 2025-10-31 |
| A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years Atogepant, Placebo for Atogepant - Chronic Migraine | Phase 3 | Recruiting | AbbVie | 420 | 2025-02-13 | 2026-10-09 |
| Efficacy of Nerve Block Versus Botox in Chronic Migraine Management Nerve Block Injections, Botulinum Toxin A - Chronic Migraine, Chronic Migraine, Headache | Not applicable | Recruiting | Zagazig University | 64 | 2024-11-10 | 2024-11-12 |
| Efficacy and Safety of Stellate Ganglion Block With Lidocaine Combined Platelet-rich Plasma to Treat Chronic Migraine No interventions, Not have interventions - Platelet-rich Plasma, Chronic Migraine | Completed | Beijing Tiantan Hospital | 200 | 2024-10-20 | 2026-02-12 | |
| Cannabis for Chronic Headaches in Adolescents: the CAN-CHA Trial MPL-001 - Chronic Migraine | Phase 2 | Recruiting | University of Manitoba | 20 | 2024-10-11 | 2025-05-29 |
| A Study to Evaluate IPN10200 Safety and Efficacy in the Prevention of Episodic or Chronic Migraine in Adults Corabotase, Placebo, Corabotase dose A - Episodic Migraine, Chronic Migraine | Phase 2 | Active not recruiting | Ipsen | 670 | 2024-10-10 | 2026-09-08 |
| Post-Marketing Study to Assess the Safety and Effectiveness of Oral Atogepant in Korean Adult Participants for the Prevention of Chronic or Episodic Migraine Atogepant - Chronic Migraine, Episodic Migraine | Recruiting | AbbVie | 3000 | 2024-09-24 | 2026-07-22 |
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Migraine Disorders (56) · Headache (26) · Migraine with Aura (13) · Migraine without Aura (12) · Headache Disorders, Secondary (10) · Headache Disorders (9) · Pain (7) · Fibromyalgia (3) · Tension-Type Headache (3) · Anxiety Disorders (2) · Chronic Pain (2) · Depression (2) · Temporomandibular Joint Disorders (2) · Acute Pain (1) · Arthritis (1)
Nervous System Diseases (71) · Brain Diseases (68) · Central Nervous System Diseases (68) · Headache Disorders, Primary (61) · Headache Disorders (58) · Pathological Conditions, Signs and Symptoms (35) · Signs and Symptoms (32) · Neurologic Manifestations (31) · Pain (23) · Mental Disorders (6) · Musculoskeletal Diseases (5) · Pathologic Processes (5) · Behavior (4) · Muscular Diseases (4) · Migraine Disorders (3)
Botulinum Toxins, Type A (13) · atogepant (8) · Sodium Chloride (5) · galcanezumab (5) · Topiramate (4) · erenumab (4) · Bupivacaine (3) · Ligands (3) · Musculoskeletal Manipulations (3) · Transcranial Direct Current Stimulation (3) · fremanezumab (3) · Dexamethasone (2) · Diet, Ketogenic (2) · Lidocaine (2) · Milnacipran (2)
IRCCS National Neurological Institute "C. Mondino" Foundation (9) · AbbVie (5) · University of Florence (5) · Cady, Roger, M.D. (4) · Allergan (3) · Chordate Medical (3) · Mayo Clinic (3) · University of Liege (3) · Assiut University (2) · Beijing Tiantan Hospital (2) · Beni-Suef University (2) · Children's Hospital Medical Center, Cincinnati (2) · Danish Headache Center (2) · Eli Lilly and Company (2) · Ipsen (2)
United States (48) · Italy (25) · Canada (13) · Spain (12) · Germany (10) · United Kingdom (10) · Denmark (9) · Egypt (8) · France (8) · Czechia (6) · Poland (6) · Belgium (5) · China (5) · Japan (5) · Netherlands (5)
Cristina Tassorelli, MD (3) · Roger K Cady, MD (3) · Delphine Magis, MD,PhD (2) · Roger K Cady, M.D. (2) · Scott Powers, PhD (2) · Shuu-Jiun Wang, M.D. (2) · Abby Rhoads, DO (1) · Adriana Conforto, MD,PHD (1) · Ahmed Bessar, MD, PhD (1) · Alexandre DaSilva, DDS, DMedSc (1) · Amaal Starling, MD (1) · Amal Fawzy, Ph.d (1)
PMID 30446596, PMID 14510929, PMID 15822542, PMID 15985582, PMID 16340383, PMID 17105455, PMID 17300356, PMID 17405970, PMID 17441971, PMID 17445114, PMID 19719543, PMID 20396496, PMID 24020994, PMID 24030685, PMID 24335848, PMID 25297013, PMID 25338927, PMID 25828648, PMID 26432181, PMID 26813845, PMID 27296456, PMID 27412146, PMID 28733943, PMID 28862758, PMID 29171818, PMID 29171821, PMID 29722276, PMID 29800211, PMID 29813147, PMID 30120138, PMID 30326932, PMID 30360965, PMID 30462830, PMID 3052850, PMID 30594122, PMID 30651064, PMID 30836766, PMID 30962877, PMID 31104507, PMID 31132795, PMID 31291516, PMID 31482569, PMID 31952501, PMID 32209650, PMID 32321288, PMID 32576229, PMID 32648205, PMID 32715736, PMID 32930994, PMID 33069214
2018 (3), K01NS124911 (2), 2008 (1), 2015 (1), 2023 (1), K23NS125004 (1), R01NS094413 (1), U01AT010132 (1)