253 completed, 48 unknown, 31 recruiting, 21 not yet recruiting. 236 Not applicable, 32 Phase 3, 27 Phase 2, 24 Phase 4, 10 Phase 1.
Follow Chronic Low Back Pain: new trials by email Literature Review of Chronic Low Back Pain trials Research Report on Chronic Low Back Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sensory Stimulation Belt for Chronic Low Back Pain in Office Workers Active Sensory Stimulation Belt, Sham Sensory Stimulation Belt - Chronic Low Back Pain | Not applicable | Not yet recruiting | Mahidol University | 72 | 2028-01-01 | 2026-09-03 |
| Optimization of Lumbar Sensory Stimulation Parameters in Office Workers With Chronic Low Back Pain Lumbar sensory stimulation - Chronic Low Back Pain | Not applicable | Not yet recruiting | Mahidol University | 36 | 2027-01-01 | 2026-09-03 |
| Investigating Novel Interventions for Low Back Pain in US Military Veterans: A Randomized Controlled Adaptive Phase II Trial Pregnenolone, DHEA, Placebo - Chronic Low Back Pain | Phase 2 | Not yet recruiting | VA Office of Research and Development | 108 | 2026-12-01 | 2026-09-08 |
| Stanford Spine Keeper - Managing Your Low Back Pain Mobile health applications (mHealth apps) based intervention - Chronic Low Back Pain | Not applicable | Suspended | Stanford University | 500000 | 2026-12-01 | 2026-01-09 |
| Visual Feedback-Assisted Sensorimotor Training in Chronic Nonspecific Low Back Pain Visual Feedback-Assisted Sensorimotor Training, Conventional Exercise Training - Chronic Low Back Pain | Not applicable | Not yet recruiting | Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital | 70 | 2026-11-15 | 2026-10-21 |
| Durability of Yoga for Veterans With Low Back Pain Standard Yoga, Enhanced Yoga - Chronic Low Back Pain | Not applicable | Not yet recruiting | VA Office of Research and Development | 176 | 2026-11-01 | 2026-09-04 |
| SERENITY Study of Chronic Pain Interference in Adults Chronic Low Back Pain, Spinal Cord Injury | Not yet recruiting | University of Minnesota | 400 | 2026-11-01 | 2026-10-13 | |
| Veterans' Intervention Blending NeuRomodulation and YogA for Chronic Low BackPaiN Treatment: VIBRANT intermittent theta burst stimulation, LoveYourBrain Yoga Program - Chronic Low Back Pain, Musculoskeletal Pain | Phase 3 | Not yet recruiting | VA Office of Research and Development | 213 | 2026-10-14 | 2026-09-28 |
| Pain Neuroscience Education and Neuromuscular Exercise in Individuals With Chronic Low Back Pain and Central Sensitization Pain Neuroscience Education, Neuromuscular Exercise - Low Back Pain, Chronic Low Back Pain | Not applicable | Not yet recruiting | Izmir Katip Celebi University | 66 | 2026-10-01 | 2026-10-15 |
| Evaluation of an Online Peri-operative Health Education Platform for Patients Undergoing Spine Surgery: Ready Set Recover Ready Set Recover - Medium-/Long-segment Spinal Fusion Patients, Spine Surgeons | Early Phase 1 | Not yet recruiting | National University of Natural Medicine | 60 | 2026-09-30 | 2026-08-17 |
| Assessment of Pain Perception and the Impact of Central Sensitization on Biopsychosocial Manifestations During Physical Activity in Patients With Chronic Low Back Pain Exercise rehabilitation on an ergocycle - Chronic Low Back Pain | Not applicable | Not yet recruiting | University Hospital, Brest | 40 | 2026-09-20 | 2026-09-18 |
| SPINE-RISK VE: Multimodal Predictive Model for Failed Back Surgery Syndrome in Venezuelan Surgical Patients SPINE-RISK VE multimodal preoperative assessment - Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine, Chronic Low Back Pain | Not yet recruiting | juan jose valero quintero,MD | 150 | 2026-09-04 | 2026-07-10 | |
| Effect of Alexithymia on Treatment Response to Transforaminal Epidural Steroid Injections in Chronic Low Back Pain Psychometric Assessment and Clinical Follow-up Battery - Chronic Low Back Pain, Radiculopathy | Not yet recruiting | Marmara University | 60 | 2026-09-01 | 2026-09-18 | |
| Association of Subcutaneous Fat Index, Paraspinal Muscle Characteristics, and Facet Morphology With Lumbar Facet Joint Degeneration Lumbar Magnetic Resonance Imaging (MRI) - Chronic Low Back Pain, Lumbar Facet Joint Degeneration | Recruiting | Marmara University | 300 | 2026-09-01 | 2026-10-06 | |
| Personalized and Automated Digital Coaching in People With Non-specific Chronic Low Back Pain Personalized and automated digital coaching using a mobile application - Chronic Low Back Pain | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 330 | 2026-09-01 | 2026-05-06 |
| Efficacy of Low-Dose Laser Acupuncture for Low Back Pain Low-Dose Laser Acupuncture, Sham Laser Acupuncture - Chronic Low Back Pain | Not applicable | Not yet recruiting | Mun Fei Yam | 80 | 2026-09-01 | 2026-08-11 |
| The Prediction of Clinical Outcome Using the Serum BDNF Level Erector Spinae Plane Block, Blood sampling for ELISA - Chronic Low Back Pain, Brain Derived Neurotrophic Factor Level | Recruiting | Keimyung University Dongsan Medical Center | 70 | 2026-08-13 | 2026-08-21 | |
| Study of Correlation Between the Level of Intradiscal Periostin Expression and Pfirrmann Grading posterior lumbar interbody fusion, lumbar discectomy - Chronic Low Back Pain, Spinal Stenosis Lumbar | Recruiting | Keimyung University Dongsan Medical Center | 20 | 2026-08-13 | 2026-08-25 | |
| Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain Chronic Pain, PERIPHERAL NEUROPATHY | Recruiting | Yale University | 80 | 2026-06-20 | 2026-08-21 | |
| Impact of Leisure Activities on Quality of Life in Low Back Pain Questionnaires - Chronic Low Back Pain | Recruiting | Centre Hospitalier Valida | 148 | 2026-06-01 | 2026-09-15 |
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Low Back Pain (85) · Chronic Pain (33) · Pain (28) · Back Pain (23) · Motor Activity (18) · Intervertebral Disc Degeneration (10) · Bronchiolitis Obliterans Syndrome (8) · Agnosia (7) · Depression (6) · Neuralgia (6) · Fibromyalgia (5) · Osteoarthritis (5) · Anxiety Disorders (4) · Failed Back Surgery Syndrome (4) · Intervertebral Disc Displacement (4)
Pathological Conditions, Signs and Symptoms (152) · Neurologic Manifestations (149) · Signs and Symptoms (149) · Pain (120) · Back Pain (82) · Musculoskeletal Diseases (31) · Behavior (28) · Nervous System Diseases (28) · Neuromuscular Diseases (20) · Bone Diseases (18) · Spinal Diseases (18) · Peripheral Nervous System Diseases (14) · Mental Disorders (12) · Pathologic Processes (12) · Rheumatic Diseases (12)
Exercise (14) · Cognitive Behavioral Therapy (9) · Transcutaneous Electric Nerve Stimulation (9) · Yoga (8) · Acupuncture Therapy (7) · Transcranial Direct Current Stimulation (7) · Duloxetine Hydrochloride (5) · Hydrocodone (5) · Musculoskeletal Manipulations (5) · Standard of Care (5) · Educational Status (4) · Naproxen (4) · Physical Therapy Modalities (4) · Sugars (4) · Exercise Therapy (3)
VA Office of Research and Development (14) · Charite University, Berlin, Germany (5) · Federal University of São Paulo (5) · Relievant Medsystems, Inc. (5) · Stanford University (5) · University Hospital, Clermont-Ferrand (5) · Bayero University Kano, Nigeria (4) · Hacettepe University (4) · NEMA Research, Inc. (4) · University of North Texas Health Science Center (4) · University of Sao Paulo (4) · Vrije Universiteit Brussel (4) · AbbVie (prior sponsor, Abbott) (3) · Al-Azhar University (3) · Centre Hospitalier Universitaire de Nīmes (3)
United States (150) · Brazil (25) · Belgium (22) · France (20) · Turkey (Türkiye) (20) · Germany (12) · United Kingdom (11) · South Korea (9) · Spain (8) · Canada (7) · Netherlands (7) · Taiwan (6) · Italy (5) · Pakistan (5) · Switzerland (5)
Pedro Quintana Diez, MD (3) · Thais Chaves, PhD (3) · Bobby Tay, MD (2) · Debra K. Weiner, MD (2) · Erik J. Groessl, PhD BA BS (2) · Jerrilyn Cambron, DC, MPH, PhD (2) · John C Licciardone, DO, MS, MBA (2) · Kevin Macadaeg, MD (2) · Leonardo Kapural, MD (2) · Leonardo OP Costa, PhD (2) · Peemongkon Wattananon, PhD (2) · Ru-Lan Hsieh, MD (2) · Sean Mackey, MD, PhD (2)
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R01AT007987 (2), 1UG3AR076573-01 (1), 2017 (1), 2018 (1), I01CX002667 (1), I21RX003169 (1), IK2CX002646-01A2 (1), K23AT008477 (1), K23DA020681 (1), K23GM071400 (1), P20NR016605 (1), R01AG056587 (1), R01AT010555 (1), R01HD047709 (1), R01HD088417 (1)