30 completed, 12 unknown, 10 recruiting, 4 active not recruiting. 65 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 65 | Completed 30, Unknown 12, Recruiting 10, Active not recruiting 4, Not yet recruiting 4, Terminated 3, Withdrawn 2 |
Follow Chorea: new trials by email Literature Review of Chorea trials Research Report on Chorea
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Creatine and Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation Plus Home-Based Exercise for Sarcopenia in Huntington's Disease Creatine monohydrate, Beta-hydroxy-beta-methylbutyrate (HMB), Placebo (microcrystalline cellulose) - Huntington Disease, Sarcopenia | Not applicable | Not yet recruiting | Universidad de Burgos | 88 | 2026-11-01 | 2026-10-28 |
| Optimizing Parameters of Low-Intensity Focused Ultrasound for Pallidal Modulation in Huntington's Disease Low-Intensity Focused Ultrasound Stimulation（LIFU） - Huntington Disease | Not applicable | Recruiting | First Affiliated Hospital of Fujian Medical University | 24 | 2026-04-20 | 2026-04-29 |
| Autobiographical Memory, Future Thought, and Eye Movements in Huntington's Disease neuropsychological tests, Eye tracker use - Huntington Disease, Autobiographical Memory | Not applicable | Not yet recruiting | University Hospital, Angers | 80 | 2026-04-01 | 2026-04-06 |
| Modification of Threat Interpretation Bias to Reduce Anxiety in Neurodegenerative Movement Disorders (Aim 3) MindTrails-Movement, Waitlist Control - Huntington Disease, Parkinson Disease | Not applicable | Active not recruiting | University of Virginia | 136 | 2025-11-20 | 2026-07-20 |
| Home-based TDCS (Transcranial Direct Current Stimulation) for Cognitive and Behavioral Symptoms in Huntington's Disease Transcranial direct current stimulation (tDCS), Sham tDCS - Huntington Disease | Not applicable | Recruiting | The University of Texas Health Science Center at San Antonio | 16 | 2025-09-02 | 2026-02-11 |
| Transcranial Static Magnetic Stimulation (tSMS) in Huntington's Disease (HD) Portable ergonomic helmet for real tSMS, portable ergonomic helmet for placebo tSMS - Huntington Disease | Not applicable | Not yet recruiting | Neuromed IRCCS | 30 | 2025-09-01 | 2025-05-16 |
| Early Biomarkers in Premanifest Huntington's Disease Gene Carriers: a Pilot Study brain functional MRI - Huntington Disease | Not applicable | Recruiting | University Hospital, Grenoble | 20 | 2025-02-20 | 2025-01-20 |
| Neural Correlates of Movement Disorders Associated With PRRT2 Related Paroxysmal Kinesigenic Dyskinesia - an Ancillary Study of AMEDYST Research Voluntary and involuntary conditions - Paroxysmal Dyskinesia | Not applicable | Recruiting | Institut National de la Santé Et de la Recherche Médicale, France | 1 | 2025-01-21 | 2026-06-05 |
| Longitudinal SV2A PET and MRI in Premanifest HD Diagnostic Test: 18F-SynVesT-1 PET, Volumetric MRI - Huntington Disease | Not applicable | Active not recruiting | Universitaire Ziekenhuizen KU Leuven | 40 | 2024-12-04 | 2026-05-05 |
| Comparison Between [11C]UCB-J and [18F]SynVest-1 PET in HD. [11C]UCB-J PET, [18F]SynVest-1 PET - Huntington Disease | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 35 | 2024-11-18 | 2025-07-30 |
| Study to Evaluate Music Therapy on Irritability and Impulsivity in Patients With Huntington's Disease (MUSIC-HD) Music Intervention - Huntington Disease | Not applicable | Recruiting | Poitiers University Hospital | 15 | 2024-10-15 | 2025-12-29 |
| Gene Therapy Development and Validation for Huntington's Disease Fibro TG-HD skin biopsy - Huntington Disease | Not applicable | Completed | University Hospital, Angers | 20 | 2024-09-23 | 2026-08-10 |
| Time-Restricted Eating in Huntington's Disease: A Clinical Pilot Study Time-Restricted Eating Diet - Huntington Disease | Not applicable | Completed | Oregon Health and Science University | 22 | 2024-08-29 | 2025-06-04 |
| Gait Analysis Parameter and Upper Limb Evaluation in Adult Patients With Neurological or Metabolic Pathology Syde, Dynamometric measurements of muscle strength, The 6-minute walk test (6MWT) - Neuromuscular Diseases, Obesity (Disorder) | Not applicable | Recruiting | Centre Hospitalier Universitaire de Liege | 300 | 2024-03-29 | 2025-08-22 |
| Innovative Imaging and Cognitive BIOmarkers to Predict Huntington's Disease Progression radiotracer injection - Huntington Disease | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 80 | 2024-03-21 | 2024-05-07 |
| Long Term Follow-up Grafted Huntington's Disease Patients Follow-up - Huntington Disease | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 39 | 2024-01-01 | 2024-01-08 |
| Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers Jumpstart Guide - Dementia, Dementia, Vascular | Not applicable | Active not recruiting | University of Washington | 1802 | 2023-09-11 | 2026-09-21 |
| Home-based Transcranial Direct Current Stimulation Open Trial for Behavioral and Cognitive Symptoms in Huntington's Disease active tDCS - Huntington Disease | Not applicable | Recruiting | The University of Texas Health Science Center, Houston | 10 | 2023-06-21 | 2026-02-11 |
| Striatum and Hippocampus on Different Time Scales Temporal perception tasks - Huntington Disease, Alzheimer Disease | Not applicable | Unknown | Assistance Publique - Hôpitaux de Paris | 104 | 2023-01-06 | 2023-07-12 |
| N- Homocysteinylated Huntingtin in Huntington's Disease skin biopsy - Huntington Disease | Not applicable | Unknown | Central Hospital, Nancy, France | 32 | 2022-04-01 | 2022-03-09 |
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Huntington Disease (63) · Parkinson Disease (13) · Alzheimer Disease (5) · Cognitive Dysfunction (5) · Lewy Body Disease (5) · Anxiety Disorders (3) · Motor Activity (3) · Neurodegenerative Diseases (3) · Stroke (3) · Amyotrophic Lateral Sclerosis (2) · Dementia (2) · Dyskinesias (2) · Frontotemporal Lobar Degeneration (2) · Myotonic Dystrophy (2)
Central Nervous System Diseases (65) · Nervous System Diseases (65) · Movement Disorders (64) · Basal Ganglia Diseases (63) · Brain Diseases (63) · Cognition Disorders (63) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (63) · Dyskinesias (63) · Genetic Diseases, Inborn (63) · Heredodegenerative Disorders, Nervous System (63) · Mental Disorders (63) · Neurocognitive Disorders (63) · Dementia (61) · Neurodegenerative Diseases (60)
Exercise (3) · Neuropsychological Tests (3) · Transcranial Direct Current Stimulation (3) · Blood Specimen Collection (2) · Deep Brain Stimulation (2) · Acoustic Stimulation (1) · Creatine (1) · Eye-Tracking Technology (1) · Functional Neuroimaging (1) · Haloperidol (1) · Immunoglobulins, Intravenous (1) · Interview, Psychological (1) · Laughter Therapy (1) · Melatonin (1) · Mindfulness-Based Cognitive Therapy (1)
Assistance Publique - Hôpitaux de Paris (7) · University Hospital, Angers (6) · Institut National de la Santé Et de la Recherche Médicale, France (5) · Universitaire Ziekenhuizen KU Leuven (4) · Centre Hospitalier Universitaire, Amiens (3) · Cardiff University (2) · Johns Hopkins University (2) · Massachusetts General Hospital (2) · Ohio State University (2) · The University of Texas Health Science Center, Houston (2) · University Hospital, Montpellier (2) · University of Virginia (2) · University of Zurich (2) · Anne Kloos (1) · Beijing Municipal Administration of Hospitals (1)
France (25) · United States (17) · Belgium (4) · Switzerland (4) · Spain (3) · United Kingdom (3) · Canada (2) · China (2) · Germany (2) · Austria (1) · South Africa (1)
Fanny Mochel, MD, PhD (3) · Alexander Pantelyat (1) · Alfons Schnitzler, Prof Dr (1) · Amie Hiller, MD (1) · Andres Lozano, MD (1) · Anne Kloos, PT, PhD (1) · Anne Kloos, PhD (1) · Anne-Marie Wills, MD (1) · Barry Gordon, M.D., Ph.D. (1) · Christine Till, PhD (1) · Christophe Verny, PU-PH (1)
PMID 10378380, PMID 1341966, PMID 13679594, PMID 16178020, PMID 1838577, PMID 21868369, PMID 22517114, PMID 23527646, PMID 23930667, PMID 25568297, PMID 25987537, PMID 27230813, PMID 27534418, PMID 28390970, PMID 28453532, PMID 28747452, PMID 29258585, PMID 29315899, PMID 29445514, PMID 30734924, PMID 30776016, PMID 30776019, PMID 31101920, PMID 31142272, PMID 31381524, PMID 32555262, PMID 32577299, PMID 32595978, PMID 32651242, PMID 33760890, PMID 34413240, PMID 35029800, PMID 35609815, PMID 35766355, PMID 35794169, PMID 35809488, PMID 35995551, PMID 36084356, PMID 36902788, PMID 37023134, PMID 37629202, PMID 37722831, PMID 38383091, PMID 38696602, PMID 38795650, PMID 39934473, PMID 40056659, PMID 40131943, PMID 40381377, PMID 41582160
K23NR020210 (1), KL2TR003016 (1), R01AG078169 (1)