9 completed, 8 unknown, 2 active not recruiting, 2 recruiting. 9 Phase 2, 8 Phase 1, 4 Phase 3, 3 Not applicable, 2 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Cannabidiol on Stress and Nicotine Withdrawal Epidiolex - CBD, Stress | Phase 1 | Recruiting | Johns Hopkins University | 90 | 2025-08-25 | 2026-08-10 |
| Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms Stress Intervention - CBD, Cannabidiol | Not applicable | Recruiting | University of Minnesota | 125 | 2025-06-16 | 2026-07-22 |
| A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration (FTLD) Syndromes PAMSys, LEGSys - PSP, CBD | Active not recruiting | Massachusetts General Hospital | 60 | 2023-07-28 | 2026-01-21 | |
| CBD (Cannabidiol) Intraoral Application and TMD (Temporomandibular Disorders) 5% polymer gel with CBD application, 10% polymer gel with CBD application, Placebo intervention - Temporomandibular Disorder, Myofascial Pain | Phase 2 / Phase 3 | Unknown | Medical University of Silesia | 30 | 2023-07-18 | 2023-07-21 |
| Drug-gene-nutraceutical Interactions of Cannabidiol and Tacrolimus Tacrolimus single dose, Epidiolex single dose, Epidiolex steady-state and tacrolimus single dose - CBD, Transplant Complication | Phase 1 | Completed | Indiana University | 57 | 2022-10-31 | 2026-09-30 |
| The Use of Cannabinoid Patch for Knee Osteoarthritis Topical CBD Patch, Placebo Patch - Knee Osteoarthritis, CBD | Phase 2 | Withdrawn | Northwell Health | 2022-10-01 | 2023-01-19 | |
| Sex Differences in Neural Response to Cannabidiol Cannabidiol, Placebo - CBD, Neural Responses | Early Phase 1 | Completed | Yale University | 19 | 2022-06-07 | 2023-12-21 |
| RCT of CBD for Anxiety in Advanced Breast Cancer Cannabidiol, Placebo - Advanced Breast Cancer, Anxiety | Phase 2 | Active not recruiting | Dana-Farber Cancer Institute | 60 | 2022-01-19 | 2026-08-19 |
| Hippocampal Response to Acute Oral Doses of CBD During an fMRI Memory Task CBD, Placebo - CBD | Phase 1 / Phase 2 | Unknown | Hartford Hospital | 20 | 2021-12-15 | 2024-04-12 |
| A Study to Investigate the Bioavailability and Skin Absorption of CBD and THC From GT4 Technology in Healthy Adults CBD and THC with GT4 technology - Biological Availability, Skin Absorption | Phase 1 | Completed | Gefion Canada Inc. | 18 | 2021-11-27 | 2022-06-01 |
| A Study of Cybis™ 10:25 THC:CBD Oil in Adults With Chronic Back/Neck Pain Cybis™ 10:25 THC:CBD oil - Chronic Pain, Neck Pain | Phase 1 / Phase 2 | Completed | Cymra Life Sciences | 28 | 2021-09-20 | 2022-07-07 |
| The Study of Hemp Oil CBD for Evaluation of Efficacy and Safety in Treatment of Pain, Anxiety and Insomnia Management CBD - CBD, Pain, Chronic | Phase 1 | Unknown | Advanced Pain and Rehab Specialists | 30 | 2021-09-01 | 2021-08-06 |
| Effects of Cannabidiol (CBD) on the Brain Cannabidiol, Placebo - CBD, Fear | Not applicable | Unknown | Auburn University | 15 | 2021-07-15 | 2023-08-16 |
| EMERALD TRIAL Open Label Extension Study MediCabilis CBD oil - Amyotrophic Lateral Sclerosis, Cannabis | Phase 4 | Unknown | Gold Coast Hospital and Health Service | 7 | 2021-05-17 | 2023-04-03 |
| CBD-Microglia PET Study [11C]PBR28, Low-dose lipopolysaccharide, Intradermal Capsaicin - CBD, Healthy | Early Phase 1 | Completed | Yale University | 28 | 2021-05-07 | 2026-04-29 |
| Synthetic CBD as a Therapy for COVID-19 CBD, Placebo - Covid19, CBD | Phase 1 | Unknown | Sheba Medical Center | 50 | 2021-01-20 | 2021-09-28 |
| Methodology for Developing an Occlusal Appliance With CBD Active Carrier CBD occlusal appliance, Acrylic resin occlusal appliance - Temporomandibular Disorder, Myofascial Pain | Phase 2 / Phase 3 | Unknown | Medical University of Silesia | 40 | 2021-01-01 | 2021-03-01 |
| Cannabidiol and Management of Endometriosis Pain Cannabidiol (CBD) Extract, Norethindrone Acetate, Placebo - Endometriosis, CBD | Phase 3 | Terminated | Milton S. Hershey Medical Center | 12 | 2020-12-04 | 2025-04-04 |
| Efficacy of Inhaled Cannabis for Acute Migraine Treatment THC ~5%, CBD ~12%, THC ~5% and CBD ~12% - Migraine, Cannabis | Phase 2 | Completed | University of California, San Diego | 92 | 2020-11-20 | 2023-02-28 |
| Clinico-Pathologic-Genetic-Imaging Study of Neurodegenerative and Related Disorders C-11 PiB, AV1451 Tau, C-11 ER176 - PSP, CBD | Enrolling by invitation | Mayo Clinic | 500 | 2020-11-01 | 2025-11-21 |
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Marijuana Abuse (4) · Chronic Pain (3) · Anxiety Disorders (2) · Frontotemporal Dementia (2) · Temporomandibular Joint Disorders (2) · Amyotrophic Lateral Sclerosis (1) · Aphasia (1) · Apraxias (1) · Back Pain (1) · Benign essential blepharospasm (1) · Blepharospasm (1) · Bruxism (1) · COVID-19 (1) · Corticobasal Degeneration (1) · Endometriosis (1)
Mental Disorders (10) · Pathological Conditions, Signs and Symptoms (8) · Neurologic Manifestations (7) · Signs and Symptoms (7) · Chemically-Induced Disorders (5) · Nervous System Diseases (5) · Substance-Related Disorders (5) · Central Nervous System Diseases (4) · Pain (4) · Behavior (3) · Brain Diseases (3) · Joint Diseases (3) · Metabolic Diseases (3) · Musculoskeletal Diseases (3) · Neurodegenerative Diseases (3)
Cannabidiol (9) · Dronabinol (3) · nabiximols (2) · (methyl-(11)C)N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine (1) · 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (1) · Crisis Intervention (1) · Lipopolysaccharides (1) · Magnetic Resonance Spectroscopy (1) · Norethindrone Acetate (1) · THC 5 (1) · Tacrolimus (1) · salicylhydroxamic acid (1)
Medical University of Silesia (2) · Yale University (2) · Advanced Pain and Rehab Specialists (1) · Auburn University (1) · Cymra Life Sciences (1) · Dana-Farber Cancer Institute (1) · Gefion Canada Inc. (1) · Gold Coast Hospital and Health Service (1) · Hartford Hospital (1) · Indiana University (1) · Johns Hopkins University (1) · Massachusetts General Hospital (1) · Mayo Clinic (1) · Milton S. Hershey Medical Center (1) · Northwell Health (1)
United States (17) · Australia (2) · Poland (2) · Canada (1) · Israel (1) · United Kingdom (1)
David Crowley, MD (1) · Dustin C. Lee, PhD (1) · Godfrey Pearlson, MD (1) · Howard Amital, MD, MHA (1) · Ilana Braun, MD (1) · Jennifer L Robinson, Ph.D. (1) · Leslie Lundahl, PhD (1) · Magdalena Antonowicz, Adiunct (1) · Michael Eadon, MD (1) · Mohini Ranganathan, MD (1) · Nathaniel M Schuster, MD (1) · Richard Chye (1) · Robert Duarte, MD (1) · Sarah D. Lichenstein, PhD (1)
PMID 35032682, PMID 36308640, PMID 36642667, PMID 36750134, PMID 37606606, PMID 38416223, PMID 39601108, PMID 39680411, PMID 41252210, PMID 41469488, PMID 41517391
R01AT011463 (1), R01DA027232 (1)