29 completed, 6 unknown, 4 terminated, 3 recruiting. 17 Phase 3, 8 Phase 2, 7 Phase 4, 6 Not applicable, 4 Phase 1.
Follow Norethindrone Acetate: new trials by email Literature Review of Norethindrone Acetate trials Research Report on Norethindrone Acetate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Brain and Blood Vessel Health Following Endometriosis Treatment in People With Endometriosis Investigate how norethindrone acetate, a commonly used medication used to treat symptoms of endometriosis, impact biomarkers of brain health, Investigate how Orlissa, a commonly used medication used to treat symptoms of endometriosis, impact biomarkers of brain health, Investigate how Oriahnn, a commonly used medication used to treat symptoms of endometriosis, impact biomarkers of brain health - Endometriosis, Endometriosis and Dysmenorrhea | Phase 4 | Not yet recruiting | Colorado State University | 45 | 2026-10-01 | 2026-09-02 |
| IUD and Norethindrone Acetate for Treatment of Endometriosis norethindrone acetate (NETA), Placebo - Endometriosis | Phase 2 | Withdrawn | Boston Children's Hospital | 2026-01-01 | 2025-03-21 | |
| Heavy Menstrual Bleeding Progestin Treatment in Bleeding Disorders Study Levonorgestrel Intrauterine System, Norethindrone Acetate - Heavy Menstrual Bleeding, Bleeding Disorder | Recruiting | Oregon Health and Science University | 300 | 2025-09-24 | 2025-12-17 | |
| MYFEMBREE®: A Retrospective Cohort Study Using an Administrative Healthcare Database to Assess Pregnancy Outcomes in Women Treated With Relugolix Combination Therapy Relugolix + Estradiol + Norethindrone Acetate - Pregnancy Related, Pregnancy Complications | Active not recruiting | Sumitomo Pharma Switzerland GmbH | 530 | 2025-04-30 | 2025-08-01 | |
| The Effect of Medical Management Following Excisional Surgery for Endometriosis: A Randomized Controlled Trial 40 mg relugolix, 1 mg estradiol, 0.5 mg norethindrone acetate - Endometriosis | Phase 3 | Recruiting | Main Line Health | 110 | 2024-08-15 | 2026-06-12 |
| Phenotyping of Idiopathic Pelvic Pain With Real-time Uterine Imaging and Relugolix-Combination Therapy Treatment Relugolix (40 mg) /estradiol (1 mg)/norethisterone acetate (0.5 mg) oral tablet - Pelvic Pain | Phase 2 | Withdrawn | Endeavor Health | 2024-06-01 | 2025-08-28 | |
| A Trial of Norethisterone Acetate and Expectant Management in Treatment of Simple Ovarian Cysts norethisterone acetate - Ovarian Cyst Simple | Phase 4 | Unknown | Assiut University | 66 | 2022-10-01 | 2022-03-24 |
| Metabolism of 0.35mg Norethindrone vs 5mg Norethindrone Acetate Norethindrone Acetate 5 MG, Norethindrone 0.35 MG - Contraception | Phase 4 | Completed | Milton S. Hershey Medical Center | 6 | 2022-07-22 | 2024-07-16 |
| Micronized Progesterone Versus Norethisterone Acetate in Combination With Estrogen as Menopausal Hormone Therapy Micronized progesterone in continuous combination with oral estrogen, Norethisterone acetate in continuous combination with oral estrogen - Menopausal Symptoms | Phase 3 | Recruiting | Angelica Lindén Hirschberg | 520 | 2022-03-15 | 2024-06-04 |
| The Association of Hormonal Intake and Demographic Factors With Breast Cancer Risk. An Egyptian Case-controlled Study Dydrogesterone Tablets, Norethisterone acetate, Ethinyl estradiol, Drospirenone and ethinyl estradiol - Observational Study | Unknown | NewGiza University | 200 | 2021-11-16 | 2021-11-26 | |
| Management of Uterine Leiomyomata and Adenomyosis Norethisterone acetate - Abnormal Uterine Bleeding | Unknown | Ahmed Ali Mahmoud | 100 | 2021-04-10 | 2021-12-10 | |
| The Effect of Dienogest vs. Norethindrone Acetate Treatment in Endometriosis Dienogest Pill, Norethindrone Acetate - Endometriosis | Not applicable | Completed | Uludag University | 70 | 2021-04-01 | 2023-07-21 |
| Effects of a Progestin on Frequent and/or Prolonged Bleeding With Nexplanon™ Norethindrone acetate (NTA), Placebo - Birth Control, Contraception | Phase 4 | Terminated | Baylor Research Institute | 51 | 2021-02-11 | 2024-02-02 |
| Cannabidiol and Management of Endometriosis Pain Cannabidiol (CBD) Extract, Norethindrone Acetate, Placebo - Endometriosis, CBD | Phase 3 | Terminated | Milton S. Hershey Medical Center | 12 | 2020-12-04 | 2025-04-04 |
| Effects of Tranexemic Acid Versus Norethisterone Acetate on Endometrial Vasculature . norethisterone acetate, tranexamic acid tablets - Dysfunctional Uterine Bleeding | Phase 3 | Unknown | Cairo University | 120 | 2020-04-22 | 2020-03-16 |
| Low-Dose Naltrexone in Combination With Standard Treatment in Women With Endometriosis Naltrexone, Norethindrone Acetate, Placebo - Endometriosis | Phase 3 | Terminated | Milton S. Hershey Medical Center | 9 | 2020-01-16 | 2022-11-03 |
| A Study to Evaluate Safety and Efficacy of Elagolix in Participants With Endometriosis With Associated Moderate to Severe Pain elagolix, estradiol/norethindrone acetate (E2/NETA) - Endometriosis | Phase 3 | Terminated | AbbVie | 11 | 2017-12-27 | 2019-11-27 |
| Long-Term Safety Study of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women Elagolix, Estradiol /norethindrone acetate (E2/NETA), E2/NETA Placebo - Heavy Menstrual Bleeding, Uterine Fibroids | Phase 3 | Completed | AbbVie | 478 | 2017-09-13 | 2025-07-22 |
| Dopamine Receptor Agonist Therapy for Pain Relief in Women Suffering From Endometriosis: A Pilot Study Cabergoline, Norethindrone acetate - Endometriosis | Phase 2 | Completed | Boston Children's Hospital | 10 | 2016-05-01 | 2020-02-05 |
| Efficacy and Safety of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women (Replicate Study) Elagolix, Placebo for Estradiol/Norethindrone Acetate, Estradiol/Norethindrone Acetate - Uterine Fibroids, Heavy Menstrual Bleeding | Phase 3 | Completed | AbbVie | 378 | 2016-02-03 | 2021-07-13 |
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Endometriosis (12) · Menorrhagia (8) · Leiomyoma (6) · Metrorrhagia (4) · Pelvic Pain (4) · Dysmenorrhea (3) · Endometrial Hyperplasia (2) · Acquired Immunodeficiency Syndrome (1) · Breast Carcinoma In Situ (1) · Breast Neoplasms (1) · Contraception Behavior (1) · Cystic Fibrosis (1) · Disease (1) · Dyspareunia (1) · Hemostatic Disorders (1)
AbbVie (5) · Novo Nordisk A/S (5) · Boston Children's Hospital (3) · Milton S. Hershey Medical Center (3) · Mansoura University (2) · Teva Pharmaceuticals USA (2) · University of Southern California (2) · Warner Chilcott (2) · AbbVie (prior sponsor, Abbott) (1) · Ahmed Ali Mahmoud (1) · Angelica Lindén Hirschberg (1) · Assiut University (1) · Baylor Research Institute (1) · Cairo University (1) · Colorado State University (1)
United States (25) · Sweden (5) · Canada (4) · Norway (4) · Egypt (3) · Germany (3) · Belgium (2) · Finland (2) · France (2) · Italy (2) · Puerto Rico (2) · Switzerland (2) · Austria (1) · Denmark (1) · Poland (1)
Herman Ellman, MD (2) · Paul Y Tam, M.D., F.R.C.P., F.A.C.P. (2) · Allison Wheeler (1) · Amy D DiVasta, MD, MMSc (1) · Amy DiVasta (1) · Brian T Nguyen, MD, MSc (1) · C. Rageth, MD, PD (1) · Charlotte Owens, MD (1) · Gurkan Uncu, Prof. (1) · Hatem Abu Hashim, MD MRCOG (1) · Hatem Abu Hashim, MD. MRCOG (1) · Hisham Mo Taleb, Md (1)
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2004 (2)