42 completed, 31 recruiting, 11 not yet recruiting, 7 unknown. 43 Not applicable, 31 Phase 2, 13 Phase 1, 6 Early Phase 1, 6 Phase 4.
Follow Cannabis Use Disorder: new trials by email Literature Review of Cannabis Use Disorder trials Research Report on Cannabis Use Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tirzepatide for the Treatment of Cannabis Use Disorder Tirzepatide, Placebo - Cannabis Use Disorder | Phase 2 | Not yet recruiting | Brigham and Women's Hospital | 6 | 2027-03-01 | 2026-10-09 |
| Transcranial Magnetic Stimulation for Adolescents and Young Adults With Cannabis Use Disorder Magstim SuperRapid2, Sham rTMS - Cannabis Use, Cannabis Use Disorder | Not applicable | Not yet recruiting | University of Minnesota | 50 | 2027-03-01 | 2026-06-09 |
| Semaglutide for the Treatment of Cannabis Use Disorder semaglutide - Cannabis Use Disorder, Cue-reactivity | Phase 2 | Not yet recruiting | Massachusetts General Hospital | 40 | 2027-01-10 | 2026-10-19 |
| Trial of Tirzepatide for the Treatment of Cannabis Use Disorder Tirzepatide, Placebo - Cannabis Use Disorder | Phase 2 | Not yet recruiting | National Institute on Drug Abuse (NIDA) | 100 | 2026-11-15 | 2026-09-21 |
| Delayed-Release, Extended-Release Methylphenidate (Jornay PM) for Adolescents and Young Adults With Attention-Deficit/Hyperactivity Disorder and Cannabis Use Disorder Delayed-release, extended-release methylphenidate, Placebo - ADHD, Cannabis Use Disorder | Phase 4 | Not yet recruiting | Massachusetts General Hospital | 66 | 2026-11-01 | 2026-09-28 |
| Lemborexant for Cannabis Use Disorder Lemborexant 10mg, Placebo, Brief Behavioural Intervention - Cannabis Use Disorder | Phase 1 / Phase 2 | Not yet recruiting | University of Calgary | 28 | 2026-11-01 | 2026-09-22 |
| Endocannabinoids in Reward Dronabinol, Placebo - Cannabis Use Disorder | Phase 2 | Recruiting | Medical University of South Carolina | 78 | 2026-10-01 | 2026-10-05 |
| Pregnenolone for Cannabis Use Disorder and Depression Pregnenolone - Cannabis Use Disorder, Major Depressive Disorder (MDD) | Phase 1 / Phase 2 | Not yet recruiting | University of Texas Southwestern Medical Center | 20 | 2026-09-01 | 2026-07-06 |
| Applying Neuromodulation to Boost the Efficacy of Motivational Interviewing transcranial alternating current stimulation, sham transcranial alternating current stimulation, Motivational interviewing (MI) - Cannabis Use Disorder | Not applicable | Not yet recruiting | The Mind Research Network | 82 | 2026-08-01 | 2026-08-27 |
| Emotional Brain Training for Addiction Medicine Treatment - A Pilot Study Emotional Brain Training, Standard addiction counseling and medical therapy - Cannabis Use Disorder, Stimulant Use Disorder | Not applicable | Not yet recruiting | Loma Linda University | 54 | 2026-08-01 | 2026-04-23 |
| Neuroimaging of Adolescent Cannabis Use Treatment Contingency Management, Elastic Net Regression - Cannabis Use, Cannabis Dependence | Not applicable | Recruiting | Indiana University | 80 | 2026-06-15 | 2026-06-22 |
| Effect of Semaglutide on Cannabis Use in Adults With Cannabis Use Disorder semaglutide, Placebo - Cannabis Use Disorder, Cannabis Use Disorders | Phase 2 | Recruiting | Anders Fink-Jensen, MD, DMSci | 100 | 2026-04-30 | 2026-05-14 |
| Sex Differences in Neurobehavioral Response to THC Dronabinol, Placebo - Cannabis Use Disorder | Phase 2 | Terminated | Medical University of South Carolina | 5 | 2026-04-27 | 2026-10-06 |
| Effects of Action-Based Cognitive Remediation on Substance Misuse in Early Phase Psychosis Action-Based Cognitive Remediation - Psychosis, Alcohol Use Disorder | Not applicable | Recruiting | Nova Scotia Health Authority | 50 | 2026-03-27 | 2026-04-07 |
| Cannabis Reduction and Functional Outcomes CBT4CBT (Computerized Cognitive Behavioral Therapy), Motivational Interviewing, Contingency Management - Cannabis Use Disorder | Not applicable | Recruiting | Medical University of South Carolina | 176 | 2026-03-13 | 2026-03-19 |
| Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use Amplification of Positivity - Cannabis Use (AMP-C) - Depression - Major Depressive Disorder, Cannabis Use Disorder | Not applicable | Recruiting | Massachusetts General Hospital | 80 | 2026-02-23 | 2026-06-02 |
| Testing the Efficacy of the Cannabis Clinic for Patients With Psychosis (CCP) Intervention for Cannabis Use Reduction/Cessation in Patients With First Episode Psychosis (FEP) CCP Intervention - Psychosis, Cannabis Use Disorder | Not applicable | Not yet recruiting | King's College London | 80 | 2025-12-01 | 2025-11-24 |
| RS-tDCS for Cannabis Use Disorder: The C.A.R.E.S. Initiative Active Transcranial Direct Current Stimulation (tDCS), Sham Transcranial Direct Current Stimulation (tDCS), Mindfulness meditation - Cannabis Use Disorder | Not applicable | Recruiting | NYU Langone Health | 46 | 2025-11-12 | 2026-04-21 |
| Study of an Oral Fluid Testing Approach Biologic testing for THC - Cannabis Use, Cannabis Intoxication | Recruiting | Boston Children's Hospital | 200 | 2025-10-27 | 2026-10-22 | |
| Exercise Intervention as Treatment for People Using Cannabis (ExIT-C) Indoor Cycling - Cannabis Abuse, Cannabis Dependence | Not applicable | Recruiting | The University of Hong Kong | 60 | 2025-07-02 | 2025-07-29 |
Showing 20 of 103. Sign in to see all of them.
Marijuana Abuse (38) · Substance-Related Disorders (18) · Psychotic Disorders (8) · Schizophrenia (7) · Alcoholism (6) · Depression (6) · Mental Disorders (5) · Tobacco Use Disorder (5) · Behavior, Addictive (4) · Anxiety Disorders (3) · Attention Deficit Disorder with Hyperactivity (3) · Bipolar Disorder (2) · Coitus (2) · Depressive Disorder, Major (2) · Marijuana Smoking (2)
Mental Disorders (58) · Chemically-Induced Disorders (52) · Substance-Related Disorders (34) · Behavior (18) · Schizophrenia Spectrum and Other Psychotic Disorders (12) · Behavioral Symptoms (6) · Alcohol-Related Disorders (5) · Compulsive Behavior (4) · Impulsive Behavior (4) · Mood Disorders (4) · Attention Deficit and Disruptive Behavior Disorders (3) · Neurodevelopmental Disorders (3) · Pathological Conditions, Signs and Symptoms (3) · Signs and Symptoms (3) · Bipolar and Related Disorders (2)
Dronabinol (7) · Motivational Interviewing (5) · Transcranial Magnetic Stimulation (5) · Cognitive Behavioral Therapy (4) · Cannabidiol (3) · Transcranial Direct Current Stimulation (3) · Varenicline (3) · nabiximols (3) · Acetylcysteine (2) · Mindfulness (2) · Sugars (2) · Therapeutics (2) · Tirzepatide (2) · lorcaserin (2) · semaglutide (2)
Medical University of South Carolina (11) · Centre for Addiction and Mental Health (7) · Yale University (7) · Massachusetts General Hospital (5) · University of Colorado, Denver (5) · New York State Psychiatric Institute (4) · Dartmouth-Hitchcock Medical Center (3) · Johns Hopkins University (3) · The University of Hong Kong (3) · Boston Children's Hospital (2) · Ciusss de L'Est de l'Île de Montréal (2) · Florida State University (2) · NYU Langone Health (2) · National Institute on Drug Abuse (NIDA) (2) · Stanford University (2)
United States (66) · Canada (15) · Hong Kong (3) · France (2) · Germany (2) · United Kingdom (2) · Australia (1) · Belgium (1) · Denmark (1) · Netherlands (1) · Spain (1) · Switzerland (1)
Richard J Macatee, PhD (3) · Alexandre Dumais, MD, PhD (2) · Leigh Charvet, PhD (2) · Tony George, M.D., FRCPC (2) · Aimee L. Mcrae-Clark, PharmD (1) · Aimee McRae-Clark, PharmD (1) · Alan I Green, MD (1) · Alan J Budney, Ph.D (1) · Albert Garcia-Romeu, Ph.D. (1) · Albert KK Chung, MBBS (1) · Albert KK Chung, MBBS(HK) (1) · Amal Abdel Baki, MD, MSc (1) · Barbara J. Mason, Ph.D. (1) · Bernard Le Foll, MD,PhD,MCFP (1) · Brenden Tervo-Clemmens, PhD (1)
PMID 21865014, PMID 32735782, PMID 33160719, PMID 34264732, PMID 34390300, PMID 35129994, PMID 35690891, PMID 35733201, PMID 36384966, PMID 36427227, PMID 36598543, PMID 37032954, PMID 38214479, PMID 39021751, PMID 39348366, PMID 39910268, PMID 40700630, PMID 41733532, PMID 41983248, PMID 42622852
P50DA056408 (2), R01DA054314 (2), U54DA037842 (2), 1UG3DA061594 (1), 1UG3DA063344-01 (1), 1UG3DA066242-01 (1), 2025 (1), F31DA039644 (1), I01CX002357 (1), K12DA000357 (1), K12DA031794 (1), K23DA043628 (1), K23DA045099 (1), K23DA045957 (1), K23DA054299 (1)