73 completed, 26 unknown, 12 not yet recruiting, 11 recruiting. 60 Not applicable, 16 Phase 2, 9 Phase 1, 8 Phase 4, 4 Early Phase 1.
Follow Brain Injury: new trials by email Literature Review of Brain Injury trials Research Report on Brain Injury
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Creatine Supplementation in Pediatric Brain Injury Creatine monohydrate, Microcrystalline Cellulose - Brain Injury, Traumatic Brain Injury | Not applicable | Not yet recruiting | Spaulding Rehabilitation Hospital | 46 | 2026-10-01 | 2026-08-10 |
| Early Prophylactic Versus Late Salvage Recombinant Human Endostatin in Managing Radiosurgery-Induced Brain Injury for NSCLC Brain Metastases Recombinant Human Endostatin (Endostar) - Lung Cancer (Non-Small Cell), Radiation | Phase 2 | Not yet recruiting | Jiangmen Central Hospital | 49 | 2026-09-01 | 2026-10-01 |
| Temporal Interference Stimulation for Disorders of Consciousness Temporal Interference - Disorder of Consciousness, Minimally Conscious State | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de Liege | 4 | 2026-09-01 | 2026-10-19 |
| fNIRS for Disorders of Consciousness Functional Near-Infrared Spectroscopy Monitoring - Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness | Recruiting | University of California, Los Angeles | 55 | 2026-05-01 | 2026-06-08 | |
| The Coma Family Program (COMA-F): A Resilience Program for Caregivers of Patients With Severe Acute Brain Injury Coma Family Program 1, Coma Family Program 2 - Caregiver Distress, Emotional Distress | Not applicable | Not yet recruiting | Massachusetts General Hospital | 150 | 2026-05-01 | 2026-02-20 |
| The Association Between Tau & GFAP and Postoperative Neurological Impairment in Patients Undergoing Cardiac Surgery Collecting discarded blood samples - Cardiac Surgery Requiring Cardiopulmonary Bypass, Brain Injury | Not yet recruiting | Boston Children's Hospital | 100 | 2026-05-01 | 2026-03-17 | |
| Effects of Virtual Reality With Multisensory Stimulation on Emotional and Behavioral Disorders in Individuals With Acquired Brain Injury and Disability Requiring Institutional Care: a Single Case Experimental Design (SCED) Study. Virtual reality - Brain Injury, Virtual Reality | Not applicable | Not yet recruiting | Hopital La Musse | 3 | 2026-02-15 | 2026-01-27 |
| Neuroprotective Effect of Mild Hypothermia Versus Normothermia During Cardiopulmonary Bypass of Coronary Artery Surgery Normothermic cardiopulmonary bypass, Hypothermic cardiopulmonary bypass - Coronary Artery Disease, Brain Injury | Not applicable | Not yet recruiting | Turku University Hospital | 160 | 2026-01-01 | 2026-01-05 |
| Effectiveness of Nintendo Switch Combined With Occupational Therapy to Reduce Fall Risk in Patients With Hemiparesis After Acquired Brain Injury Nintendo Switch Exergaming Combined With Occupational Therapy, Conventional - Brain Injury, Ictus | Not applicable | Completed | Universidad Rey Juan Carlos | 20 | 2025-12-12 | 2026-07-06 |
| Multifaceted Intervention to Restore Resilience and Overcome Risk webSTAIR, ExpoTx, PsychoEd - Military Sexual Trauma, Intimate Partner Violence | Not applicable | Recruiting | Icahn School of Medicine at Mount Sinai | 136 | 2025-09-12 | 2026-09-21 |
| Paired Vagus Nerve Stimulation in Mobilization of Patients With Prolonged Disorders of Consciousness Transcutaneous vagus nerve stimulation (taVNS), Physical therapy using Hocoma, Standard of Care - Consciousness Disorders, Brain Injury | Not applicable | Recruiting | Icahn School of Medicine at Mount Sinai | 15 | 2025-08-12 | 2026-06-18 |
| A Feasibility Study in Combat Athletes With Mild Traumatic Brain Injury Hyberbaric Oxygen Therapy - Mild Traumatic Brain Injury (mTBI), Brain Injury | Not applicable | Enrolling by invitation | Michael Harl | 10 | 2025-08-07 | 2025-08-13 |
| Q Therapeutic System for Chronic Stroke Recovery Q Therapeutic System (BQ 3.0) - Active - Stroke, Hemorrhage | Not applicable | Recruiting | Burke Rehabilitation Hospital | 25 | 2025-05-26 | 2025-08-12 |
| The Study on the Efficacy of tDCS Stimulation of the Cerebellum Combined With XingNaoJing Injection in Patients With Consciousness Disorders After Cranial Injury XinNaoJing injection, tDCS - tDCS, Cerebellum | Phase 4 | Not yet recruiting | The Second Affiliated Hospital of Kunming Medical University | 200 | 2025-04-25 | 2025-04-15 |
| Cognitive Functions in Severe Acquired Brain Injury After Cranioplasty improvement of cognitive functions and psychological aspects - Brain Injury, Neuropsychological Deficits | Active not recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 20 | 2025-03-18 | 2025-08-19 | |
| Early Myofascial Manual Treatment in Subjects With Spasticity Following Acquired Brain Injury Manual myofascial treatment direct to upper and lower limb, Rehabilitative treatment following rehabilitation project - Brain Injury, Brain Injury, Vascular | Not applicable | Active not recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 24 | 2025-03-13 | 2025-04-02 |
| Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy Surgery Remifentanil, Methadone - Brain Injury, Brain Tumors | Early Phase 1 | Recruiting | University of Virginia | 40 | 2025-03-10 | 2026-05-04 |
| University of Central Florida CereBank Biospecimen Donation, Brain Injury | Recruiting | University of Central Florida | 50000 | 2025-02-25 | 2025-03-14 | |
| Validation of a 3D Instrumented Serious Game to Evaluate Upper Limb Impairments in Children With Neuromotor Disorders instrumented 3D serious game (BE API 3.0) - Cerebral Palsy, Brain Injury | Not applicable | Not yet recruiting | University Hospital, Geneva | 40 | 2025-02-01 | 2025-01-14 |
| Expanding Access to mTBI Treatment for Veterans and Service Members With Co-occurring Substance Use Integrated Model of Care - Concussion, Mild Traumatic Brain Injury, Brain Injury | Not applicable | Not yet recruiting | Shepherd Center, Atlanta GA | 360 | 2025-02-01 | 2024-10-01 |
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Brain Injuries (140) · Brain Injuries, Traumatic (18) · Stroke (17) · Cerebral Palsy (8) · Coma (6) · Consciousness Disorders (6) · Craniocerebral Trauma (6) · Brain Concussion (5) · Persistent Vegetative State (5) · Cognitive Dysfunction (4) · Depression (4) · Premature Birth (4) · Stress Disorders, Post-Traumatic (4) · Wounds and Injuries (4) · Anxiety Disorders (3)
Central Nervous System Diseases (140) · Brain Diseases (139) · Nervous System Diseases (139) · Trauma, Nervous System (138) · Wounds and Injuries (136) · Craniocerebral Trauma (134) · Pathological Conditions, Signs and Symptoms (40) · Signs and Symptoms (33) · Cardiovascular Diseases (31) · Vascular Diseases (29) · Cerebrovascular Disorders (25) · Mental Disorders (25) · Neurologic Manifestations (21) · Neurocognitive Disorders (16) · Brain Damage, Chronic (13)
Standard of Care (3) · Dexmedetomidine (2) · Magnetic Resonance Spectroscopy (2) · Occupational Therapy (2) · Sevoflurane (2) · Sodium Chloride (2) · Transcranial Direct Current Stimulation (2) · Acetylcysteine (1) · Acupuncture Therapy (1) · Airway Extubation (1) · Albumins (1) · Amantadine (1) · Angong Niuhuang Pill (1) · Apomorphine (1) · Botulinum Toxins, Type A (1)
Assistance Publique - Hôpitaux de Paris (5) · VA Office of Research and Development (5) · Duke University (4) · Alyn Pediatric & Adolescent Rehabilitation Hospital (3) · Icahn School of Medicine at Mount Sinai (3) · Ospedale Generale Di Zona Moriggia-Pelascini (3) · Copenhagen University Hospital, Rigshospitalet (2) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (2) · Hospices Civils de Lyon (2) · Intermountain Health Care, Inc. (2) · Kessler Foundation (2) · Nantes University Hospital (2) · National Center for Research Resources (NCRR) (2) · Poitiers University Hospital (2) · Sheba Medical Center (2)
United States (66) · France (14) · Italy (8) · United Kingdom (8) · Canada (6) · China (5) · Israel (5) · Germany (4) · Spain (4) · Denmark (3) · Finland (2) · Switzerland (2) · Taiwan (2) · Brazil (1) · Egypt (1)
Julia K. Waid-Ebbs, PhD (2) · Maria Kajankova, PhD (2) · Randall Urban (2) · Abbot Laptook, MD (1) · Andres Salazar, M.D. (1) · Andrey A Belkin, Prof., MD, Phd (1) · Anthony Chen, MD MA (1) · Anthony Lequerica, PhD (1) · Aurore Thibaut (1) · Bahia Hakiki (1) · Bijan Najafi, PhD (1) · Borut Gersak, MD, PhD (1) · Carmelo Graffagnino, MD (1)
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