38 completed, 18 unknown, 13 terminated, 8 recruiting. 88 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 88 | Completed 38, Unknown 18, Terminated 13, Recruiting 8, Not yet recruiting 6, Withdrawn 3, Enrolling by invitation 1, Suspended 1 |
Follow Brain Injuries: new trials by email Literature Review of Brain Injuries trials Research Report on Brain Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intravenous Metoclopramide Versus Intravenous Acetaminophen for Acute Concussion Treatment Metoclopramide 10mg, Acetaminophen - Concussion Post Syndrome, Head Trauma Injury | Phase 4 | Not yet recruiting | Montefiore Medical Center | 200 | 2026-10-01 | 2026-10-01 |
| Anti-inflammatory Effect of MgSO₄ in Patients With Moderate Traumatic Brain Injury by Measurming Nucleotide-binding Oligomerization Domain-Like Receptor Pyrin Domain-containing 3 (NLRP3) Inflammasome-a Multiprotein Complex Magnesium sulfate (MgSO4), Normal Saline - Traumatic Brain Injuries | Phase 4 | Not yet recruiting | Assiut University | 64 | 2026-10-01 | 2026-08-13 |
| Impact of Dexmedetomidine Versus Propofol on Intracranial Pressure in Adult Traumatic Brain Injury Patients: Randomized Controlled Double-Blind Trial Propofol, Dexmedetomidine - Traumatic Brain Injuries | Phase 4 | Not yet recruiting | Assiut University | 80 | 2026-10-01 | 2026-09-10 |
| Suvorexant 3 - PE-PC Suvorexant, Placebo, Prolonged Exposure Therapy for Primary Care (PE-PC) - PTSD - Post Traumatic Stress Disorder, Insomnia | Phase 4 | Not yet recruiting | Northern California Institute of Research and Education | 142 | 2026-09-01 | 2026-07-07 |
| Effects of Recombinant Human Growth Hormone in Elderly Patients With Moderate to Severe Acute Brain Injury (GH-ABI-RCT) Recombinant Human Growth Hormone (rhGH) Injection, Standard Care (Treatment as Usual) - Acute Brain Injuries, Moderate to Severe Traumatic Brain Injury | Phase 4 | Not yet recruiting | Anhui Provincial Hospital | 160 | 2026-04-10 | 2026-03-19 |
| Methylprednisolone for Moderate to Severe Traumatic Brain Injury Placebo, Methylprednisolone (MP) - Traumatic Brain Injury | Phase 4 | Recruiting | Zhangjiagang First People's Hospital | 520 | 2026-03-29 | 2026-09-22 |
| Individualised Cryoneurolysis to Treat Pain in the Context of Spasticity in the Upper and Lower Extremities Cryoneurolysis, Botulinum toxin - Centreal Neurological Condition, Acquired Brain Injury (Including Stroke) | Phase 4 | Recruiting | Oxford University Hospitals NHS Trust | 50 | 2025-12-02 | 2026-11-05 |
| Evaluation of the Efficacy of STRATAFIX for Neurosurgical Cranial and Spine Procedures STRATAFIX PDS and Monocryl suture - Wound Closure, Brain Tumor Adult | Phase 4 | Recruiting | University of Michigan | 160 | 2025-11-01 | 2025-11-05 |
| Comparison of C-Reactive Protein Levels in Traumatic Brain Injury Patients Undergoing Craniotomy With and Without Dexmedetomidine Dexmedetomidine, Sufentanyl - Traumatic Brain Injury | Phase 4 | Completed | Universitas Jenderal Soedirman | 25 | 2025-10-27 | 2026-02-17 |
| Early Post-Traumatic Seizures Prevention Trial (E-PTS Trial) Phenytoin, Levetiracetam, Placebo - Seizures, Traumatic Brain Injuries | Phase 4 | Recruiting | All India Institute of Medical Sciences, Jodhpur | 1260 | 2025-07-23 | 2026-10-29 |
| The Study on the Efficacy of tDCS Stimulation of the Cerebellum Combined With XingNaoJing Injection in Patients With Consciousness Disorders After Cranial Injury XinNaoJing injection, tDCS - tDCS, Cerebellum | Phase 4 | Not yet recruiting | The Second Affiliated Hospital of Kunming Medical University | 200 | 2025-04-25 | 2025-04-15 |
| Seizure Prevention in Traumatic Brain Injury With Levetiracetam and Lacosamide levetiracetam, lacosamide - Traumatic Brain Injury | Phase 4 | Recruiting | Wake Forest University Health Sciences | 600 | 2025-04-18 | 2026-04-24 |
| Ketamine for Sedation in Severe Traumatic Brain Injury Ketamine with propofol, Standard of Care propofol, fentanyl, dexmedetomidine, morphine, hydromorphone, midazolam, or lorazepam - Severe Traumatic Brain Injury, Intracranial Hypertension | Phase 4 | Suspended | Henry M. Jackson Foundation for the Advancement of Military Medicine | 50 | 2024-09-23 | 2025-07-14 |
| Methylphenidate for the Treatment of PTSD With Associated Neurocognitive Complaints Methylphenidate, Placebo - Posttraumatic Stress Disorder (PTSD) | Phase 4 | Recruiting | VA Office of Research and Development | 70 | 2024-02-05 | 2026-08-19 |
| Antiseizure Medication in Seizure Networks at Early Acute Brain Injury Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product - Brain Injuries, Acute, Brain Injuries, Traumatic | Phase 4 | Terminated | University of North Carolina, Chapel Hill | 5 | 2023-11-20 | 2025-11-14 |
| The Anaesthetic Ketamine as Treatment for Patients With Severe Acute Brain Injury S-ketamine, Isotonic saline (placebo) - Subarachnoid Hemorrhage, Aneurysmal, Intracerebral Hemorrhage | Phase 4 | Recruiting | Copenhagen University Hospital, Rigshospitalet | 400 | 2023-09-15 | 2024-06-26 |
| MEXIDOL® in the Rehabilitation Treatment of Patients With Acute Cerebral Failure Mexidol - Ischemic Stroke, Acute | Phase 4 | Completed | Pharmasoft | 60 | 2023-04-17 | 2025-04-27 |
| Aerosolized Endotracheal Lidocaine to Avoid Intracranial Pressure Spikes in Patients With Severe Traumatic Brain Injury aerosolized 2% lidocaine (20mg/ml), instilled 0.9% sodium chloride (NS), instilled 2% lidocaine solution - Traumatic Brain Injury | Phase 4 | Completed | The University of Texas Health Science Center, Houston | 10 | 2021-11-09 | 2026-08-07 |
| Beta Blocker Effects in Traumatic Brain Injury Propranolol, Saline - Trauma, Brain | Phase 4 | Completed | Menoufia University | 40 | 2021-10-01 | 2023-03-17 |
| Ketamine in Acute Brain Injury Patients. Ketamine, Placebo - Brain Injuries, Traumatic | Phase 4 | Unknown | Geert Meyfroidt, MD, PhD | 100 | 2021-09-06 | 2024-08-22 |
Showing 20 of 88. Sign in to see all of them.
Brain Injuries, Traumatic (60) · Stroke (9) · Brain Concussion (5) · Craniocerebral Trauma (5) · Intracranial Hemorrhages (5) · Subarachnoid Hemorrhage (5) · Intracranial Hypertension (4) · Wounds and Injuries (4) · Attention Deficit Disorder with Hyperactivity (3) · Coma (3) · Depression (3) · Dwarfism, Pituitary (3) · Muscle Spasticity (3) · Seizures (3)
Brain Diseases (88) · Central Nervous System Diseases (88) · Nervous System Diseases (87) · Trauma, Nervous System (85) · Wounds and Injuries (83) · Craniocerebral Trauma (82) · Pathological Conditions, Signs and Symptoms (24) · Cardiovascular Diseases (21) · Vascular Diseases (21) · Cerebrovascular Disorders (18) · Signs and Symptoms (17) · Neurologic Manifestations (13) · Pathologic Processes (12) · Mental Disorders (10)
Dexmedetomidine (5) · Levetiracetam (5) · Sodium Chloride (5) · Human Growth Hormone (4) · Methylphenidate (4) · Midazolam (4) · Propranolol (4) · Amantadine (3) · Botulinum Toxins, Type A (3) · Acetaminophen (2) · Buspirone (2) · Citalopram (2) · Consciousness Monitors (2) · Enoxaparin (2) · Growth Hormone (2)
Pfizer (3) · VA Office of Research and Development (3) · Assiut University (2) · Damanhour University (2) · Loyola University (2) · The University of Texas Health Science Center, Houston (2) · University Hospital, Clermont-Ferrand (2) · University Hospital, Grenoble (2) · University of North Carolina, Chapel Hill (2) · Wake Forest University Health Sciences (2) · Advanced Circulatory Systems (1) · Ain Shams University (1) · Ali Amini Harandi (1) · All India Institute of Medical Sciences, Jodhpur (1) · Anhui Provincial Hospital (1)
United States (42) · China (7) · France (7) · Egypt (3) · Italy (3) · United Kingdom (3) · Canada (2) · Israel (2) · Spain (2) · Australia (1) · Belgium (1) · Colombia (1) · Denmark (1) · Hong Kong (1) · India (1)
Adrian Nugraha Putra (1) · Amy O Bowles, MD (1) · Anthony Lequerica, PhD (1) · Ayman El-Menyar, MD (1) · Benjamin W Friedman, MD,MS (1) · Brad Kurowski, MS, MD (1) · Bradley Dengler, MD (1) · Carlos A Cadavid, MD (1) · Carmelo Graffagnino, MD FRCPC (1) · Chet A Morrison, M.D. (1) · Christopher M Miles, MD (1) · DaiWai M Olson, PhD RN CCRN (1) · David J Sharp (1) · David Ripley, MD (1)
PMID 11383749, PMID 12794404, PMID 15644669, PMID 18465388, PMID 20441723, PMID 22342434, PMID 23136160, PMID 24992948, PMID 26471212, PMID 27276999, PMID 27603763, PMID 28219399, PMID 29477412, PMID 29878826, PMID 30169436, PMID 31494820, PMID 31853446, PMID 32250330, PMID 32712569, PMID 33076939, PMID 34876207, PMID 35033158, PMID 39179700, PMID 40437634, PMID 40721263, PMID 41217349, PMID 42101960
2008 (1), 2014 (1), 2017 (1), 2025 (1), R01HD057098 (1)