53 completed. 53 Phase 2, 16 Phase 1, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 53 | Completed 53 |
| Phase 1 | 16 | Completed 16 |
| Phase 3 | 3 | Completed 3 |
Follow Brain Damage, Chronic: new trials by email Literature Review of Brain Damage, Chronic trials Research Report on Brain Damage, Chronic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Metformin for Motor and Cognitive Improvement in Children With Cerebral Palsy: A Feasibility Study Metformin - Cerebral Palsy | Phase 2 | Completed | Holland Bloorview Kids Rehabilitation Hospital | 3 | 2023-11-14 | 2026-03-02 |
| Therapeutic Photobiomodulation and Tretament of Spasticity Photobiomodulation, Institution's Standard Physiotherapy, Photobiomodulation Placebo - Muscle Spasticity, Cerebral Palsy | Phase 2 / Phase 3 | Completed | University of Nove de Julho | 12 | 2023-08-15 | 2026-05-01 |
| ADX-629 Therapy for Sjogren-Larsson Syndrome ADX-629 - Sjogren-Larsson Syndrome | Phase 1 / Phase 2 | Completed | University of Nebraska | 8 | 2023-01-02 | 2026-05-05 |
| A Study to Investigate the Safety and Efficacy of UC-MSCs in Pediatric Patients With Cerebral Palsy UDI-001 - Cerebral Palsy, Periventricular Leukomalacia | Phase 1 / Phase 2 | Completed | Rohto Pharmaceutical Co., Ltd. | 6 | 2021-06-02 | 2025-04-06 |
| A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy for the Treatment of Traumatic Brain Injury and Hypoxic-Ischemic Encephalopathy HB-adMSCs - Traumatic Brain Injury | Phase 1 / Phase 2 | Completed | Hope Biosciences LLC | 24 | 2020-01-01 | 2026-01-15 |
| A Study of UCB and MSCs in Children With CP: ACCeNT-CP Infusion of allogeneic umbilical cord blood, Infusion of MSCs - Cerebral Palsy | Phase 1 / Phase 2 | Completed | Joanne Kurtzberg, MD | 91 | 2018-04-10 | 2021-08-19 |
| A Promising Tool for Predicting Consciousness Evolution in Prolonged Disorders of Consciousness Zolpidem Tartrate Tablets - Disorder of Consciousness | Phase 2 | Completed | Xijing Hospital | 36 | 2017-12-01 | 2022-05-31 |
| Hyperbaric Oxygen for Traumatic and Non-traumatic Brain Injury Hyperbaric Oxygen, Minimal pressure air - Brain Injury, Chronic | Phase 2 | Completed | Lindell Weaver | 49 | 2017-09-06 | 2022-08-04 |
| Intranasal Inhalations of Bioactive Factors Produced by M2 Macrophages in Patients With Organic Brain Syndrome Intranasal auto-M2-BFs - Organic Brain Syndrome, Nonpsychotic, Neurocognitive Disorders | Phase 1 / Phase 2 | Completed | Russian Academy of Medical Sciences | 30 | 2016-03-01 | 2021-02-18 |
| Calcium Channel Blockers Compared to Magnesium Sulfate in Fetal Cerebral Blood Flow Magesium sulphate, Nifedipine, Doppler on fetal middle cerebral artery - Preterm Labor, Cerebral Palsy | Phase 2 / Phase 3 | Completed | Kasr El Aini Hospital | 130 | 2015-12-01 | 2017-11-17 |
| Outcomes of Stem Cells for Cerebral Palsy Autologous Bone Marrow Mononuclear Cells - Cerebral Palsy | Phase 2 | Completed | Vinmec Healthcare System | 30 | 2015-11-05 | 2018-05-07 |
| Mechanism of Allogeneic UCB Therapy in Cerebral Palsy allogeneic cord blood transplantation - Cerebral Palsy, Child Development | Phase 1 / Phase 2 | Completed | Bundang CHA Hospital | 90 | 2015-07-29 | 2020-11-04 |
| Tau Imaging of Chronic Traumatic Encephalopathy [F18]-T807, [F18]-Florbetapir, MRI/MRS - Chronic Traumatic Encephalopathy | Phase 2 | Completed | Brigham and Women's Hospital | 30 | 2015-01-01 | 2018-05-17 |
| The Baby CHAMP Study (Children With Hemiparesis Arm and Movement Project) Neurorehabilitation therapy with cast, Neurorehabilitation therapy with splint, Neurorehabilitation bimanual - Hemiparesis, Cerebral Palsy | Phase 1 / Phase 2 | Completed | Virginia Polytechnic Institute and State University | 58 | 2015-01-01 | 2022-03-11 |
| tDCS on Precuneus in MCS: Repeated Stimulations transcranial direct current stimulation - Patients in Minimally Conscious State After a Severe Brain Injury | Phase 2 | Completed | Hangzhou Normal University | 33 | 2014-12-01 | 2016-03-08 |
| Erythropoietin Therapy for Children With Cerebral Palsy Erythropoietin, Placebo erythropoietin - Cerebral Palsy | Phase 2 | Completed | Bundang CHA Hospital | 11 | 2014-09-01 | 2017-10-12 |
| Treatment With Xeomin Versus Botox in Children With Spastic Equine and Equinovarus Foot Deformation in Pediatric Cerebral Palsy Xeomin, Botox® - Cerebral Palsy, Spastic Paraplegia and Hemiparesis | Phase 2 | Completed | Merz Pharmaceuticals GmbH | 64 | 2014-07-01 | 2017-01-26 |
| 18F-AV-1451 and Florbetapir F 18 PET (Positron Emission Tomography) Imaging in Subjects at Risk for Chronic Traumatic Encephalopathy florbetapir F 18, Flortaucipir F18 - Chronic Traumatic Encephalopathy | Phase 2 | Completed | Avid Radiopharmaceuticals | 41 | 2014-06-01 | 2020-09-07 |
| Enhancing Motor Plasticity After Perinatal Stroke Using tDCS Interventional TDCS, Sham TDCS - Perinatal Stroke, Cerebral Palsy | Phase 2 | Completed | University of Calgary | 23 | 2014-05-01 | 2015-05-28 |
| Outcomes of Stem Cells for Cerebral Palsy Autologous Bone Marrow Mononuclear Cells - Cerebral Palsy | Phase 2 | Completed | Vinmec Healthcare System | 40 | 2014-04-01 | 2015-10-16 |
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Cerebral Palsy (45) · Brain Injuries, Traumatic (4) · Muscle Spasticity (4) · Chronic Traumatic Encephalopathy (3) · Consciousness Disorders (3) · Paresis (3) · Persistent Vegetative State (3) · Stroke (3) · Brain Injuries (2) · Brain Injury, Chronic (2) · Hypoxia-Ischemia, Brain (2) · Intracranial Hemorrhages (2) · Leukomalacia, Periventricular (2) · Amyotrophic Lateral Sclerosis (1) · Arthrogryposis (1)
Brain Diseases (53) · Central Nervous System Diseases (53) · Nervous System Diseases (53) · Pathological Conditions, Signs and Symptoms (22) · Signs and Symptoms (17) · Neurologic Manifestations (15) · Wounds and Injuries (11) · Craniocerebral Trauma (10) · Trauma, Nervous System (10) · Mental Disorders (9) · Pathologic Processes (9) · Brain Injuries (8) · Cardiovascular Diseases (7) · Cerebrovascular Disorders (7)
Botulinum Toxins, Type A (3) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (2) · Acupuncture Therapy (2) · Baclofen (2) · Hyperbaric Oxygenation (2) · Stem Cell Transplantation (2) · Transcranial Direct Current Stimulation (2) · florbetapir (2) · incobotulinumtoxinA (2) · ADX-629 (1) · Botulinum Toxins (1) · Cell Count (1) · Cetuximab (1) · Constraint Induced Movement Therapy (1) · Diffusion Tensor Imaging (1)
Bundang CHA Hospital (2) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (2) · Holland Bloorview Kids Rehabilitation Hospital (2) · Joanne Kurtzberg, MD (2) · University of Oklahoma (2) · University of Southern California (2) · Vinmec Healthcare System (2) · Virginia Polytechnic Institute and State University (2) · Agency for Healthcare Research and Quality (AHRQ) (1) · Avid Radiopharmaceuticals (1) · Brigham and Women's Hospital (1) · Children's Hospital Los Angeles (1) · Eli Lilly and Company (1) · Hangzhou Normal University (1) · Hanyang University Seoul Hospital (1)
United States (26) · Canada (3) · South Korea (3) · Vietnam (3) · Belgium (2) · China (2) · Egypt (2) · Russia (2) · Brazil (1) · France (1) · Hong Kong (1) · Iran (1) · Japan (1) · Norway (1) · Switzerland (1)
Charles S Cox, MD (2) · Darcy Fehlings, MD, MSc (2) · Joanne Kurtzberg, MD (2) · Liem T Nguyen, MD., PhD. (2) · Minyoung Kim, M.D., Ph.D. (2) · Adam Kirton, MD, MSc (1) · Ahmed M Kamel, M.D. (1) · Alexander A Ostanin, MD, PhD (1) · Ali Reza Zali, MD (1) · Ariane Zoll (1) · Burris Duncan (1) · Burris Duncan, M.D. (1) · Diane L Damiano, Ph.D. (1)
PMID 38114596, PMID 28403842, PMID 28688787, PMID 18065878, PMID 18676556, PMID 18990048, PMID 19811515, PMID 22071153, PMID 22541308, PMID 22747635, PMID 22776958, PMID 23106988, PMID 24607242, PMID 24969309, PMID 25157725, PMID 25534356, PMID 25863661, PMID 27187300, PMID 27927938, PMID 28109298, PMID 28867665, PMID 29080265, PMID 30107811, PMID 30782701, PMID 30969506, PMID 31438885, PMID 34649982, PMID 35811372, PMID 36477478, PMID 37555886, PMID 38087394, PMID 905874
P50AT000008 (1), R21AR051564 (1), R21HD054697 (1)