263 completed, 45 terminated, 24 recruiting, 23 unknown. 378 Phase 3, 71 Phase 2.
Follow Basal Ganglia Diseases: new trials by email Literature Review of Basal Ganglia Diseases trials Research Report on Basal Ganglia Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Trial of ONO-2808 in Participants With the Parkinsonian Subtype of Multiple System Atrophy (MSA-P) ONO-2808, Placebo - Multiple System Atrophy, Parkinson Variant | Phase 3 | Not yet recruiting | Ono Pharmaceutical Co., Ltd. | 486 | 2027-01-01 | 2026-09-17 |
| Effect of Botulinum Toxin on Resting Tremor of the Refractory Upper Limb in Parkinsonians Injection of Dysport then placebo, Injection of placebo then Dysport - PARKINSON DISEASE (Disorder) | Phase 3 | Not yet recruiting | University Hospital, Toulouse | 39 | 2026-10-01 | 2026-09-22 |
| Trientine Tetrahydrochloride Administered Once a Day for the First Line Treatment of Wilson's Disease Patients. TETA 4HCl formulation, D-Penicillamine - Wilson's Disease | Phase 3 | Recruiting | Orphalan | 38 | 2026-09-03 | 2026-10-15 |
| Efficacy and Safety of Butylphthalide in the Treatment of Multiple System Atrophy 3-N-butylphthalide - Multiple System Atrophy | Phase 2 / Phase 3 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 150 | 2026-08-27 | 2026-10-16 |
| Phase Ⅲ Clinical Trial to Evaluate the Efficacy and Safety of TJ0113 Capsules in Patients With Early-Onset Parkinson's Disease TJ0113 200mg, TJ0113 400mg, Placebo - Parkinson's Disease (PD), Parkinson Disease 6, Early-Onset | Phase 3 | Not yet recruiting | Hangzhou PhecdaMed Co., Ltd. | 300 | 2026-08-03 | 2026-08-12 |
| VG081821AC Tablets for Early to Mid-stage Parkinson's Disease VG081821AC, Placebo - Parkinson Disease (PD) | Phase 2 / Phase 3 | Recruiting | Zhejiang Vimgreen Pharmaceuticals, Ltd. | 152 | 2026-07-17 | 2026-09-03 |
| Pridopidine Phase 3 Study in Huntington's Disease Pridopidine, Placebo - Huntington Disease | Phase 3 | Recruiting | Prilenia | 400 | 2026-07-01 | 2026-10-28 |
| A Study to Evaluate the Efficacy of NIO752 in Participants With Progressive Supranuclear Palsy NIO752, Placebo - Progressive Supranuclear Palsy Richardson Syndrome (PSP-RS) | Phase 3 | Recruiting | Novartis Pharmaceuticals | 300 | 2026-06-03 | 2026-10-15 |
| Safinamide vs Placebo for Pain in Patients With Parkinson's Disease and Motor Fluctuations Safinamide, Placebo - PARKINSON DISEASE (Disorder), Pain | Phase 3 | Recruiting | Universita di Verona | 60 | 2026-04-28 | 2026-08-13 |
| An Extension of SKY-0515 in Participants With Huntington's Disease SKY-0515 - Huntington's Disease (HD) | Phase 2 / Phase 3 | Enrolling by invitation | Skyhawk Therapeutics, Inc. | 500 | 2026-04-10 | 2026-07-24 |
| A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease Votoplam (blinded), Placebo - Huntington Disease | Phase 3 | Recruiting | Novartis Pharmaceuticals | 770 | 2026-03-24 | 2026-09-22 |
| MSA-01 in Multiple System Atrophy MSA-01, Placebo - Multiple System Atrophy (MSA) | Phase 3 | Recruiting | Tokyo University | 140 | 2026-02-09 | 2026-03-04 |
| Effect of Repetitive Bihemispheric Anodal Transcranial Direct Current Stimulation on Motor Function of Patients With Parkinson's Disease Transcranial Direct Current Stimulation - PARKINSON DISEASE (Disorder), Parkinson Disease | Phase 3 | Not yet recruiting | Dr. Ram Manohar Lohia Hospital | 30 | 2026-02-01 | 2026-02-09 |
| A Study of Buntanetap in Participants With PD buntanetap/posiphen - Parkinson's Disease (PD), Deep Brain Stimulation | Phase 2 / Phase 3 | Recruiting | Annovis Bio Inc. | 500 | 2026-01-09 | 2026-10-30 |
| Study to Evaluate the Pharmacodynamics, Safety and Efficacy of SKY-0515 in Participants With Huntington's Disease SKY-0515, SKY-0515 Placebo - Huntington Disease | Phase 2 / Phase 3 | Recruiting | Skyhawk Therapeutics, Inc. | 400 | 2026-01-06 | 2026-10-29 |
| Pharmacologically Modulating the Noradrenergic Arousal System to Reduce Freezing of Gait in Parkinson's Disease: a Multi-centre and Multi-modal Approach Atomoxetine, Placebo - Parkinson's Disease (PD), Freezing of Gait | Phase 3 | Recruiting | Radboud University Medical Center | 60 | 2026-01-01 | 2026-02-27 |
| A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease Prasinezumab, Placebo - Parkinson's Disease | Phase 3 | Recruiting | Hoffmann-La Roche | 900 | 2025-11-24 | 2026-10-06 |
| Metformin in Parkinson Disease Levodopa Carbidopa, Metformin - Parkinson Disease | Phase 2 / Phase 3 | Recruiting | Tanta University | 60 | 2025-11-10 | 2025-11-21 |
| Vinpocetine in Patients With Parkinsonian Disease Levodopa Carbidopa, Vinpocetine - Parkinson Disease | Phase 2 / Phase 3 | Recruiting | Tanta University | 60 | 2025-11-10 | 2025-12-10 |
| Intestinal Levodopa + Entacapone Therapy (Lecigon®) to Counteract Dopaminergic Desensitization and Neuropsychiatric Complications in Parkinson's Disease LECIG (levodopa, carbidopa, entacapone intestinal gel), Best oral medication - PARKINSON DISEASE (Disorder) | Phase 3 | Recruiting | University Hospital Tuebingen | 150 | 2025-10-27 | 2026-07-13 |
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Parkinson Disease (289) · Huntington Disease (29) · Dyskinesias (24) · Tourette Syndrome (21) · Parkinsonian Disorders (18) · Multiple System Atrophy (15) · Movement Disorders (11) · Lewy Body Disease (10) · Tic Disorders (10) · Dementia (9) · Neurodegenerative Diseases (9) · Supranuclear Palsy, Progressive (9) · Brain Diseases (8) · Central Nervous System Diseases (8) · Hypotension, Orthostatic (8)
Nervous System Diseases (371) · Brain Diseases (370) · Central Nervous System Diseases (370) · Movement Disorders (366) · Neurodegenerative Diseases (365) · Synucleinopathies (307) · Parkinsonian Disorders (280) · Mental Disorders (69) · Pathological Conditions, Signs and Symptoms (63) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (61) · Signs and Symptoms (61) · Genetic Diseases, Inborn (59) · Heredodegenerative Disorders, Nervous System (59) · Neurologic Manifestations (55)
Pramipexole (18) · rasagiline (18) · carbidopa, levodopa drug combination (17) · Levodopa (16) · rotigotine (14) · istradefylline (11) · Apomorphine (10) · safinamide (10) · ropinirole (9) · Aripiprazole (7) · Droxidopa (6) · deutetrabenazine (6) · pardoprunox (6) · Carbidopa (5) · perampanel (5)
UCB Pharma (15) · Boehringer Ingelheim (12) · Teva Branded Pharmaceutical Products R&D, Inc. (11) · AbbVie (10) · GlaxoSmithKline (9) · Kyowa Kirin Co., Ltd. (8) · Newron Pharmaceuticals SPA (8) · Impax Laboratories, LLC (7) · Solvay Pharmaceuticals (7) · Adamas Pharmaceuticals, Inc. (6) · Chelsea Therapeutics (5) · Kyowa Kirin, Inc. (5) · Otsuka Pharmaceutical Development & Commercialization, Inc. (5) · Radboud University Medical Center (5) · Assistance Publique - Hôpitaux de Paris (4)
United States (189) · Germany (91) · Canada (86) · France (71) · Spain (71) · Italy (66) · United Kingdom (63) · Poland (51) · Australia (43) · Czechia (34) · Hungary (32) · Austria (30) · Ukraine (30) · China (28) · Israel (27)
Eva Kohegyi, MD (5) · Neil Sussman, MD (4) · Phyllis Salzman, Ph.D. (4) · Will Sullivan (4)
PMID 27538531, PMID 28494751, PMID 36602886, PMID 38588457, PMID 19126811, PMID 20519680, PMID 21542016, PMID 23667214, PMID 25185211, PMID 26523919, PMID 26882318, PMID 28265459, PMID 29532440, PMID 30425824, PMID 33864229, PMID 34024025, PMID 35747889, PMID 36865634, PMID 38070039, PMID 38557959, PMID 39825184, PMID 41045349, PMID 41626017, PMID 42475649, PMID 14676468, PMID 14718694, PMID 15965209, PMID 16216957, PMID 16381181, PMID 16943402, PMID 17052655, PMID 17502459, PMID 17509486, PMID 17881719, PMID 17895872, PMID 18175337, PMID 18378947, PMID 18413464, PMID 18538636, PMID 19029129, PMID 19058133, PMID 19064745, PMID 19454631, PMID 19771175, PMID 19776408, PMID 19959398, PMID 20008998, PMID 20021666, PMID 20483969, PMID 20582993
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