799 completed, 172 unknown, 141 recruiting, 109 terminated. 386 Not applicable, 275 Phase 2, 159 Phase 1, 153 Phase 3, 72 Phase 4.
Follow Precancerous Conditions: new trials by email Literature Review of Precancerous Conditions trials Research Report on Precancerous Conditions
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Papilozumib Vaginal Gel for Exocervical Mucosal Restoration in Women With Human Papillomavirus (HPV) Papilozumib vaginal gel, Papilozumib oral supplement - Human Papillomavirus Infection, Human Papillomavirus Infections | Not applicable | Not yet recruiting | Hifas da Terra S.L. | 81 | 2027-07-01 | 2026-10-05 |
| Minimally Invasive Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Cancer, SOS5C Trial Cancer Screening, Computer-Assisted Intervention, Endoscopic Procedure - Barrett Esophagus, Esophageal Adenocarcinoma | Not applicable | Not yet recruiting | Mayo Clinic | 1010 | 2026-12-01 | 2026-06-24 |
| Pilot Study of Salivary Bile Acids and Pepsin as Predictive Biomarkers of Reflux Disease After Sleeve Gastrectomy Reflux Disease, Gastro-Esophageal, Sleeve Gastrectomy | Not yet recruiting | Hospital de Mataró | 60 | 2026-12-01 | 2026-05-26 | |
| Lucid BE Biomarkers Study Tissue - Barrett's Esophagus, Barrett's Esophagus With Dysplasia | Not yet recruiting | UNC Lineberger Comprehensive Cancer Center | 40 | 2026-12-01 | 2026-10-21 | |
| Efficacy and Safety of Cryotherapy Followed by Tirbanibulin Ointment for Actinic Keratosis on the Scalp and Forehead Cryotherapy + Tirbanibulin - Keratosis, Actinic Keratoses | Phase 3 | Not yet recruiting | University Hospital, Lille | 59 | 2026-11-30 | 2026-05-22 |
| C-3002: Enhancing Cervical Cancer Screening Access and Follow-up Care at 'CASCADE' Clinical Sites in the United States Qualitative interviews, Focus groups - Human Immunodeficiency Virus (HIV), Human Papillomavirus (HPV) | Not yet recruiting | UNC Lineberger Comprehensive Cancer Center | 3500 | 2026-11-10 | 2026-10-20 | |
| Ursodeoxycholic Acid in Barrett's Endotherapy Barrett's Esophagus With Dysplasia | Not yet recruiting | Columbia University | 15 | 2026-11-01 | 2026-08-11 | |
| Therapeutic Induction of Dermal Remodeling in Veterans to Prevent Actinic Neoplasia Caused by Chronic Environmental Exposure to Ultraviolet Radiation Microneedling, Trichloroacetic acid peel - Nonmelanoma Skin Cancer, Actinic Keratosis | Not applicable | Not yet recruiting | VA Office of Research and Development | 96 | 2026-11-01 | 2026-10-06 |
| Exploratory Study of the Efficacy of HAL-PDT in CIN 3 Hexaminolevulinate (HAL) - Cervical Intraepithelial Neoplasia Grade 3 | Phase 2 | Not yet recruiting | Tongji Hospital | 260 | 2026-11-01 | 2026-10-23 |
| Feasibility Study Comparing One vs Two Probes for Thermal Ablation Among Cervical Cancer Screen Positive Women Living With HIV in C1001P-CS7 Zimbabwe Thermal ablation (TA) with 1 probe, Thermal ablation (TA) with 2 probes - HIV (Human Immunodeficiency Virus), HPV | Not applicable | Recruiting | Fred Hutchinson Cancer Center | 300 | 2026-10-15 | 2026-10-19 |
| Feasibility Study Comparing One vs Two Probes for TA Among Cervical Cancer Screen Positive WLWH in C1001P-CS5 Rwanda Thermal ablation (TA) with 1 probe, Thermal ablation (TA) with 2 probes - HIV (Human Immunodeficiency Virus), HPV | Not applicable | Recruiting | Fred Hutchinson Cancer Center | 300 | 2026-10-15 | 2026-10-19 |
| Feasibility Study Comparing One vs Two Probes for Thermal Ablation Among Cervical Cancer Screen Positive WLWH in C1001P-CS9 South Africa Thermal ablation (TA) with 1 probe, Thermal ablation (TA) with 2 probes - HIV (Human Immunodeficiency Virus), HPV | Not applicable | Recruiting | Fred Hutchinson Cancer Center | 200 | 2026-10-15 | 2026-10-20 |
| Feasibility Study Comparing Use of One Or Two Probes for Thermal Ablation Among Screen Positive Women Living With HIV in C1001P-CS2 Kenya Thermal ablation (TA) with 1 probe, Thermal ablation (TA) with 2 probes - HIV (Human Immunodeficiency Virus), HPV | Not applicable | Recruiting | Fred Hutchinson Cancer Center | 300 | 2026-10-12 | 2026-10-20 |
| Basal Cell Carcinoma Chemoprevention Trial 5% Imiquimod cream, Placebo Vehicle Control Cream - Basal Cell Carcinoma | Phase 3 | Recruiting | VA Office of Research and Development | 1630 | 2026-10-06 | 2026-10-19 |
| Evaluating the Impact of a 12-month Multi-Modal Lifestyle Management Intervention on Disease Relevant Biomarkers The Multimodal Lifestyle Intervention - Monoclonal Gammopathy of Uncertain Significance, Smoldering Myeloma | Not applicable | Not yet recruiting | Hackensack Meridian Health | 67 | 2026-10-01 | 2026-08-24 |
| Preoperative Predictors of Symptom Improvement After Laparoscopic Fundoplication Laparoscopic Nissen fundoplication, Laparoscopic Toupet fundoplication - Gastroesophageal Reflux Disease, Hiatal Hernia | Recruiting | Minia University | 470 | 2026-09-20 | 2026-09-22 | |
| Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions 5-Amino Levulinic Acid - Oral Cancer, Oral Cavity Cancer | Phase 2 | Not yet recruiting | University of Massachusetts, Boston | 65 | 2026-09-01 | 2026-03-19 |
| Adjuvant 5-Fluorouracil Following Thermal Ablation to Improve HPV Treatment Outcomes in Women With HIV in Kenya 5% 5-fluorouracil Topical Cream, Placebo Cream - HIV Infections, HPV Infection | Phase 2 | Not yet recruiting | UNC Lineberger Comprehensive Cancer Center | 140 | 2026-09-01 | 2026-08-27 |
| Multimodal Laser Treatment of Photodamaged Skin 1927-nm thulium laser, 1550-nm Er:Glass laser, Intense Pulsed Light - Photo-damage, Actinic Keratosis (AK) | Not applicable | Recruiting | Merete Haedersdal | 35 | 2026-09-01 | 2026-09-09 |
| 5-Fluorouracil and Calcipotriene for Field Treatment of Actinic Keratoses Combination field therapy with 5-fluorouracil and calcipotriene (5FU/C) - Actinic Keratoses | Phase 1 | Not yet recruiting | Cedars-Sinai Medical Center | 96 | 2026-09-01 | 2026-10-05 |
Showing 20 of 1390. Sign in to see all of them.
Uterine Cervical Dysplasia (384) · Keratosis, Actinic (340) · Barrett Esophagus (304) · Uterine Cervical Neoplasms (185) · Smoldering Multiple Myeloma (99) · Multiple Myeloma (89) · Papillomavirus Infections (76) · Monoclonal Gammopathy of Undetermined Significance (72) · Gastroesophageal Reflux (69) · Esophageal Neoplasms (58) · Adenocarcinoma Of Esophagus (57) · Lymphoma (54) · Neoplasms, Plasma Cell (54) · Leukemia (51)
Neoplasms (1354) · Genital Diseases (428) · Urogenital Diseases (428) · Neoplasms by Site (424) · Female Urogenital Diseases (410) · Female Urogenital Diseases and Pregnancy Complications (409) · Genital Diseases, Female (406) · Uterine Diseases (405) · Skin and Connective Tissue Diseases (400) · Uterine Cervical Diseases (399) · Skin Diseases (389) · Digestive System Diseases (337) · Gastrointestinal Diseases (332) · Keratosis (329)
Imiquimod (45) · 3-ingenyl angelate (42) · Aminolevulinic Acid (38) · Biopsy (32) · Photochemotherapy (29) · Fluorouracil (28) · Cryotherapy (21) · Colposcopy (19) · Lenalidomide (19) · Cyclophosphamide (15) · Dexamethasone (15) · Endoscopy (15) · methyl 5-aminolevulinate (15) · Conization (13) · Endoscopy, Digestive System (13)
National Cancer Institute (NCI) (54) · Mayo Clinic (47) · LEO Pharma (31) · M.D. Anderson Cancer Center (23) · Massachusetts General Hospital (23) · Peplin (21) · Case Comprehensive Cancer Center (16) · Northwestern University (15) · Almirall, S.A. (14) · British Columbia Cancer Agency (12) · Dana-Farber Cancer Institute (12) · GlaxoSmithKline (12) · University of Colorado, Denver (11) · DUSA Pharmaceuticals, Inc. (10) · Galderma R&D (10)
United States (716) · Germany (101) · China (68) · France (63) · United Kingdom (59) · Canada (55) · Netherlands (55) · Italy (46) · Australia (36) · Belgium (33) · Spain (29) · Denmark (28) · South Korea (22) · Brazil (21) · Sweden (19)
Prateek Sharma, MD (13) · Michele Follen, MD, PhD (9) · Stuart Marcus, MD, PhD (9) · Nicholas Shaheen, MD, MPH (8) · Guillermo Tearney, MD, PhD (6) · Rachel L Winer, PhD, MPH (6) · Sachin Wani, MD (6) · Ting Wu, Ph. D. (6) · Ziad Hilal, M.D. (6) · Irene Ghobrial, MD (5) · Joel Palefsky, MD (5) · Kenneth K Wang, MD (5) · Lei Li, M.D. (5) · Murad Alam, MD (5)
PMID 22417254, PMID 23553119, PMID 38125671, PMID 39532605, PMID 39584361, PMID 19586656, PMID 22315471, PMID 22914404, PMID 24165758, PMID 24435414, PMID 24765228, PMID 25057165, PMID 25584134, PMID 25950503, PMID 26253018, PMID 26300464, PMID 28173776, PMID 30195193, PMID 33196758, PMID 33549871, PMID 33567191, PMID 35314199, PMID 38513982, PMID 10451482, PMID 10607349, PMID 10764464, PMID 10796771, PMID 10880770, PMID 11229684, PMID 11493098, PMID 11966728, PMID 12533168, PMID 12544628, PMID 12807941, PMID 1305466, PMID 14520092, PMID 14745410, PMID 14990651, PMID 14992310, PMID 15097955, PMID 15168956, PMID 1550088, PMID 15668895, PMID 15888991, PMID 15944071, PMID 15986031, PMID 16150255, PMID 16152582, PMID 16232104, PMID 16264158
P30CA023074 (9), U01CA121947 (8), P30CA015083 (7), P30CA016672 (7), P30CA043703 (7), U24CA275417 (6), 2014 (5), 2016 (5), 2018 (5), 2023 (5), P30CA068485 (5), 2015 (4), P01CA082710 (4), P30CA006973 (4), P30CA022453 (4)