11 completed, 3 terminated, 2 withdrawn, 1 unknown. 12 Phase 1, 5 Phase 2, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 12 | Completed 10, Terminated 1, Unknown 1 |
| Phase 2 | 5 | Completed 2, Terminated 2, Withdrawn 1 |
| Not applicable | 1 | Withdrawn 1 |
Follow 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a: new trials by email Literature Review of 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a trials Research Report on 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Photodynamic Therapy With HPPH Compared to Standard of Care Surgery in Treating Patients With Oral Cavity Cancer HPPH, Laboratory Biomarker Analysis, Photodynamic Therapy - Stage I Oral Cavity Squamous Cell Carcinoma, Stage II Oral Cavity Squamous Cell Carcinoma | Phase 2 | Terminated | Roswell Park Cancer Institute | 2 | 2018-03-07 | 2022-06-02 |
| HPPH Photodynamic Therapy for Patients With Esophageal Cancer HPPH 2.5 mg/m2, HPPH 3 mg/m2, HPPH 3.5 mg/m2 - Esophageal Cancer | Phase 1 | Unknown | Zhejiang Hisun Pharmaceutical Co. Ltd. | 30 | 2015-06-03 | 2018-11-29 |
| A Trial of Photodynamic Therapy With HPPH for Treatment of Dysplasia, Carcinoma in Situ and T1 Carcinoma of the Oral Cavity and/or Oropharynx HPPH - Dysplasia, Carcinoma of the Oral Cavity | Phase 1 | Completed | Roswell Park Cancer Institute | 29 | 2010-06-08 | 2018-10-16 |
| Photodynamic Therapy Using HPPH in Treating Patients With Recurrent Dysplasia, Carcinoma in Situ, or Stage I Oral Cavity Cancer HPPH - Head and Neck Cancer | Phase 1 | Terminated | Roswell Park Cancer Institute | 11 | 2010-06-01 | 2016-03-16 |
| Study for Determination of Feasibility and Toxicity of Pre-Treatment With HPPH (2-1[1-Hexyloxyethyl]-2 Devinyl Pyropheophorbide-a) Photodynamic Therapy Prior to Chemoradiation in Non-Operable Patients With Obstructive Esophageal Cancer HPPH 2-1[1-hexyloxyethyl]-2-devinyl Pyropheophorbide-a) - Esophageal Neoplasm | Not applicable | Withdrawn | Roswell Park Cancer Institute | 2009-12-01 | 2012-07-02 | |
| Photodynamic Therapy Using HPPH in Treating Patients With Dysplasia, Cancer in Situ, or Invasive Cancer of the Larynx HPPH, laser therapy - Head and Neck Cancer | Phase 1 | Completed | Roswell Park Cancer Institute | 29 | 2008-04-25 | 2018-10-17 |
| Photodynamic Therapy Using HPPH in Treating Patients With Advanced Non-Small Cell Lung Cancer That Blocks the Air Passages HPPH, endoscopic procedure - Lung Cancer | Phase 2 | Terminated | Roswell Park Cancer Institute | 6 | 2007-08-01 | 2014-06-10 |
| Photodynamic Therapy Using HPPH in Treating Patients Undergoing Surgery for Primary or Recurrent Head and Neck Cancer HPPH, photodynamic therapy, conventional surgery - Recurrent Adenoid Cystic Carcinoma of the Oral Cavity, Recurrent Basal Cell Carcinoma of the Lip | Phase 1 | Completed | Roswell Park Cancer Institute | 15 | 2006-10-19 | 2022-07-25 |
| Photodynamic Therapy in Treating Patients With Precancerous Esophageal Conditions or Early Stage Esophageal Cancer HPPH - Esophageal Cancer, Precancerous Condition | Phase 2 | Completed | Roswell Park Cancer Institute | 60 | 2004-02-01 | 2014-01-03 |
| Photodynamic Therapy Using HPPH in Treating Patients With Stage 0 Non-Small Cell Lung Cancer HPPH - Lung Cancer | Phase 1 | Completed | Roswell Park Cancer Institute | 17 | 2004-02-01 | 2023-08-04 |
| Photodynamic Therapy in Treating Patients With Lung Cancer HPPH, photodynamic therapy, therapeutic bronchoscopy - Adenocarcinoma of the Lung, Large Cell Lung Cancer | Phase 1 | Completed | Roswell Park Cancer Institute | 17 | 2004-02-01 | 2014-07-31 |
| Study To Determine The Maximum Range of Light Doses At Two HPPH Doses With Acceptable Normal Tissue Toxicity For PDT Treatment Of High Grade Dysplasia,CIS or Early Adenocarcinoma In Barrett's Esophagus HPPH - Barrett's Esophagus, CIS | Phase 1 | Completed | Roswell Park Cancer Institute | 18 | 2003-03-01 | 2014-12-02 |
| Photodynamic Therapy With HPPH in Treating Patients With Non-Small Cell Lung Cancer HPPH - Lung Cancer | Phase 1 | Completed | Roswell Park Cancer Institute | 2001-06-01 | 2011-03-07 | |
| Study of Photodynamic Therapy (PDT) Using HPPH in Barrett's Esophagus HPPH - Barrett's Esophagus, CIS | Phase 1 | Completed | Roswell Park Cancer Institute | 18 | 2000-08-01 | 2014-01-13 |
| Photodynamic Therapy in Treating Patients With Basal Cell Skin Cancer HPPH - Non-melanomatous Skin Cancer | Phase 1 | Completed | Roswell Park Cancer Institute | 6 | 2000-01-01 | 2011-03-07 |
| Photodynamic Therapy Using HPPH in Treating Patients With Obstructive Esophageal Tumors HPPH - Esophageal Cancer | Phase 1 / Phase 2 | Completed | Roswell Park Cancer Institute | 11 | 1997-01-01 | 2011-03-09 |
| Photodynamic Therapy With HPPH in Treating Patients With Squamous Cell Carcinoma of the Oral Cavity HPPH, Light Infusion Therapy™, therapeutic conventional surgery - Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity, Recurrent Squamous Cell Carcinoma of the Oropharynx | Phase 2 | Withdrawn | Roswell Park Cancer Institute | 2016-04-21 |
Adenocarcinoma of Lung (4) · Carcinoma, Non-Small-Cell Lung (4) · Esophageal Neoplasms (4) · Squamous Cell Carcinoma of Head and Neck (4) · Lung Neoplasms (3) · Barrett Esophagus (2) · Head and Neck Neoplasms (2) · Mouth Neoplasms (2) · Adenocarcinoma Of Esophagus (1) · Adenocarcinoma, Follicular (1) · Carcinoma, Basal Cell (1) · Esthesioneuroblastoma, Olfactory (1) · Laryngeal Neoplasms (1) · Oropharyngeal Neoplasms (1) · Precancerous Conditions (1)
Roswell Park Cancer Institute (16) · Zhejiang Hisun Pharmaceutical Co. Ltd. (1)
United States (15) · China (1)
Hassan Arshad, MD (3) · Hassan Arshad (2) · Hector Nava, MD (2) · Hector R. Nava, MD, FACS (2) · Allan R. Oseroff, MD, PhD (1) · Gregory M. Loewen, DO, FCCP (1) · Huilong Liu, PhD (1) · Jon Chan (1) · Nikhil Khushalani, MD (1) · Samjot Dhillon (1) · Samjot Dhillon, MD (1) · Todd L. Demmy, MD (1)
P30CA016056 (3), P01CA055791 (1)