9 completed, 3 recruiting, 3 unknown, 2 terminated. 18 Phase 2, 2 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 18 | Completed 9, Recruiting 3, Unknown 3, Terminated 2, Active not recruiting 1 |
| Phase 3 | 2 | Completed 1, Terminated 1 |
| Phase 1 | 1 | Unknown 1 |
Follow Barrett Esophagus: new trials by email Literature Review of Barrett Esophagus trials Research Report on Barrett Esophagus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus Biopsy Procedure, Biospecimen Collection, Endoscopic Procedure - Barrett Esophagus, Clinical Stage I Esophageal Adenocarcinoma AJCC v8 | Phase 2 | Recruiting | National Cancer Institute (NCI) | 76 | 2026-06-23 | 2026-09-14 |
| Obeticholic Acid for Prevention in Barrett's Esophagus Biospecimen Collection, Esophageal Biopsy, Esophagogastroduodenoscopy - Barrett Esophagus, Esophageal Adenocarcinoma | Phase 2 | Recruiting | National Cancer Institute (NCI) | 30 | 2024-01-03 | 2026-08-11 |
| Oral Bevacizumab-800CW and Cetuximab-800CW Administration to Detect Early Esophageal Adenocarcinomas Avastin, Erbitux, Fluorescence endoscopy and multi-diameter single fiber reflectance/single fiber fluorescence (MDSFR/SFF) spectroscopy - Barrett's Esophagus Without Dysplasia, Barrett Oesophagitis With Dysplasia | Phase 2 | Recruiting | University Medical Center Groningen | 25 | 2023-09-15 | 2026-04-13 |
| Detection of Early Esophageal Cancer by NIR-FME. Bevacizumab-IRDye800CW, Fluorescence endoscopy - Barrett Esophagus | Phase 2 | Unknown | University Medical Center Groningen | 60 | 2019-07-29 | 2020-11-04 |
| "Acetic Acid Chromoendoscopy in Barrett's Esophagus Surveillance Chromoendoscopy using Acetic Acid 2.5%, Standard random esophageal biopsies - Barrett's Esophagus | Phase 2 / Phase 3 | Terminated | DHR Health Institute for Research and Development | 60 | 2017-03-10 | 2021-08-27 |
| Aspirin in Preventing Disease Recurrence in Patients With Barrett Esophagus After Successful Elimination by Radiofrequency Ablation Aspirin, Laboratory Biomarker Analysis, Placebo Administration - Barrett Esophagus, Esophageal Adenocarcinoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 21 | 2016-01-15 | 2026-09-11 |
| Effect of Dexlansoprazole 60 mg QD and 60 mg BID on Recurrence of Intestinal Metaplasia in Subjects Who Have Achieved Complete Eradication of Barrett's Esophagus With Radiofrequency Ablation Dexlansoprazole, Dexlansoprazole Placebo - Barrett's Esophagus | Phase 2 | Terminated | Takeda | 6 | 2014-07-01 | 2017-05-11 |
| YF476 in Barrett's Esophagus YF476, YF476 placebo - Barrett's Esophagus | Phase 2 | Completed | Trio Medicines Ltd. | 27 | 2013-05-15 | 2021-04-12 |
| Accuracy, Yield and Clinical Impact of a Low-Cost HRME in the Early Diagnosis of Esophageal Adenocarcinoma Proflavine, high resolution imaging - Barrett's Esophagus | Phase 2 | Unknown | Anandasabapathy, Sharmila, M.D. | 100 | 2012-09-01 | 2021-01-14 |
| Metformin Hydrochloride in Preventing Esophageal Cancer in Patients With Barrett Esophagus metformin hydrochloride, placebo - Barrett Esophagus, Esophageal Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 93 | 2012-06-01 | 2014-07-21 |
| Radiofrequency Ablation for Barrett Oesophagus With Low Grade Dysplasia Endoscopic radiofrequency ablation, Endoscopic surveillance - Barrett Oesophagus, Low Grade Dysplasia | Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 125 | 2010-12-22 | 2025-09-12 |
| Trial of a Gastrin Receptor Antagonist in Barrett's Esophagus YF476, Placebo - Barrett's Esophagus | Phase 2 | Completed | Columbia University | 27 | 2010-06-01 | 2021-11-23 |
| Ursodiol in Treating Patients With Barrett Esophagus and Low-Grade Dysplasia Ursodiol, Laboratory Biomarker Analysis - Barrett Esophagus, Esophageal Carcinoma | Phase 2 | Completed | National Cancer Institute (NCI) | 36 | 2010-04-01 | 2017-12-19 |
| Tethered Capsule Endoscope in Screening Participants for Barrett Esophagus questionnaire administration, comparison of screening methods, diagnostic endoscopic procedure - Esophageal Cancer, Precancerous Condition | Phase 1 / Phase 2 | Unknown | US Department of Veterans Affairs | 50 | 2009-05-01 | 2014-01-10 |
| Esomeprazole Magnesium With or Without Aspirin in Preventing Esophageal Cancer in Patients With Barrett Esophagus acetylsalicylic acid, esomeprazole magnesium, placebo - Barrett Esophagus, Esophageal Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 122 | 2007-04-01 | 2014-07-02 |
| Efficacy and Safety of Sunitinib in Metastatic Gastric Cancer Sunitinib-Malate - Gastric Adenocarcinoma, Barrett Esophagus | Phase 2 | Completed | Johannes Gutenberg University Mainz | 52 | 2006-12-01 | 2011-01-20 |
| Endoscopic Therapy of Early Cancer in Barretts Esophagus Endoscopic Mucosal Resection, Photodynamic Therapy - Early Stage Esophageal Adenocarcinoma, Barrett Esophagus | Phase 2 | Completed | Mayo Clinic | 73 | 2005-09-01 | 2015-12-24 |
| Biomarkers in Phototherapy of Barrett's Esophagus Photodynamic therapy, radiofrequency ablation of barrett's esophagus - Barrett's Esophagus, High Grade Dysplasia | Phase 2 / Phase 3 | Completed | Mayo Clinic | 208 | 2002-12-01 | 2017-11-22 |
Adenocarcinoma Of Esophagus (6) · Esophageal Neoplasms (4) · Gastroesophageal Reflux (2) · Precancerous Conditions (1)
Digestive System Diseases (18) · Esophageal Diseases (18) · Gastrointestinal Diseases (18) · Neoplasms (18) · Precancerous Conditions (17) · Digestive System Neoplasms (4) · Gastrointestinal Neoplasms (4) · Head and Neck Neoplasms (4) · Neoplasms by Site (4) · Deglutition Disorders (2) · Esophageal Motility Disorders (2)
Aspirin (2) · Endoscopy (2) · Endoscopy, Digestive System (2) · Photochemotherapy (2) · Specimen Handling (2) · YF 476 (2) · Bevacizumab (1) · Biopsy (1) · Cetuximab (1) · Dexlansoprazole (1) · Dihematoporphyrin Ether (1) · Endoscopic Mucosal Resection (1) · Esomeprazole (1) · Gastroscopy (1) · Itraconazole (1)
National Cancer Institute (NCI) (6) · Mayo Clinic (2) · University Medical Center Groningen (2) · Anandasabapathy, Sharmila, M.D. (1) · Assistance Publique - Hôpitaux de Paris (1) · Columbia University (1) · DHR Health Institute for Research and Development (1) · Johannes Gutenberg University Mainz (1) · Takeda (1) · Trio Medicines Ltd. (1) · US Department of Veterans Affairs (1)
United States (14) · Canada (2) · Netherlands (2) · United Kingdom (2) · France (1) · Germany (1) · Puerto Rico (1)
Ajay Bansal, MD (1) · Amitabh Chak (1) · Bhaskar Banerjee (1) · Ingrid M Chacon, MD (1) · Jason A. Dominitz, MD (1) · Julian A Abrams, MD MS (1) · Julian A Abrams, MD, MS (1) · Kenneth K Wang, MD (1) · Kenneth K. Wang, M.D. (1) · Markus Moehler, MD (1) · Paul Limburg (1) · Prashanthi Thota (1) · Robert S Bresalier (1)
PMID 22796132, PMID 25218668, PMID 26253018, PMID 29948566, PMID 33685969, PMID 33782049
P30CA046592 (2), UG1CA242632 (2), N01CN00034 (1), N01CN35000 (1), N01CN35158 (1), P30CA016672 (1), P30CA023074 (1), P50CA095060 (1), R01CA111603 (1)