12 completed, 2 unknown, 1 not yet recruiting, 1 recruiting. 17 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 17 | Completed 12, Unknown 2, Not yet recruiting 1, Recruiting 1, Terminated 1 |
| Phase 2 | 1 | Completed 1 |
Follow Appendicitis: new trials by email Literature Review of Appendicitis trials Research Report on Appendicitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Piperacillin/Tazobactam Versus Ceftriaxone and Metronidazole for Children With Perforated Appendicitis Piperacillin/Tazobactam, Ceftriaxone + Metronidazole - Appendicitis Perforated, Appendectomy, Laparoscopic | Phase 3 | Not yet recruiting | McMaster Children's Hospital | 180 | 2027-04-01 | 2026-10-09 |
| Intravenous Ketorolac Vs. Morphine In Children With Acute Abdominal Pain Ketorolac Tromethamine, Morphine Sulfate, normal saline - Acute Pain, Abdomen, Acute | Phase 3 | Recruiting | University of Calgary | 495 | 2024-05-27 | 2024-06-24 |
| Comparison of Ketorolac at Three Doses in Children With Acute Pain Ketorolac Tromethamine - Acute Pain, Abdominal Pain | Phase 3 | Completed | Hamilton Health Sciences Corporation | 171 | 2023-06-01 | 2025-07-09 |
| Ketorolac for Moderate to Severe Abdominal Pain in Children Ketorolac Tromethamine 10 MG/ML, Morphine Sulfate 10Mg/1mL Injection - Abdominal Pain, Appendicitis | Phase 3 | Completed | Hamilton Health Sciences Corporation | 105 | 2021-05-05 | 2023-02-28 |
| Non-operative Treatment of Acute Non-perforated Appendicitis Meronem and flagyl, Appendectomy - Acute Appendicitis | Phase 2 / Phase 3 | Completed | King Edward Medical University | 180 | 2018-09-01 | 2021-02-18 |
| The Onset Time of Rocuronium in Emergency and Elective Surgery Rocuronium elective surgery, Rocuronium emergency surgery, Propofol - Inguinal Hernia, Acute Appendicitis | Phase 3 | Unknown | Diskapi Yildirim Beyazit Education and Research Hospital | 50 | 2015-12-01 | 2015-12-18 |
| Feasibility of Outpatient Appendectomy for Acute Appendicitis outpatient surgery - Acute Appendicitis | Phase 3 | Completed | Centre Hospitalier Universitaire, Amiens | 120 | 2013-04-01 | 2025-09-22 |
| Laparoscopic Appendectomy by Multi-port vs Single Port. Single incision laparoscopic appendectomy, Multiport laparoscopic appendectomy - Acute Appendicitis | Phase 3 | Unknown | Associazione Chirurghi Ospedalieri Italiani | 300 | 2013-03-01 | 2012-11-05 |
| A Safety and Tolerability Study of Doripenem Compared With Meropenem in Children Hospitalized With Complicated Intra-abdominal Infections Doripenem, Meropenem placebo, Meropenem - Abscess, Intra-Abdominal, Abdominal Abscess | Phase 3 | Terminated | Janssen Research & Development, LLC | 41 | 2010-12-01 | 2014-07-15 |
| A Randomised Controlled Trial on LESS Versus Conventional Laparoscopic Appendicectomy. LESS appendectomy, Conventional 3-port laparoscopic appendectomy - Appendicitis | Phase 3 | Completed | Chinese University of Hong Kong | 200 | 2009-10-01 | 2011-07-21 |
| Single Incision Versus Conventional Laparoscopic Appendectomy Single Incision Laparoscopic Appendectomy, Conventional appendectomy - Appendicitis | Phase 3 | Completed | Hospital Universitario Virgen de la Arrixaca | 184 | 2009-09-01 | 2012-01-24 |
| Diagnosis of Acute Appendicitis: Low-dose Computed Tomography (CT) Versus Standard-dose CT Diagnostic CT - Appendicitis | Phase 3 | Completed | Seoul National University Bundang Hospital | 891 | 2009-09-01 | 2011-09-12 |
| Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures Metronidazole, Cefuroxime, Amoxicillin (+ clavulanic acid) and Fluconazole, Placebo - Acute Appendicitis, Perforated Gastroduodenal Ulcer | Phase 3 | Completed | The Faculty Hospital Na Bulovce | 187 | 2008-07-01 | 2012-02-08 |
| Early Versus Interval Appendectomy for Ruptured Appendicitis in Children early appendectomy, interval appendectomy - Ruptured Appendicitis | Phase 3 | Completed | University of Tennessee | 128 | 2006-10-01 | 2010-01-12 |
| Doripenem in the Treatment of Complicated Intra-Abdominal Infections doripenem - Bacterial Infections and Mycoses, Appendicitis | Phase 3 | Completed | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | 483 | 2004-03-01 | 2011-06-10 |
| Doripenem in the Treatment of Complicated Intra-Abdominal Infections Doripenem - Bacterial Infections and Mycoses, Appendicitis | Phase 3 | Completed | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | 478 | 2004-03-01 | 2011-06-10 |
| Laparoscopic Appendectomy for Chronic Right Lower Abdominal Pain laparoscopic appendectomy or not (surgery) - Chronic or Recurrent Appendicitis | Phase 3 | Completed | Maxima Medical Center | 40 | 1994-09-01 | 2006-12-20 |
Abdominal Pain (5) · Peritonitis (3) · Abdomen, Acute (2) · Acute Pain (2) · Bacterial Infections and Mycoses (2) · Cholecystitis (2) · Emergencies (2) · Pancreatitis (2) · Abdominal Abscess (1) · Agnosia (1) · Anxiety Disorders (1) · Bronchiolitis Obliterans Syndrome (1) · Hernia, Inguinal (1) · Ileus (1)
Cecal Diseases (17) · Digestive System Diseases (17) · Gastroenteritis (17) · Gastrointestinal Diseases (17) · Intestinal Diseases (17) · Intraabdominal Infections (17) · Infections (16) · Pathological Conditions, Signs and Symptoms (7) · Neurologic Manifestations (5) · Pain (5) · Signs and Symptoms (5) · Signs and Symptoms, Digestive (5) · Pathologic Processes (3) · Peritoneal Diseases (3) · Biliary Tract Diseases (2)
Doripenem (3) · Ketorolac Tromethamine (3) · Metronidazole (3) · Meropenem (2) · Morphine (2) · Saline Solution (2) · Ambulatory Surgical Procedures (1) · Amoxicillin (1) · Amoxicillin-Potassium Clavulanate Combination (1) · Appendectomy (1) · Benchmarking (1) · Ceftriaxone (1) · Cefuroxime (1) · Clavulanic Acid (1) · Fentanyl (1)
Hamilton Health Sciences Corporation (2) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (2) · Associazione Chirurghi Ospedalieri Italiani (1) · Centre Hospitalier Universitaire, Amiens (1) · Chinese University of Hong Kong (1) · Diskapi Yildirim Beyazit Education and Research Hospital (1) · Hospital Universitario Virgen de la Arrixaca (1) · Janssen Research & Development, LLC (1) · King Edward Medical University (1) · Maxima Medical Center (1) · McMaster Children's Hospital (1) · Seoul National University Bundang Hospital (1) · The Faculty Hospital Na Bulovce (1) · University of Calgary (1) · University of Tennessee (1)
Canada (3) · United States (2) · Argentina (1) · Brazil (1) · Chile (1) · China (1) · Colombia (1) · Czechia (1) · France (1) · Italy (1) · Latvia (1) · Lithuania (1) · Pakistan (1) · Panama (1) · South Korea (1)
Mohamed Eltorki, MBChB (2) · Anthony Y Teoh, FRCSEd (Gen) (1) · Barbara Culbreath, RN (1) · Ferdinando Agresta, MD (1) · Kyoung Ho Lee, MD (1) · Kyuseok Kim, MD (1) · Luigi Boni, MD, FACS (1) · Martin L Blakely, MD (1) · Nereo Vettoretto, MD (1) · Ondrej Ryska, MD (1) · Rudi Roumen, PhD, MD (1)
PMID 19670912, PMID 20211892, PMID 21339413, PMID 22533576, PMID 23154391, PMID 23386239, PMID 27437029, PMID 31096041, PMID 35383071, PMID 41066173
2009 (1)