10 completed, 2 unknown, 1 active not recruiting, 1 not yet recruiting. 16 Phase 2, 2 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 16 | Completed 10, Unknown 2, Active not recruiting 1, Not yet recruiting 1, Terminated 1, Withdrawn 1 |
| Phase 1 | 2 | Unknown 1, Withdrawn 1 |
| Phase 3 | 1 | Completed 1 |
Follow Appendicitis: new trials by email Literature Review of Appendicitis trials Research Report on Appendicitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Patient Choice Between Antibiotics and Appendectomy in Uncomplicated Appendicitis (FRENCH 47 - ALACARTE) Shared decision-making, amoxicillin-clavulanate, Appendectomy - Acute Appendicitis | Phase 2 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 560 | 2026-10-01 | 2026-10-05 |
| Piperacillin/Tazobactam Versus ceftriAxone and Metronidazole for Children With Perforated Appendicitis (ALPACA) Piperacillin/tazobactam, Normal saline, CefTRIAXone Injection - Appendicitis Perforated | Phase 2 | Completed | McMaster Children's Hospital | 16 | 2024-09-09 | 2026-07-07 |
| Antibiotic Instillation in Appendicitis Ceftriaxone, Intra-peritoneal Fluid Aspiration - Complicated Appendicitis, Acute Appendicitis | Phase 2 | Completed | Johns Hopkins All Children's Hospital | 190 | 2023-01-05 | 2025-03-13 |
| Laparoscopically Guided Rectus Sheath Block in Pediatric Appendicitis Rectus Sheath Block with 0.25% bupivicaine with 1:200 000 epinephrine, Local Anesthetic Infiltration with 0.25% bupivicaine with 1:200 000 epinephrine - Appendicitis Acute | Phase 2 | Completed | University of Alberta | 42 | 2021-05-28 | 2024-03-12 |
| Use of Antibiotic Irrigation to Decrease Wound Infections in Pediatric Perforated Appendicitis antibiotic rinse with suction, suction only - Perforated Appendicitis | Phase 2 | Active not recruiting | Prisma Health-Upstate | 200 | 2019-07-25 | 2026-01-27 |
| The Role of Contrast Enhanced Ultrasound in Appendicitis Sulfur hexafluoride lipid-type A microspheres - Acute Appendicitis | Phase 2 | Completed | Children's Mercy Hospital Kansas City | 37 | 2019-01-04 | 2023-09-08 |
| Non-operative Treatment of Acute Non-perforated Appendicitis Meronem and flagyl, Appendectomy - Acute Appendicitis | Phase 2 / Phase 3 | Completed | King Edward Medical University | 180 | 2018-09-01 | 2021-02-18 |
| Intraperitoneal Administration of Fosfomycin, Metronidazole and Molgramostim Versus Intravenous Antibiotics for Perforated Appendicitis Combination of fosfomycin, metronidazole and rhGM-CSF (administered together intraperitoneally) and three days of antibiotics p.o., Standard antibiotics intravenously - Appendicitis Perforated | Phase 2 | Completed | Herlev Hospital | 13 | 2018-02-14 | 2018-10-16 |
| Narcotic vs. Non-narcotic Pain Regimens After Pediatric Appendectomy Non-narcotic pain control - Appendicitis, Pain, Postoperative | Phase 1 / Phase 2 | Withdrawn | University of Utah | 2017-09-05 | 2020-02-07 | |
| The Safety and Pharmacokinetics of Intraperitoneal Administration in Patients Undergoing Appendectomy for Uncomplicated Appendicitis A combination of fosfomycin, metronidazole and GM-CSF i.p. - Appendicitis | Phase 2 | Completed | Herlev Hospital | 14 | 2017-02-24 | 2019-05-29 |
| Clinical Trial Comparing ERAT vs Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis Ertapenem, Levofloxacin and Metronidazole, Endoscopic retrograde appendicitis therapy (ERAT), Appendectomy - Acute Appendicitis | Phase 2 | Unknown | First Affiliated Hospital Xi'an Jiaotong University | 240 | 2016-05-01 | 2016-06-03 |
| Dilute Povidone-iodine Irrigation vs No Irrigation for Children With Acute, Perforated Appendicitis Povidone-iodine irrigation, No irrigation - Acute, Perforated Appendicitis | Phase 2 | Completed | The University of Texas Health Science Center, Houston | 100 | 2016-04-01 | 2019-04-17 |
| Nebulized Analgesia for Laparoscopic Appendectomy Trial Ropivacaine, Normal saline - Appendicitis | Phase 1 / Phase 2 | Unknown | McGill University Health Centre/Research Institute of the McGill University Health Centre | 200 | 2016-01-01 | 2016-03-22 |
| Transversus Abdominis Plane (TAP) Versus Local Anesthetic for Lap Appendectomies Ropivacaine, Bupivacaine - Appendicitis | Phase 2 | Terminated | Nationwide Children's Hospital | 3 | 2012-10-01 | 2015-08-24 |
| Laparoscopic Management of Periappendicular Abscess Laparoscopic appendectomy, Conservative management with percutaneous drainage - Appendicitis, Abdominal Abscess | Phase 2 | Completed | Helsinki University Central Hospital | 60 | 2011-01-01 | 2014-09-23 |
| Study of Conservative Versus Surgical Treatment of Appendicitis cefotaxim and metronidazol - Appendicitis | Phase 2 | Completed | Göteborg University | 360 | 2006-05-01 | 2009-04-21 |
Abdominal Abscess (1) · Agnosia (1) · Pain, Postoperative (1) · Patient Preference (1) · Patient Satisfaction (1)
Cecal Diseases (16) · Digestive System Diseases (16) · Gastroenteritis (16) · Gastrointestinal Diseases (16) · Infections (16) · Intestinal Diseases (16) · Intraabdominal Infections (16) · Behavior (2) · Health Behavior (2) · Treatment Adherence and Compliance (2) · Abscess (1) · Nervous System Diseases (1) · Neurobehavioral Manifestations (1) · Neurologic Manifestations (1) · Pain (1)
Metronidazole (5) · Appendectomy (3) · Ceftriaxone (2) · Ropivacaine (2) · Saline Solution (2) · Amoxicillin-Potassium Clavulanate Combination (1) · Benchmarking (1) · Bupivacaine (1) · Cefotaxime (1) · Clindamycin (1) · Conservative Treatment (1) · Ertapenem (1) · Gentamicins (1) · Levofloxacin (1) · Meropenem (1)
Herlev Hospital (2) · Assistance Publique - Hôpitaux de Paris (1) · Children's Mercy Hospital Kansas City (1) · First Affiliated Hospital Xi'an Jiaotong University (1) · Göteborg University (1) · Helsinki University Central Hospital (1) · Johns Hopkins All Children's Hospital (1) · King Edward Medical University (1) · McGill University Health Centre/Research Institute of the McGill University Health Centre (1) · McMaster Children's Hospital (1) · Nationwide Children's Hospital (1) · Prisma Health-Upstate (1) · The University of Texas Health Science Center, Houston (1) · University of Alberta (1) · University of Utah (1)
United States (6) · Canada (3) · Denmark (2) · China (1) · Finland (1) · France (1) · Pakistan (1) · Sweden (1)
Kent Lundholm (1) · KuoJen Tsao, MD (1) · Michael H Livingston, MD, MSc (1) · Nicole M. Chandler, MD (1) · Panu Mentula, M.D. Ph.D. (1) · Robert Baird, MDCM MSc (1) · Robert Gates, MD (1) · Siv Fonnes, MD (1) · Stephen J Fenton, MD (1) · Tarun Bhalla, MD (1) · Tolulope Oyetunji, MD (1) · Troy Perry, MD (1) · Yingchao Li, MD,PhD (1)
PMID 11427329, PMID 19358184, PMID 21958060, PMID 25581711, PMID 27437029, PMID 30366723, PMID 31040341, PMID 31567357, PMID 32432123, PMID 41202087
2025 (1)