71 completed, 11 recruiting, 10 unknown, 6 active not recruiting. 54 Not applicable, 3 Phase 4, 2 Phase 1, 1 Phase 2.
Follow Joint Instability: new trials by email Literature Review of Joint Instability trials Research Report on Joint Instability
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Regenerative Medicine for Joint Hypermobility and Instability Dextrose 20% Prolotherapy, Autologous Platelet-Rich Plasma, Doxycycline Hyclate Injectable (Investigational) - Ehlers-Danlos Syndrome Hypermobility Type (hEDS), Ehlers-Danlos Syndrome (EDS) | Phase 1 / Phase 2 | Not yet recruiting | Manhattan Pain Medicine, PLLC | 100 | 2027-01-15 | 2026-10-06 |
| Stabilization Exercises for Young Adults With Habitual Knuckle Cracking Stabilization Exercise Program - Habitual Knuckle Cracking | Not applicable | Not yet recruiting | Borna Farhoomand | 42 | 2026-10-01 | 2026-09-11 |
| A Study on Associations Between Multidimensional Human Phenotypic Traits and Human Growth and Development Fingerprint Morphological Characteristics - Musculoskeletal Growth and Development | Recruiting | Nanfang Hospital, Southern Medical University | 500 | 2026-09-01 | 2026-10-19 | |
| Collagen Scaffold Bioaugmentation for ATFL Repair in Chronic Ankle Instability Arthroscopic Anterior Talofibular Ligament Repair, Internal Brace Augmentation, REGENETEN Bioinductive Collagen Scaffold - Chronic Ankle Instability, Ankle Sprain | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 84 | 2026-09-01 | 2026-10-16 |
| Neurocognitive Loading Following Anterior Shoulder Stabilization: A Randomized Controlled Trial Standard Rehabilitation, Neurocognitive Loading - Shoulder Instability, Joint Instability | Not applicable | Not yet recruiting | Hacettepe University | 32 | 2026-07-01 | 2026-06-08 |
| Hamstring Strengthening in Hypermobile Conditions Progressive resistance exercise with an emphasis on eccentric hamstring loading. - Hypermobile EDS (hEDS), Hypermobile Ehlers-Danlos Syndrome | Not applicable | Not yet recruiting | University of Calgary | 20 | 2026-06-01 | 2026-06-04 |
| Effect of Core Stability Training With Foot Exercises in Chronic Ankle Instability Patients conventional physical therapy, Core stability training, intrinsic foot muscle exercises - Instability, Joint | Not applicable | Recruiting | Cairo University | 80 | 2026-05-01 | 2026-07-28 |
| Characteristics of the Functional State of the Musculoskeletal System, Body Awareness, and Quality of Life in Individuals With Joint Hypermobility, Their Associations, and Guidelines for Intervention. No intervention - Joint Hypermobility | Enrolling by invitation | Lithuanian University of Health Sciences | 511 | 2026-02-01 | 2026-03-17 | |
| Investigation of Medial Longitudinal Arch and Foot Function in Patients With Lipedema Lipedema, Hypermobility Syndrome (Disorder) | Recruiting | Marmara University | 32 | 2026-01-01 | 2026-01-02 | |
| Hypermobility, Foot Posture, and Scoliosis Severity Assessment - Joint Hypermobility, Adolescent Idiopathic Scoliosis | Completed | Istinye University | 22 | 2025-12-15 | 2026-06-26 | |
| Prenatal Pilates and Postpartum Ligamentous Laxity Laxity of Ligament, Pregnancy | Completed | Ankara Medipol University | 42 | 2025-11-20 | 2026-01-22 | |
| Comparative Effects of Closed Kinetic Chain Exercises and Thrower's Ten Exercises in Glenohumeral Instability closed kinetic chain exercises, thrower's ten exercises - Instability, Joint | Not applicable | Recruiting | Riphah International University | 40 | 2025-10-15 | 2026-08-12 |
| Effect of Kinesio-taping With Routine Physical Therapy in Wrist Joint Hypermobility Routine Physical Therapy Protocol for Wrist Joint, Kinesio Taping (Y-strip Technique) - Wrist Joint Hypermobility | Not applicable | Completed | University of Lahore | 38 | 2025-09-30 | 2026-07-08 |
| Frequency of Hypermobility-Related Problems in Patients With Anorexia Nervosa Anorexia Nervosa, Atypical, Anorexia Nervosa | Enrolling by invitation | Vastra Gotaland Region | 100 | 2025-09-15 | 2026-08-25 | |
| Prenatal Hormonal Markers and Sleep Characteristics in Young Adults With Joint Hypermobility The Beighton Scoring system, 2D:4D Digit Ratio - Joint Hypermobility, Healty Controls | Completed | Nigde Omer Halisdemir University | 180 | 2025-08-20 | 2025-12-24 | |
| Sleep Characteristics in Infants With Joint Hypermobility Beighton Scoring system, Brief Infant Sleep Questionnaire - Joint Hypermobility Syndrome, Sleep | Completed | Nigde Omer Halisdemir University | 60 | 2025-08-15 | 2026-02-12 | |
| Joint Hypermobility and Associated Factors in Patients With Lipedema Lipedema, Hypermobility, Joint | Completed | Dokuz Eylul University | 130 | 2025-08-15 | 2026-09-08 | |
| Whole-Body Vibration and Postural Stability in Painful HSD Conventional Exercise Program, Whole-Body Vibration - Hypermobility Spectrum Disorder | Not applicable | Active not recruiting | Gökalp Arif Utkugün | 30 | 2025-07-03 | 2026-09-23 |
| The Effect of Lower Extremity Rotational Profile on Postural Control, Muscle Strength, Functional Capacity and Lower Extremity Function in Children With Generalized Joint Hypermobility Rotational Profile- Hip Internal and External Rotation Measurement, Rotational Profile- Craig's Test Measurement, Rotational Profile- Foot/Thigh Angle Measurement - Joint Hypermobility, Femoral Anteversion | Completed | Bezmialem Vakif University | 48 | 2025-07-01 | 2025-07-15 | |
| Ultrasonographic Evaluation of the Ulnar Nerve in Individuals With and Without Generalized Joint Hypermobility no intervention - Hypermobility, Joint | Not yet recruiting | Beylikduzu State Hospital | 60 | 2025-07-01 | 2025-07-01 |
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Ankle Injuries (18) · Shoulder Dislocation (7) · Osteoarthritis, Knee (6) · Sprains and Strains (6) · Osteoarthritis (5) · Ehlers-Danlos Syndrome (4) · Joint Dislocations (4) · Motor Activity (4) · Anterior Cruciate Ligament Injuries (3) · Arthritis, Rheumatoid (3) · Ehlers-Danlos syndrome type 3 (3) · Flatfoot (3) · Joint Diseases (3) · Pain (3)
Musculoskeletal Diseases (112) · Joint Diseases (111) · Wounds and Injuries (41) · Leg Injuries (23) · Pathological Conditions, Signs and Symptoms (21) · Signs and Symptoms (16) · Neurologic Manifestations (15) · Rheumatic Diseases (12) · Connective Tissue Diseases (11) · Skin and Connective Tissue Diseases (11) · Arthritis (10) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (9) · Joint Dislocations (9) · Pathologic Processes (9) · Bone Diseases (8)
Exercise (3) · Glucose (3) · Anterior Cruciate Ligament Reconstruction (2) · Arthrocentesis (1) · Arthroplasty, Replacement, Knee (1) · Arthroscopy (1) · Bone Wires (1) · Braces (1) · Control Groups (1) · Exercise Movement Techniques (1) · Genetic Testing (1) · Hand Strength (1) · Ketorolac (1) · Methods (1) · Orthopedic Procedures (1)
Gazi University (4) · Istituto Ortopedico Rizzoli (4) · University of Southern Denmark (4) · Aesculap AG (3) · Peking University Third Hospital (3) · Peter Brehm GmbH (3) · University of Calgary (3) · Bezmialem Vakif University (2) · Cairo University (2) · Centre Hospitalier Universitaire de Nice (2) · Federal University of São Paulo (2) · Hacettepe University (2) · Kutahya Health Sciences University (2) · Nigde Omer Halisdemir University (2) · Riphah International University (2)
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Behnam Liaghat, MSc (3) · Birgit Juul-Kristensen, PhD (2) · Dong Jiang, MD (2) · Emrah Afsar, Phd (2) · Nicholas Mohtadi, MD, FRCSC (2) · Alain Blum, MD, PhD (1) · Alan Getgood, MD FRCS (1) · Andrew Tummon (1) · Angela Contri, MA, OMPT (1) · Arnaldo J Hernandez, PhD, MSc, MD (1)
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2023 (1), M01RR000109 (1), U01AR076144 (1)