20 completed, 2 terminated, 2 unknown, 1 active not recruiting. 25 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 25 | Completed 20, Terminated 2, Unknown 2, Active not recruiting 1 |
| Phase 2 | 3 | Completed 1, Terminated 1, Unknown 1 |
Follow Ankle Injuries: new trials by email Literature Review of Ankle Injuries trials Research Report on Ankle Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Counterpain PXM Versus Diclofenac Versus Piroxicam Piroxicam plus Counterirritant (brand name Counterpain® PXM)., Diclofenac Sodium 10 mg (Brand Name Hotin® DCL), Piroxicam 0.5% (Brand name Pirofel® gel) - Ankle Sprain, Back Pain | Phase 3 | Completed | Taisho Pharmaceutical Indonesia | 180 | 2025-11-04 | 2026-03-16 |
| Phase III Trial to Evaluate the Efficacy and Safety in Patients With Ankle Sprains. Esflurbiprofen Topical System (EFTS), Placebo Patch - Ankle Sprains | Phase 3 | Completed | Teikoku Seiyaku Co., Ltd. | 69 | 2025-03-31 | 2025-11-26 |
| Efficacy of Nasal Oxygen Therapy to Reduce Postoperative Complications in Ankle Trauma Surgery in At-risk Patients: a Randomized Pilot Study. Oxygen, no oxygen therapy - Ankle Fractures | Phase 3 | Active not recruiting | Nantes University Hospital | 200 | 2022-04-09 | 2026-01-14 |
| Voltaren Emulgel 2% Acute Ankle Sprain Non Inferiority Study Diclofenac diethylamine 2.32% gel, Diclofenac diethylamine 1.16% gel, Placebo - Pain | Phase 3 | Completed | GlaxoSmithKline | 313 | 2019-10-24 | 2022-04-12 |
| Clinical Application of Mg Based Biodegradable Material for Fracture Fixation in the Adult Skeleton BRI.MAG 2 - Fracture of Medial Malleolus | Phase 2 / Phase 3 | Completed | Medical University of Graz | 20 | 2018-07-09 | 2023-01-31 |
| TRAUMED - a Clinical Trial in Acute Ankle Sprain Traumeel®, Diclofenac sodium gel 1%, Placebo - Ankle Sprain | Phase 3 | Completed | Biologische Heilmittel Heel GmbH | 809 | 2018-02-26 | 2024-01-31 |
| Effects of Gait Biofeedback and Impairment-based Rehabilitation in Individuals With Chronic Ankle Instability Gait Biofeedback - Ankle Sprains, Ankle Injuries | Phase 3 | Unknown | University of Virginia | 60 | 2018-02-15 | 2018-05-16 |
| Ropivacaine Versus Bupivacaine as Preemptive Analgesia in Surgical Site in Ankle Fracture Patients Ropivacaine, Bupivacaine - Ankle Fractures, Pain, Postoperative | Phase 3 | Completed | Instituto Mexicano del Seguro Social | 93 | 2016-09-01 | 2018-12-31 |
| Liposomal Bupivacaine With Bupivacaine in Ankle Fracture Open Reduction Internal Fixation (ORIF) Liposomal Bupivacaine with Bupivacaine - Ankle Fracture | Phase 3 | Completed | Jamaica Hospital Medical Center | 84 | 2014-12-01 | 2017-10-20 |
| Safety and Efficacy of Generic Diclofenac Epolamine Acute Pain Due to Minor Ankle Sprain Diclofenac epolamine, Placebo - Ankle Sprain | Phase 3 | Completed | Actavis Inc. | 658 | 2014-05-01 | 2020-06-24 |
| 5% Topical Ibuprofen (IBU) for Ankle Sprain Topical IBU twice daily, Placebo twice daily, Topical IBU three times daily - Ankle Injuries | Phase 3 | Completed | Pfizer | 304 | 2013-11-01 | 2016-05-26 |
| Chiropractic Care and a Specific Regimen of Nutritional Supplementation for Patients With Acute Ankle Sprain Dietary supplement - Ankle Sprains | Phase 3 | Terminated | Logan University, Inc. | 73 | 2013-01-01 | 2016-01-25 |
| Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Applied Four Times Daily in Subjects With Acute Ankle Sprain Diclofenac Sodium, Placebo - Acute Ankle Sprain | Phase 3 | Completed | Novartis | 205 | 2011-01-01 | 2013-01-24 |
| Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Applied 4 Times Daily in Subjects With Acute Ankle Sprain Diclofenac sodium topical gel 1%, Placebo - Ankle Sprain | Phase 3 | Completed | Novartis | 206 | 2010-11-01 | 2012-10-04 |
| MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Ankle Sprains MRX-7EAT, Placebo, Lidocaine - Ankle Sprains | Phase 3 | Completed | MEDRx USA, Inc. | 600 | 2010-09-01 | 2018-01-17 |
| Compression Stockings in Ankle Sprain compression stockings, standard non compressive stockings - Ankle Sprain | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 130 | 2010-01-01 | 2012-07-31 |
| TAASS-Traumeel Ointment and Gel Compared With a Topical NSAID in Athletes With Acute Ankle Sprain Traumeel S ointment, Traumeel S gel, Diclofenac gel - Sprain of Ankle | Phase 3 | Completed | Biologische Heilmittel Heel GmbH | 449 | 2009-08-01 | 2014-01-09 |
| Evaluate the Efficacy and Safety of Diclofenac Diethylamine 2.32% Gel Applied Twice or Three Times Daily in Patients With Acute Ankle Sprain diclofenac diethylamine gel 2.32%, Placebo - Grade I/II Ankle Sprain | Phase 3 | Completed | Novartis | 242 | 2009-07-01 | 2012-04-20 |
| HKT-500 in the Treatment of Adult Patients With Ankle Sprain Ketoprofen Patch, Placebo Patch - Ankle Sprain | Phase 3 | Completed | Hisamitsu Pharmaceutical Co., Inc. | 240 | 2009-07-01 | 2015-06-04 |
| Medico Economic Evaluation of Dermal Substitute Integra® for Coverage of Inferior Limb Traumatic Skin Loss INTEGRA®, Flap technique - Leg Injuries, Ankle Injuries | Phase 3 | Completed | University Hospital, Bordeaux | 72 | 2009-06-01 | 2026-05-14 |
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Ankle Fractures (5) · Soft Tissue Injuries (4) · Pain (3) · Leg Injuries (2) · Sprains and Strains (2) · Acute Pain (1) · Athletic Injuries (1) · Back Pain (1) · Emergencies (1) · Foot Injuries (1) · Motor Activity (1) · Osteoarthritis (1) · Pain, Postoperative (1) · Pulmonary Embolism (1)
Wounds and Injuries (24) · Leg Injuries (23) · Pathological Conditions, Signs and Symptoms (7) · Neurologic Manifestations (6) · Signs and Symptoms (6) · Fractures, Bone (5) · Pain (3) · Pathologic Processes (2) · Arm Injuries (1) · Arthritis (1) · Behavior (1) · Cardiovascular Diseases (1) · Disease Attributes (1) · Elbow Injuries (1)
Diclofenac (4) · Bupivacaine (2) · Acetaminophen (1) · Dietary Supplements (1) · Etodolac (1) · Fondaparinux (1) · Gels (1) · Hydrocodone (1) · Irritants (1) · Lidocaine (1) · Nadroparin (1) · Oxygen (1) · Piroxicam (1) · Ropivacaine (1) · Stockings, Compression (1)
Novartis (3) · Biologische Heilmittel Heel GmbH (2) · Cerimon Pharmaceuticals (2) · Hisamitsu Pharmaceutical Co., Inc. (2) · Actavis Inc. (1) · Assistance Publique - Hôpitaux de Paris (1) · GlaxoSmithKline (1) · Instituto Mexicano del Seguro Social (1) · Jamaica Hospital Medical Center (1) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (1) · Logan University, Inc. (1) · MEDRx USA, Inc. (1) · Medical University of Graz (1) · Nantes University Hospital (1) · Pfizer (1)
United States (11) · Germany (4) · France (3) · Austria (1) · China (1) · Indonesia (1) · Mexico (1) · Netherlands (1) · Spain (1)
Carlos Gonzalez de Vega, MD (1) · Cheryl K Hawk, DC, PhD (1) · Dan Levitt, MD (1) · Franz Josef Seibert, Prof.Dr. (1) · Henry Lau, PhD (1) · Jay N Hertel, PhD (1) · Kenichi Furuta (1) · Kenichi Nishiyama (1) · Martine Francis (1) · Pierre Hausfater, MD, PhD (1)
PMID 17113683, PMID 23889885, PMID 25043629, PMID 27779431, PMID 28279428, PMID 36566202, PMID 40468690
2008 (1), 2016 (1)