13 completed, 9 unknown, 2 withdrawn, 1 terminated. 9 Not applicable, 5 Phase 2, 3 Phase 1, 3 Phase 4, 2 Phase 3.
Follow Anal Fissure: new trials by email Literature Review of Anal Fissure trials Research Report on Anal Fissure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Could Preoperative Assessment of Physical and Psychological Status Help Predict Pain After Anorectal Surgery? Hemorrhoids, Anal Fistula | Unknown | Center of Endourology "Endocenter" | 200 | 2024-01-08 | 2023-10-06 | |
| Laser Versus Surgery in Anal Diseases in Inflammatory Bowel Patients treatment of anal diseases in inflammatory bowel patients, Laser, traditional surgery - Inflammatory Bowel Diseases, Anal Fissure | Not applicable | Completed | Zagazig University | 108 | 2023-09-05 | 2024-05-14 |
| Regenerative Therapy With Autologous Stromal Vascular Fraction Derived Mesenchymal Stem Cells and Platelet-rich Plasma to Treat Complex Perianal Diseases Regenerative therapy with SVF-PRP to supplement perianal surgery - Perianal Fistula, Perianal Crohn Disease | Unknown | Kantonsspital Winterthur KSW | 50 | 2023-01-25 | 2023-02-02 | |
| Microbiota in Chronic Anal Fissure and Its Association With Prognosis Anal Fissure, Microbial Colonization | Unknown | Lasse Krogsbøll | 80 | 2022-09-01 | 2022-06-06 | |
| Efficacy of Polyethylene Glycol vs Lactulose With Isabgol in Acute Fissure-in-Ano: PEGASIS Trial Polyethylene Glycol, Isabgol + Lactulose - Anal Fissure, Constipation | Phase 2 / Phase 3 | Completed | All India Institute of Medical Sciences, Bhubaneswar | 144 | 2022-05-27 | 2023-07-25 |
| Effect of Phenytoin Cream on Wound Healing After Anal Fissure Surgery. phenytoin cream, no phenytoin cream - Anal Fissure Chronic, Anal Fissure | Phase 1 | Completed | Mansoura University | 50 | 2022-01-01 | 2024-10-09 |
| Efficacy and Safety of Propionibacterium Extract Gel Versus 0.4% Glyceryl Trinitrate Ointment in the Treatment of Chronic Anal Fissure: a Randomised Controlled Trial Propionibacterium Acnes, glyceryl trinitrate - Anal Fissure Chronic, Anal Fissure | Phase 4 | Completed | Treviso Regional Hospital | 120 | 2021-10-01 | 2022-11-15 |
| Anal Fissure Among Survivors of COVID-19 Virus Infection. Anal Fissure, Corona Virus Infection | Completed | Mansoura University | 176 | 2020-09-01 | 2023-02-24 | |
| Topical vs Oral Metronidazole After Benign Anorectal Surgery Topical metronidazole, oral metronidazole - Hemorrhoids, Anal Fissure | Not applicable | Completed | Mansoura University | 108 | 2020-01-24 | 2021-09-09 |
| Comparative Evaluation of MEBO Ointment and Topical Diltiazem Ointment in the Treatment of Acute Anal Fissure Diltiazem, Mebo - Anal Fissure | Phase 2 | Unknown | American University of Beirut Medical Center | 183 | 2019-12-01 | 2025-01-29 |
| Monocentric Feasibility Study for a New Medical Device for the Treatment of Anal Fissure With Botulinum Toxin Anuscope with needles - Anal Fissure | Not applicable | Completed | Dieter Hahnloser | 4 | 2019-11-11 | 2020-11-17 |
| Effects of Sodium Pentaborat Based Gel on Perianal Benign Diseases Life7 - Hemorrhoids, Anal Fissure | Unknown | SB Istanbul Education and Research Hospital | 250 | 2019-01-01 | 2018-12-21 | |
| Topical Minoxidil Versus Topical Glyceryl Trinitrate in Treatment of Chronic Anal Fissure Minoxidil, Glyceryl trinitrate - Anal Fissure | Not applicable | Completed | Mansoura University | 62 | 2018-05-10 | 2019-10-07 |
| PK, PD and Safety Comparative Trial of Isosorbide Mononitrate Gel in Healthy Participants and With Anal Fissure Isosorbide Mononitrate - Anal Fissure | Phase 1 | Withdrawn | Biolab Sanus Farmaceutica | 2017-07-01 | 2017-07-17 | |
| Trial on Use of Coloshield in Transanal and Anal Surgery Coloshield, Control - Fistula-in-ano, Rectal Polyp | Not applicable | Unknown | Daniel Steinemann, MD | 22 | 2015-12-01 | 2015-10-19 |
| Ultrasound Guided Caudal Block for Benign Anal Surgery Ultrasound Guided Caudal Block - Anal Fissure, Anal Fistula | Not applicable | Completed | Universidad de Antioquia | 23 | 2015-11-01 | 2018-04-30 |
| Posterolateral Versus Lateral Internal Anal Sphincterotomy for Chronic Anal Fissure posterolateral sphincterotomy, lateral sphincterotomy - Anal Fissure | Not applicable | Completed | Mansoura University | 80 | 2015-01-01 | 2018-02-09 |
| A Novel Method for Chronic Anal Fissure Treatment ADRCs therapy, Celution, Tulip cannulas - Anal Fissure | Not applicable | Completed | Clinical Centre of Serbia | 6 | 2014-12-01 | 2015-12-11 |
| An Open Label Multi-Dose Study to Examine the Effect of Coated Nifedipine Suppository on Anal Fissure Pain and Healing Nifedipine 12 mg coated suppositories - Anal Fissure | Phase 1 / Phase 2 | Terminated | RDD Pharma Ltd | 33 | 2014-03-01 | 2015-11-17 |
| Pharmacokinetic,Safety and Exploratory Efficacy of RECTIV® in Adolescents With Chronic Anal Fissure Nitroglycerin Ointment 0.4% - Anal Fissure | Phase 4 | Withdrawn | Forest Laboratories | 2013-06-01 | 2015-05-04 |
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Fissure in Ano (25) · Hemorrhoids (7) · Rectal Fistula (4) · Constipation (2) · Pain, Postoperative (2) · Anemia (1) · Breast Diseases (1) · Colitis, Ulcerative (1) · Communicable Diseases (1) · Coronavirus Infections (1) · Crohn Disease (1) · Fever (1) · Inflammatory Bowel Diseases (1) · Oral Ulcer (1) · Puerperal Infection (1)
Anus Diseases (25) · Digestive System Diseases (25) · Gastrointestinal Diseases (25) · Intestinal Diseases (25) · Rectal Diseases (25) · Pathological Conditions, Signs and Symptoms (8) · Cardiovascular Diseases (7) · Vascular Diseases (7) · Digestive System Fistula (5) · Fistula (5) · Intestinal Fistula (5) · Pathological Conditions, Anatomical (5) · Signs and Symptoms (4) · Infections (3) · Pathologic Processes (3)
Botulinum Toxins, Type A (2) · Nitroglycerin (2) · Diet (1) · Diltiazem (1) · Epinephrine (1) · Lactulose (1) · Lasers (1) · Lateral Internal Sphincterotomy (1) · Lidocaine (1) · Metronidazole (1) · Minoxidil (1) · Multicenter Studies as Topic (1) · Needles (1) · Nifedipine (1) · Phenytoin (1)
Mansoura University (5) · SB Istanbul Education and Research Hospital (2) · All India Institute of Medical Sciences, Bhubaneswar (1) · American University of Beirut Medical Center (1) · Biolab Sanus Farmaceutica (1) · Center of Endourology "Endocenter" (1) · Clinical Centre of Serbia (1) · Daniel Steinemann, MD (1) · Dieter Hahnloser (1) · Forest Laboratories (1) · Huazhong University of Science and Technology (1) · Ipsen (1) · Kantonsspital Winterthur KSW (1) · Lasse Krogsbøll (1) · Onze Lieve Vrouwe Gasthuis (1)
Egypt (6) · Switzerland (3) · China (1) · Colombia (1) · Czechia (1) · India (1) · Israel (1) · Italy (1) · Lebanon (1) · Netherlands (1) · Poland (1) · Romania (1) · Russia (1) · Tunisia (1) · Turkey (Türkiye) (1)
Adriana M Cadavid, MD (1) · Daniel C Steinemann, MD (1) · Dieter Hahnloser, Prof. (1) · Eman Sbaity, MD (1) · Feyzullah Ersoz (1) · Gilberto De Nucci, PhD (1) · Katarina Andjelkov, MD, PhD (1) · Liegang Liu, PhD (1) · Michael Gerhards, MD (1) · Michel Adamina, MD, PD, MSc, EMBA HSG (1) · Nir Barak, MD (1) · Paul Hyman, MD (1) · Prakash Kumar Sasmal, MBBS, MS (1)
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