165 completed, 59 recruiting, 56 unknown, 28 terminated. 87 Not applicable, 87 Phase 2, 74 Phase 1, 32 Phase 3, 13 Phase 4.
Follow this condition Literature Review of Anus Diseases trials Research Report on Anus Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Improving Clinic Delivery of HIV-related Anal Health Services PEACHES 2.0 Implementation Strategies - HIV, Gonorrhea | Not applicable | Not yet recruiting | Albert Einstein College of Medicine | 8 | 2028-02-01 | 2026-10-13 |
| COQ10 and Vitamin E for Off-Target Radiation Toxicity Coenzyme Q10 Cap/Tab, Vitamin E Cap/Tab - Prostate Cancer, Uterine Cancer | Phase 1 / Phase 2 | Not yet recruiting | University of Nebraska | 200 | 2026-12-01 | 2026-10-08 |
| Swabs in Screening for HPV (SWISH) Self-collected anal swab - Anal Cancer, Human Papilloma Virus (HPV) | Not applicable | Not yet recruiting | Kirby Institute | 700 | 2026-11-01 | 2026-08-27 |
| Epidemiology of Anal Human Papillomavirus Carriage in Female Solid Organ Transplant Recipients With More Than 10 Years of Immunosuppression Anal Self-Sampling for High-Risk HPV Detection - Human Papillomavirus Infection, Anal HPV Infection | Not applicable | Not yet recruiting | University Hospital, Montpellier | 190 | 2026-10-01 | 2026-10-05 |
| Mind-Body Sexual Well-Being Program for Female GI Cancer Survivors Mind-Body Group Intervention, Enhanced Usual Care Control (EUCC) - Colorectal Cancer (Diagnosis), Anal Cancer | Not applicable | Not yet recruiting | Massachusetts General Hospital | 100 | 2026-10-01 | 2026-09-08 |
| Phase 2 Study of Pembrolizumab and Lenvatinib in Anal Squamous Cell Cancer Lenvatinib, Pembrolizumab - Anal Squamous Cell Carcinoma | Phase 2 | Not yet recruiting | University of Texas Southwestern Medical Center | 17 | 2026-09-30 | 2026-07-02 |
| Blood Biomarkers Based Screening for HPV-driven OPC HPV16-E6 serology and HPV ctDNA - Head and Neck Squamous Cell Carcinoma, Anal Cancer | Not applicable | Not yet recruiting | UNICANCER | 10000 | 2026-09-01 | 2026-05-26 |
| Shortening Radiation Course Duration Using Simultaneous Integrated Boost With Lower Intensity Elective Nodal Dosing and Concurrent Chemotherapy for High-Risk Anal Squamous Cell Carcinoma Hypofractionated Radiation Therapy - Anal Cancer | Phase 2 | Enrolling by invitation | University of Vermont Medical Center | 24 | 2026-08-26 | 2026-09-15 |
| GLP-1 Receptor Agonists and Early Proctologic Effects in Morbid Obesity GLP-1 receptor agonist therapy - Morbid Obesity, Anorectal Diseases | Not yet recruiting | Gazi University | 100 | 2026-08-01 | 2026-06-25 | |
| AI-Assisted Written Information in Chronic Anal Fissure AI-assisted written patient information, Standardized verbal counseling - Chronic Anal Fissure | Not applicable | Recruiting | Sanliurfa Education and Research Hospital | 220 | 2026-07-15 | 2026-09-09 |
| A Study of IDP-001 in Advanced or Metastatic Solid Tumors IDP-001 - Advanced Solid Tumor, Metastatic Solid Tumor | Phase 1 / Phase 2 | Recruiting | InduPro, Inc. | 132 | 2026-07-08 | 2026-09-03 |
| Disease Evolution and Risk Factors of AIDS-related Prevalent Cancers HIV (Human Immunodeficiency Virus), AIDS | Not yet recruiting | Shenzhen Third People's Hospital | 1000 | 2026-07-01 | 2026-07-10 | |
| ctHPVDNA Response-Adapted Chemoradiation +/- Retifanlimab Treatment in Locally-Advanced Anal Cancer HPV ctDNA Response based radiation, Chemotherapy, Retifanlimab - Anal Cancer, HPV-Related Carcinoma | Phase 2 | Recruiting | Jennifer Dorth | 33 | 2026-06-19 | 2026-08-14 |
| Topical Nitroglycerin Versus Lateral Internal Sphincterotomy for Chronic Anal Fissure Topical 0.2% Glyceryl Trinitrate (Nitroglycerin) Ointment, Lateral Internal Sphincterotomy - Chronic Anal Fissure | Not applicable | Completed | Sheikh Zayed Federal Postgraduate Medical Institute | 72 | 2026-06-15 | 2026-10-21 |
| CASCADE: Testing for Safety and Immune Effects of PDS0101, an Anti-HPV Therapy, Among People Living With HIV PDS0101 - HPV Associated Cancers, HIV (Human Immunodeficiency Virus) | Phase 2 | Withdrawn | University of California, San Diego | 2026-04-30 | 2026-08-19 | |
| Assessment of Sexual Quality of Life Following Local Treatment (Radiotherapy With or Without Surgery) in Patients With HPV-positive Pelvic Cancer: a Descriptive Longitudinal Study Assessment of sexual quality of life - Pelvic Cancer, Anal Cancer | Not applicable | Not yet recruiting | Institut du Cancer de Montpellier - Val d'Aurelle | 42 | 2026-04-02 | 2026-04-13 |
| The Impact of Perianal Disease on Patient's Sex Life Patient Reported Outcome Assessment (Questionnaires) - Perianal Crohn Disease, Perianal Fistula | Recruiting | AHEPA University Hospital | 60 | 2026-03-31 | 2026-04-09 | |
| Sintilimab Versus Mitomycin in Combination With Capecitabine and IMRT for Limited-stage Anal Squamous Cell Carcinoma Intensity-Modulated Radiotherapy (IMRT), Capecitabine, Sintilimab - Anal Squamous Cell Carcinoma, Limited-stage | Phase 3 | Recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 350 | 2026-03-17 | 2026-07-09 |
| Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer Biospecimen Collection, Prasterone, Survey Administration - Anal Carcinoma, Cervical Carcinoma | Phase 2 | Recruiting | Ohio State University Comprehensive Cancer Center | 25 | 2026-03-12 | 2026-04-21 |
| Distance-Based Exercise to Preserve Function and Prevent Disability Exercise intervention, Telemedicine, Aerobic Exercise Intervention - Localized Malignant Solid Neoplasm, Anal Cancer | Not applicable | Recruiting | Alliance for Clinical Trials in Oncology | 104 | 2026-02-11 | 2026-10-02 |
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Anus Neoplasms (294) · Uterine Cervical Neoplasms (86) · Fissure in Ano (62) · Rectal Neoplasms (57) · Stomach Neoplasms (52) · Pancreatic Neoplasms (47) · Esophageal Neoplasms (46) · Vulvar Neoplasms (46) · Colonic Neoplasms (45) · Penile Neoplasms (40) · Breast Neoplasms (36) · Neoplasms (36) · Squamous Cell Carcinoma of Head and Neck (34) · Vaginal Neoplasms (33) · Prostatic Neoplasms (32)
Digestive System Diseases (361) · Gastrointestinal Diseases (360) · Intestinal Diseases (360) · Rectal Diseases (358) · Digestive System Neoplasms (294) · Neoplasms by Site (294) · Intestinal Neoplasms (293) · Gastrointestinal Neoplasms (287) · Colorectal Neoplasms (264) · Neoplasms (260) · Rectal Neoplasms (237) · Urogenital Diseases (152) · Genital Diseases (145) · Female Urogenital Diseases and Pregnancy Complications (110)
Fluorouracil (26) · Mitomycin (18) · Radiotherapy (18) · Capecitabine (13) · Cisplatin (12) · pembrolizumab (11) · Cyclophosphamide (9) · Magnetic Resonance Spectroscopy (9) · Biopsy (8) · Paclitaxel (8) · Radiation (8) · Carboplatin (7) · Drug Therapy (7) · Nivolumab (7) · Specimen Handling (7)
National Cancer Institute (NCI) (22) · AIDS Malignancy Consortium (11) · M.D. Anderson Cancer Center (8) · Mansoura University (8) · Stanford University (6) · University Health Network, Toronto (5) · Aarhus University Hospital (4) · Medical College of Wisconsin (4) · Memorial Sloan Kettering Cancer Center (4) · Sahlgrenska University Hospital (4) · UNICANCER (4) · Alliance for Clinical Trials in Oncology (3) · Beijing Health Guard Biotechnology, Inc (3) · ECOG-ACRIN Cancer Research Group (3) · Glaxo Wellcome (3)
United States (166) · France (26) · China (18) · Canada (17) · Italy (14) · United Kingdom (14) · Spain (13) · Australia (12) · Denmark (12) · Sweden (12) · Egypt (10) · Germany (10) · Belgium (7) · Brazil (7) · Norway (7)
Joel Palefsky, MD (4) · Alan Nyitray, PhD (3) · Cathy Eng (3) · Mark Lane Welton (3) · Yongjiang Liu, Bachelor (3) · Charalampos Floudas, M.D. (2) · Christian S Hinrichs, MD (2) · Elizabeth Stier, MD (2) · Irving Salit, MD (2) · Jaffer A. Ajani, MD (2) · Jervoise Andreyev, MD (2) · Jian Zhang, Doctor (2) · Joseph A. Sparano, MD (2) · Lakshmi Rajdev (2)
PMID 23578724, PMID 28223062, PMID 11668104, PMID 18430910, PMID 20354531, PMID 20956625, PMID 28453692, PMID 29779044, PMID 31534737, PMID 32530769, PMID 8874455, PMID 10395629, PMID 10626860, PMID 11052511, PMID 12041718, PMID 12194122, PMID 12196376, PMID 12393999, PMID 13680282, PMID 15129311, PMID 15479678, PMID 15540293, PMID 15629599, PMID 15906136, PMID 15933795, PMID 15949202, PMID 16254521, PMID 17096178, PMID 17103253, PMID 17665247, PMID 18085337, PMID 18191265, PMID 18470481, PMID 18629515, PMID 18637925, PMID 18954306, PMID 19139424, PMID 19225835, PMID 19643599, PMID 19690306, PMID 19801930, PMID 20068553, PMID 20177691, PMID 20187965, PMID 20339140, PMID 20436836, PMID 20564111, PMID 20628272, PMID 20852198, PMID 20940607
U01CA121947 (8), UM1CA121947 (5), 2018 (4), U10CA180820 (4), 2015 (2), 2019 (2), P30CA015083 (2), P30CA016672 (2), P30CA068485 (2), K01AT008219 (1), N01CM00032 (1), N01CM00038 (1), N01CM00039 (1), N01CM00071 (1), N01CM00099 (1)