18 completed, 5 unknown, 4 terminated, 3 recruiting. 13 Phase 4, 8 Phase 2, 3 Phase 1, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 13 | Completed 8, Recruiting 2, Unknown 2, Terminated 1 |
| Phase 2 | 8 | Completed 5, Unknown 2, Recruiting 1 |
| Phase 1 | 3 | Completed 3 |
| Phase 3 | 3 | Terminated 2, Suspended 1 |
Follow cangrelor: new trials by email Literature Review of cangrelor trials Research Report on cangrelor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Bridging Antiplatelet Therapy With Cangrelor 2 Study Cangrelor - Coronary Arterial Disease (CAD) | Phase 4 | Recruiting | University of Florida | 50 | 2026-02-18 | 2026-11-06 |
| Cangrelor on Top of anticoagUlation in Patients With myocaRdial Infarction-related Cardiogenic Shock/Cardiac Arrest receiVIng VA-ECMO Cangrelor - Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication | Phase 2 | Recruiting | IRCCS San Raffaele | 50 | 2024-04-01 | 2025-01-27 |
| Effects of Cangrelor on MIcRovAscular Disfunction During Elective Percutaneous CORonary Intervention Cangrelor 50 MG - Coronary Artery Disease | Phase 4 | Recruiting | Federico II University | 80 | 2023-11-01 | 2025-03-13 |
| Intravenous CAngrelor in High-bleeding Risk Patients Undergoing percutaneouS Coronary Intervention (ICARUS) Registry Cangrelor - Bleeding, Coronary Artery Disease | Unknown | Universita degli Studi di Genova | 900 | 2022-06-06 | 2022-08-18 | |
| REperfusion With P2Y12 Inhibitors in Addition to mEchanical thRombectomy for perFUsion Imaging Selected Acute Stroke patiEnts Cangrelor, best medical management - Acute Ischemia | Phase 3 | Suspended | Fondation Ophtalmologique Adolphe de Rothschild | 368 | 2022-03-02 | 2026-09-25 |
| Pharmacodynamic Effects of Cangrelor in ACS or CCS Patients Undergoing PCI (POMPEII Registry) Cangrelor - Percutaneous Coronary Intervention | Completed | Federico II University | 150 | 2021-03-16 | 2025-08-07 | |
| Pharmacodynamic and Pharmacokinetic of Switching From Cangrelor to Prasugrel in ACS Patients Undergoing PCI Cangrelor, Prasugrel - Coronary Artery Disease, Acute Coronary Syndrome | Phase 4 | Completed | University of Florida | 359 | 2021-02-18 | 2024-03-20 |
| PD and PK Profiles of Switching Between Cangrelor and Ticagrelor Following Ticagrelor Pre-treatment Cangrelor, Placebo - Coronary Artery Disease | Phase 4 | Completed | University of Florida | 22 | 2021-02-09 | 2023-05-16 |
| Dutch Cangrelor Registry Cangrelor - STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI | Completed | Isala | 250 | 2019-12-17 | 2020-07-28 | |
| Cangrelor in Comatose Survivors of OHCA Undergoing Primary PCI Cangrelor 50 MG - Out-Of-Hospital Cardiac Arrest, Acute Coronary Syndrome | Phase 4 | Completed | University Medical Centre Ljubljana | 30 | 2019-07-01 | 2021-12-03 |
| Maintenance Of aNtiplatElet Therapy in Patients With Coronary Stenting Undergoing Surgery (MONET BRIDGE) Cangrelor - Platelet Aggregation Inhibitors | Phase 2 | Unknown | Ospedale Santa Croce-Carle Cuneo | 140 | 2019-06-01 | 2019-03-05 |
| Cangrelor vs. Ticagrelor for Early Platelet Inhibition in STEMI Ticagrelor, Cangrelor Tetrasodium - Acute Coronary Syndrome, Myocardial Infarction | Phase 4 | Unknown | University of Aarhus | 80 | 2018-09-01 | 2018-06-28 |
| Dual Antiplatelet Therapy For Shock Patients With Acute Myocardial Infarction Cangrelor, Ticagrelor - Acute Myocardial Infarction, Cardiogenic Shock | Phase 4 | Completed | Faculty Hospital Kralovske Vinohrady | 605 | 2018-08-01 | 2025-04-02 |
| Platelet Inhibition With Cangrelor and Crushed Ticagrelor in STEMI Cangrelor, Placebo - ST Segment Elevation Myocardial Infarction, Percutaneous Coronary Intervention | Phase 4 | Completed | University of Florida | 50 | 2017-11-20 | 2020-09-09 |
| Platelet Inhibition to Target Reperfusion Injury Cangrelor - STEMI | Phase 2 | Unknown | National Heart Centre Singapore | 228 | 2017-10-01 | 2022-04-26 |
| Add-on Cangrelor in STEMI-triggered Cardiac Arrest Cangrelor, Placebo, Prasugrel - Cardiopulmonary Arrest With Successful Resuscitation, ACS - Acute Coronary Syndrome | Phase 4 | Unknown | Medical University of Vienna | 60 | 2017-09-01 | 2017-09-13 |
| Antiplatelet Effects of Tirofiban vs. Cangrelor N-STEMI Patients Undergoing Percutaneous Coronary Intervention Tirofiban, Cangrelor - Non-ST Elevation Myocardial Infarction (NSTEMI) | Terminated | Inova Health Care Services | 10 | 2017-08-23 | 2023-12-11 | |
| Cangrelor Following Ticagrelor Loading vs Ticagrelor Loading Alone in STEMI Ticagrelor 180 mg loading dose, Cangrelor 30 mcg/kg bolus + 4 mcg/kg/min - STEMI | Phase 4 | Completed | Attikon Hospital | 30 | 2017-07-28 | 2017-12-27 |
| Randomized Comparison of Cangrelor, Tirofiban and Prasugrel in Patients With STEMI Referred for Primary PCI. Cangrelor, Tirofiban, Prasugrel - Coronary Artery Disease, STEMI - ST Elevation Myocardial Infarction | Phase 4 | Completed | Insel Gruppe AG, University Hospital Bern | 122 | 2017-07-04 | 2020-02-21 |
| Cangrelor Neonatal PK/PD and Safety Study Cangrelor - Partial Obstruction of Systemic to Pulmonary Artery Shunt, Complete Obstruction of Systemic to Pulmonary Artery Shunt | Phase 1 | Completed | Chiesi Farmaceutici S.p.A. | 22 | 2017-01-03 | 2023-02-15 |
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Acute Coronary Syndrome (10) · Coronary Artery Disease (10) · ST Elevation Myocardial Infarction (10) · Myocardial Infarction (4) · Non-ST Elevated Myocardial Infarction (3) · Hemorrhage (2) · Shock, Cardiogenic (2) · Angina, Stable (1) · Angina, Unstable (1) · Atherosclerosis (1) · Death (1) · Heart Arrest (1) · Hypothermia (1) · Out-of-Hospital Cardiac Arrest (1)
The Medicines Company (8) · University of Florida (4) · Federico II University (2) · Attikon Hospital (1) · Chiesi Farmaceutici S.p.A. (1) · Faculty Hospital Kralovske Vinohrady (1) · Fondation Ophtalmologique Adolphe de Rothschild (1) · IRCCS San Raffaele (1) · Icahn School of Medicine at Mount Sinai (1) · Inova Health Care Services (1) · Insel Gruppe AG, University Hospital Bern (1) · Isala (1) · Khaled Ziada, MD (1) · Medical University of Vienna (1) · National Heart Centre Singapore (1)
United States (16) · Italy (5) · France (2) · Austria (1) · Czechia (1) · Denmark (1) · Germany (1) · Greece (1) · Netherlands (1) · Poland (1) · Singapore (1) · Slovakia (1) · Slovenia (1) · Switzerland (1) · United Kingdom (1)
David J. Schneider, MD (2) · Deepak L. Bhatt, MD (2) · Francesco Franchi, MD (2) · Robert A. Harrington, MD (2) · Simona Skerjanec, PharmD (2) · Annapoorna S Kini, MD MRCP (1) · David J. Schneider (1) · Deepak L Bhatt, MD, MPH, MBA. (1) · Derek John Hausenloy (1) · Dimitrios Alexopoulos, MD (1) · Dominick Angiolillo, MD, PhD (1) · Dominick J Angiolillo, MD, PhD (1) · Eric Topol, MD (1) · Giovanni Esposito, MD, PhD (1)
PMID 19915221, PMID 19915222, PMID 22253393, PMID 22305835, PMID 27902833, PMID 28382371, PMID 28988157, PMID 29632238, PMID 35196863, PMID 38551015, PMID 19923168, PMID 23048167, PMID 23473369, PMID 23491524, PMID 23500251, PMID 23768460, PMID 23921301, PMID 23991622, PMID 25175921, PMID 25660931, PMID 26381736, PMID 30421441, PMID 30630341, PMID 31129911, PMID 31466479, PMID 32096064, PMID 32795098, PMID 33078501, PMID 33258102, PMID 36317958, PMID 37609698, PMID 38335531, PMID 38742915, PMID 39284439, PMID 40109258, PMID 40375762, PMID 41543923
2016 (2), 2018 (1)