138 completed, 34 unknown, 17 recruiting, 10 not yet recruiting. 221 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 221 | Completed 138, Unknown 34, Recruiting 17, Not yet recruiting 10, Terminated 10, Withdrawn 8, Active not recruiting 4 |
Follow Acidosis: new trials by email Literature Review of Acidosis trials Research Report on Acidosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The BRIGHT Study (Device Name: HALO System) The HALO System - Diabetes Mellitus - Type 1, Diabetes Mellitus - Type 2 | Not applicable | Not yet recruiting | Indigo Diabetes NV | 12 | 2026-12-01 | 2026-08-04 |
| Acute Effects of Ketone Monoester Co-Ingestion With Dietary Protein on Whole-Body Phenylalanine Oxidation, Phenylalanine Retention, and Myofibrillar Protein Breakdown Following Resistance Exercise in Older Males Ketone Monoester + Dietary Protein (KET+PRO), Dietary Protein (PRO), Resistance Exercise - Ketosis, Resistance Exercise | Not applicable | Not yet recruiting | McGill University | 18 | 2026-11-01 | 2026-10-20 |
| LIfestyle MEtabotype Study B (LIME-B) βHB drink (ketone ester), Carbohydrate drink - Nutritional and Metabolic Diseases, Prediabetes | Not applicable | Recruiting | German Institute of Human Nutrition | 300 | 2026-10-26 | 2026-10-28 |
| Acute Effects of Ketone Monoester Co-ingestion With Dietary Protein on Whole-body Phenylalanine Oxidation, Phenylalanine Retention, and Myofibrillar Protein Breakdown Following Resistance Exercise in Young Males. Ketone Monoester + Dietary Protein (KET+PRO), Dietary Protein (PRO), Resistance Exercise - Post-exercise Period, Ketosis | Not applicable | Recruiting | McGill University | 18 | 2026-10-23 | 2026-10-23 |
| Extracorporeal Carbon Dioxide Removal Plus Noninvasive Ventilation in Patients With COPD Not Eligible for Intubation Extracorporeal Carbon Dioxide Removal, Noninvasive Ventilation - Acute Exacerbation of Chronic Obstructive Pulmonary Disease | Not applicable | Not yet recruiting | Hospital del Mar Research Institute (IMIM) | 14 | 2026-09-01 | 2026-08-25 |
| Ketosis, Immune Function and Metabolic Adaptation in Response to Short-term Fasting in Critical Illness Delayed nutrition, Standard nutrition, Fasting - Critical Illness, Fasting State | Not applicable | Not yet recruiting | Karolinska University Hospital | 200 | 2026-08-31 | 2026-09-01 |
| Combining Fasting and Fibre Interventions to Optimise Their Gut Microbiome-mediated Health Benefits Fibre Arm, Control Arm - Fasting, Dietary Fibre | Not applicable | Recruiting | Buchinger Wilhelmi Development & Holding GmbH | 75 | 2026-08-31 | 2026-09-30 |
| Pilot Trial of Oral Sodium Bicarbonate Versus Higher Dialysate Bicarbonate in Hemodialysis Patients With Metabolic Acidosis Oral sodium bicarbonate, Increased Dialysate Bicarbonate - End-stage Renal Disease (ESRD), Chronic Hemodialysis | Not applicable | Not yet recruiting | University of Sfax | 37 | 2026-07-01 | 2026-07-21 |
| Nasal High Flow Versus Non-invasive Ventilation for Early Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Hypercapnic Acidosis Ventilatory support via nasal high flow, Ventilatory support via NIV - Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Hypercapnic Acidosis | Not applicable | Recruiting | University Hospital, Montpellier | 174 | 2026-06-16 | 2026-06-22 |
| Ketogenic Diet for Post-Traumatic Stress Disorder (PTSD) Ketogenic diet - Post-Traumatic Stress Disorder, PTSD | Not applicable | Completed | Bundeswehr University Munich | 6 | 2026-03-12 | 2026-08-13 |
| Hemodynamic Effects of Ketone Esters in Patients With Sepsis Induced Cardiomyopathy Ketone ester, Placebo - Sepsis Induced Cardiomyopathy | Not applicable | Not yet recruiting | Tor Biering-Sørensen | 12 | 2026-03-10 | 2026-03-04 |
| Undiluted and Diluted Nutrition Enteral fluid, Intravenous fluid - Critical Illness, Gastro Intestinal Surgery | Not applicable | Not yet recruiting | John Paul II Catholic University of Lublin | 80 | 2026-02-02 | 2026-01-20 |
| Evaluation of the Ketogenic Diet to Improve Post Operative Cognitive Decline in Cardiac Surgery Ketogenic diet, Control diet - Postoperative Cognitive Dysfunction | Not applicable | Withdrawn | University of Missouri-Columbia | 2026-01-15 | 2026-06-02 | |
| Continuous Glucose Monitoring Using a New Subcutaneous Insulin Protocol for Mild to Moderate Diabetic Ketoacidosis CGM with alerts - Diabetic Ketoacidosis, Hyperglycemia | Not applicable | Withdrawn | HealthPartners Institute | 2026-01-01 | 2026-03-11 | |
| Endurance Trial: Ketone and Carbohydrate Supplementation Carbohydrate beverage, (R)-1,3-butanediol, Pre-exercise non-caloric placebo - Athletic Performance, Exercise | Not applicable | Recruiting | University of Sao Paulo | 12 | 2025-12-18 | 2026-08-28 |
| Nutritional Ketosis: a Novel Metabolic Strategy to Treat Lymphedema Patients? Ketogenic diet, Isocaloric diet, Ketone ester supplementation - Lymphedema, Ketogenic Dieting | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 81 | 2025-10-01 | 2025-12-03 |
| Recovery With Exogenous Ketones and Antipsychotics Medium chain triglyceride oil - First Episode Psychosis | Not applicable | Recruiting | Université de Sherbrooke | 15 | 2025-08-26 | 2026-05-22 |
| Evaluation of the Effects on Carbon Dioxide (paCO2) of a New Oronasal Mask in Patients With Severe COPD Exacerbation Requiring Non-Invasive Mechanical Ventilation OptiNIV, Visairo - COPD, Respiratory Acidosis | Not applicable | Not yet recruiting | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 21 | 2025-08-01 | 2025-07-23 |
| Ketogenic Metabolic Therapy in Schizophrenia, Bipolar Disorder, Major Depressive Disorder: Deep Omic Profiling LCHF Ketogenic Diet, Diet-as-Usual (DAU) - Schizophrenia, Schizophrenia and Related Disorders | Not applicable | Not yet recruiting | Stanford University | 120 | 2025-07-01 | 2025-05-16 |
| Impact of Clinical Nursing Guideline on Outcomes of Children With Diabetic Ketoacidosis. Evidence-Based Nursing Guideline for Children with Diabetic Ketoacidosos - Diabetic Ketoacidosis | Not applicable | Completed | Hawler Medical University | 60 | 2025-05-14 | 2026-03-12 |
Showing 20 of 221. Sign in to see all of them.
Ketosis (138) · Diabetic Ketoacidosis (27) · Acidosis, Respiratory (14) · Diabetes Mellitus (13) · Motor Activity (13) · Diabetes Mellitus, Type 1 (12) · Obesity (11) · Diabetes Mellitus, Type 2 (10) · Acidosis, Lactic (9) · Hyperglycemia (8) · Hypoxia (8) · Insulin Resistance (8) · Renal Insufficiency, Chronic (8) · Fasting (6)
Acid-Base Imbalance (221) · Nutritional and Metabolic Diseases (220) · Metabolic Diseases (218) · Pathological Conditions, Signs and Symptoms (69) · Endocrine System Diseases (52) · Signs and Symptoms (45) · Glucose Metabolism Disorders (43) · Diabetes Mellitus (36) · Pathologic Processes (34) · Behavior (28) · Diabetes Complications (26) · Ketosis (26) · Urogenital Diseases (25) · Female Urogenital Diseases and Pregnancy Complications (24)
Diet, Ketogenic (13) · formic acid 4-(3-oxobutyl)phenyl ester (12) · Sodium Bicarbonate (8) · Ketones (6) · 3-Hydroxybutyric Acid (5) · Ringer's Lactate (5) · Blood Specimen Collection (4) · Insulin (4) · Resistance Training (4) · Angptl4 protein, mouse (3) · Continuous Glucose Monitoring (3) · Glucose (3) · Insulin Glargine (3) · Saline Solution (3) · Urinalysis (3)
Université de Sherbrooke (15) · University of Aarhus (12) · University of British Columbia (11) · McGill University (5) · Ohio State University (5) · KU Leuven (4) · University of Colorado, Denver (4) · Western University, Canada (4) · Boston Children's Hospital (3) · Gødstrup Hospital (3) · Laval University (3) · University of Florida (3) · Assistance Publique - Hôpitaux de Paris (2) · Augusta University (2) · Central Jutland Regional Hospital (2)
United States (60) · Canada (41) · Denmark (21) · Belgium (10) · United Kingdom (10) · Germany (9) · France (8) · Italy (5) · Poland (4) · Spain (3) · Taiwan (3) · Argentina (2) · Brazil (2) · Egypt (2) · Israel (2)
Stephen Cunnane, PhD (4) · Antonio Paoli, MD (2) · Jacob T Mey, PhD, RD (2) · Jeff Volek, PhD (2) · Jessica Kendrick, MD (2) · Jonathan Little, PhD (2) · Niels Jessen, Professor (2) · Peter Lemon, PhD (2) · Peter WR Lemon, PhD (2) · Stephen C Cunnane, PhD (2) · Stephen Cunnane, Ph.D. (2)
PMID 42458538, PMID 32071135, PMID 33074729, PMID 39804761, PMID 41315088, PMID 10064682, PMID 11604980, PMID 15840076, PMID 19856249, PMID 20492042, PMID 20492047, PMID 20621273, PMID 21323778, PMID 22931483, PMID 23245705, PMID 23388470, PMID 23604057, PMID 23689789, PMID 24035670, PMID 24963569, PMID 25275931, PMID 25346490, PMID 25758624, PMID 25889594, PMID 26013711, PMID 26123384, PMID 26855664, PMID 27035371, PMID 27912960, PMID 28389705, PMID 28434475, PMID 28682955, PMID 29716903, PMID 29735284, PMID 29897851, PMID 29955713, PMID 30057058, PMID 30065082, PMID 30506451, PMID 30600227, PMID 30760224, PMID 31918761, PMID 32694649, PMID 32717058, PMID 32844188, PMID 33301007, PMID 33367782, PMID 33410985, PMID 33561274, PMID 33687988
2018 (1), 2023 (1), K01HL169491 (1), P30AG028740 (1), P30AG059297 (1), R01DK072433 (1), R01DK138309 (1), R01HL060644 (1), R01NS052592 (1), R01NS052619 (1), R25TW009337 (1)