39 completed, 34 recruiting, 15 unknown, 10 not yet recruiting. 21 Not applicable, 18 Phase 2, 14 Phase 1, 9 Phase 4, 6 Phase 3.
Follow Antiphospholipid Syndrome: new trials by email Literature Review of Antiphospholipid Syndrome trials Research Report on Antiphospholipid Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Anticoagulant Cessation After Antiphospholipid Autoantibodies Loss in Thrombotic Antiphospholipid Syndrome Vitamin K Antagonist - Drug, Anticoagulant Therapy Discontinuation - Antiphospholipid Syndrome, Thrombotic Antiphospholipid Syndrome | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 234 | 2026-12-01 | 2026-10-15 |
| Inflammatory Disease Biobank for Immunophenotyping and Cardiovascular Research Pericarditis, Tako-TSUBO Cardiomyopathy | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 300 | 2026-09-01 | 2026-08-10 | |
| Thrombocytopenia Trajectories in Antiphospholipid Syndrome: A Multicenter Cohort Study Platelet count - Antiphospholipid Syndrome | Not applicable | Recruiting | New Valley University | 200 | 2026-07-01 | 2026-10-28 |
| Autoimmune Hemolytic Anemia and Its Clinical Implication on Antiphospholipid Syndrome Hemoglobin, Coombs test - Anti Phospholipid Syndrome | Not applicable | Recruiting | New Valley University | 230 | 2026-06-05 | 2026-08-10 |
| Point of Care Testing INR in Antiphospholipid Syndrome Coaguchek - Antiphospholipid Syndrome, Vitamine K Antagonist (VKA) Treatment | Not applicable | Not yet recruiting | Central Hospital, Nancy, France | 150 | 2026-06-01 | 2026-05-06 |
| A Phase I, Dose Escalation, Open-label, Multicenter Study of EA5 Injection in Adults With APS and Recurrent Thrombosis EA5 - Antiphospholipid Syndrome (APS), Thrombosis | Phase 1 | Active not recruiting | Shanghai Lanyi Therapeutics Co., Ltd. | 12 | 2026-05-25 | 2026-06-08 |
| Anifrolumab in Adults With Primary Antiphospholipid Syndrome (AnifAPS Trial) Anifrolumab - Antiphospholipid Syndrome (APS) | Phase 2 | Recruiting | National and Kapodistrian University of Athens | 20 | 2026-04-29 | 2026-06-02 |
| A Study to Evaluate Crovalimab in People With Antiphospholipid Syndrome (APS) Crovalimab, Placebo, VKA - Antiphospholipid Syndrome | Phase 2 | Withdrawn | Hoffmann-La Roche | 2026-03-16 | 2026-03-02 | |
| Safety and Immunogenicity of the Live Attenuated Tetravalent Butantan-Dengue Vaccine in Autoimmune Rheumatic Diseases Dengue 1,2,3,4 (attenuated) vaccine - Rheumatoid Arthritis (RA), Juvenile Idiopathic Arthritis (JIA) | Phase 4 | Recruiting | University of Sao Paulo General Hospital | 477 | 2026-03-16 | 2026-07-20 |
| YTS109 in Pediatric Relapsed/Refractory Autoimmune Diseases YTS109 cell - Systemic Lupus Erythematosus (SLE), Diffuse Systemic Sclerosis | Phase 1 | Not yet recruiting | Children's Hospital of Fudan University | 12 | 2026-03-01 | 2026-02-27 |
| A Study of CD19 UCAR-T Cells in Subjects With Autoimmune Diseases CD19 UCAR-T cells - Systemic Lupus Erythematosus, Idiopahic Inflammatory Myopathies | Not applicable | Not yet recruiting | Institute of Hematology & Blood Diseases Hospital, China | 24 | 2026-01-30 | 2025-12-19 |
| Characterization of Autoreactive b Lymphocytes in Autoimmune Diseases and Immune Deficiencies blood draw - Systemic Lupus Erythematosus, Systemic Scleroderma | Recruiting | University Hospital, Strasbourg, France | 200 | 2026-01-20 | 2026-08-20 | |
| Clinical Study of BCT301 Cell Injection Therapy for Refractory Autoimmune Diseases BCT301 - System Lupus Erythematosus, Systemic Sclerosis (SSc) | Early Phase 1 | Recruiting | Peking University Third Hospital | 10 | 2025-12-11 | 2026-09-23 |
| Observational Study to Evaluate the Effectiveness of DOACS for Secondary Thrombosis Prevention in Low-risk Thrombotic APS Patients Antiphospholipid Syndrome (APS), Venous Thrombosis (Disorder) | Recruiting | Infanta Leonor University Hospital | 600 | 2025-12-01 | 2026-01-30 | |
| Hematological Markers MPV, PLR, and NLR in Primary Versus Secondary Antiphospholipid Syndrome • Complete blood count , MPV, Calculation of PLR: Platelet count / Lymphocyte count and Calculation of NLR:, Antiphospholipid antibody profile - Antiphospholipid Syndrome | Recruiting | New Valley University | 150 | 2025-11-27 | 2026-07-31 | |
| An Exploratory Clinical Study of YTS109 Cell for R/R Autoimmune Diseases YTS109 cell - Systemic Lupus Erythematosus, Lupus Nephritis (LN) | Phase 1 | Recruiting | China Immunotech (Beijing) Biotechnology Co., Ltd. | 18 | 2025-11-24 | 2026-03-04 |
| Exploratory Clinical Study on YTS109 Cell Therapy for Autoimmune Diseases YTS109 cell - Systemic Lupus Erythematosus (SLE), Systemic Sclerosis | Phase 1 | Recruiting | China Immunotech (Beijing) Biotechnology Co., Ltd. | 18 | 2025-11-13 | 2026-03-02 |
| Prevalence and Consequences of Antiphospholipid Syndrome in Patients Aged 65 and Over With Ischemic Strokes (IS) Collectio nof blood - Antiphospholipid Syndrome | Not applicable | Recruiting | CHU de Reims | 400 | 2025-09-16 | 2025-11-25 |
| DOAC Versus VKA in Patients With Non-high-risk APS : Prospective Cohort Study Additional blood collection during routine blood sampling at the inclusion (33.9 ml) and at the thrombotic recurrence (between 3.5 and 5 ml), Completion of a questionnaire on compliance with anticoagulant treatment, Completion of a questionnaire on satisfaction with treatment anticoagulant - Antiphospholipid Syndrome (APS), Cohort Study | Not yet recruiting | Central Hospital, Nancy, France | 310 | 2025-09-15 | 2025-06-13 | |
| A Clinical Study of YTS109 Cells for the Treatment of R/R Autoimmune Diseases YTS109 cell - Systemic Lupus Erythematosus (SLE), Lupus Nephritis (LN) | Phase 1 | Recruiting | China Immunotech (Beijing) Biotechnology Co., Ltd. | 18 | 2025-08-13 | 2026-10-21 |
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Lupus Erythematosus, Systemic (28) · Scleroderma, Systemic (19) · Myositis (18) · Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (16) · Sjogren's Syndrome (15) · Thrombosis (10) · Arthritis, Rheumatoid (9) · Thrombophilia (6) · Autoimmune Diseases (5) · Behcet Syndrome (5) · Dermatomyositis (5) · Venous Thrombosis (5) · Abortion, Habitual (4) · Stroke (4)
Immune System Diseases (111) · Autoimmune Diseases (108) · Vascular Diseases (43) · Cardiovascular Diseases (42) · Skin and Connective Tissue Diseases (32) · Connective Tissue Diseases (31) · Nervous System Diseases (28) · Musculoskeletal Diseases (27) · Skin Diseases (25) · Muscular Diseases (23) · Neuromuscular Diseases (23) · Joint Diseases (22) · Arthritis (21) · Pathological Conditions, Signs and Symptoms (21) · Skin Diseases, Vascular (21)
Hydroxychloroquine (6) · Rivaroxaban (5) · Warfarin (5) · Aspirin (4) · Blood Specimen Collection (3) · Enoxaparin (3) · Acenocoumarol (2) · Acetaminophen (2) · Hematologic Tests (2) · Platelet Aggregation Inhibitors (2) · Rituximab (2) · apixaban (2) · telitacicept (2) · Agouti Signaling Protein (1) · Antimalarials (1)
Central Hospital, Nancy, France (7) · China Immunotech (Beijing) Biotechnology Co., Ltd. (6) · Assistance Publique - Hôpitaux de Paris (5) · Centre Hospitalier Universitaire de Nīmes (5) · Hospital for Special Surgery, New York (5) · Institute of Hematology & Blood Diseases Hospital, China (3) · New Valley University (3) · Assiut University (2) · Cardioangiologisches Centrum Bethanien (2) · Chugai Pharmaceutical (2) · Hospices Civils de Lyon (2) · Imperial College London (2) · Johns Hopkins University (2) · Mohamed Sayed Abdelhafez (2) · National and Kapodistrian University of Athens (2)
France (29) · China (24) · United States (19) · Egypt (7) · Canada (6) · Germany (5) · Italy (5) · Spain (5) · United Kingdom (5) · Taiwan (3) · Australia (2) · Austria (2) · Brazil (2) · Bulgaria (2) · Croatia (2)
Doruk Erkan, MD (4) · Jean-Christophe Gris, MD, PhD (2) · Jiuliang Zhao, M.D. (2) · Lei Zhang, MD (2) · Mohamed I Eid, Dr (2) · Mohamed S Abdelhafez, Dr (2) · Raj Rai, MRCOG (2) · Abdelmageed F Mashaly, Prof (1) · Ahmed Badawy, Prof (1) · Ahmed El-Zayadi, Dr (1) · Ahmed M Sayed (1) · Anabel Franco-Moreno, MD, PhD (1) · Anne-Sophie Korganow, MD, PhD (1)
PMID 32358837, PMID 10649166, PMID 20131296, PMID 21251653, PMID 21417950, PMID 21445332, PMID 21540203, PMID 21859696, PMID 22089462, PMID 22269862, PMID 22274142, PMID 22275304, PMID 22298793, PMID 22908326, PMID 22931582, PMID 22949223, PMID 22992045, PMID 23044629, PMID 23123020, PMID 23124321, PMID 23215886, PMID 23525305, PMID 23818263, PMID 24040574, PMID 24961747, PMID 25244877, PMID 25603823, PMID 25617818, PMID 26098843, PMID 26421409, PMID 26429521, PMID 26432463, PMID 26745506, PMID 26835148, PMID 26990620, PMID 28126966, PMID 28400421, PMID 28480528, PMID 28532221, PMID 28968874, PMID 29371202, PMID 30002145, PMID 30016929, PMID 30166293, PMID 30962246, PMID 31101755, PMID 31227334, PMID 31773973, PMID 32188491, PMID 32346486
2025 (2), 2005 (1), 2017 (1), N01AR002248 (1), R01AI118855 (1), R01AR049772 (1), SC2HL110393 (1), U01AI101990 (1)