27 completed, 6 unknown, 4 withdrawn, 3 recruiting. 20 Not applicable, 17 Phase 2, 8 Phase 3, 6 Phase 1, 4 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pilot Trial of Xylitol for C. Difficile De-Colonization in Patients With Inflammatory Bowel Disease Xylitol - Inflammatory Bowel Disease (IBD), Clostridioides Difficile Infection | Early Phase 1 | Not yet recruiting | Brigham and Women's Hospital | 69 | 2026-09-01 | 2025-12-16 |
| Xylitol Use for Decolonization of C. Difficile in Patients With IBD Xylitol, Placebo - Inflammatory Bowel Diseases, Clostridioides Difficile Infection | Phase 1 | Not yet recruiting | Brigham and Women's Hospital | 99 | 2026-08-01 | 2026-02-25 |
| Effect of Enzymatic-Containing Mouth Spray (Oral7®) on Xerostomia Symptoms, Salivary Flow Rate, and Oral Health-Related Quality of Life in Older Patients Oral7® mouth spray contains Natural Enzymes (Lactoperoxidase, Glucose Oxidase, Lactoferrin, Lysozyme), Calcium, Xylitol, Aloe Vera, Natural peppermint. - Xerostomia, Geriatric | Not applicable | Recruiting | ZAINAB MAT YUDIN | 100 | 2025-09-18 | 2026-05-22 |
| Peritoneal Ultrafiltration in Cardio Renal Syndrome. PolyCore (Polydextrin, L-Carnitine, D-xylitol) - Congestive Heart Failure | Phase 1 / Phase 2 | Recruiting | Iperboreal Pharma Srl | 84 | 2025-04-16 | 2025-05-16 |
| Effects of Caffeine and Nicotine Gum on Balance Performance in Athletes Caffeine Gum 3mg/kg, Nicotine Gum (4 mg), Placebo Gum (Xylitol) - Athletic Performance, Postural Stability | Not applicable | Completed | Gülbin Rudarlı | 20 | 2024-01-08 | 2025-12-04 |
| Xylitol BSI Multisite - Reduction of Bloodstream Infections From Oral Organisms in Pediatric Stem Cell Transplant Xylitol, Placebo - Allogeneic Stem Cell Transplantation | Phase 2 | Terminated | Children's Hospital Medical Center, Cincinnati | 256 | 2023-04-04 | 2026-09-28 |
| Effects of Oral Xylitol on Subsequent Energy Intake Xylitol, Sucrose, Acesulfame Potassium - Energy Intake, Gastrointestinal Hormones | Not applicable | Completed | University Hospital, Basel, Switzerland | 21 | 2023-01-27 | 2024-08-19 |
| Effect of a Novel Topical Composition on the Incidence of Severe Oral Mucositis in Head & Neck Cancer Radiated Patients and Quality of Life Assessed by PROMs. XCM-OM118 Composition comprising olive oil, betaine and xylitol - Oral Mucositis, Quality of Life | Not applicable | Recruiting | Mucosa Innovations, S.L. | 63 | 2022-10-11 | 2026-04-15 |
| Effect on Cytokines IL-1ß, TNF-α, IL-4, and Total Bacterial Load of a Composition Comprising Olive Oil, Trimethylglycine and Xylitol Delivered as a Toothpaste Toothpaste with olive oil, trimethylglycine and xylitol, Toothpaste without olive oil, trimethylglycine nor xylitol - Inflammation, Interleukin-1beta | Not applicable | Completed | Mucosa Innovations, S.L. | 26 | 2022-06-13 | 2025-03-10 |
| Impact of GSE and Xylitol (Xlear) on COVID-19 Symptoms and Time to PCR Negativisation in COVID-19 Patients GSE and Xylitol, Control Placebo - Covid19 | Phase 3 | Withdrawn | Larkin Community Hospital | 2021-12-16 | 2023-10-16 | |
| Effect of Daily Erythritol Versus Sucrose Intake Over 5 Weeks on Glucose Tolerance in Adolescents Erythritol, Sucrose, Glucose - Insulin Resistance, Glucose Tolerance | Not applicable | Active not recruiting | University Hospital, Basel, Switzerland | 30 | 2021-08-18 | 2026-09-30 |
| Effect of the Use of Xylitol Gum in the Prevention of Caries Lesions in Children Living in Ladakh Administration of sugar-free gums sugar-free gums containing 100% Xylitol as sweetener, Administration of sugar-free gums sugar-free gums containing containing a polyols mixture plus a low amount of Xylitol (22%) - Caries | Not applicable | Withdrawn | University of Bern | 2021-08-01 | 2025-09-26 | |
| Effects of a Composition on the Oral Microbiome, pH, Nitrite/Nitrate Ratio, Elastases and Inflammation in Oral Dysbiosis Test composition Saliactive® (olive product, betaine and xylitol), Placebo, Control - Oral Dysbiosis | Phase 2 / Phase 3 | Completed | Mucosa Innovations, S.L. | 100 | 2021-07-13 | 2024-07-08 |
| Consumption of Oral Artificial Sweeteners on Platelet Aggregation and Polyol Excretion xylitol, 30g, erythritol, 30g, xylitol, 5g - Cardiovascular Risk Factor | Not applicable | Completed | The Cleveland Clinic | 50 | 2021-03-10 | 2026-07-13 |
| Blinded Dry Mouth Spray Crossover Study Remineralizing Extreme Dry Mouth Spray with Xylitol, Alcohol-Free Moisturizing Dry Mouth Spray - Xerostomia, Head and Neck Cancer | Not applicable | Completed | Jonas Johnson | 129 | 2021-01-14 | 2024-02-01 |
| A Novel Approach in Reducing Dental Pain and Anxiety of Pediatric Patient During Local Anesthesia. Lidocaine Hydrochloride, Virtual reality device (Harga Miniso Vr Glass 3d terbaru), Xylitol - Anxiety, Pain | Not applicable | Completed | Riyadh Elm University | 31 | 2020-11-01 | 2021-11-11 |
| Vitamin D in School Children Oral vitamin D spray, Placebo - Vitamin D Deficiency, Musculoskeletal Diseases | Not applicable | Unknown | University of Ulster | 118 | 2019-11-01 | 2021-08-24 |
| Ultrafiltration Efficacy of a PD Solution Containing Icodextrin-Xylitol-Carnitine Icodextrin, xylitol and carnitine solution for peritoneal dialysis, EXTRANEAL 7.5G/100Ml Peritoneal Dialysis Solution - End Stage Renal Disease (ESRD) | Phase 2 | Withdrawn | Iperboreal Pharma Srl | 2019-10-02 | 2024-10-01 | |
| Xylitol - Healthcare Associated Infection Reduction in Stem Cell Transplant Patients Xylitol, Placebo - Allogeneic Hematopoietic Cell Transplantation | Phase 2 | Terminated | Children's Hospital Medical Center, Cincinnati | 46 | 2019-09-27 | 2023-02-08 |
| Efficacy and Safety Assessments of a Peritoneal Dialysis Solution Containing Glucose, Xylitol, and L-Carnitine in CAPD 1.5% Xylitol, 0.5% Glucose, and 0.02% L-carnitine, 0.7% Xylitol, 0.5% Glucose, and 0.02% L-carnitine - End Stage Renal Disease | Phase 2 | Terminated | Iperboreal Pharma Srl | 11 | 2019-09-01 | 2023-03-03 |
Showing 20 of 46. Sign in to see all of them.
Dental Caries (6) · Xerostomia (4) · Gingivitis (3) · Mucositis (3) · Clostridium Infections (2) · Cystic Fibrosis (2) · Dental Plaque (2) · Endocrine System Diseases (2) · Head and Neck Neoplasms (2) · Inflammatory Bowel Diseases (2) · Kidney Failure, Chronic (2) · Pain (2) · Plaque, Amyloid (2) · Sinusitis (2) · Stomatitis (2)
University Hospital, Basel, Switzerland (6) · Iperboreal Pharma Srl (3) · Mucosa Innovations, S.L. (3) · Brigham and Women's Hospital (2) · Children's Hospital Medical Center, Cincinnati (2) · Joseph Zabner (2) · Augusta University (1) · Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (1) · Cairo University (1) · Dr. Krupa NC (1) · Finnish Institute for Health and Welfare (1) · Gülbin Rudarlı (1) · Hadassah Medical Organization (1) · Jonas Johnson (1) · King Abdulaziz University (1)
United States (16) · Switzerland (6) · Italy (3) · Spain (3) · Finland (2) · Russia (2) · Saudi Arabia (2) · Brazil (1) · China (1) · Colombia (1) · Egypt (1) · Estonia (1) · India (1) · Israel (1) · Kuwait (1)
Christoph Beglinger, Prof. (2) · Eino Honkala, PhD (2) · Lakshmi Durairaj, M.D. (2) · Mario Bonomini, MD (2) · AbdulRahman Alasmari, Resident (1) · Alison J Lunsford, MD (1) · Anne Christin Meyer-Gerspach (1) · Christoph Beglinger, MD (1) · Christoph Beglinger, Prof (1) · Christopher Dandoy, MD, MSc (1) · Deyu Hu, Ph.D. (1) · Domenico Dalessandri, Prof. (1)
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1UG3DE030401-01 (1), R21CA158530 (1), U01DE018038 (1)