25 completed, 9 unknown, 2 terminated, 1 recruiting. 13 Not applicable, 12 Phase 3, 6 Phase 1, 3 Early Phase 1, 3 Phase 4.
Follow Pilocarpine: new trials by email Literature Review of Pilocarpine trials Research Report on Pilocarpine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of NV701 (Pilocarpine 1.25%) Compared With Vuity (Pilocarpine 1.25%) on Pupil Size in Subjects With Presbyopia NV701, Pilocarpine 1.25% Eye drop - Pupil Constriction | Early Phase 1 | Completed | Novus Vision LLC | 55 | 2025-01-30 | 2025-09-05 |
| Efficacy of Pilocarpine As a Secretagogue Versus Artificial Tears for the Treatment of Dry Eye Pilocarpine, artificial tears - Dry Eye Disease (DED) | Not applicable | Completed | Al-Azhar University | 40 | 2024-10-01 | 2024-12-30 |
| Xerostomia in Patients With a Life-limiting Condition or Frailty Pilocarpine, Placebo - Xerostomia, Dry Mouth | Phase 3 | Unknown | Maastricht University Medical Center | 120 | 2023-01-01 | 2022-08-18 |
| Safety and Efficacy of Nyxol Eye Drops as a Single Agent and With Adjunctive Low-Dose Pilocarpine Eye Drops in Subjects With Presbyopia Phentolamine Opthalmic Solution 0.75%, Placebo, Low dose pilocarpine - Presbyopia | Phase 3 | Completed | Opus Genetics, Inc | 333 | 2022-12-22 | 2026-07-13 |
| Pharmacological Treatment of Presbyopia Pilocarpine 1.25% Eye drop - Near Vision | Early Phase 1 | Unknown | Shahid Beheshti University of Medical Sciences | 75 | 2022-08-01 | 2022-10-04 |
| Wearing-Off Period of Pharmacological Dilation and Anisocoria Tropicamide, 1% Pilocarpine, Proparacaine Hydrochloride - Anisocoria | Phase 4 | Completed | Prisma Health-Upstate | 11 | 2022-04-01 | 2023-03-07 |
| A Study to Assess Safety and Efficacy in Participants Age 40 to 55 With Presbyopia (Old Eye) Who Receive AGN-190584 in Both Eyes Twice Daily Pilocarpine HCl, Vehicle - Presbyopia | Phase 3 | Completed | Allergan | 230 | 2021-09-02 | 2023-03-21 |
| Pilocarpine, Brimonidine, Oxymetazoline (PBO) Compound to Control Presbyopia Symptoms Pilocarpine, brimonidine, oxymetazoline, hyaluronic acid, bromfenac (PBOHB) compound - Presbyopia | Phase 1 | Unknown | Optall Vision | 11 | 2021-08-14 | 2021-08-17 |
| Comparison of a Compound With Pilocarpine and Brimonidine to Improve Near Vision in Healthy Presbyopic Patients Compound Pilocarpine, Brimonidine, Oxymetazoline, Hyaluronic acid, Bromfenac, Pilocarpine Hydrochloride, Brimonidine Tartrate - Presbyopia | Phase 1 | Unknown | Optall Vision | 11 | 2021-08-10 | 2021-08-19 |
| A Study to Assess the Impact and Adverse Events of Topical Eyedrops of AGN-190584 on Night-driving Performance in Participants, 40 to 55 Years of Age AGN-190584, Vehicle - Presbyopia | Phase 3 | Completed | AbbVie | 43 | 2021-05-14 | 2024-10-10 |
| Safety and Efficacy of Nyxol With Pilocarpine Eye Drops in Subjects With Presbyopia Phentolamine Ophthalmic Solution 0.75%, Pilocarpine, Placebo - Presbyopia | Phase 2 | Completed | Opus Genetics, Inc | 150 | 2021-02-15 | 2025-10-10 |
| Compound to Control Presbyopia Symptoms PBO to control presbyopia symptoms - Presbyopia | Phase 1 | Completed | Optall Vision | 11 | 2020-06-01 | 2021-08-19 |
| Pilocarpine After Combined Cataract/Trabectome Surgery Pilocarpine, Ofloxacin, Prednisolone - Open Angle Glaucoma, Ocular Hypertension | Phase 3 | Withdrawn | Montefiore Medical Center | 2019-06-05 | 2022-04-07 | |
| Pilocarpine Use After Kahook Goniotomy Pilocarpine, Prednisolone, Ofloxacin - Glaucoma | Phase 3 | Recruiting | Montefiore Medical Center | 142 | 2019-05-01 | 2025-11-10 |
| Pilocarpine and Brimonidine in Patients With Monofocal Lenses Brimonidine, pilocarpine - Presbyopia, Pseudophakia | Early Phase 1 | Unknown | Massachusetts Eye and Ear Infirmary | 33 | 2019-01-21 | 2019-01-31 |
| Measuring Sweat Glucose of Patients With Diabetes - The ENGAGE Study Adhesive glucose sensor, Pilocarpine - Diabetes Mellitus | Not applicable | Terminated | University of California, San Diego | 2 | 2018-05-01 | 2020-07-09 |
| Investigating the Stability, Variability and Mechanism of Incorporation of Lipid Mediators Into Eccrine Sweat Ibuprofen, Physiological induction of sweating, Pilocarpine - Stability & Variability of Lipid-derived Molecules in Sweat | Not applicable | Completed | USDA, Western Human Nutrition Research Center | 14 | 2016-11-28 | 2018-06-01 |
| The Diurnal and Nocturnal Effect of Pilocarpine on Intraocular Pressure and Ocular Perfusion Pressure Pilocarpine - Glaucoma, Open-angle, Hypertension, Ocular | Not applicable | Completed | University of Colorado, Denver | 27 | 2016-07-01 | 2019-11-07 |
| Anterior Segment Imaging With Ultrahigh-resolution OCT in Patients With Glaucoma and PEX - a Pilot Study Pilocarpine - Glaucoma | Not applicable | Unknown | Medical University of Vienna | 90 | 2016-04-20 | 2022-04-07 |
| Effect of Pilocarpine in Patients With Xerostomia Pilocarpine, Spray without Pilocarpine - Xerostomia | Phase 4 | Unknown | University of Sao Paulo | 80 | 2016-04-01 | 2016-12-05 |
Showing 20 of 38. Sign in to see all of them.
Xerostomia (11) · Presbyopia (9) · Head and Neck Neoplasms (3) · Cataract (2) · Dry Eye Syndromes (2) · Glaucoma (2) · Glaucoma, Open-Angle (2) · Ocular Hypertension (2) · Anisocoria (1) · Breast Neoplasms (1) · Diabetes Mellitus (1) · Glaucoma, Angle-Closure (1) · Hypopharyngeal Neoplasms (1) · Laryngeal Neoplasms (1) · Lymphoid Interstitial Pneumonia (1)
Roxane Laboratories (4) · Optall Vision (3) · Astellas Pharma Europe B.V. (2) · Montefiore Medical Center (2) · Opus Genetics, Inc (2) · Radiation Therapy Oncology Group (2) · AbbVie (1) · Al-Azhar University (1) · Alberta Health services (1) · Allergan (1) · Alliance for Clinical Trials in Oncology (1) · Federal University of São Paulo (1) · Jeong-seong Kwon (1) · Maastricht University Medical Center (1) · Massachusetts Eye and Ear Infirmary (1)
United States (19) · Canada (4) · Mexico (3) · Brazil (2) · South Korea (2) · United Kingdom (2) · Australia (1) · Austria (1) · Chile (1) · China (1) · Egypt (1) · Germany (1) · Iran (1)
Daniel V Freeland, DO (4) · Cesar Alejandro S Galeana, MD (2) · Camila Tirapelli, PhD (1) · Cesar Alejandro S Galeana (1) · Changwon Kee, M.D. (1) · Charles L. Loprinzi, MD (1) · Cristian Vera-Kellet, MD (1) · David Warr, MD (1) · Edward C Chao, DO (1) · Francis G. LeVeque, DDS (1) · Jeong-Seung Kwon, DDS,MSD,PhD (1)
PMID 12788192, PMID 16424527, PMID 16700739, PMID 16724649, PMID 16759558, PMID 17000452, PMID 17043506, PMID 21702402, PMID 22252927, PMID 24527846, PMID 24692737, PMID 25065774, PMID 25639487, PMID 25841622, PMID 26001395, PMID 26065354, PMID 26563850, PMID 26867879, PMID 27479825, PMID 27767109, PMID 28302178, PMID 29432648, PMID 37612654, PMID 38044272
2014 (1), 2015 (1), UL1TR001082 (1), UL1TR001442 (1)