141 completed, 37 unknown, 18 terminated, 12 not yet recruiting. 228 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 228 | Completed 141, Unknown 37, Terminated 18, Not yet recruiting 12, Recruiting 10, Withdrawn 8, Active not recruiting 1, Enrolling by invitation 1 |
Follow Vomiting: new trials by email Literature Review of Vomiting trials Research Report on Vomiting
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Broadening Antiemetics Research by Comparing the Effectiveness of Fosaprepitant and Metoclopramide Fosaprepitant for Injection, Metoclopramide Injection - Nausea and Vomiting, Nausea | Phase 4 | Not yet recruiting | Montefiore Medical Center | 212 | 2026-12-01 | 2026-06-29 |
| Effect of Ketamine-Propofol Total Intravenous Anesthesia Versus Sevoflurane-Based Anesthesia on Postoperative Vomiting in Children Undergoing Strabismus Surgery Ketamine and Propofol, Sevoflurane - Postoperative Vomiting, Postoperative Nausea and Vomiting | Phase 4 | Not yet recruiting | Assiut University | 50 | 2026-11-01 | 2026-10-13 |
| Study to Assess Safety and Tolerability of KarXT With Administration of Antiemetics in Healthy Volunteers KarXT, Trimethobenzamide, Ondansetron - Healthy Volunteers | Phase 4 | Recruiting | Karuna Therapeutics, Inc., a Bristol Myers Squibb company | 180 | 2026-09-03 | 2026-10-15 |
| Time to First Rescue Antiemetic With Ondansetron Plus Metoclopramide Versus Dexamethasone Plus Metoclopramide for PONV Prophylaxis in Laparoscopic Cholecystectomy ondansetron 4 mg, Dexamethasone (intravenous), Metoclopramide 10mg - Postoperative Nausea and Vomiting | Phase 4 | Recruiting | Faisalabad Medical University | 264 | 2026-09-01 | 2026-09-04 |
| Sleep Quality - Comparing the Effect of Ondansetron or Dexamethasone Given as Routine Prophylaxis Intraoperatively to Prevent Post Operative Nausea and Vomiting (SCORPION) Dexamethasone (IV), Ondansetron iv - Postoperative Sleep Quality, Postoperative Behaviour | Phase 4 | Not yet recruiting | Telethon Kids Institute | 500 | 2026-08-17 | 2026-08-20 |
| A Randomized Controlled Trial Comparing the Effects of Different Anesthetic Sedatives on PONV in Laparoscopic Cholecystectomy Propofol, Ciprofol, Remimazolam - Cholelithiasis, Postoperative Nausea and Vomiting | Phase 4 | Completed | Xi'an Aerospace General Hospital | 114 | 2026-08-15 | 2026-11-10 |
| Routine Antiemetic Prophylaxis for Nonfasted Parturients Undergoing Cesarean Sections Under Spinal Anesthesia Ondansetron 4mg, metoclopramide - Intraoperative Nausea-retching-vomiting Episodes, Spinal Aneshtesia | Phase 4 | Recruiting | Sanliurfa Education and Research Hospital | 120 | 2026-07-30 | 2026-10-01 |
| Aprepitant to Improve Same Day Discharge for TKA Aprepitant Injection, Ondansetron (Zofran), Dexamethasone - PONV | Phase 4 | Not yet recruiting | Endeavor Health | 350 | 2026-07-01 | 2026-06-10 |
| Effect of Aprepitant on Post-operative Nausea and Vomiting in Otologic Surgery Aprepitant, Placebo - Otologic Disease | Phase 4 | Not yet recruiting | Sir Mortimer B. Davis - Jewish General Hospital | 100 | 2026-06-01 | 2026-01-28 |
| Dexmedetomidine for Improving Emergence Quality in Thyroid Surgery Dexmedetomidine, Standard General Anesthesia - Thyroid Diseases | Phase 4 | Recruiting | Bach Mai Hospital | 100 | 2026-04-13 | 2026-04-15 |
| General Anaesthesia vs Spinal Anaesthesia: Patient Outcomes and Success in Outpatient Primary Total Knee and Hip Arthroplasty General Anaesthesia, Spinal Anesthesia (bupivacaine) - Osteo Arthritis Knee and Hip, Osteo Arthritis | Phase 4 | Not yet recruiting | Region Örebro County | 600 | 2026-04-01 | 2026-01-12 |
| An Exploratory Study on Efficacy and Safety of Fosaprepitant and Palonosetron Hydrochloride for Injection in Preventing CINV From Multi-Agent HEC Fosrolapitant and Palonosetron Hydrochloride for Injection, Dexamethasone, Olanzapine - Chemotherapy-induced Nausea and Vomiting | Phase 4 | Recruiting | Shanghai 6th People's Hospital | 200 | 2026-03-10 | 2026-04-30 |
| Granisetron Combined With Dexamethasone or Metoclopramide for PONV Prevention After Laparoscopic Cholecystectomy Granisetron - Postoperative Nausea and Vomiting (PONV) | Phase 4 | Not yet recruiting | Assiut University | 102 | 2026-03-01 | 2026-01-22 |
| Spinal Morphine and Atropine Added to General Anaesthesia for Nausea and Pain After Abdominal Laparoscopy Intrathecal bupivacaine, morphine and atropine, General anaesthesia, Multimodal analgesia and antiemetic prophylaxis - Postoperative Nausea and Vomiting, Postoperative Pain | Phase 4 | Completed | Universitas Indonesia | 63 | 2026-02-02 | 2026-10-01 |
| Steroids for Rhinoplasty: Pain, Nausea, Edema and Ecchymosis Medrol 4 MG Oral Tablet Includes Medrol Dosepak - Edema, Bruising | Phase 4 | Withdrawn | Vanderbilt University Medical Center | 2026-01-01 | 2025-11-18 | |
| Peritoneal Lavage Using Saline or Saline With Ondansetron for Pain Control After Laparoscopic Cholecystectomy Ondansetron Intraperitoneal Lavage, Saline Intraperitoneal Lavage - Postoperative Pain Management, Laparoscopic Cholecystectomy | Phase 4 | Active not recruiting | Instituto Mexicano del Seguro Social | 40 | 2025-12-01 | 2025-12-16 |
| Efficacy of Palonosetron Plus Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Gynaecological Laparoscopic Surgery Palonosetron and Dexamethason, Palonosetron - Postoperative Nausea and Vomiting | Phase 4 | Completed | Bangladesh Medical University | 76 | 2025-09-10 | 2026-09-10 |
| Dexamethasone to Prevent Side Effects of Spinal Anesthesia in Cesarean Delivery Dexamethasone, Placebo - Hypotension During Cesarean Delivery, Postoperative Nausea and Vomiting (PONV) | Phase 4 | Enrolling by invitation | University Medical Center Ho Chi Minh City (UMC) | 176 | 2025-08-01 | 2026-05-29 |
| Oliceridine on Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery Oliceridine, Sufentanil - Gynecologic Surgical Procedures, Postoperative Nausea and Vomiting (PONV) | Phase 4 | Completed | YanYing Xiao | 96 | 2025-07-21 | 2026-06-09 |
| Ginger to Prevent Nausea and Vomiting After Laparoscopic Cholecystectomy Ginger, Placebo - Postoperative Nausea and Vomiting, Laparoscopic Cholecystectomy | Phase 4 | Recruiting | University Tunis El Manar | 102 | 2025-07-05 | 2026-04-28 |
Showing 20 of 228. Sign in to see all of them.
Postoperative Nausea and Vomiting (142) · Nausea (66) · Pain, Postoperative (44) · Pain (10) · Neoplasms (7) · Postoperative Complications (7) · Agnosia (6) · Pruritus (6) · Obesity (4) · Osteoarthritis, Knee (4) · Personal Satisfaction (4) · Abdominal Pain (3) · Breast Neoplasms (3) · Constipation (3)
Pathological Conditions, Signs and Symptoms (228) · Signs and Symptoms (227) · Signs and Symptoms, Digestive (226) · Pathologic Processes (154) · Postoperative Complications (141) · Nausea (126) · Neurologic Manifestations (65) · Pain (49) · Nervous System Diseases (16) · Digestive System Diseases (9) · Musculoskeletal Diseases (9) · Skin Diseases (9) · Skin and Connective Tissue Diseases (9) · Behavior (8)
Dexamethasone (55) · Ondansetron (49) · Aprepitant (28) · Sodium Chloride (24) · Saline Solution (23) · Palonosetron (22) · Granisetron (13) · Metoclopramide (13) · Propofol (11) · Calcium Dobesilate (10) · Lidocaine (9) · ramosetron (9) · Acetaminophen (7) · Bupivacaine (7) · Ketamine (7)
Assiut University (7) · Yonsei University (7) · Merck Sharp & Dohme LLC (6) · Hvidovre University Hospital (5) · Pontificia Universidade Catolica de Sao Paulo (4) · Copenhagen University Hospital, Hvidovre (3) · Hospital for Special Surgery, New York (3) · Medical University of Warsaw (3) · The Second Affiliated Hospital of Chongqing Medical University (3) · Aga Khan University (2) · Ankara University (2) · Bezmialem Vakif University (2) · Dr. Stephen Freedman (2) · Duke University (2) · Hospital Federal de Bonsucesso (2)
United States (56) · China (17) · South Korea (17) · Turkey (Türkiye) (14) · Brazil (13) · Denmark (11) · Egypt (10) · Canada (9) · Pakistan (8) · Italy (5) · Poland (5) · Switzerland (5) · France (4) · Malaysia (4) · Germany (3)
Nicolai Bang Foss, Dr.med. (3) · Eduardo T Moro, Professor (2) · Gideon Koren, MD (2) · He Huang, MD (2) · Saeed S Hamid, FRCP, FACG (2) · Sajid B Soofi, MD (2) · Shaul Cohen, MD (2) · Stephen Freedman, MD (2) · Zulfiqar Bhutta, MD (2)
PMID 34002866, PMID 10485781, PMID 21079721, PMID 32467512, PMID 10078396, PMID 10227938, PMID 10433490, PMID 10475299, PMID 10485753, PMID 10598635, PMID 10624646, PMID 10718794, PMID 10730546, PMID 10740539, PMID 10910848, PMID 11028830, PMID 11189177, PMID 11266262, PMID 11273930, PMID 11323159, PMID 11454483, PMID 11474424, PMID 11475180, PMID 11772809, PMID 11812709, PMID 11826129, PMID 12067003, PMID 12358867, PMID 12670812, PMID 12768180, PMID 12818945, PMID 14504060, PMID 14570668, PMID 14574212, PMID 14620731, PMID 15064259, PMID 15120791, PMID 15139789, PMID 15189396, PMID 15275765, PMID 1531705, PMID 1535245, PMID 15915040, PMID 16000093, PMID 1609990, PMID 16306743, PMID 16464423, PMID 16528908, PMID 16679671, PMID 16717343
2017 (2), 2008 (1), 2018 (1), 2019 (1), 2023 (1), 2025 (1)