322 completed, 42 unknown, 37 recruiting, 32 terminated. 140 Not applicable, 124 Phase 2, 101 Phase 3, 43 Phase 1, 37 Phase 4.
Follow Pruritus: new trials by email Literature Review of Pruritus trials Research Report on Pruritus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Tolerance of THC 25: CBD 25 in Patients With Severe Pruritus: a Multicenter, Double-blind, Randomized, Placebo-controlled Study Cannabis oil, Placebo - Pruritus | Phase 2 | Not yet recruiting | University Hospital, Brest | 218 | 2027-01-01 | 2026-06-12 |
| Efficacy and Safety of ATTO-1310 in the Treatment of Participants With Chronic Pruritus of Unknown Origin ATTO-1310, Placebo - Chronic Pruritus of Unknown Origin | Phase 2 | Not yet recruiting | Attovia Therapeutics Inc | 300 | 2026-12-21 | 2026-09-22 |
| Topical Minocycline for CARP Topical Minocycline Foam FXFM244, Control - Confluent and Reticulated Papillomatosis (CARP) | Early Phase 1 | Not yet recruiting | Medical University of South Carolina | 35 | 2026-12-15 | 2026-10-22 |
| J-LINX: Japan LINerixibat eXtension Study Linerixibat - Pruritus | Phase 3 | Not yet recruiting | GlaxoSmithKline | 40 | 2026-10-09 | 2026-10-06 |
| A Study to Learn About the Study Medicine Abrocitinib in People With Severe Atopic Dermatitis Who Have Switched From Other Therapies abrocitinib - Dermatitis, Atopic | Not yet recruiting | Pfizer | 120 | 2026-10-01 | 2026-10-21 | |
| Efficacy and Speed of Response of Lebrikizumab in High-Burden Prurigo Nodularis Patients Lebrikizumab - Prurigo Nodularis (PN) | Phase 2 | Not yet recruiting | University of Maryland, Baltimore | 15 | 2026-09-01 | 2026-09-03 |
| Safety and Tolerability of Difelikefalin in Adolescents on Haemodialysis With Moderate-to-Severe Pruritus Difelikefalin - Pruritus, Chronic Kidney Diseases | Phase 2 | Recruiting | Vifor Fresenius Medical Care Renal Pharma | 18 | 2026-08-04 | 2026-10-23 |
| Obtaining Descriptive Classifications of Pruritus and Assessing Change in Pruritus Over Time in Atopic Dermatitis Patients Using Topical Roflumilast Cream. Roflumilast Cream 0.15% - ITCH, Atopic Dermatitis | Phase 4 | Recruiting | Integrative Skin Science and Research | 40 | 2026-07-21 | 2026-08-13 |
| A Phase 1b Study of ZYG24004 in Participants With Tinea Pedis Caused by Dermatophytes ZYG24004 1% topical film-forming formulation, ZYG24004 3% topical film-forming formulation, Placebo topical formulation - Tinea Pedis | Phase 1 | Recruiting | Sinomune Pharmaceutical Co., Ltd | 64 | 2026-07-21 | 2026-08-04 |
| Efficacy and Safety Study to Evaluate SD-101 in Epidermolysis Bullosa SD-101 Dermal Cream (6%), Vehicle (SD-101 0%) - Epidermolysis Bullosa (EB) | Phase 3 | Recruiting | Paradigm Therapeutics | 80 | 2026-07-21 | 2026-10-15 |
| High-power Laser Therapy for Notalgia Paresthetica. High-power laser, Sham Laser - Notalgia Paresthetica | Not applicable | Recruiting | Uşak University | 40 | 2026-07-17 | 2026-07-20 |
| Using Digital Health Technology to Monitor Patients With Primary Biliary Cholangitis (PBC) Primary Biliary Cholangitis (PBC) | Enrolling by invitation | Stanford University | 30 | 2026-07-01 | 2026-06-11 | |
| Efficacy and Safety of HA35 Gel for Ultra-Rapid Skin Pruritus Relief 10% High-Concentration 35 kDa Hyaluronan (HA35) Topical Anti-Pruritic Gel - Skin Pruritus, Itch | Not applicable | Completed | Nakhia Impex LLC | 30 | 2026-06-20 | 2026-09-22 |
| Serum Substance P, Neuropathic Pain, and Central Sensitization Across Treatment Groups in Chronic Plaque Psoriasis IL-17 Inhibitor Therapy, Conventional Systemic Therapy - Chronic Plaque-type Psoriasis | Recruiting | Istanbul Training and Research Hospital | 100 | 2026-06-11 | 2026-09-28 | |
| A Study to Evaluate the Multiple Dose Ascending of PG-033 in Healthy Adult Participants. PG-033 tablets, PG-033 placebo comparator - Lichen Simplex Chronicus | Phase 1 | Not yet recruiting | Prime Gene Therapeutics Co., Ltd. | 30 | 2026-06-04 | 2026-06-01 |
| TH104 for the Treatment of Pruritus in Primary Biliary Cholangitis Nalmefene, Placebo - Pruritus, Primary Biliary Cholangitis | Phase 2 | Not yet recruiting | Tharimmune Inc | 40 | 2026-06-01 | 2025-09-09 |
| The Safety and Efficacy of Upadacitinib in Refractory Autoimmune Related Cholangitis and Atopic Dermatitis With Moderate to Severe Itching Upadacitinib 15 MG - Primary Biliary Cholangitis (PBC), Primary Sclerosing Cholangitis (PSC) | Phase 2 | Not yet recruiting | RenJi Hospital | 44 | 2026-06-01 | 2026-07-01 |
| The Effect of Intraoperative Esketamine Infusion on Pruritus in Elderly Surgical Patients Esketamine, Normal Saline - Senile Pruritus | Not applicable | Not yet recruiting | Tianjin Medical University General Hospital | 200 | 2026-05-15 | 2026-05-19 |
| Methotrexate Versus Apremilast for Pruritus in Psoriasis Apremilast, Methotrexate - Psoriasis, Pruritus | Phase 4 | Not yet recruiting | Zarmeen Khawar | 80 | 2026-05-14 | 2026-05-15 |
| Effects of Non-Invasive Vagus Nerve Stimulation in Adolescent Burn Patients Non-Invasive Vagus Nerve Stimulation, Conventional Physiotherapy - Burn Injury | Not applicable | Enrolling by invitation | Fenerbahce University | 60 | 2026-05-11 | 2026-07-07 |
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Dermatitis, Atopic (73) · Tinea Pedis (69) · Eczema (44) · Psoriasis (33) · Pain (24) · Skin Diseases (22) · Urticaria (20) · Kidney Failure, Chronic (19) · Dermatitis (16) · Liver Cirrhosis, Biliary (15) · Renal Insufficiency, Chronic (15) · Chronic Urticaria (14) · Cholestasis (13) · Plaque, Amyloid (10)
Skin and Connective Tissue Diseases (489) · Pathological Conditions, Signs and Symptoms (487) · Signs and Symptoms (487) · Skin Manifestations (484) · Skin Diseases (467) · Immune System Diseases (117) · Hypersensitivity, Immediate (97) · Skin Diseases, Eczematous (94) · Hypersensitivity (93) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (84) · Dermatitis (83) · Infections (83) · Genetic Diseases, Inborn (80) · Pathologic Processes (80) · Skin Diseases, Genetic (78)
Histamine (17) · difelikefalin (13) · Sodium Chloride (9) · secukinumab (9) · Morphine (8) · naftifine (8) · serlopitant (8) · Saline Solution (7) · dupilumab (7) · tofacitinib (7) · Gabapentin (6) · Lidocaine (6) · Tablets (6) · Aprepitant (5) · Blood Specimen Collection (5)
Aalborg University (25) · Novartis Pharmaceuticals (15) · Cara Therapeutics, Inc. (14) · University Hospital, Brest (13) · GlaxoSmithKline (12) · Incyte Corporation (10) · Pfizer (10) · Sun Pharmaceutical Industries, Inc. (8) · Mirum Pharmaceuticals, Inc. (7) · Vyne Therapeutics Inc. (7) · Merz North America, Inc. (6) · University Hospital, Basel, Switzerland (6) · Johns Hopkins University (5) · Pierre Fabre Dermo Cosmetique (4) · Shiraz University of Medical Sciences (4)
United States (182) · Germany (57) · Canada (52) · Poland (43) · China (39) · France (37) · United Kingdom (32) · Denmark (29) · Spain (28) · Turkey (Türkiye) (24) · Netherlands (20) · Taiwan (20) · Belgium (19) · Hungary (17) · Italy (17)
Gil Yosipovitch, MD (3) · Simon Mueller, PD Dr. med. (3) · Alan Fleischer, MD (2) · Anya Loncaric (2) · Daniel Piacquadio, MD (2) · Dennis West, PhD (2)
PMID 33283264, PMID 32816215, PMID 36039153, PMID 33982267, PMID 37968132, PMID 39037824, PMID 11050519, PMID 25971957, PMID 26149717, PMID 28396102, PMID 32632956, PMID 33658996, PMID 33957195, PMID 35305260, PMID 36016762, PMID 36264430, PMID 37341961, PMID 37888917, PMID 37953500, PMID 38698175, PMID 38780109, PMID 39375281, PMID 39546129, PMID 40266487, PMID 41678112, PMID 42825996, PMID 10690153, PMID 11453873, PMID 11525858, PMID 12761013, PMID 12770663, PMID 15471273, PMID 16014882, PMID 16597655, PMID 16918326, PMID 17058231, PMID 17085262, PMID 17175106, PMID 17298105, PMID 17522250, PMID 17535226, PMID 17901734, PMID 18048820, PMID 18181978, PMID 18611915, PMID 18806056, PMID 18809192, PMID 19081121, PMID 19663845, PMID 19692680
2023 (9), 2017 (6), 2018 (4), 2016 (3), 2009 (2), 2015 (2), 2019 (2), 2008 (1), 2014 (1), 2025 (1), R03DK055618 (1), R21AR062357 (1)