9 completed, 5 recruiting, 5 unknown, 1 not yet recruiting. 5 Phase 2, 4 Not applicable, 4 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Recruiting 3, Completed 2 |
| Not applicable | 4 | Completed 2, Unknown 2 |
| Phase 3 | 4 | Completed 2, Not yet recruiting 1, Recruiting 1 |
| Phase 4 | 1 | Unknown 1 |
Follow Tuberculous Meningitis: new trials by email Literature Review of Tuberculous Meningitis trials Research Report on Tuberculous Meningitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Characteristics, Treatment, Diagnostic Findings, and Outcomes of Tuberculous Meningitis in Indonesia, 2022-2025 No intervention (observational study) - Tuberculous Meningitis | Recruiting | Ina-Respond | 300 | 2026-09-24 | 2026-11-10 | |
| BPaLMZ for TB Meningitis BPaLMZ Regimen - Tuberculous Meningitis, HIV | Phase 2 | Recruiting | David Boulware | 312 | 2026-07-28 | 2026-10-16 |
| Intensified Short Course Regimen for TBM in Adults High dose rifampicin (25mg/kg), Moxifloxacin 400mg, Aspirin 150 mg - Tuberculous Meningitis | Phase 3 | Not yet recruiting | Indian Council of Medical Research | 372 | 2024-03-01 | 2023-12-21 |
| Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous Meningitis Rifampicin (RIF), Isoniazid (INH), Linezolid (LZD) - Tuberculous Meningitis | Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 330 | 2023-12-07 | 2026-06-02 |
| Tnf Inhibitors to Reduce Mortality in HIV-1 Infected PAtients With Tuberculosis meNIngitis Adalimumab Injection - Tuberculous Meningitis, HIV I Infection | Phase 2 | Recruiting | ANRS, Emerging Infectious Diseases | 130 | 2023-04-11 | 2025-12-15 |
| Diagnostic Accuracy of Imaging Findings in TBM/Spinal Tubercular Arachnoiditis and Correlation With Outcomes MRI Brain and spine, Reference standard diagnostic criteria - Tuberculous Meningitis, Tuberculous Arachnoiditis | Unknown | All India Institute of Medical Sciences | 120 | 2022-01-27 | 2022-12-05 | |
| Intensified Tuberculosis Treatment to Reduce the Mortality of Patients With Tuberculous Meningitis Aspirin, Placebo of aspirin, WHO TBM treatment - Tuberculous Meningitis | Phase 3 | Recruiting | ANRS, Emerging Infectious Diseases | 768 | 2021-02-07 | 2026-06-24 |
| Evaluation of New Biomarker-based Approaches for Improving the Diagnosis of Childhood Tuberculous Meningitis Tuberculous Meningitis | Completed | University of Stellenbosch | 332 | 2020-04-01 | 2025-12-16 | |
| Optimizing Antituberculosis Therapy in Adults With Tuberculous Meningitis Isoniazid - Tuberculous Meningitis | Not applicable | Unknown | Beijing Chest Hospital | 676 | 2019-03-04 | 2021-02-01 |
| Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Meningitis Dexamethasone, Placebo - Tuberculosis, Tuberculous Meningitis | Phase 3 | Completed | Oxford University Clinical Research Unit, Vietnam | 702 | 2018-02-12 | 2025-06-17 |
| Retrospective Real-word Study of Linezolid for the Treatment of Tuberculous Meningitis Linezolid - Tuberculous Meningitis | Unknown | Huashan Hospital | 150 | 2018-01-01 | 2019-04-02 | |
| Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial) Dexamethasone, Placebo - Tuberculosis, Tuberculous Meningitis | Phase 3 | Completed | Oxford University Clinical Research Unit, Vietnam | 520 | 2017-05-25 | 2024-03-22 |
| Driving Reduced AIDS-associated Meningo-encephalitis Mortality DREAMM - AIDS-Related Opportunistic Infections, Meningo-encephalitis | Not applicable | Completed | St George's, University of London | 495 | 2016-04-23 | 2022-05-04 |
| The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis Dexamethasone acetate - Tuberculous Meningitis | Phase 4 | Unknown | Hui Bu | 200 | 2015-11-01 | 2015-10-29 |
| Xpert MTB/RIF Assay for Diagnosis of Tuberculous Meningitis (TBM) in Maharaj Nakorn Chiang Mai Hospital Xpert MTB/RIF - Tuberculous Meningitis | Not applicable | Completed | Chiang Mai University | 62 | 2015-01-01 | 2023-03-23 |
| A Pilot Study of Adjunctive Aspirin for the Treatment of HIV Negative Adults With Tuberculous Meningitis 81mg aspirin, 1000mg aspirin, Placebo - Tuberculous Meningitis | Phase 2 | Completed | Oxford University Clinical Research Unit, Vietnam | 120 | 2014-10-17 | 2017-03-07 |
| Rifampicin Explorative PK Study for Tuberculous Meningitis Comparing Oral and Intravenous Preparation Rifampicin intravenous, Oral rifampicin - Tuberculous Meningitis | Phase 2 | Completed | Universitas Padjadjaran | 30 | 2013-06-01 | 2014-06-17 |
| Diagnosis of Tuberculous Meningitis by ESAT-6 in CSF Tuberculous Meningitis | Completed | Xijing Hospital | 316 | 2010-09-01 | 2014-08-20 | |
| Intrathecal Therapy for Adult Tuberculous Meningitis: Impact on Clinical Outcomes Intrathecal Therapy - Tuberculous Meningitis | Completed | Beijing Chest Hospital | 837 | 2010-01-01 | 2025-02-06 | |
| Immediate Versus Deferred Antiretroviral Therapy for HIV-Associated Tuberculous Meningitis Combivir and efavirenz - HIV Infections, Tuberculous Meningitis | Not applicable | Unknown | University of Oxford | 253 | 2005-09-01 | 2008-08-07 |
Tuberculosis, Meningeal (20) · Tuberculosis (4) · Chemical and Drug Induced Liver Injury (2) · Meningitis (2) · AIDS-Related Opportunistic Infections (1) · Acquired Immunodeficiency Syndrome (1) · Central Nervous System Diseases (1) · Disease (1) · HIV Infections (1) · Latent Tuberculosis (1) · Meningitis, Bacterial (1) · Meningitis, Cryptococcal (1) · Toxoplasmosis, Cerebral (1)
Actinomycetales Infections (20) · Bacterial Infections (20) · Bacterial Infections and Mycoses (20) · Central Nervous System Bacterial Infections (20) · Central Nervous System Infections (20) · Gram-Positive Bacterial Infections (20) · Infections (20) · Mycobacterium Infections (20) · Nervous System Diseases (20) · Neuroinflammatory Diseases (20) · Tuberculosis, Central Nervous System (20) · Tuberculosis, Extrapulmonary (20) · Central Nervous System Diseases (19) · Meningitis, Bacterial (19) · Meningitis (18)
Aspirin (3) · Isoniazid (3) · Rifampin (3) · Dexamethasone (2) · Linezolid (2) · Pyrazinamide (2) · Adalimumab (1) · Ethambutol (1) · Moxifloxacin (1) · Observation (1) · Steroids (1) · dexamethasone acetate (1) · efavirenz (1) · lamivudine, zidovudine drug combination (1)
Oxford University Clinical Research Unit, Vietnam (3) · ANRS, Emerging Infectious Diseases (2) · Beijing Chest Hospital (2) · All India Institute of Medical Sciences (1) · Chiang Mai University (1) · David Boulware (1) · Huashan Hospital (1) · Hui Bu (1) · Ina-Respond (1) · Indian Council of Medical Research (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · St George's, University of London (1) · Universitas Padjadjaran (1) · University of Oxford (1) · University of Stellenbosch (1)
Vietnam (5) · China (3) · India (3) · Indonesia (3) · South Africa (3) · Brazil (2) · Malawi (2) · Tanzania (2) · Uganda (2) · Cameroon (1) · Côte d’Ivoire (1) · Kenya (1) · Madagascar (1) · Mexico (1) · Mozambique (1)
Guy Thwaites, MD (2) · Angela Loyse, MD (1) · David Boulware, MD (1) · Estee Torok (1) · Fabrice Bonnet, M.D., Ph.D. (1) · Gang Zhao, Dr. (1) · Guy Thwaites, MD, PhD (1) · Hongfei Duan, MD (1) · Nguyen H Phu, MD, PhD (1) · Novel Chegou, Prof (1) · Rovina Ruslami, M.D., PhD (1) · dr. Hendro Birowo, Sp.N, Subsp.NKI(K) (1) · dr. Maria Lawrensia Tampubolon, Sp.S (1)
PMID 33283229, PMID 29482717, PMID 35506251, PMID 35767219, PMID 36348453, PMID 37802567, PMID 37819954, PMID 38693583, PMID 41540106