8 completed, 1 terminated, 1 unknown. 10 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 10 | Completed 8, Terminated 1, Unknown 1 |
Follow Trypanosomiasis: new trials by email Literature Review of Trypanosomiasis trials Research Report on Trypanosomiasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With CCC Sacubitril/valsartan, Enalapril - Chagas Disease, Heart Failure | Phase 4 | Completed | Novartis Pharmaceuticals | 922 | 2019-12-10 | 2026-05-11 |
| Reveal Chagas: Clinical Evidence of the Implantable Cardiac Monitor in Patients With Chagas Disease Implantable Cardiac Monitor, Standard of Care - Chagas Disease, Heart Diseases | Phase 4 | Terminated | Medtronic Cardiac Rhythm and Heart Failure | 12 | 2013-07-01 | 2016-10-12 |
| Population Pharmacokinetics in Benznidazole-treated Adults With Chronic With Chagas Disease Benznidazole - Chagas Disease | Phase 4 | Completed | Barcelona Centre for International Health Research | 52 | 2012-12-01 | 2015-05-27 |
| Clinical Assessment, Neuroimaging and Immunomarkers in Chagas Disease Study (CLINICS) Aspirin - Chagas Disease With Heart Failure | Phase 4 | Unknown | Federal University of Bahia | 500 | 2012-07-01 | 2023-03-03 |
| Population Pharmacokinetics Study of Benznidazole in Children With Chagas'Disease Benznidazole 12,5mg or 100mg - Chagas' Disease | Phase 4 | Completed | Drugs for Neglected Diseases | 80 | 2011-05-01 | 2018-06-25 |
| Optimization of PCR Technique to Assess Parasitological Response for Patients With Chronic Chagas Disease Benznidazole - Chagas Disease | Phase 4 | Completed | Drugs for Neglected Diseases | 220 | 2011-04-01 | 2018-06-25 |
| Outcomes of an Anticoagulation Clinic in an University Hospital Anticoagulation clinic, Standard anticoagulation care - Cardiopathy, Chagas Disease | Phase 4 | Completed | Federal University of Minas Gerais | 280 | 2009-11-01 | 2011-10-25 |
| Clinical Study to Assess the Tolerability, Feasibility and Effectiveness of Nifurtimox and Eflornithine (NECT) for the Treatment of Trypanosoma Brucei Gambiense Human African Trypanosomiasis (HAT) in the Meningo-encephalitic Phase Nifurtimox-Eflronithine Combination Treatment (NECT) - Human African Trypanosomiasis | Phase 4 | Completed | Drugs for Neglected Diseases | 630 | 2009-04-01 | 2013-05-31 |
| Exercise Training in Chagas Cardiomyopathy Exercise training - Chagas Disease, Cardiomyopathy | Phase 4 | Completed | Federal University of Minas Gerais | 37 | 2007-03-01 | 2015-08-13 |
| A Randomized Trial of Carvedilol in Chronic Chagas Cardiomyopathy RASi plus carvedilol - Chagas Cardiomyopathy, Heart Failure | Phase 4 | Completed | Federal University of Minas Gerais | 42 | 2003-05-01 | 2015-08-13 |
Chagas Disease (8) · Heart Failure (3) · Chagas Cardiomyopathy (2) · Heart Diseases (2) · Cardiomyopathies (1) · Cardiomyopathy, Dilated (1) · Dementia (1) · Disease (1) · Hemorrhage (1) · Stroke (1) · Thrombosis (1) · Trypanosomiasis, African (1)
Euglenozoa Infections (10) · Infections (10) · Parasitic Diseases (10) · Protozoan Infections (10) · Vector Borne Diseases (10) · Cardiovascular Diseases (6) · Heart Diseases (4) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2) · Vascular Diseases (2) · Brain Diseases (1) · Cardiomegaly (1) · Cardiomyopathies (1) · Central Nervous System Diseases (1)
benzonidazole (2) · Aspirin (1) · Carvedilol (1) · Clinical Trials as Topic (1) · Control Groups (1) · Double-Blind Method (1) · Eflornithine (1) · Enalapril (1) · Exercise (1) · Nifurtimox (1) · Random Allocation (1) · Standard of Care (1) · sacubitril and valsartan sodium hydrate drug combination (1)
Drugs for Neglected Diseases (3) · Federal University of Minas Gerais (3) · Barcelona Centre for International Health Research (1) · Federal University of Bahia (1) · Medtronic Cardiac Rhythm and Heart Failure (1) · Novartis Pharmaceuticals (1)
Brazil (5) · Argentina (3) · Colombia (2) · Bolivia (1) · Mexico (1) · Republic of the Congo (1) · Spain (1)
Antonio L Ribeiro, MD, PhD (2) · Claudio Muratore, MD (1) · Daniel D Ribeiro, Physician (1) · Diego Venagas, MD (1) · Fernando A Botoni, MD, PhD (1) · Jaime Altcheh, MD (1) · Jamary Oliveira-Filho, MD, PhD (1) · Johannes Blum, MD (1) · Jose Carlos Pachon Mateos, MD (1) · Lourdes Loza, Biochemist (1) · Luis Medesani, MD (1) · Maria Auxiliadora P Martins, Pharmacist (1)
PMID 17383291, PMID 20412275, PMID 20675669, PMID 23209861, PMID 23232458, PMID 25098373, PMID 25824212, PMID 29351667, PMID 30509941, PMID 31986140, PMID 34748572, PMID 37256863, PMID 39111953, PMID 41335448
R01NS064905 (1)