37 recruiting, 28 completed, 15 unknown, 14 active not recruiting. 58 Not applicable, 3 Phase 3, 2 Phase 4, 1 Phase 1.
Follow Tricuspid Regurgitation: new trials by email Literature Review of Tricuspid Regurgitation trials Research Report on Tricuspid Regurgitation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Biventricular Remodeling in Transcatheter Tricuspid Valve Replacement - Acute Hemodynamic Instability Study Tricuspid Regurgitation, Heart Failure | Enrolling by invitation | Columbia University | 140 | 2027-01-01 | 2026-02-12 | |
| The CLASP III TR CED Study PASCAL Precision system Treated, Medicare Eligible Untreated Patients - Tricuspid Regurgitation, Heart Valve Diseases | Not yet recruiting | Edwards Lifesciences | 2350 | 2026-10-15 | 2026-10-06 | |
| Comparing the Effects of Newer Pacemakers and Their Effects on the Heart and Valve Function in the Short-term. Temporary left bundle branch area pacing, Temporary leadless right ventricular pacing - Pacemaker-Induced Cardiomyopathy, Tricuspid Regurgitation | Recruiting | Guy's and St Thomas' NHS Foundation Trust | 20 | 2026-08-18 | 2026-08-21 | |
| TRicuspid Uk STudy transcatheter edge to edge repair, Placebo - Tricuspid Regurgitation | Not applicable | Not yet recruiting | Barts & The London NHS Trust | 150 | 2026-07-31 | 2026-02-27 |
| Evaluation of a Management Algorithm for TAVI Patients With Concomitant Mitral or Tricuspid Regurgitation Aortic Stenosis, Mitral Regurgitation | Not yet recruiting | Josep Rodes-Cabau | 300 | 2026-06-05 | 2026-06-03 | |
| Active Post-Market Surveillance of Innovative Devices for Valvular Heart Disease Transcatheter Aortic Valve Replacement, Transcatheter Edge-to-Edge Repair, Transcatheter Tricuspid Valve Annuloplasty - Aortic Stenosis, Aortic Regurgitation | Not yet recruiting | Beijing Anzhen Hospital | 5500 | 2026-05-10 | 2026-05-26 | |
| TriClip Japan Post-Approval Study The TriClip System - Tricuspid Regurgitation | Recruiting | Abbott Medical Devices | 250 | 2026-03-02 | 2026-04-03 | |
| Combined Mitral and Tricuspid Versus Isolated Mitral Transcatheter Edge-to-Edge Repair for Mitral Regurgitation With Tricuspid Regurgitation (DUAL-TEER Trial) Transcatheter Edge-to-Edge Repair (TEER) System - Mitral Regurgitation, Tricuspid Regurgitation | Not applicable | Not yet recruiting | Nanjing First Hospital, Nanjing Medical University | 404 | 2026-02-01 | 2026-01-20 |
| 3D Transthoracic Echocardiographic Evaluation on Tricuspid Regurgitation Progression and Clinical Outcomes in Patients With Cardiac Implantable Electronic Device 3D Transthoracic echocardiographic evaluation - Tricuspid Regurgitation, CIED Implantation | Recruiting | Samsung Medical Center | 1000 | 2026-01-22 | 2026-08-31 | |
| TARGET 2.0 Study: Safety and Performance of the Cardiovalve TR Replacement System Cardiovalve TR valve replacement System - Tricuspid Regurgitation | Not applicable | Recruiting | Cardiovalve Ltd. | 150 | 2026-01-20 | 2026-05-11 |
| The STTAR-US Study: A Pivotal Study of Transcatheter Tricuspid Annular Repair in the US MIA_T Device - Tricuspid Regurgitation Functional, Tricuspid Regurgitation | Not applicable | Not yet recruiting | Micro Interventional Devices | 600 | 2025-12-31 | 2025-11-26 |
| A Multicenter Study on the Normal Reference Range and Clinical Significance of the Right Atrioventricular Coupling Index Assessed by Artificial Intelligence-Based Three-Dimensional Echocardiography Healthy Adults, Pulmonary Hypertension | Not yet recruiting | First Hospital of China Medical University | 2640 | 2025-12-01 | 2025-12-18 | |
| Early Phase Study Using the 'Pivot Extend' System as a Treatment for Patients With Tricuspid Regurgitation Pivot Extend - Tricuspid Regurgitation | Not applicable | Recruiting | Tau Medical Australia Pty Ltd | 10 | 2025-11-11 | 2025-12-09 |
| Safety and Feasibility Study: Transcatheter Valve Repair in Severe Symptomatic Functional Tricuspid Regurgitation Tricuspid Annular Therapy System - Tricuspid Regurgitation Functional, Tricuspid Regurgitation (TR) | Not applicable | Recruiting | Tangent Cardiovascular Inc. | 25 | 2025-07-15 | 2026-10-13 |
| TriClip CED RWE Study The TriClip System - Tricuspid Regurgitation | Recruiting | Abbott Medical Devices | 2200 | 2025-07-08 | 2025-08-11 | |
| Application of Comprehensive Non-invasive Assessment To Phenotype Tricuspid Regurgitation ReDs Pro, Fibroscan - Tricuspid Regurgitation | Recruiting | Prince of Wales Hospital, Shatin, Hong Kong | 450 | 2025-04-01 | 2026-09-16 | |
| Pacemaker-related Tricuspid Regurgitation Progression and Long-term Outcomes Pacemaker implantation - Tricuspid Regurgitation, Pacemaker | Recruiting | Haiyan Wang | 200 | 2025-04-01 | 2025-04-30 | |
| TTVR STRONG Under Coverage With Evidence Development (CED) Study EVOQUE - Tricuspid Regurgitation | Recruiting | Edwards Lifesciences | 2044 | 2025-03-19 | 2026-09-29 | |
| Optimization of Heart Failure (HF) Medical Therapy After Transcatheter Valve Intervention (TVI) in Patients With Heart Failure With Reduced Ejection Fraction (HFrEF) Rapid Uptitration of Guideline-Directed Medical Therapy, Elecsys® NT-proBNP - Roche Diagnostics, Rapid Up-Titration GDMT Group with Hospital Monitoring - Heart Failure, Valvulopathy | Not applicable | Not yet recruiting | IRCCS Ospedale San Raffaele | 160 | 2025-02-01 | 2024-11-04 |
| Evaluation of the Impact of Interventional Treatments for Symptomatic, Severe Tricuspid Valve Insufficiency on Renal Integrity and Function, as Well as on Physical Function and Activity in Older Adults. Transcatheter edge-to-edge repair (TEER) - Tricuspid Regurgitation, Tricuspid Valve Insufficiency | Recruiting | Robert Bosch Medical Center | 100 | 2025-02-01 | 2026-03-11 |
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Tricuspid Valve Insufficiency (114) · Heart Failure (16) · Mitral Valve Insufficiency (15) · Heart Valve Diseases (12) · Aortic Valve Stenosis (6) · Aortic Valve Insufficiency (4) · Cardiovascular Diseases (4) · Heart Diseases (3) · Mitral Valve Stenosis (3) · Gastroesophageal Reflux (2) · Ventricular Dysfunction, Right (2) · Aortic Valve Disease (1) · Atrial Fibrillation (1) · Atrial Remodeling (1) · Carcinoid Heart Disease (1)
Heart Diseases (111) · Cardiovascular Diseases (110) · Heart Valve Diseases (102) · Aortic Valve Disease (6) · Ventricular Outflow Obstruction (6) · Pathological Conditions, Signs and Symptoms (5) · Pathologic Processes (4) · Cardiovascular Abnormalities (2) · Congenital Abnormalities (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Deglutition Disorders (2) · Digestive System Diseases (2) · Esophageal Diseases (2) · Esophageal Motility Disorders (2) · Gastrointestinal Diseases (2)
Hydroxyethyl Starch Derivatives (3) · Carvedilol (1) · Caves (1) · Drug Delivery Systems (1) · Echocardiography (1) · Enavogliflozin (1) · Exercise Test (1) · Nutrition Therapy (1) · Preoperative Exercise (1) · Surgical Procedures, Operative (1) · Transcatheter Aortic Valve Replacement (1) · dapagliflozin (1) · empagliflozin (1)
Edwards Lifesciences (7) · LMU Klinikum (5) · Abbott Medical Devices (4) · Asan Medical Center (3) · Cardiovalve Ltd. (3) · Hangzhou Valgen Medtech Co., Ltd (3) · Konkuk University Medical Center (3) · Michele De Bonis (3) · Shanghai Huihe Medical Technology Co., Ltd (3) · 4Tech Cardio Ltd. (2) · Beijing Anzhen Hospital (2) · Charite University, Berlin, Germany (2) · CroiValve Limited (2) · First Hospital of China Medical University (2) · Heart and Diabetes Center North-Rhine Westfalia (2)
Germany (29) · United States (29) · China (16) · Italy (14) · France (11) · South Korea (9) · Spain (8) · Canada (7) · Belgium (6) · Netherlands (6) · United Kingdom (6) · Austria (5) · Denmark (4) · Poland (4) · Switzerland (4)
Daniel Braun, MD (2) · Georg Nickenig, MD (2) · Adam Rdzanek, MD PhD (1) · Aldo Rinaldi, MD (1) · Allen Anderson, MD (1) · Andrea Scotti, MD (1) · Andreas Baumbach (1) · Annetine C. Gelijns, PhD (1) · Antonio Colombo, MD (1) · Azeem Latib, MD (1) · Brian P O'Neill, MD (1) · Charles Davidson, MD (1) · Chunsheng Wang, MD (1) · Chunyan Ma, MD (1)
PMID 23487435, PMID 24698557, PMID 30255476, PMID 30999993, PMID 33046437, PMID 33413863, PMID 33478647, PMID 33509390, PMID 33559474, PMID 33722059, PMID 33744150, PMID 34294396, PMID 34767705, PMID 35576863, PMID 36517335, PMID 36669972, PMID 36876753, PMID 37137586, PMID 37278243, PMID 38818766, PMID 38938712, PMID 39222896, PMID 39466215, PMID 39570246, PMID 39602173, PMID 39663060, PMID 39903153, PMID 40159089, PMID 40637674, PMID 40707240, PMID 41235431, PMID 41243777, PMID 41258847, PMID 41575411, PMID 41706073, PMID 41881643, PMID 41955173, PMID 42736580, PMID 42855029, PMID 42866868
2023 (1), U01HL088942 (1)