111 completed, 33 unknown, 13 recruiting, 6 active not recruiting. 154 Not applicable, 4 Phase 2, 2 Phase 1, 2 Phase 3.
Follow Malocclusion, Angle Class II: new trials by email Literature Review of Malocclusion, Angle Class II trials Research Report on Malocclusion, Angle Class II
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Treatment of Skeletal Class II Malocclusion With Modified Twin-Block Appliance With Clear Plates Modified Twin-Block Appliance with Clear Plates., Traditional Twin-Block appliance - Malocclusion, Angle Class II | Not applicable | Recruiting | Hama University | 32 | 2027-03-15 | 2026-09-16 |
| 3D Printed Occlusal Splints for Intraoperative Use Formlabs 3D printed occlusal splint, Industry made occlusal splint - Malocclusion, Angle Class I, Malocclusion, Angle Class II | Not applicable | Not yet recruiting | Johns Hopkins University | 70 | 2026-12-30 | 2026-08-11 |
| Comparing 3D-Printed and Milled Titanium Plates in Jaw Surgery (Le Fort I): Accuracy and Operative Time 3D-Printed Patient-Specific Titanium Plates, Milled Patient-Specific Titanium Plates - Malocclusion, Angle Class II, Malocclusion, Angle Class III | Not applicable | Recruiting | Future University in Egypt | 12 | 2026-10-01 | 2026-09-25 |
| Maxillary Arch Distalization With Infrazygomatic Crest Miniscrews for Class II Malocclusion Infrazygomatic Crest Miniscrews - Class II Malocclusion | Not applicable | Recruiting | Mansoura University | 16 | 2026-09-15 | 2026-10-20 |
| Treatment of Mild Class II Malocclusion in Adult Patients With Clear Aligners Versus Fixed Multibracket Therapy clear aligners, traditional treatment Fixed appliances with class II elastics. - Malocclusion, Class II Malocclusion | Not applicable | Recruiting | Hama University | 24 | 2026-08-25 | 2026-09-16 |
| Long-term Stability of Treatment With the Twin Block Appliance Malocclusion, Angle Class II, Overbite (Excessive) Horizontal | Enrolling by invitation | Region Jönköping County | 72 | 2026-07-10 | 2026-08-07 | |
| Twin-Block and LIPUS for TMJ Outcomes in Skeletal Class II Patients ultrasound - CLASS II DIVISION 1 MALOCCLUSION | Not applicable | Recruiting | Al-Azhar University | 24 | 2026-06-18 | 2026-06-30 |
| Modified Versus Clear Twin Block for Skeletal Class II Malocclusion Modified Twin Block Appliance, Conventional Clear Twin Block Appliance - Skeletal Class II Malocclusion | Not applicable | Active not recruiting | University of Aleppo | 40 | 2026-05-17 | 2026-07-14 |
| LLLLT vs Piezocision in Accelerating Orthodontic Canine Retraction Low Level Laser Therapy, Piezocision - Malocclusion, Angle Class II, Division 1, Bimaxillary Protrusion | Not applicable | Recruiting | Hesham Nabil Ali Al-Qamhawy | 21 | 2026-04-01 | 2026-05-11 |
| The Effectiveness of the Twin Block and Carriere Motion Appliances in Post-pubertal Patients and an Evaluation of the Impact of Class II Malocclusion and Its Correction on Oral Health-related Quality of Life CTB, CMA - CLASS II DIVISION 1 MALOCCLUSION, Class II Malocclusion | Not applicable | Not yet recruiting | Aslam Alkadhimi | 88 | 2026-03-01 | 2025-12-18 |
| Comparison of Early Interceptive Orthodontic Appliances (Traditional and Novel) and Later Fixed Appliance Treatment in Class II Malocclusion. Head gear activator, Twin Block, Invisalign mandibular advancement - Class II Malocclusion, Class II Malocclusion, Division 1 | Not applicable | Not yet recruiting | Vastra Gotaland Region | 144 | 2026-01-15 | 2026-02-11 |
| Effects of Anterior Bite Turbos on Deep Bite Treatment and Chewing Muscles Anterior Bite Turbo, Fixed Orthodontic Treatment - Deep Bite Malocclusion | Not applicable | Completed | Ankara University | 28 | 2025-10-20 | 2026-10-01 |
| EVALUATION OF TREATMENT CHANGES IN CLASS II DIVISION 1 MALOCCLUSION DURING EN MASSE RETRACTION OF UPPER ANTERIOR TEETH USING MINI IMPLANTS PLACED AT INFRAZYGOMATIC CREST AND INTERRADICULAR SITES A RANDOMIZED CLINICAL TRIAL. retraction of anterior teeth using mini implants placed at infrazygomatic crest., retraction of anterior teeth using mini implants placed at interradicular sites. - CLASS II DIVISION 1 MALOCCLUSION | Not applicable | Recruiting | Postgraduate Institute of Dental Sciences Rohtak | 30 | 2025-10-01 | 2026-02-12 |
| Evaluation of a Novel Lip Bumper With Integrated Distal Shoe Appliance in Preventing Second Molar Impaction in Children With Anterior Deep Bite Lip Bumper with Integrated Distal Shoe, Conventional Lip Bumper - Bite, Orthodontics | Not applicable | Not yet recruiting | Dar Al Uloom University | 40 | 2025-09-15 | 2025-08-22 |
| Effects of Different Anchorage Methods and Low-Level Laser Therapy in Power Bar Distalization Power Bar Distalization Appliance, Mandibular Miniscrew Anchorage, Mandibular Orthodontic Button Anchorage - Class II Malocclusion | Not applicable | Completed | TC Erciyes University | 57 | 2025-09-10 | 2026-10-22 |
| Root Shortening With Three Methods of Upper Front Teeth Retraction Bidimensional Bracket System, Hybrid Dual-Section Archwire, Conventional Sliding Mechanics - CLASS II DIVISION 1 MALOCCLUSION | Not applicable | Completed | Damascus University | 60 | 2025-07-02 | 2026-08-04 |
| A Novel Bi-dimensional Archwire for Miniscrew-supported En-masse Retraction Bi-dimensional archwire - Malocclusion Class II, CLASS II DIVISION 1 MALOCCLUSION | Not applicable | Completed | Damascus University | 6 | 2025-07-01 | 2026-06-24 |
| Three-Dimensional Evaluation of Pharyngeal Airway and Facial Dimension Changes in Skeletal Class II Patients Treated With Twin Block Versus Myobrace Appliances myobrace appliance, Twin block - Class II Division 1 Adolescent Patients | Not applicable | Enrolling by invitation | University of Baghdad | 50 | 2025-05-20 | 2025-05-16 |
| Microbial Adherence, Surface Roughness, Effectiveness and Impact on Patients Between Conventional and 3D Printed Twin Block Appliances Conventional TBA, 3D TBA - Orthodontic Appliances, Removable, Orthodontic Appliance Complication | Not applicable | Recruiting | University of Malaya | 32 | 2025-05-01 | 2025-06-18 |
| Dentoskeletal Effects of 3D-Printed Fixed Twin Block Versus MARA Appliances in Management of Skeletal Class II MARA appliance, fixed twin block - Class II Malocclusion, Mandibular Deficiency | Not applicable | Recruiting | Mansoura University | 60 | 2025-04-27 | 2026-01-14 |
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Overbite (69) · Malocclusion (18) · Malocclusion, Angle Class III (8) · Malocclusion, Angle Class I (7) · Pain (4) · Retrognathia (4) · Micrognathism (3) · Bites and Stings (2) · Dentofacial Deformities (2) · Arthritis, Juvenile (1) · Root Resorption (1) · Sleep Apnea, Obstructive (1) · Wounds and Injuries (1)
Stomatognathic Diseases (176) · Tooth Diseases (176) · Malocclusion (158) · Musculoskeletal Diseases (9) · Congenital Abnormalities (8) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (8) · Craniofacial Abnormalities (8) · Maxillofacial Abnormalities (8) · Musculoskeletal Abnormalities (8) · Stomatognathic System Abnormalities (8) · Jaw Abnormalities (7) · Jaw Diseases (7) · Mandibular Diseases (4) · Neurologic Manifestations (4)
Low-Level Light Therapy (10) · Orthodontic Appliances, Fixed (6) · Orthodontics (6) · Orthodontic Appliances, Functional (4) · Piezosurgery (4) · Lasers (3) · Activator Appliances (2) · Electric Stimulation (2) · Lasers, Solid-State (2) · Myofunctional Therapy (2) · Orthodontic Appliances, Removable (2) · morpholinopropane sulfonic acid (2) · Acceleration (1) · Blood Grouping and Crossmatching (1) · Dental Health Services (1)
Damascus University (37) · Al-Azhar University (15) · Postgraduate Institute of Dental Sciences Rohtak (11) · Mansoura University (9) · Cairo University (7) · Future University in Egypt (5) · Ain Shams University (4) · Bezmialem Vakif University (4) · University of Alberta (4) · Wroclaw Medical University (4) · Hama University (3) · University of Rome Tor Vergata (3) · Alexandria University (2) · Aristotle University Of Thessaloniki (2) · Atlas University (2)
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