45 completed. 45 Phase 3, 10 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 45 | Completed 45 |
| Phase 2 | 10 | Completed 10 |
Follow Tooth Demineralization: new trials by email Literature Review of Tooth Demineralization trials Research Report on Tooth Demineralization
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Study to Evaluate the Anti-cavity Efficacy of Three Dentifrices: An In Situ Model Fluoride free toothpaste in a chalk base, Fluoride Toothpaste, Fluoride free toothpaste in a PCC/RNCC base - Demineralization, Remineralization | Phase 3 | Completed | Colgate Palmolive | 36 | 2025-10-09 | 2026-02-06 |
| Evaluation of the Anti-cavity Efficacy of Three Dentifrices Using an Intra-oral Enamel Demineralization - Remineralization In-Situ Model Fluoride Toothpaste, Fluoride free toothpaste in a chalk base, Fluoride free toothpaste in a PCC/RNCC base - Enamel Lesions, Demineralization, Tooth | Phase 3 | Completed | Colgate Palmolive | 36 | 2025-03-13 | 2025-08-06 |
| Clinical Assessment of Injectable Flowable Composite with Giomer Technology Vs High Viscosity Glass Ionomer Restorations in ART for Cancer Patients giomer, high viscosity glass ionomer - Secondary Caries, Fracture Tooth | Phase 3 | Completed | Cairo University | 190 | 2023-02-07 | 2024-09-25 |
| Investigate a Varnish to Protect From Erosive Toothwear Varnishes, Fluoride - Tooth Erosion | Phase 3 | Completed | Colgate Palmolive | 24 | 2022-04-08 | 2023-11-18 |
| A Comparison of Oral Sedation-related Events of Three Multiagent Oral Sedation Regimens in Pediatric Dental Patients Regimen 1, Regimen #2, Regimen #3 - Anxiety, Dental, Dental Decay | Phase 3 | Completed | Loma Linda University | 60 | 2022-02-14 | 2024-10-02 |
| Caries Removal in Primary Teeth Using Er:YAG Laser Er:YAG laser system (Doctor smile, Pluser, Italy), Master Torque high/low-speed air rotor handpiece (KaVo Dental, Charlotte, North Carolina, USA) - Dental Caries | Phase 3 | Completed | King Abdulaziz University | 40 | 2020-01-01 | 2023-06-22 |
| 2-year Caries Clinical Study: Arginine Fluoride-Free Toothpastes vs. NaF Toothpaste 0.32% Sodium Fluoride Dentifrice Toothpaste, 1.5% Arginine Dentifrice, 8.0% Arginine Dentifrice - Dental Caries | Phase 3 | Completed | Colgate Palmolive | 6000 | 2019-04-15 | 2022-10-03 |
| Antibacterial Effect and Clinical Performance of Chitosan Modified Glass Ionomer Glass Ionomer, Chitosan Low Molecular Weight (20-200 Mpa.S), Chlorhexidine Diacetate - Reversible Pulpitis, Pulpitis | Phase 3 | Completed | Ain Shams University | 65 | 2019-01-15 | 2021-01-12 |
| Fluoride Release,Compressive Strength and Clinical Performance of a Bioactive Restorative Material in ART Fuji IX EXTRA, ACTIVA KIDS bioactive restorative material - Dental Caries | Phase 3 | Completed | Marina F Fahmy, MD | 110 | 2018-11-17 | 2023-01-19 |
| Child Discomfort and Parental Acceptability of Silver Diamine Fluoride and Alternative Restorative Treatment SDF, ART - Dental Caries, Child Discomfort | Phase 2 / Phase 3 | Completed | Nourhan M.Aly | 80 | 2018-10-12 | 2020-12-04 |
| Antibacterial Effect of Nano Silver Fluoride vs Chlorhexidine on Occlusal Carious Molars Treated With Partial Caries Removal Technique Nano silver fluoride solution, Cavity Cleanser - Dental Caries | Phase 3 | Completed | Cairo University | 44 | 2018-04-01 | 2021-09-16 |
| In Situ Erosion Study to Investigate the Effectiveness of an Experimental Toothpaste 0.254% w/w sodium fluoride and 5% KNO3, 0.454% w/w stannous fluoride, 5% KNO3 - Tooth Erosion | Phase 3 | Completed | GlaxoSmithKline | 62 | 2017-11-13 | 2020-09-16 |
| The Caries-arresting Effect of Incorporating fTCP to NaF Varnish Applied Following AgNO3 in Preschool Children 25% AgNO3 solution followed by 5% NaF, 25% AgNO3 solution followed by 5% NaF with fTCP - Early Childhood Caries | Phase 3 | Completed | The University of Hong Kong | 408 | 2017-09-01 | 2020-11-04 |
| Evaluation of Triple Antibiotic Paste Pulp Therapy Compared to Vitapex in Primary Molars. triple antibiotic paste (TAP), Vitapex (calcium hydroxide/iodoform paste) - Dental Pulp Cavity | Phase 3 | Completed | King Abdulaziz University | 54 | 2017-06-01 | 2020-09-14 |
| Evaluation in Vivo of Mouthwash With Nanoencapsulated Fluoride Mouthwash 100% Nano-F, Mouthwash 50% Nano-F, Mouthwash standard - Dental Caries | Phase 3 | Completed | Fabio Correia Sampaio | 21 | 2016-11-01 | 2021-12-03 |
| Stopping Cavities Study: Diammine Silver Fluoride 38% diammine silver fluoride, Water - Dental Caries | Phase 3 | Completed | Advantage Dental Services, LLC | 66 | 2016-01-01 | 2020-01-23 |
| Consumption of Probiotics on Salivary Bacteria Causing Dental Caries probiotic, placebo - Dental Caries | Phase 2 / Phase 3 | Completed | Sharda University | 40 | 2015-04-01 | 2016-04-27 |
| A Clinical Trial to Assess the Retention and Caries Preventive Effect of Resin Based Sealants Versus ART Sealants Helioseal - F, ART sealant - Dental Caries | Phase 2 / Phase 3 | Completed | Dr. Praveen B.H | 180 | 2015-03-01 | 2021-01-06 |
| Fluoride Application on Preventing and Arresting Root Caries in Fluoridated and Non-fluoridated Areas water as placebo, silver diammine fluoride - Dental Caries | Phase 2 / Phase 3 | Completed | The University of Hong Kong | 534 | 2012-10-01 | 2016-04-18 |
| Ceramic Versus Composite in the Treatment of Posterior Teeth by Inlays or Onlays ceramic (Empress CAD, Ivoclar Vivadent), composite (Lava Ultimate, 3M Espe) - Dental Caries, Inlays | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 355 | 2012-09-13 | 2018-03-13 |
Showing 20 of 45. Sign in to see all of them.
Dental Caries (43) · Tooth Erosion (2) · Anxiety Disorders (1) · Bicuspid Aortic Valve Disease (1) · Fluorosis, Dental (1) · Hypersensitivity (1) · Kidney Diseases (1) · Migraine Disorders (1) · Neurologic Manifestations (1) · Periodontal Diseases (1) · Plaque, Amyloid (1) · Pulpitis (1) · Tooth Discoloration (1) · Tooth Fractures (1)
Stomatognathic Diseases (45) · Tooth Diseases (45) · Congenital Abnormalities (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Nervous System Diseases (2) · Pathological Conditions, Signs and Symptoms (2) · Tooth Wear (2) · Aortic Valve Disease (1) · Brain Diseases (1) · Cardiovascular Abnormalities (1) · Cardiovascular Diseases (1) · Central Nervous System Diseases (1) · Dental Enamel Hypomineralization (1) · Dental Pulp Diseases (1)
Water (3) · silver diamine fluoride (3) · Fluorides (2) · Probiotics (2) · chlorhexidine gluconate (2) · 4-fluoro-1-(1-(2-thienyl)cyclohexyl)piperidine (1) · Adhesives (1) · Bisco Cavity Cleanser (1) · CMW cement (1) · Calcium Hydroxide (1) · Chlorhexidine (1) · Dental Implants (1) · Dentifrices (1) · Early Intervention, Educational (1) · Fluorides, Topical (1)
Colgate Palmolive (4) · GlaxoSmithKline (4) · The University of Hong Kong (4) · University of Washington (3) · Cairo University (2) · Federal University of Pelotas (2) · King Abdulaziz University (2) · University of California, San Francisco (2) · Advantage Dental Services, LLC (1) · Ain Shams University (1) · Assistance Publique - Hôpitaux de Paris (1) · CES University (1) · Carelon Research (1) · Dr. Praveen B.H (1) · Fabio Correia Sampaio (1)
United States (18) · Brazil (7) · China (5) · Egypt (5) · Saudi Arabia (2) · Canada (1) · Colombia (1) · France (1) · India (1) · United Kingdom (1)
Edward CM Lo, BDS, PhD (3) · Maximiliano S Cenci, PhD (2) · Alexandra Saldarriaga, Master of Sience (1) · Amel M Ahmed, Phd (1) · Amid Ismail (1) · Ana R Romano, PhD (1) · Athena Papas, DMD, PhD (1) · Athena Papas, PhD DMD (1) · Chun Hung Chu, Ph.D (1) · David Bartlett, Dr (1) · Domenick T Zero, DDS MS (1) · Francisco J Ramos-Gomez, DDS,MS, MPH (1) · Francisco Ramos-Gomez, DDS, MPH (1)
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R01DE012215 (1), R01DE014403 (1), U01DE011886 (1), U01DE011894 (1), U01DE016755 (1), U01DE017753 (1), U01DE018038 (1), U54DE014261 (1)