48 completed, 3 not yet recruiting, 3 recruiting, 3 unknown. 37 Phase 3, 7 Not applicable, 6 Phase 2, 5 Phase 1, 4 Phase 4.
Follow Lactic Acid: new trials by email Literature Review of Lactic Acid trials Research Report on Lactic Acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Lactate and Glycerol Contribution to Gluconeogenesis Glycerol, Lactate, Glucose - Type 2 Diabetes, Obesity | Not applicable | Not yet recruiting | Rutgers, The State University of New Jersey | 48 | 2026-07-01 | 2025-12-02 |
| Correlation of Cardiac Index Measured by the PRAM Method With NIRS and Lactate Levels in Pediatric Aortic Coarctation Surgery MostCare (PRAM), Near-Infrared Spectroscopy (NIRS), Arterial Blood Gas with Lactate - Aortic Coarctation, Cardiac Output, Low | Not yet recruiting | Konya City Hospital | 43 | 2026-05-01 | 2026-05-05 | |
| A Study to Evaluate the Safety, Efficacy, and Pharmacodynamics of PLL001 in ALS Patients PLL001 or placebo daily subcutaneous injections - Amyotrophic Lateral Sclerosis, ALS | Phase 1 / Phase 2 | Not yet recruiting | PLL TX AUSTRALIA PTY LTD | 153 | 2026-04-08 | 2026-03-19 |
| Does Co-administration of Lactate Affect Postprandial Nutrient Absorption and Fat Disposition? Placebo + mixed meal, Lactate + mixed meal, PET-scan - Pre Diabetes, Metabolic Syndrome | Not applicable | Recruiting | University of Aarhus | 25 | 2024-08-22 | 2025-06-19 |
| A Safety and Efficacy Trial of Istaroxime for Cardiogenic Shock Stage C Istaroxime, Placebo - Cardiogenic Shock | Phase 1 / Phase 2 | Active not recruiting | Windtree Therapeutics | 20 | 2024-06-01 | 2025-08-20 |
| Does Co-administration of Lactate to an Oral Glucose Tolerance Test Lower the Glucose Response? Lactate, Placebo - PreDiabetes, Metabolic Syndrome | Not applicable | Completed | University of Aarhus | 12 | 2024-04-11 | 2024-09-25 |
| Combined Microneedling With Either 1% Lactic Acid Solution or Vitamin D3 or Triamcinolone Acetonide in The Treatment of Alopecia Areata Lactic Acid, vit D, Triamcinolone Acetonide - Alopecia Areata | Not applicable | Recruiting | Zagazig University | 88 | 2023-12-15 | 2026-01-26 |
| STA363 in the Treatment of Lumbar Disc Herniation Lactic Acid, Placebo - Lumbar Disc Herniation | Phase 1 | Completed | Stayble Therapeutics | 25 | 2023-07-25 | 2025-12-10 |
| Safety of Serum for Post-Inflammatory on Hyperpigmentation Skin Serum with low concentration AHA (1% Glycolic acid and Lactic acid) and PGA - Healthy | Not applicable | Completed | USMARI Research & Innovation Centre | 34 | 2023-07-01 | 2026-03-06 |
| Biperiden Trial for Epilepsy Prevention Biperiden, Placebo - Brain Injury Traumatic Moderate, Brain Injury Traumatic Severe | Phase 3 | Recruiting | Hospital Sirio-Libanes | 312 | 2023-01-10 | 2024-03-26 |
| Physiotherapy for Persistent COVID-19 Disease Using Aerobic Exercise Experimental, Control - COVID-19, Genetic Predisposition to Disease | Not applicable | Completed | Universidad Francisco de Vitoria | 30 | 2022-03-01 | 2023-08-14 |
| Effect of Propolis on Patients Infected With H. Pylori propolis solved in lactic acid solvent, Amoxicillin-Clarithromycin-Lansoprazole, IV saline 0.9% - Helicobacter Pylori Infection | Phase 4 | Unknown | Fatma Zehra Arvas | 96 | 2022-02-22 | 2022-02-28 |
| Exploring the Effect of Lactate Administration After Ischemic Stroke on Brain Metabolism Lactate, Placebo - Stroke, Acute | Phase 2 | Terminated | Centre Hospitalier Universitaire Vaudois | 28 | 2021-08-05 | 2025-04-17 |
| Study Investigating STA363 Compared to Placebo in Patients With Chronic Discogenic Low Back Pain STA363 containing 90 mg (60 mg/mL) lactic acid, STA363 containing 180 mg (120 mg/mL) lactic acid, Placebo - Discogenic Pain | Phase 2 | Completed | Stayble Therapeutics | 110 | 2020-07-31 | 2025-12-10 |
| Effects of Goat Milk Yogurt on Postprandial Glycemic Responses, Arterial Blood Pressure and Energy Intake Glucose as reference food, Goat milk as test food, Goat milk and currants as test food - Potential Abnormality of Glucose Tolerance, Appetite; Lack or Loss, Nonorganic Origin | Not applicable | Completed | Agricultural University of Athens | 62 | 2019-04-06 | 2021-10-06 |
| Comparison of 12% Ammonium Lactate and 10% Urea Cream in Geriatric With Xerosis Cutis Ammonium Lactate, Urea - Xerosis Cutis | Phase 3 | Completed | Universitas Indonesia | 40 | 2017-04-01 | 2019-10-15 |
| Serum Lactate in Convulsive Syncopes Compared to Non-convulsive Syncopes Lactate, prolactin and creatine kinase conc. - Syncope, Lactate Blood Increase | Unknown | RWTH Aachen University | 100 | 2017-01-01 | 2017-03-06 | |
| Lactate Levels During Cardiopulmonary Bypass in Pediatric Patients Lactate - Heart Defects, Congenital | Completed | Assiut University | 40 | 2015-12-01 | 2016-03-07 | |
| Study of Resting and Exercising Body Functioning in Freeman-Sheldon Syndrome and Related Conditions Lactate, Glucose, and Adenosine Triphosphate Blood Levels, Physiological Stress Test, Functional Enquiry Form - Arthrogryposis, Craniofacial Abnormalities | Withdrawn | Freeman-Sheldon Research Group, Inc. | 2014-03-01 | 2022-06-06 | ||
| A Phase I/II to Assess Safety, Tolerability and Efficacy of DL-lactic Acid Syrup in Children With Recurrent Tonsillitis DL - Lactic Acid, Raspberry flavored syrup - Recurrent Tonsillitis in Children | Phase 1 / Phase 2 | Completed | Yali Pharmaceuticals | 51 | 2013-12-01 | 2016-10-07 |
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Arthrogryposis (2) · Craniofacial Abnormalities (2) · Metabolic Syndrome (2) · Alopecia Areata (1) · Amyotrophic Lateral Sclerosis (1) · Aortic Coarctation (1) · Brain Injuries (1) · COVID-19 (1) · Cardiac Output, Low (1) · Depression (1) · Depressive Disorder (1) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 2 (1) · Epilepsy (1) · Epilepsy, Post-Traumatic (1)
Sanofi (37) · Freeman-Sheldon Research Group, Inc. (2) · Stayble Therapeutics (2) · University of Aarhus (2) · Agricultural University of Athens (1) · Assiut University (1) · Centre Hospitalier Universitaire Vaudois (1) · Fatma Zehra Arvas (1) · Heidelberg University (1) · Hospital Sirio-Libanes (1) · Institut d'Anesthesiologie des Alpes Maritimes (1) · Konya City Hospital (1) · National Taiwan University Hospital (1) · PLL TX AUSTRALIA PTY LTD (1) · RWTH Aachen University (1)
Brazil (36) · United States (4) · Denmark (2) · Egypt (2) · France (2) · Germany (2) · Israel (2) · Italy (2) · Poland (2) · Spain (2) · Argentina (1) · Austria (1) · Finland (1) · Greece (1) · Guatemala (1)
Jaderson Lima (31) · Jaderson Lima, MD (2) · Ankit Shah, MD (1) · Bedia Mine Hanedan, MD (1) · Claus P Schmitt, M.D. (1) · David Varillas Delgado, PhD (1) · Eliana Garzon, MD, PhD (1) · Jan Willem Kallewaard, MD, PhD (1) · Jean-Christophe Orban, MD (1) · Judith Diaz, Md (1) · Lorenz Hirt, MD (1) · Luiz E Mello, MD, PhD (1)
PMID 23124784, PMID 26174733, PMID 26178231, PMID 26494722, PMID 28034943, PMID 28264711, PMID 36084082
2019 (2)