68 completed, 16 recruiting, 12 unknown, 8 not yet recruiting. 49 Not applicable, 20 Phase 3, 13 Phase 2, 7 Phase 1, 6 Phase 4.
Follow Spasticity: new trials by email Literature Review of Spasticity trials Research Report on Spasticity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Lateral Cord Stimulation as a New Treatment for Refractory Spastic Cerebral Palsy Lateral spinal cord surgical implant of electrodes - Cerebral Palsy, Spasticity | Not applicable | Not yet recruiting | Juan Carlos M. Andreani MD | 40 | 2027-06-01 | 2026-04-28 |
| A Study to Investigate Arbaclofen ER Tablets for the Treatment of Spasticity in Patients With Multiple Sclerosis Arbaclofen, Placebo - Spasticity | Phase 3 | Not yet recruiting | RVL Pharmaceuticals, Inc. | 442 | 2027-01-01 | 2025-12-03 |
| Early Botulinum Toxin for Muscle Stiffness Reduction in First-Time Stroke Patients: Improving Recovery and Independence Botulinum Toxin Type A (BoNT-A) - Spasticity, Stroke | Early Phase 1 | Not yet recruiting | Instituto Mexicano del Seguro Social | 200 | 2026-12-01 | 2026-11-04 |
| Addressing Spasticity and Motor Function With Epidural Spinal Cord Stimulation Epidural implant stimulation device - SCI - Spinal Cord Injury, Spasticity | Not applicable | Recruiting | Kessler Foundation | 8 | 2026-10-01 | 2026-10-22 |
| Extracorporeal Shockwave Therapy as an Additional Treatment for Spasticity Secondary to Spinal Cord Injury Focused extracorporeal shockwave therapy, Botulinum toxin, Sham - Spinal Cord Injury, Spasticity | Phase 2 | Recruiting | Kessler Foundation | 30 | 2026-09-21 | 2026-11-04 |
| Collagenase Injection for Spasticity Management XIAFLEX Collagenase injection - Spasticity | Early Phase 1 | Not yet recruiting | The University of Texas Health Science Center, Houston | 15 | 2026-09-01 | 2026-07-09 |
| The Use of Photobiomodulation in the Treatment of Spasticity After Stroke. Photobiomodulation Therapy, Placebo PBM, Standard Multidisciplinary Rehabilitation Program for Spasticity - Stroke, Spasticity | Phase 1 / Phase 2 | Recruiting | University of Nove de Julho | 42 | 2026-08-28 | 2026-09-01 |
| Co-contraction and Corticoreticular Excitability in Spinal Cord Injury Corticoreticular excitability and co-contraction measurement - Spinal Cord Injury, Spasticity | Not applicable | Enrolling by invitation | Taipei Veterans General Hospital, Taiwan | 20 | 2026-07-27 | 2026-10-14 |
| Dorsal Root Electrical Stimulation in Children With Cerebral Palsy Constant Current Stimulator, Cadwell Guardian System - Cerebral Palsy (CP), Cerebral Palsy | Not applicable | Recruiting | Martin Piazza | 15 | 2026-07-16 | 2026-08-11 |
| Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain Chronic Pain, PERIPHERAL NEUROPATHY | Recruiting | Yale University | 80 | 2026-06-20 | 2026-08-21 | |
| Effects of Functional Electrical Stimulation on Spasticity, Quadriceps Muscle Strength and Functional Mobility in Individuals With Paraplegia Conventional Neurorehabilitation, Functional Electrical Stimulation (FES) of Quadriceps Muscle, Sham FES group: Conventional neurorehabilitation + sham/placebo FES - Spinal Cord Injury, Paraplegia | Not applicable | Withdrawn | Istanbul Medipol University Hospital | 2026-05-10 | 2026-10-28 | |
| Spinal Cord Stimulation for Children With Cerebral Palsy Transcutaneous Spinal Cord Stimulation (tSCS) - Cerebral Palsy, Spasticity | Not applicable | Recruiting | Martin Piazza | 30 | 2026-03-30 | 2026-04-07 |
| At Home Use of Stimulation Suits for Managing MS Symptoms electro-stimulation suit, Usual Care - Multiple Sclerosis, MS (Multiple Sclerosis) | Not applicable | Recruiting | Daphne Kos | 70 | 2026-03-16 | 2026-10-08 |
| Shockwave for Elbow and Wrist Spasticity in People With Spinal Cord Injury Focused extracorporeal shockwave therapy - Spinal Cord Injury, Spasticity | Phase 1 | Recruiting | Kessler Foundation | 12 | 2026-03-06 | 2026-10-22 |
| Effects Of Spiral Strapping Systems On Upper Limb Function In Unilateral Spastic Cerebral Palsy TheraTogs® Spiral Strapping System, TogRite™ Spiral Strapping System, Upper Limb Rehabilitation and Home Exercise Program - Cerebral Palsy (CP), Hand Grip Strength | Not applicable | Not yet recruiting | Abant Izzet Baysal University | 27 | 2026-02-15 | 2026-02-18 |
| Leg Stretching Using an Exoskeleton on Demand for People With Spasticity Wearable Robotic Exoskeleton - Spasticity, Movement Disorders | Not applicable | Recruiting | VA Office of Research and Development | 10 | 2026-02-09 | 2026-10-02 |
| Classification of Upper and Lower Limb Spasticity Patterns and Their Impact on Quality of Life in Patients With Multiple Sclerosis Observational Assessment - Multiple Sclerosis, Spasticity | Completed | Marmara University | 77 | 2026-01-01 | 2026-11-03 | |
| Effects of Low-level Laser Therapy on Spasticity and Gait Parameters in Chronic Stroke Patients With Spastic Plantar Flexors Low Level Laser Therapy, conventional physical therapy - Stroke, Spasticity | Not applicable | Completed | Montiha Azeem | 22 | 2025-12-30 | 2026-05-05 |
| Effectiveness of an Interprofessional Approach to the Treatment of Spasticity With Botulinum Toxin & Non-pharmacological Therapies Botulinum Neurotoxin Type A, Non-pharmacological therapies - Spasticity | Not applicable | Not yet recruiting | Technical University of Bern | 30 | 2025-10-01 | 2025-09-08 |
| Static Versus Dynamic Splints for Wrist Spasticity in Stroke Patients Static Wrist-Hand Splint, Dynamic Wrist-Hand Splint - Stroke, Spasticity | Not applicable | Completed | University of Lahore | 20 | 2025-10-01 | 2025-12-24 |
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Muscle Spasticity (120) · Stroke (28) · Cerebral Palsy (24) · Multiple Sclerosis (22) · Spinal Cord Injuries (13) · Hemiplegia (6) · Brain Injuries, Traumatic (5) · Dystonia (4) · Muscle Hypertonia (4) · Pain (4) · Brain Injuries (3) · Movement Disorders (3) · Ataxia (2) · Dystonic Disorders (2) · Mobility Limitation (2)
Muscular Diseases (120) · Musculoskeletal Diseases (120) · Neurologic Manifestations (120) · Neuromuscular Manifestations (120) · Pathological Conditions, Signs and Symptoms (120) · Signs and Symptoms (120) · Nervous System Diseases (118) · Muscle Hypertonia (116) · Central Nervous System Diseases (66) · Brain Diseases (53) · Cardiovascular Diseases (30) · Cerebrovascular Disorders (29) · Vascular Diseases (29) · Brain Damage, Chronic (24) · Autoimmune Diseases (22)
Botulinum Toxins, Type A (12) · nabiximols (7) · Dry Needling (6) · Baclofen (4) · Botulinum Toxins (3) · Extracorporeal Shockwave Therapy (3) · Physical Therapy Modalities (3) · arbaclofen placarbil (3) · Clinical Trials, Phase II as Topic (2) · Clinical Trials, Phase III as Topic (2) · Electric Stimulation (2) · Low-Level Light Therapy (2) · Transcutaneous Electric Nerve Stimulation (2) · abobotulinumtoxinA (2) · incobotulinumtoxinA (2)
Ipsen (6) · Jazz Pharmaceuticals (6) · Kessler Foundation (6) · Vanderbilt University (6) · Foundation University Islamabad (3) · RVL Pharmaceuticals, Inc. (3) · Sun Pharma Advanced Research Company Limited (3) · The University of Texas Health Science Center, Houston (3) · Abant Izzet Baysal University (2) · Martin Piazza (2) · Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC (2) · Tanta University (2) · Universidad San Jorge (2) · Universiteit Antwerpen (2) · University Hospital of Mont-Godinne (2)
United States (42) · Spain (10) · United Kingdom (7) · Belgium (6) · Pakistan (6) · Russia (6) · Brazil (5) · Germany (5) · Italy (5) · South Korea (5) · Turkey (Türkiye) (5) · Ukraine (5) · Hungary (4) · Poland (4) · Taiwan (4)
David Charles, M.D. (2) · David Charles, MD (2) · Joseph T Hull, PhD (2) · Martin G Piazza, MD (2) · Sheng Li, MD, PhD (2) · Alessio Baricich (1) · Andrew Marshall, PhD (1) · Arnon Karni, MD (1) · Beom Seon Gwon, Ph.D (1) · Brad Dicianno, MD (1) · Chanqing Kao, MD, Ph.D. (1)
PMID 25475413, PMID 17086911, PMID 17355549, PMID 20360543, PMID 21362108, PMID 21878454, PMID 22200394, PMID 22878432, PMID 23468866, PMID 24151639, PMID 24607242, PMID 26030192, PMID 26157986, PMID 26276377, PMID 27149465, PMID 27547509, PMID 27871449, PMID 28867665, PMID 29753889, PMID 32488238, PMID 33057730, PMID 33106968, PMID 33156735, PMID 33551975, PMID 33923397, PMID 33978513, PMID 34339951, PMID 34532852, PMID 34894776, PMID 35727368, PMID 36136523, PMID 36831273, PMID 37090974, PMID 38770827, PMID 39001514, PMID 39394126, PMID 39675122, PMID 40050906, PMID 41082260
2025 (1), I21RX004652 (1), R21HD123083 (1)