14 completed, 3 unknown, 1 not yet recruiting, 1 recruiting. 9 Not applicable, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 9 | Completed 6, Unknown 2, Terminated 1 |
| Phase 4 | 2 | Completed 2 |
Follow Sinus Node Dysfunction: new trials by email Literature Review of Sinus Node Dysfunction trials Research Report on Sinus Node Dysfunction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Predicting Severe Cardiac Arrhythmias in the Perioperative Period Using AI-ECG digital single-channel ECG recording - Atrial Fibrillation, Atrioventricular Block, Second and Third Degree | Not yet recruiting | I.M. Sechenov First Moscow State Medical University | 300 | 2026-12-31 | 2026-02-10 | |
| Safety, Performance, and Clinical Benefit of Pacing the Left Bundle Branch Area - Post-Market Clinical Follow-up Pacemaker lead - Bradycardia, Atrioventricular Block | Recruiting | Boston Scientific Corporation | 140 | 2025-12-19 | 2026-10-07 | |
| BIOTRONIK Conduction System Pacing With the Solia Lead - Solia CSP S Solia CSP S lead - Sinus Node Dysfunction, Bradycardia | Not applicable | Completed | Biotronik, Inc. | 192 | 2024-12-18 | 2026-07-14 |
| LBBAP Data Collection Registry Implantation of the Tendril 2088 lead in the LBBA - Bradycardia, Sinus Node Dysfunction | Completed | Abbott Medical Devices | 221 | 2023-04-25 | 2024-10-08 | |
| Allometric-Pace Study Pacemaker lower rate setting - Sinus Node Dysfunction | Completed | Medtronic Cardiac Rhythm and Heart Failure | 73 | 2023-03-20 | 2025-02-07 | |
| Permanent Pacemaker Implantation or Cardioneuroablation in Sinus Node Dysfunction Permament pacemaker implantation, Cardioneuroablation - Sinus Node Dysfunction | Not applicable | Unknown | Stec, Sebastian, MD, PhD, FESC | 60 | 2022-06-01 | 2023-03-07 |
| Cardioneuroablation Versus Pacemaker Implantation for the Treatment of Symptomatic Sinus Node Dysfunction Cardioneuroablation, Permanent dual chamber pacemaker implantation - Sinus Node Dysfunction, Sick Sinus Syndrome | Not applicable | Unknown | Hospital Clinico Universitario de Santiago | 40 | 2021-11-01 | 2022-01-11 |
| Suture Closure AFtEr VEIN Access for Cardiac Procedures (SAFE-VEIN) Trial Perclose ProGlide Suture-Mediated Closure System (SMC) - LARGE-BORE PROCEDURES, Figure 8 Suture - LARGE-BORE PROCEDURES - Atrial Fibrillation, Atrial Flutter | Not applicable | Completed | Wake Forest University Health Sciences | 107 | 2021-04-23 | 2024-10-03 |
| The Fluoroless-CSP Trial Using Electroanatomic Mapping Conventional fluoroscopy guided Conduction System Pacing(CSP), Electroanatomic Mapping (Fluoroless) guided Conduction System Pacing(CSP) - Sinus Node Dysfunction, Heart Block AV | Not applicable | Completed | Rush University Medical Center | 2 | 2020-10-26 | 2025-02-28 |
| Left Bundle Area Versus Selective His Bundle Pacing Select Secure pacing lead - Bradycardia, Sinus Node Dysfunction | Not applicable | Terminated | David Haines, MD | 9 | 2019-10-07 | 2022-08-17 |
| Physiologic Pacing Registry Physiologic pacing device implant - Bradycardia, Sinus Node Dysfunction | Completed | Abbott Medical Devices | 870 | 2018-11-27 | 2024-08-19 | |
| Effectiveness of Closed Loop Stimulation (CLS) With His Bundle Lead Placement Treadmill/Bicycle exercise testing - Sinus Node Dysfunction | Not applicable | Completed | NYU Langone Health | 5 | 2018-07-19 | 2019-11-18 |
| Atrial Fibrillation With Sinus Node Dysfunction: Intensive Device Follow-up programing of pacemaker, AF ablation, Anti arryhthmic drugs - Sinus Node Dysfunction, Atrial Fibrillation | Unknown | The First Affiliated Hospital with Nanjing Medical University | 200 | 2018-07-04 | 2018-07-31 | |
| ImageReady(TM) MR Conditional Pacing System Clinical Study MRI, ImageReady System implant - Bradycardia, Sinus Node Dysfunction | Not applicable | Completed | Boston Scientific Corporation | 363 | 2013-02-01 | 2019-12-03 |
| Safety and Performance Study of the INGEVITY Lead INGEVITY lead - Bradycardia, Sinus Node Dysfunction | Not applicable | Completed | Boston Scientific Corporation | 1060 | 2012-10-01 | 2020-03-10 |
| Registry to Improve the Adoption of Consensus Treatment Guidelines (IMPROVE Brady) Evidence based guidelines and tools - Sinus Node Dysfunction | Completed | Medtronic Cardiac Rhythm and Heart Failure | 1342 | 2012-07-01 | 2021-09-17 | |
| Evolution of the PR Interval in Patients Implanted With a Pacemaker Using the SafeR Mode dual chamber pacemaker with SafeR algorithm - Sinus Node Dysfunction, Atrioventricular Block | Completed | LivaNova | 848 | 2012-04-01 | 2017-10-18 | |
| A Comparison of Rate Response Performance in Pacemaker Patients With an Indication of Sinus Node Dysfunction Reprogramming dual chamber pacemaker - Sinus Node Dysfunction | Completed | Arun Rao | 8 | 2011-11-01 | 2018-04-25 | |
| Prevention of Atrial Arrhythmia in Patients Without Atrioventricular (AV) Conduction Disease PACEMAKER SYMPHONY 2550 - Sinus Node Dysfunction, Brady Tachy Syndrome | Phase 4 | Completed | LivaNova | 400 | 2004-07-01 | 2010-07-27 |
| Spontaneous Atrio Ventricular Conduction Preservation Symphony D 2450, Symphony DR 2550 - Sinus Node Dysfunction, Bradycardia-Tachycardia Syndrome | Phase 4 | Completed | LivaNova | 622 | 2003-11-01 | 2008-04-09 |
Sick Sinus Syndrome (20) · Bradycardia (11) · Atrioventricular Block (6) · Atrial Fibrillation (3) · Heart Block (3) · Cardiomyopathies (2) · Heart Failure (2) · Syncope (2) · Tachycardia, Ventricular (2) · Arrhythmias, Cardiac (1) · Atrial Flutter (1) · Bundle-Branch Block (1) · Heart Failure, Systolic (1) · Neoplasm Metastasis (1) · Pulmonary Embolism (1)
Arrhythmia, Sinus (20) · Cardiac Conduction System Disease (20) · Cardiovascular Diseases (20) · Heart Diseases (20) · Pathologic Processes (20) · Pathological Conditions, Signs and Symptoms (20) · Arrhythmias, Cardiac (19) · Heart Block (17) · Consciousness Disorders (2) · Nervous System Diseases (2) · Neurobehavioral Manifestations (2) · Neurologic Manifestations (2) · Signs and Symptoms (2) · Tachycardia (2) · Unconsciousness (2)
Boston Scientific Corporation (3) · LivaNova (3) · Abbott Medical Devices (2) · Medtronic Cardiac Rhythm and Heart Failure (2) · Arun Rao (1) · Biotronik, Inc. (1) · David Haines, MD (1) · Hospital Clinico Universitario de Santiago (1) · I.M. Sechenov First Moscow State Medical University (1) · NYU Langone Health (1) · Rush University Medical Center (1) · Stec, Sebastian, MD, PhD, FESC (1) · The First Affiliated Hospital with Nanjing Medical University (1) · Wake Forest University Health Sciences (1)
United States (11) · France (7) · Italy (6) · Germany (5) · Spain (5) · Belgium (4) · United Kingdom (4) · Australia (3) · Canada (3) · China (3) · India (3) · Singapore (3) · Austria (2) · Hong Kong (2) · Malaysia (2)
Kwangdeok Lee (2) · Arun Rao, MD (1) · Carlos Minguito Carazo, MD (1) · Charles Love, MD (1) · Chirag Barbhaiya, MD (1) · David Haines, MD (1) · Mohammad E Mortada, MD (1) · Ronald Berger, MD, PhD (1) · Sebastian Stec, MD, PhD (1)