Evolution of the PR Interval in Patients Implanted With a Pacemaker Using the SafeR Mode

This observational trial aims to study the evolution of the PR interval in patients implanted with a dual chamber pacemaker with the SafeR mode. The investigators will assess the prevalence and the incidence of PR lengthening and the investigators will study the long PR interval management by physicians, depending on the data embedded in the pacemaker.

• dual chamber pacemaker with SafeR algorithm (Device), also known as Reply DR (Sorin Devices): SafeR is an AVB management algorithm: it provides AAI pacing while continuously monitoring AV conduction, it switches to DDD when detecting AVB I, II or III, according to the following criteria: (1) AVB I: 6 long PR intervals, (2) AVB II: 3 blocked atrial events/12 cycles, (3) AVB III: 2 consecutive blocked atrial events. It switches back to AAI mode when needed.

Primary outcomes

• Prolonged PR interval (> 200ms) in patients without AVB I at baseline (Incidence of "clinical" AVB1) [at 12 months]: This incidence will be measured using PR/AR histograms stored in the device memory

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* Patient implanted (primo-implant, replacement, upgrade) with a Sorin Group™ dual chamber pacemaker according to current available guidelines and IFU from less than three months.
* Since implantation, the device is programmed in SafeR mode
* Patient agreed to participate, after having received the appropriate and mandatory information

Exclusion Criteria:

* Patient contraindicated for cardiac pacing, according to current available guidelines
* Permanent atrial fibrillation
* Permanent high-degree AV block
* Patient not available for routine follow-up visits
* Patient already included in another clinical study
* Inability to understand the purpose of the study / refusal to cooperate
* minor age
* Pregnancy
* Life expectancy less than 12 months
* Under guardianship

• Jérôme TAIEB, MD, Principal investigator, CH du Pays d'Aix - Aix en Provence